N Dillon

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint The role of enhancers as centres for general transcription factor recruitment
    Henrietta Szutorisz
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Trends Biochem Sci 30:593-9. 2005
  2. doi request reprint Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, UK
    Bioessays 34:194-204. 2012
  3. ncbi request reprint Gene regulation and large-scale chromatin organization in the nucleus
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Chromosome Res 14:117-26. 2006
  4. ncbi request reprint Functional gene expression domains: defining the functional unit of eukaryotic gene regulation
    N Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, London
    Bioessays 22:657-65. 2000
  5. doi request reprint The impact of gene location in the nucleus on transcriptional regulation
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12ONN, UK
    Dev Cell 15:182-6. 2008
  6. ncbi request reprint Unravelling heterochromatin: competition between positive and negative factors regulates accessibility
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, UK W12 0NN
    Trends Genet 18:252-8. 2002
  7. pmc The postdoctoral system under the spotlight
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London
    EMBO Rep 4:2-4. 2003
  8. pmc Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation
    P Sabbattini
    Gene Regulation and Chromatin Group and Central Research Facility, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    EMBO J 20:2812-22. 2001
  9. pmc Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region
    P Sabbattini
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Mol Cell Biol 19:671-9. 1999
  10. ncbi request reprint Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice
    J Strouboulis
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, London, UK
    Genes Dev 6:1857-64. 1992

Collaborators

Detail Information

Publications27

  1. ncbi request reprint The role of enhancers as centres for general transcription factor recruitment
    Henrietta Szutorisz
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Trends Biochem Sci 30:593-9. 2005
    ..We propose that an important role of some enhancers is to function as nucleation centres for the assembly of the pre-initiation complex to regulate the timing of gene activation during development, differentiation and the cell cycle...
  2. doi request reprint Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, UK
    Bioessays 34:194-204. 2012
    ..The overall effect of factor-mediated priming is to initiate the input of information required for cell differentiation before the first lineage choices have been made...
  3. ncbi request reprint Gene regulation and large-scale chromatin organization in the nucleus
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Chromosome Res 14:117-26. 2006
    ..There is also evidence that transcription is organized into structures called 'factories' and that this can lead to inter-chromosomal contacts between genes that have the potential to influence their regulation...
  4. ncbi request reprint Functional gene expression domains: defining the functional unit of eukaryotic gene regulation
    N Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, London
    Bioessays 22:657-65. 2000
    ..As a result, insulators would often be found near the borders of domains without necessarily being selected to act as boundaries...
  5. doi request reprint The impact of gene location in the nucleus on transcriptional regulation
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12ONN, UK
    Dev Cell 15:182-6. 2008
    ..A growing body of data identifies the nuclear envelope as a major organizer of location-specific interactions for both silent and active genes...
  6. ncbi request reprint Unravelling heterochromatin: competition between positive and negative factors regulates accessibility
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, UK W12 0NN
    Trends Genet 18:252-8. 2002
    ....
  7. pmc The postdoctoral system under the spotlight
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London
    EMBO Rep 4:2-4. 2003
  8. pmc Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation
    P Sabbattini
    Gene Regulation and Chromatin Group and Central Research Facility, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    EMBO J 20:2812-22. 2001
    ....
  9. pmc Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region
    P Sabbattini
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Mol Cell Biol 19:671-9. 1999
    ....
  10. ncbi request reprint Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice
    J Strouboulis
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, London, UK
    Genes Dev 6:1857-64. 1992
    ..These results suggest that multiple changes in DNA sequences and transcription factor balance must have occurred for the human gamma-globin gene to have evolved into a fetal gene...
  11. ncbi request reprint Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes
    J A Skok
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Nat Immunol 2:848-54. 2001
    ..However, this differential recruitment and expression of Ig alleles was not typically seen among transformed B cell lines. These data raise the possibility that epigenetic factors help maintain the monoallelic expression of Ig...
  12. ncbi request reprint Chromatin domains as potential units of eukaryotic gene function
    N Dillon
    National Institute for Medical Research, London, UK
    Curr Opin Genet Dev 4:260-4. 1994
    ....
  13. ncbi request reprint A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin
    M Berry
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK
    Nature 358:499-502. 1992
    ..We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults...
  14. pmc Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage
    Henrietta Szutorisz
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    Mol Cell Biol 25:1804-20. 2005
    ..These results suggest that localized epigenetic marking is important for establishing the transcriptional competence of the lambda5 and VpreB1 genes as early as the pluripotent ES cell stage...
  15. ncbi request reprint Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication
    Veronique Azuara
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Nat Cell Biol 5:668-74. 2003
    ..These findings emphasise that chromosomal location is important for defining the replication timing of genes and show that retarded sister-chromatid resolution is a novel feature of inactive chromatin...
  16. doi request reprint Cohesins functionally associate with CTCF on mammalian chromosome arms
    Vania Parelho
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell 132:422-33. 2008
    ..Recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because CTCF binding is sensitive to DNA methylation, allows cohesin positioning to integrate DNA sequence and epigenetic state...
  17. pmc A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells
    Pierangela Sabbattini
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    EMBO J 26:4657-69. 2007
    ....
  18. ncbi request reprint [Suppression of non-specific transcription by the proteasome in embryonic stem cells]
    Henrietta Szutorisz
    Med Sci (Paris) 23:351-3. 2007
  19. ncbi request reprint Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits
    Elizabeth C Thompson
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Immunity 26:335-44. 2007
    ..Aiolos expression was controlled by pre-BCR signals via the adaptor protein SLP-65. Thus, pre-BCR signaling regulates Aiolos and the silencing of Igll1 via a developmental-stage-specific feedback loop...
  20. ncbi request reprint The proteasome restricts permissive transcription at tissue-specific gene loci in embryonic stem cells
    Henrietta Szutorisz
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Cell 127:1375-88. 2006
    ....
  21. ncbi request reprint Gene autonomy: positions, please
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 425:457. 2003
  22. ncbi request reprint Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain
    Sophia Minaee
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Mol Immunol 42:1283-92. 2005
    ..The VpreB1 and Topo3beta genes have entirely different expression patterns despite the fact that the two promoters are separated by a distance of only 1.5 kb...
  23. pmc Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division
    Cheok Man Chow
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London W12 0NN, UK
    EMBO Rep 6:354-60. 2005
    ..Our results suggest that H3.3 is deposited principally through the action of chromatin-remodelling complexes associated with transcriptional initiation, with deposition mediated by RNA polymerase II elongation having only a minor role...
  24. ncbi request reprint The lambda5-VpreB1 locus--a model system for studying gene regulation during early B cell development
    Pierangela Sabbattini
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Semin Immunol 17:121-7. 2005
    ..Silencing of lambda5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure...
  25. ncbi request reprint Heterochromatin structure and function
    Niall Dillon
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Biol Cell 96:631-7. 2004
    ..Finally, very recent studies using genetic and biochemical approaches have indicated that the RNAi machinery plays an important role in the formation of heterochromatin...
  26. ncbi request reprint The epigenetic basis for embryonic stem cell pluripotency
    Henrietta Szutorisz
    Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    Bioessays 27:1286-93. 2005
    ....
  27. pmc The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes
    Katalin Takacs
    Lymphocyte Development Group, Gene Regulation and Chromatin Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College of Science, Technology, Du Cane Road, London W12 ONN, United Kingdom
    Proc Natl Acad Sci U S A 101:16298-303. 2004
    ..These results show that antigen-mediated regulation of memory lymphocytes can be used as a strategy for delivering therapeutic proteins in vivo...