Research Topics
Species | Subrata K BoseSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imagingSubrata K Bose
MRC Clinical Sciences Centre, Imperial College London, United Kingdom
Schizophr Res 106:148-55. 2008..Overall, these analyses have shown the potential utility of pattern recognition tools in the classification of psychiatric patients based upon molecular imaging of a single target...
The effect of ageing on grey and white matter reductions in schizophreniaSubrata K Bose
MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
Schizophr Res 112:7-13. 2009..This suggests that illness related factors may differentially affect grey and white matter, with implications for understanding the pathophysiology of schizophrenia and related psychotic disorders...
Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging studyOliver D Howes
Hammersmith Hospital, London, UK
Am J Psychiatry 168:1311-7. 2011..The authors addressed this issue by measuring dopamine synthesis capacity in individuals at ultra-high risk of psychosis and then following them to determine their clinical outcome...
Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an exampleFederico E Turkheimer
MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
J Cereb Blood Flow Metab 32:70-80. 2012..Test-retest results demonstrated a tight linear relationship between BP(D) calculated either with plasma or with a reference input and high reproducibility...
Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brainSubrata K Bose
PET Methodology, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London, UK
Neuropsychopharmacology 36:2258-65. 2011..This latter finding may reflect differences in 5-HT tone between individuals, and highlights probable substrates sensitive to variations in DRN 5-HT function...
The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET studyKit Wu
Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK
Brain 135:2449-57. 2012....
Inflammation after trauma: microglial activation and traumatic brain injuryAnil F Ramlackhansingh
Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
Ann Neurol 70:374-83. 2011..In this study, we investigate whether an inflammatory response to TBI persists, and whether this response relates to structural brain abnormalities and cognitive function...
Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesiasImtiaz Ahmed
Centre for Neuroscience, Imperial College, London, UK
Brain 134:979-86. 2011..They support the hypothesis that blockade of glutamate transmission may have a place in the management of disabling dyskinesias in Parkinson's disease...
Characterization of the anterior cingulate's role in the at-risk mental state using graph theoryLouis David Lord
Department of Experimental Medicine, Imperial College London, London, UK
Neuroimage 56:1531-9. 2011..These findings provide evidence of network abnormalities and anterior cingulate cortex dysfunction in people with prodromal signs of schizophrenia...
Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformityAlice Egerton
Institute of Psychiatry, King s College London, London, UK
Neuroimage 53:777-81. 2010..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunctionNicola Pavese
Department of Medicine, Centre for Neuroscience, Imperial College, London, UK
Brain 133:3434-43. 2010..These findings imply that strategies to increase brain level of serotonin would be a rational approach for relieving fatigue symptoms in Parkinson's disease and may also be relevant to alleviating fatigue in other clinical conditions...
Increased frontoparietal integration after stroke and cognitive recoveryDavid J Sharp
Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital Campus, London, UK
Ann Neurol 68:753-6. 2010..This change reflects greater top-down control of speech comprehension and provides a mechanism by which language impairments after stroke may be compensated for...
