James I Elliott

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis
    James I Elliott
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    EMBO Rep 4:189-94. 2003
  2. ncbi request reprint Phosphatidylserine exposure in B lymphocytes: a role for lipid packing
    James I Elliott
    Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London, W12 0NN, United Kingdom
    Blood 108:1611-7. 2006
  3. ncbi request reprint Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
    James I Elliott
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 7:808-16. 2005
  4. pmc The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products
    James I Elliott
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Arthritis Res Ther 7:R468-75. 2005
  5. ncbi request reprint Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes
    James I Elliott
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Diabetes 53:2012-7. 2004
  6. ncbi request reprint Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death
    Simon R J Taylor
    Medical Research Council, Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 180:300-8. 2008
  7. pmc Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses
    Simon R J Taylor
    Division of Medicine, Imperial College, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    J Leukoc Biol 85:978-86. 2009
  8. ncbi request reprint A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome
    Christiane Albrecht
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    Blood 106:542-9. 2005
  9. ncbi request reprint Regulatory T cells are resistant to apoptosis via TCR but not P2X7
    Simon R J Taylor
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, U K
    J Immunol 178:3474-82. 2007
  10. pmc Multidrug transporter activity in lymphocytes
    James I Elliott
    Membrane Transport Biology Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    Br J Pharmacol 143:899-907. 2004

Collaborators

Detail Information

Publications16

  1. pmc IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis
    James I Elliott
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    EMBO Rep 4:189-94. 2003
    ..Thus, IKCa1-mediated AVD is the earliest-defined essential step in calcium-induced apoptosis, required for both PtdSer translocation and cell death...
  2. ncbi request reprint Phosphatidylserine exposure in B lymphocytes: a role for lipid packing
    James I Elliott
    Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London, W12 0NN, United Kingdom
    Blood 108:1611-7. 2006
    ..The data suggest a model in which PS redistribution may occur by a translocase-independent mechanism at energetically favorable sites of membrane perturbation where lipid packing is decreased...
  3. ncbi request reprint Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
    James I Elliott
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 7:808-16. 2005
    ..This seems to be an all-or-none effect, coordinating the activity of most or all the molecules of a target protein in each cell. The data also suggest a new approach to circumventing multidrug resistance...
  4. pmc The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products
    James I Elliott
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Arthritis Res Ther 7:R468-75. 2005
    ..Furthermore, we argue that aponecrosis as induced by P2X7 is a cell death mechanism with characteristics that potentially have particular relevance to disease pathogenesis...
  5. ncbi request reprint Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes
    James I Elliott
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, UK
    Diabetes 53:2012-7. 2004
    ..Because NOD mice express a low activation threshold allele of the P2X7 receptor and the P2X7 gene maps to a locus associated with disease, P2X7 is a good candidate susceptibility gene for NOD diabetes...
  6. ncbi request reprint Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death
    Simon R J Taylor
    Medical Research Council, Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 180:300-8. 2008
    ..The mixed apoptotic/necrotic phenotype of P2X7-stimulated cells is consistent with a potential role for this death pathway in lupus disease...
  7. pmc Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses
    Simon R J Taylor
    Division of Medicine, Imperial College, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    J Leukoc Biol 85:978-86. 2009
    ..A potential mechanism for this tissue-specific P2X(7) expression in P2X(7)(-/-) animals is discussed, as is the implication that the immune and indeed neuronal functions of P2X(7) may have been underestimated...
  8. ncbi request reprint A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome
    Christiane Albrecht
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom
    Blood 106:542-9. 2005
    ..These data identify a mutation in ABCA1 that contributes to the defective PS translocation phenotype in our patient with SS...
  9. ncbi request reprint Regulatory T cells are resistant to apoptosis via TCR but not P2X7
    Simon R J Taylor
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, U K
    J Immunol 178:3474-82. 2007
    ....
  10. pmc Multidrug transporter activity in lymphocytes
    James I Elliott
    Membrane Transport Biology Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    Br J Pharmacol 143:899-907. 2004
    ..Surprisingly, the drug specificity of P-glycoprotein appears cell type dependent. The data indicate that a range of developmentally regulated, multidrug transporters can impose a barrier to treatment of immune disorders...
  11. pmc P2X7 deficiency attenuates renal injury in experimental glomerulonephritis
    Simon R J Taylor
    MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
    J Am Soc Nephrol 20:1275-81. 2009
    ..These results support a proinflammatory role for P2X7 in immune-mediated renal injury and suggest that the P2X7 receptor is a potential therapeutic target...
  12. pmc P2 receptors in renal pathophysiology
    Clare M Turner
    Imperial College Kidney and Transplant Institute, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Purinergic Signal 5:513-20. 2009
    ..Further studies of adenosine triphosphate signalling and P2 receptor expression in renal disorders could provide us with novel insights into the role of these receptors in both normal and abnormal kidney function...
  13. ncbi request reprint Characterisation of lymphocyte responses to Ca2+ in Scott syndrome
    James I Elliott
    Thromb Haemost 91:412-5. 2004
  14. pmc Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42
    Takeshi Sato
    Department of Biochemistry and Cell Biology, Center for Structural Biology, Stony Brook University, Stony Brook, New York 11794 5215, USA
    Biochemistry 45:5503-16. 2006
    ..Importantly, the designed peptide inhibitors significantly reduce the toxicity induced by Abeta42 on cultured rat cortical neurons...
  15. ncbi request reprint Structural role of glycine in amyloid fibrils formed from transmembrane alpha-helices
    Wei Liu
    Department of Biochemistry and Cell Biology, Center for Structural Biology, Stony Brook University, Stony Brook, New York 11794 5215, USA
    Biochemistry 44:3591-7. 2005
    ..We demonstrate that fibrillization can be disrupted with a new class of inhibitors that target the molecular grooves created by glycine...
  16. ncbi request reprint Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging
    Youssef Zaim Wadghiri
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 50:293-302. 2003
    ..This approach provides an in vivo method to detect Abeta in AD transgenic mice, and suggests that diagnostic MRI methods to detect Abeta in AD patients may ultimately be feasible...