D J Elliott

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection
    D J Elliott
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland
    Proc Natl Acad Sci U S A 97:5717-22. 2000
  2. ncbi Splicing and the single cell
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland, United Kingdom
    Histol Histopathol 15:239-49. 2000
  3. ncbi An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:2117-24. 2000
  4. ncbi Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development
    D J Elliott
    Medical Research Council Genetics Unit, Western General Hospital, Edinburgh, Scotland
    J Cell Sci 111:1255-65. 1998
  5. ncbi The molecular genetics of male infertility
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Bioessays 19:801-9. 1997
  6. pmc Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm
    D J Elliott
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
    Proc Natl Acad Sci U S A 94:3848-53. 1997
  7. ncbi An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Hum Mol Genet 5:869-74. 1996
  8. ncbi Understanding the genes involved in spermatogenesis: a progress report
    H J Cooke
    Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
    Fertil Steril 69:989-95. 1998
  9. ncbi RBMY genes and AZFb deletions
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    J Endocrinol Invest 23:652-8. 2000
  10. ncbi RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing
    J P Venables
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK
    Hum Mol Genet 9:685-94. 2000

Collaborators

  • H J Cooke
  • K Ma
  • P H Vogt
  • J P Venables
  • P T Saunders
  • Alfred Ross
  • X Lu
  • Ji Wu
  • C Vernet
  • P S Burgoyne
  • B M Cattanach
  • P Rajan
  • M Szot
  • J K Thornton
  • S K Mahadevaiah
  • A T Rovio
  • B Lifschitz-Mercer
  • A Rattigan
  • C Dalgliesh
  • C N Robson
  • H Y Leung
  • A El-Sherif
  • L Gaughan
  • I E Ehrmann
  • C Dalgleish
  • K A Sergeant
  • H T Jacobs
  • E von Glasenapp
  • A Toure
  • O A Ojarikre
  • V Grigoriev
  • J M A Turner
  • E Fritsche
  • R F Harrison
  • A Eisenthal
  • B Hughes
  • T Barrett
  • D R Marchington
  • T B Hargreave
  • Y H Wei
  • J M Cummins
  • H C Schuppe
  • A L Ahola
  • S Donat
  • D M Bailey
  • L Wichmann
  • D E Barton
  • L Leider-Trejo
  • J Poulton
  • B Bar-Shira Maymon
  • L Schreiber-Bramante
  • P Laippala
  • S H Kao
  • J Abel
  • A M Jequier
  • D Mehmet
  • D McNay
  • S H Laval
  • R Lovell-Badge
  • L L Washburn
  • J R McCarrey
  • T Odorisio
  • A Farquharson
  • V B Math

Detail Information

Publications18

  1. pmc A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection
    D J Elliott
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland
    Proc Natl Acad Sci U S A 97:5717-22. 2000
    ..Our results suggest that RBM protein is an evolutionarily conserved mammalian splicing regulator which operates as a germ cell-specific cofactor for more ubiquitously expressed pre-mRNA splicing activators...
  2. ncbi Splicing and the single cell
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland, United Kingdom
    Histol Histopathol 15:239-49. 2000
    ..In this review I suggest that one important factor is the ratio of proteins in different nuclear compartments, which might be established in a cell type specific fashion...
  3. ncbi An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:2117-24. 2000
    ..The existence of an additional testis-specific hnRNP G family member provides evidence for the importance of these proteins in normal germ cell development...
  4. ncbi Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development
    D J Elliott
    Medical Research Council Genetics Unit, Western General Hospital, Edinburgh, Scotland
    J Cell Sci 111:1255-65. 1998
    ..These results suggest dynamic and possibly multiple functions for RBM in germ cell development...
  5. ncbi The molecular genetics of male infertility
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Bioessays 19:801-9. 1997
    ..These studies have shown that genes in a number of different pathways are essential for normal spermatogenesis, and also provide putative models of human infertility...
  6. pmc Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm
    D J Elliott
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
    Proc Natl Acad Sci U S A 94:3848-53. 1997
    ..In the absence of detectable RBM expression we see stages of germ cell development up to early meiosis, but not past this point into the haploid phase of spermatogenesis...
  7. ncbi An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Hum Mol Genet 5:869-74. 1996
    ..p.p. which is the time at which the Y chromosome condenses during meiotic prophase. These results suggest that Rbm is functionally involved in germline RNA metabolism...
  8. ncbi Understanding the genes involved in spermatogenesis: a progress report
    H J Cooke
    Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
    Fertil Steril 69:989-95. 1998
    ..To review the current literature on genes known to affect fertility in the human and mouse...
  9. ncbi RBMY genes and AZFb deletions
    D J Elliott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    J Endocrinol Invest 23:652-8. 2000
    ..These findings imply that important pre-mRNA processing pathways might be disrupted in the germ cells of AZFb men...
  10. ncbi RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing
    J P Venables
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK
    Hum Mol Genet 9:685-94. 2000
    ..The RNA-binding domain of RBM affected 5' splice site selection. We conclude that the hnRNP G family of proteins is involved in pre-mRNA splicing and infer that RBM may be involved in Tra2beta-dependent splicing in spermatocytes...
  11. ncbi The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo
    J K Thornton
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle, UK
    Oncogene 25:3104-12. 2006
    ....
  12. ncbi T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis
    J P Venables
    Department of Biochemistry, University of Leicester, UK
    Hum Mol Genet 8:959-69. 1999
    ..RBM and other hnRNP G family members are candidate downstream targets for regulation by T-STAR/ETOILE and SAM68...
  13. ncbi Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities
    S K Mahadevaiah
    Laboratory of Developmental Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Hum Mol Genet 7:715-27. 1998
    ..In man, deletion of the functional copies of RBM is associated with meiotic arrest rather than sperm anomalies; however, the different effects of deletion are consistent with the differences in expression between the two species...
  14. ncbi Does Rbmy have a role in sperm development in mice?
    M Szot
    Division of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Cytogenet Genome Res 103:330-6. 2003
    ..The lack of RBMY was confirmed by western blotting of lysates from purified round spermatids and elongating spermatids. The implications of these results for the proposed role for RBMY in sperm development are discussed...
  15. ncbi Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility
    A T Rovio
    Ancobio Ltd, Glasgow, Scotland
    Nat Genet 29:261-2. 2001
    ..Analysis of POLG genotypes in different populations identified an association between absence of the common, ten-repeat allele and male infertility typified by a range of sperm quality defects but excluding azoospermia...
  16. ncbi Intratubular germ cell neoplasia: associated infertility and review of the diagnostic modalities
    B Lifschitz-Mercer
    Institute of Pathology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
    Int J Surg Pathol 9:93-8. 2001
    ..Identification of ITGCN cells in testicular biopsies, however, is a diagnostic challenge and markers are sorely needed to assist in the accurate identification of the lesion...
  17. ncbi Nucleotide sequence and gene organization of sea urchin mitochondrial DNA
    H T Jacobs
    Department of Genetics, University of Glasgow, Scotland, U K
    J Mol Biol 202:185-217. 1988
    ..The separation of the ribosomal RNA genes from each other and from the putative control region imposes special demands on the transcription of the genome...
  18. doi The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor
    P Rajan
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK
    J Pathol 215:67-77. 2008
    ..These results demonstrate that Sam68 has separable effects on AR-regulated transcriptional activity and alternative splicing, both of which may affect PCa phenotypes...