Affiliation: National Institute for Medical Research
- Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infectionStefania Crotta
Department of Microbial Molecular Biology, Novartis Vaccines and Diagnostics, Siena, Italy
J Hepatol 52:183-90. 2010..We have previously demonstrated that natural killer (NK) cells can be inhibited in vitro by recombinant HCV glycoprotein E2 via cross-linking of CD81, a cellular co-receptor for the virus...
- Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggsPirada Suphaphiphat
Novartis Vaccines and Diagnostics, Cambridge, MA, USA
Virol J 7:157. 2010..Thus, we have demonstrated that molecular cloning of members of a quasispecies can help in selection of seed viruses for vaccine manufacture...
- CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytesMichela Brazzoli
Department of Molecular Immunology, Novartis Vaccines and Diagnostics, Siena, Italy
J Virol 82:8316-29. 2008..In conclusion, we describe a range of cellular events that are manipulated by HCV to coordinate interactions with its multiple coreceptors and to establish productive infections and find that CD81 is a central regulator of these events...
- Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cellsStefania Crotta
Chiron Vaccines, Siena, Italy
Eur J Immunol 36:919-29. 2006..We propose that tetraspanin engagement leads to comparable cytoskeleton reorganization in T and NK cells, which in turn results in opposite functional outcomes...
- Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell lineMichela Brazzoli
Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
J Hepatol 46:53-9. 2007....