Subrata K Bose
Affiliation: National Institute for Medical Research
- Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imagingSubrata K Bose
MRC Clinical Sciences Centre, Imperial College London, United Kingdom
Schizophr Res 106:148-55. 2008..Overall, these analyses have shown the potential utility of pattern recognition tools in the classification of psychiatric patients based upon molecular imaging of a single target...
- The effect of ageing on grey and white matter reductions in schizophreniaSubrata K Bose
MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
Schizophr Res 112:7-13. 2009..This suggests that illness related factors may differentially affect grey and white matter, with implications for understanding the pathophysiology of schizophrenia and related psychotic disorders...
- Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging studyOliver D Howes
Hammersmith Hospital, London, UK
Am J Psychiatry 168:1311-7. 2011..The authors addressed this issue by measuring dopamine synthesis capacity in individuals at ultra-high risk of psychosis and then following them to determine their clinical outcome...
- Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an exampleFederico E Turkheimer
MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
J Cereb Blood Flow Metab 32:70-80. 2012..Test-retest results demonstrated a tight linear relationship between BP(D) calculated either with plasma or with a reference input and high reproducibility...
- Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brainSubrata K Bose
PET Methodology, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London, UK
Neuropsychopharmacology 36:2258-65. 2011..This latter finding may reflect differences in 5-HT tone between individuals, and highlights probable substrates sensitive to variations in DRN 5-HT function...
- The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET studyKit Wu
Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK
Brain 135:2449-57. 2012....
- Inflammation after trauma: microglial activation and traumatic brain injuryAnil F Ramlackhansingh
Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
Ann Neurol 70:374-83. 2011..In this study, we investigate whether an inflammatory response to TBI persists, and whether this response relates to structural brain abnormalities and cognitive function...
- Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesiasImtiaz Ahmed
Centre for Neuroscience, Imperial College, London, UK
Brain 134:979-86. 2011..They support the hypothesis that blockade of glutamate transmission may have a place in the management of disabling dyskinesias in Parkinson's disease...
- Characterization of the anterior cingulate's role in the at-risk mental state using graph theoryLouis David Lord
Department of Experimental Medicine, Imperial College London, London, UK
Neuroimage 56:1531-9. 2011..These findings provide evidence of network abnormalities and anterior cingulate cortex dysfunction in people with prodromal signs of schizophrenia...
- Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformityAlice Egerton
Institute of Psychiatry, King s College London, London, UK
Neuroimage 53:777-81. 2010..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
- Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunctionNicola Pavese
Department of Medicine, Centre for Neuroscience, Imperial College, London, UK
Brain 133:3434-43. 2010..These findings imply that strategies to increase brain level of serotonin would be a rational approach for relieving fatigue symptoms in Parkinson's disease and may also be relevant to alleviating fatigue in other clinical conditions...
- Increased frontoparietal integration after stroke and cognitive recoveryDavid J Sharp
Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital Campus, London, UK
Ann Neurol 68:753-6. 2010..This change reflects greater top-down control of speech comprehension and provides a mechanism by which language impairments after stroke may be compensated for...