Research Topics
Genomes and Genes | D CarlingSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Publications
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinaseFaith V Mayer
MRC Clinical Sciences Centre, Cellular Stress Group, Hammersmith Hospital Campus, Imperial College, DuCane Road, London, UK
Cell Metab 14:707-14. 2011..Mutagenesis experiments suggest that the general mechanism by which ADP protects against dephosphorylation is strongly conserved between SNF1 and AMPK...
Bypassing the glucose/fatty acid cycle: AMP-activated protein kinaseD Carling
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U K
Biochem Soc Trans 31:1157-60. 2003....
The regulation of AMP-activated protein kinase by upstream kinasesD Carling
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
Int J Obes (Lond) 32:S55-9. 2008..This review focuses on the role of LKB1 and CaMKKbeta in the regulation of AMPK...- AMPKDavid Carling
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Curr Biol 14:R220. 2004 - The AMP-activated protein kinase cascade--a unifying system for energy controlDavid Carling
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
Trends Biochem Sci 29:18-24. 2004..AMPK could provide a link in human diseases of which the underlying cause is due to defects in energy metabolism... - Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP bindingP C Cheung
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
Biochem J 346:659-69. 2000..Labelling studies, using the reactive AMP analogue 8-azido-[(32)P]AMP, indicate that the gamma subunit may participate directly in the binding of AMP within the complex... - The regulation of AMP-activated protein kinase by phosphorylationS C Stein
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, U K
Biochem J 345:437-43. 2000..Furthermore, we provide evidence that phosphorylation of Thr(172) may be involved in the sensitivity of the AMPK complex to AMP... - The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1F C Smith
MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
FEBS Lett 453:219-23. 1999..The latter three are exact matches to the recognition motif we previously defined for SNF1 and lie within regions shown to be required for SNF1-dependent derepression and nuclear-to-cytoplasmic translocation... - Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscleC Thornton
Medical Research Council Clinical Sciences Centre, Cellular Stress Group, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, United Kingdom
J Biol Chem 273:12443-50. 1998..These results suggest that the beta isoforms have tissue-specific roles, which may involve altered responses to upstream signaling and/or downstream targeting of the AMPK complex... - The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitroA Woods
MRC Molecular Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
FEBS Lett 397:347-51. 1996..Using variant peptides, however, we show that alpha1 and alpha2 exhibit slightly different substrate preferences, which suggest that the two isoforms could play different physiological roles within the cell... - The regulation and function of mammalian AMPK-related kinasesN J Bright
Cellular Stress Group, MRC Clinical Sciences Centre, London, UK
Acta Physiol (Oxf) 196:15-26. 2009..This review outlines the general similarities in structure and function of the AMPK-related kinases before examining the specific characteristics of each, including a brief discussion of the SNRK family... - AMP-activated protein kinase and the metabolic syndromeL G D Fryer
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Biochem Soc Trans 33:362-6. 2005..Indeed, a number of physiological and pharmacological factors that are beneficial in these disorders have been shown to act, at least in part, through the activation of AMPK... - Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitroA Woods
Medical Research Council Clinical Sciences Centre, Department of Molecular Medicine, Royal Postgraduate Medical School, DuCane Road, London W12 0NN, United Kingdom
J Biol Chem 271:10282-90. 1996..These results suggest that AMPKbeta mediates the association of the heterotrimeric AMPK complex in vitro, and will facilitate future studies aimed at investigating the regulation of AMPK in vivo... - Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cellsAngela Woods
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
Cell Metab 2:21-33. 2005..These results demonstrate that AMPK is regulated by at least two upstream kinases and suggest that AMPK may play a role in Ca(2+)-mediated signal transduction pathways... - AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismBarbara B Kahn
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Cell Metab 1:15-25. 2005..Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes... - Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491Sandrine Horman
Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
J Biol Chem 281:5335-40. 2006.... - CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPKMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia
Nat Med 12:541-8. 2006.... - Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartJi Li
Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
Am J Physiol Heart Circ Physiol 291:H1927-34. 2006..Despite the pathophysiological importance of gamma(2)-isoform mutations, gamma(1)-isoform complexes account for most of the AMPK activity in the ischemic heart... - Exercise in rats does not alter hypothalamic AMP-activated protein kinase activityUlrika Andersson
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, DuCane Road, London W12 0NN, UK
Biochem Biophys Res Commun 329:719-25. 2005..Thus, changes in energy metabolism during or after exercise are likely not coordinated by changes in hypothalamic AMPK activity... - Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase betaNadine Stahmann
Institute of Molecular Cell Biology, Friedrich Schiller University of Jena, Nonnenplan 2, 07743 Jena, Germany
Mol Cell Biol 26:5933-45. 2006..We also demonstrate that endothelial cells possess two pathways to activate AMPK, one Ca2+/CaMKKbeta dependent and one AMP/LKB1 dependent... - Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascadeMatthew J Sanders
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Biochem J 403:139-48. 2007..This model accounts for activation of AMPK by two distinct signals: a Ca2+-dependent pathway, mediated by CaMKKbeta and an AMP-dependent pathway, mediated by LKB1... - Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cellsKenneth K Y Cheng
Department of Medicine, University of Hong Kong, Hong Kong, China
Diabetes 56:1387-94. 2007..Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation... - Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelinMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, S Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
Cell Metab 7:389-99. 2008..Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding... - Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expressionClaire Thornton
Medical Research Council MRC Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, United Kingdom
J Biol Chem 283:17116-22. 2008..These data support a hypothesis that modulating basal AMPK activity in the hypothalamus is essential for maintaining tight regulation of pathways contributing to food intake... - Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylationNicola J Bright
Medical Research Council Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London, United Kingdom
J Biol Chem 283:14946-54. 2008..Furthermore, stimuli that activate AMPK had no effect on BRSK1/2. Finally, we provide evidence suggesting that protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2... - The role of the AMP-activated protein kinase in the regulation of energy homeostasisDavid Carling
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Novartis Found Symp 286:72-81; discussion 81-5, 162-3, 196-203. 2007..AMPK, therefore, provides a mechanism for monitoring changes in energy metabolism within individual cells and at the level of the whole body... - Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter HorsesPatricia K Dranchak
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
Am J Vet Res 68:1079-84. 2007..To evaluate whether biochemical or genetic alterations in AMP-activated protein kinase (AMPK) play a role in the development of polysaccharide storage myopathy (PSSM) in Quarter Horses... - Structural basis for AMP binding to mammalian AMP-activated protein kinaseBing Xiao
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nature 449:496-500. 2007..The structure also suggests a mechanism for propagating AMP/ATP signalling whereby a phosphorylated residue from the alpha and/or beta subunits binds to the gamma subunit in the presence of AMP but not when ATP is bound... - Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone familyMatthew J Sanders
Cellular Stress Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College, DuCane Road, London, United Kingdom
J Biol Chem 282:32539-48. 2007..Importantly, this model may provide clues for understanding the mechanism by which AMP leads to activation of AMPK, which in turn may help in the identification of other AMPK activators... - AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neuronsMarc Claret
Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
J Clin Invest 117:2325-36. 2007.... - S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinaseVictor Aguilar
INSERM, U845, Paris F 75015, France Université Paris Descartes, UMRS 845, Paris F 75015, France
Cell Metab 5:476-87. 2007..These data indicate that S6K1 controls the energy state of the cell and the AMPK-dependent metabolic program, providing a mechanism for cell mass accumulation under high-calorie diet... - AMP-activated protein kinase: balancing the scalesDavid Carling
MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
Biochimie 87:87-91. 2005..Taken together these findings indicate that AMPK has a pivotal role in regulating pathways that control both energy expenditure and energy intake... - Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndromeJasvinder S Sidhu
Baylor College of Medicine, Houston, Tex, USA
Circulation 111:21-9. 2005..The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertrophy... - The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivityBenoit Viollet
Department of Genetic, Development, and Molecular Pathology, Institut National de la Sante et de la Recherche Medicale INSERM, Centre National de la Recherche Scientifique CNRS, Rene Descartes University, Paris, France
J Clin Invest 111:91-8. 2003..Therefore, extramuscular AMPKalpha2 catalytic subunit is important for whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity... - Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinaseReza Halse
School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne, U.K
Diabetes 52:9-15. 2003..These data support a role for AMPK in both stimulating glucose uptake and inhibiting GS in intact cells, thus promoting glucose flux through glycolysis... - Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide ribosideLee G D Fryer
Cellular Stress Group, MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London, UK
FEBS Lett 531:189-92. 2002..Our results demonstrate that careful interpretation is required when using AICA riboside in conjunction with protein kinase inhibitors to investigate the physiological role of AMPK... - Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndromeTyrone Daniel
Cellular Stress Group, MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London W12 0NN, United Kingdom
J Biol Chem 277:51017-24. 2002..These results indicate that mutations in gamma(2) have different effects on AMPK function, suggesting that they may lead to abnormal development of the heart through distinct mechanisms... - Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contractionBrian R Barnes
Department of Clinical Physiology and Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
Diabetes 51:2703-8. 2002..Activation of AMPKalpha2 in response to muscle contraction/ exercise is associated with a parallel and normal increase in glucose transport in insulin-resistant skeletal muscle... - Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)Kay Barnes
School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
J Cell Sci 115:2433-42. 2002..These enzymes, which have been implicated in stress-regulated pathways in other cell types, are therefore unlikely to play a role in transport regulation by stress in Clone 9 cells... - The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathwaysLee G D Fryer
Cellular Stress Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London W12 0NN, United Kingdom
J Biol Chem 277:25226-32. 2002..Our results demonstrate that AMPK can be activated by at least two distinct signaling mechanisms and suggest that it may play a wider role in the cellular stress response than was previously understood... - AMP-activated kinase regulates cytoplasmic HuRWengong Wang
Laboratory of Cellular and Molecular Biology, National Institute on Aging Internal Research Program, National Institutes of Health, Baltimore, Mayland 21224 6825, USA
Mol Cell Biol 22:3425-36. 2002..We therefore propose a novel function for AMPK as a regulator of cytoplasmic HuR levels, which in turn influences the mRNA-stabilizing function of HuR and the expression of HuR target transcripts... - Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunitsTyrone Daniel
Cellular Stress Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, U.K
Biochem J 365:629-38. 2002..In yeast, the glucose signalling pathway is able to activate AMPK, suggesting that the mammalian and yeast kinase pathways are conserved... - Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cellsLee G D Fryer
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road London, W12 0NN, UK
Biochem J 363:167-74. 2002..Our results add further support to the hypothesis that long-term activation of AMPK is involved in the adaptive response of muscle to exercise training... - Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseYasuhiko Minokoshi
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Nature 415:339-43. 2002..Blocking AMPK activation inhibits the phosphorylation of ACC stimulated by leptin. Our data identify AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle... - Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR functionWengong Wang
Laboratory of Cellular and Molecular Biology, NIA Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
J Biol Chem 278:27016-23. 2003..Together, our results indicate that AMPK activation can cause premature fibroblast senescence through mechanisms that likely involve reduced HuR function... - Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activationYasuo Ido
Boston Medical Center, EBRC 820, Diabetes and Metabolism Unit, Section of Endocrinology and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Diabetes 51:159-67. 2002..They also suggest that AMPK could play an important role in protecting the endothelial cell against the adverse effects of sustained hyperglycemia... - AMP-activated protein kinase plays a role in the control of food intakeUlrika Andersson
Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
J Biol Chem 279:12005-8. 2004..These findings demonstrate that AMPK plays a role in the regulation of feeding and identify AMPK as a novel target for anti-obesity drugs... - Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient statusSusan W Y Cheng
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Biol Chem 279:15719-22. 2004..These data suggest differential phosphorylation Thr2446 and Ser2448 could act as a switch mechanism to integrate signals from nutrient status and growth factors to control the regulation of protein translation... - LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeAngela Woods
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
Curr Biol 13:2004-8. 2003..These results identify a link between two protein kinases, previously thought to lie in unrelated, distinct pathways, that are associated with human diseases... - Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coliDietbert Neumann
Institute of Cell Biology, Swiss Federal Institute of Technology, , , Switzerland
Protein Expr Purif 30:230-7. 2003.... - Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinasesSeung Pyo Hong
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:8839-43. 2003..Thus, the identification of the yeast upstream kinases should facilitate identification of the corresponding, physiologically important mammalian upstream kinases... - Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acidsHilary Clark
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
Eur J Biochem 271:2215-24. 2004..The concept is discussed that activation of AMPK by an unknown fatty acid-driven signalling process provides a mechanism for a 'feed-forward' activation of fatty acid oxidation... - Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndromeJoanna K Davies
Cellular Stress Group, Medical Research Council Clinical Sciences Centre, Hammersmith Campus, Imperial College London, London W12 ONN, UK
Am J Physiol Heart Circ Physiol 290:H1942-51. 2006..The subsequent decrease in AMPK activity provides a mechanism that may explain the development of cardiac hypertrophy in this model... - Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesisAngela Woods
Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and Université de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
J Biol Chem 278:28434-42. 2003..The newly identified phosphorylation sites could play a subtle role in the regulation of AMPK, e.g. in subcellular localization or substrate recognition... - Neuregulin signaling on glucose transport in muscle cellsCarles Canto
Departament de Bioquímica i Biologia Molecular and Parc Científic de Barcelona, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
J Biol Chem 279:12260-8. 2004..The PI3K, PDK1, and PKCzeta pathway can be considered as an alternative mechanism, independent of insulin, to induce glucose uptake... - Cellular energy sensor balances the scalesCaroline J Small
Nat Med 10:681-2. 2004 - LKB1: a sweet side to Peutz-Jeghers syndrome?David Carling
Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Trends Mol Med 12:144-7. 2006..These findings should help solve the mystery surrounding the function of metformin, which has lasted for >30 years... - Low utilization of circulating glucose after food withdrawal in Snell dwarf miceNatasha L Brooks
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 282:35069-77. 2007.... - Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signalingGregory R Steinberg
St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
Cell Metab 4:465-74. 2006..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity... - A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunitsRosa Viana
Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas, Jaime Roig 11, 46010 Valencia, Spain
J Biol Chem 282:16117-25. 2007..In addition, sequential deletions from the C termini of the gamma subunits indicate that deletion of any of the CBS (cystathionine beta-synthase) motifs prevents the formation of a functional complex with the alpha and beta subunits... - Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinaseNobuyuki Kuramoto
Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuron 53:233-47. 2007..Together our results provide evidence of a neuroprotective mechanism, which, under conditions of metabolic stress or after ischemia, increases GABA(B) receptor function to reduce excitotoxicity and thereby promotes neuronal survival...