S F Cooke
Affiliation: National Institute for Medical Research
- Long-term potentiation and cognitive drug discoverySam F Cooke
National Institute for Medical Research, London, UK
Curr Opin Investig Drugs 6:25-34. 2005..In this review we describe the contributions of pharmacology to the field of synaptic plasticity, and also discuss the role of LTP in developing potential nootropic drugs to enhance learning and memory...
- Plasticity in the human central nervous systemS F Cooke
Division of Neurophysiology, National Institute for Medical Research London, UK
Brain 129:1659-73. 2006..These techniques have potential therapeutic application in manipulating neural plasticity to treat a variety of conditions, including depression, Parkinson's disease, epilepsy and neuropathic pain...
- Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouseSam F Cooke
MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Physiol 574:805-18. 2006..Thus, the autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse...
- Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndromeElise Morice
Division of Neurophysiology, National Institute for Medical Research, London NW7 1AA, United Kingdom
Learn Mem 15:492-500. 2008..Our observations also provide further evidence that STM and LTM for hippocampus-dependent tasks are subserved by parallel processing streams...
- The genetic enhancement of memoryS F Cooke
Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
Cell Mol Life Sci 60:1-5. 2003
- Synaptic plasticity, memory and the hippocampus: a neural network approach to causalityGuilherme Neves
Division of Neurophysiology, Medical Research Council National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
Nat Rev Neurosci 9:65-75. 2008..In the process, the hypothesis that synaptic plasticity is necessary and sufficient for information storage in the brain may finally be validated...
- Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memoriesNiels Plath
Molecular Neurobiology, Department of Biology Chemistry Pharmacy, Freie Universitat Berlin, 14195 Berlin, Germany
Neuron 52:437-44. 2006..In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage...
- Glycogen synthase kinase-3 inhibition is integral to long-term potentiationClaudie Hooper
MRC Centre for Neurodegeneration Research, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Eur J Neurosci 25:81-6. 2007..It follows that this role of GSK-3beta in LTP might underlie some of the cognitive dysfunction in diseases where GSK-3 dysfunction has been implicated, including Alzheimer's and other dementias...