Wendy A Bickmore

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint Chromatin organization in the mammalian nucleus
    Nick Gilbert
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Int Rev Cytol 242:283-336. 2005
  2. pmc Anterior-posterior differences in HoxD chromatin topology in limb development
    Iain Williamson
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Development 139:3157-67. 2012
  3. pmc Addressing protein localization within the nucleus
    Wendy A Bickmore
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    EMBO J 21:1248-54. 2002
  4. ncbi request reprint Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population
    Wendy A Bickmore
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Chromosome Res 10:707-15. 2002
  5. ncbi request reprint Dispatch. Chromosome position: now, where was I?
    Wendy A Bickmore
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Curr Biol 13:R357-9. 2003
  6. ncbi request reprint Perturbations of chromatin structure in human genetic disease: recent advances
    Wendy A Bickmore
    MRC Human Genetics Unit, Edinburgh EH4 2XU, Scotland, UK
    Hum Mol Genet 12:R207-13. 2003
  7. pmc Recruitment to the nuclear periphery can alter expression of genes in human cells
    Lee E Finlan
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 4:e1000039. 2008
  8. pmc Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
    Ragnhild Eskeland
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Mol Cell 38:452-64. 2010
  9. pmc Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd
    Céline Morey
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh University, Crewe Road, Edinburgh EH4 2XU, UK
    J Cell Sci 121:571-7. 2008
  10. pmc KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies
    Stephanie Briers
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
    J Cell Sci 122:937-46. 2009

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Chromatin organization in the mammalian nucleus
    Nick Gilbert
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Int Rev Cytol 242:283-336. 2005
    ..This arrangement in the nucleus presumably facilitates cellular functions to occur in an efficient and ordered fashion and exploring the link between transcription and nuclear organization will be an exciting area of further research...
  2. pmc Anterior-posterior differences in HoxD chromatin topology in limb development
    Iain Williamson
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Development 139:3157-67. 2012
    ..This is the first example of A-P differences in chromatin compaction and chromatin looping in the development of the mammalian secondary body axis (limb)...
  3. pmc Addressing protein localization within the nucleus
    Wendy A Bickmore
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    EMBO J 21:1248-54. 2002
    ....
  4. ncbi request reprint Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population
    Wendy A Bickmore
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Chromosome Res 10:707-15. 2002
    ..Lastly, it is suggested that nuclear organization of chromosomes impinges on the frequency of translocations amongst the smallest autosomes...
  5. ncbi request reprint Dispatch. Chromosome position: now, where was I?
    Wendy A Bickmore
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Curr Biol 13:R357-9. 2003
    ....
  6. ncbi request reprint Perturbations of chromatin structure in human genetic disease: recent advances
    Wendy A Bickmore
    MRC Human Genetics Unit, Edinburgh EH4 2XU, Scotland, UK
    Hum Mol Genet 12:R207-13. 2003
    ....
  7. pmc Recruitment to the nuclear periphery can alter expression of genes in human cells
    Lee E Finlan
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 4:e1000039. 2008
    ..This is compatible with the suggestion that re-localisation of genes relative to the peripheral zone of the nucleus could be used by metazoans to modulate the expression of selected genes during development and differentiation...
  8. pmc Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
    Ragnhild Eskeland
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Mol Cell 38:452-64. 2010
    ..We suggest that Ring1B-mediated chromatin compaction acts to directly limit transcription in vivo...
  9. pmc Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd
    Céline Morey
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh University, Crewe Road, Edinburgh EH4 2XU, UK
    J Cell Sci 121:571-7. 2008
    ..This shows that reorganisation of chromosome territories and chromatin decondensation can be uncoupled from transcription itself and suggests that they can therefore operate upstream of gene expression...
  10. pmc KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies
    Stephanie Briers
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
    J Cell Sci 122:937-46. 2009
    ....
  11. pmc DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction
    Nick Gilbert
    Medical Research Council Human Genetics Unit, Edinburgh, Scotland, UK
    J Cell Biol 177:401-11. 2007
    ....
  12. pmc Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression
    Céline Morey
    MRC Human Genetics Unit, Edinburgh EH4 2XU, Scotland, United Kingdom
    Genome Res 19:1184-94. 2009
    ..Hence active gene regions may loop out from CTs because they are able to, and not because they need to in order to facilitate gene expression...
  13. ncbi request reprint Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation
    Céline Morey
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Development 134:909-19. 2007
    ..However, we suggest that separate modes of regulation can modify Hoxd chromatin in different ways in different developmental contexts...
  14. ncbi request reprint Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers
    Nick Gilbert
    MRC Human Genetics Unit, Edinburgh, EH4 2XU, Scotland
    Cell 118:555-66. 2004
    ..We suggest that domains of open chromatin may create an environment that facilitates transcriptional activation and could provide an evolutionary constraint to maintain clusters of genes together along chromosomes...
  15. pmc Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription
    Séverine Chambeyron
    MRC Human Genetics Unit, Edinburgh EH4 2XU, United Kingdom
    Genes Dev 18:1119-30. 2004
    ..The choreographed looping out of decondensed chromatin from chromosome territories may then allow for activation of high levels of transcription from the sequence of genes along the cluster...
  16. pmc Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH
    Nicola L Mahy
    MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    J Cell Biol 159:753-63. 2002
    ..This is shown to be partly dependent on ongoing transcription. We suggest that local gene density and transcription, rather than the activity of individual genes, influences the organization of chromosomes in the nucleus...
  17. ncbi request reprint Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells
    Anne E Wiblin
    MRC Human Genetics Unit, Crewe Road, Edinburgh, EH4 2XU, UK
    J Cell Sci 118:3861-8. 2005
    ..Understanding this level of hES cell biology provides a framework within which other large-scale chromatin changes that may accompany differentiation can be considered...
  18. pmc Fluorescence in situ hybridization with high-complexity repeat-free oligonucleotide probes generated by massively parallel synthesis
    Shelagh Boyle
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK
    Chromosome Res 19:901-9. 2011
    ..Using this approach, we dramatically reveal the disposition of exons around the outside of a chromosome territory core and away from the nuclear periphery...
  19. pmc PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells
    Robert S Illingworth
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e34848. 2012
    ..Z still blankets polycomb target loci in the absence of Suz12, Eed (PRC2) or Ring1B (PRC1). Therefore we conclude that H2A.Z accumulates at developmentally silenced genes in ESCs in a polycomb independent manner...
  20. ncbi request reprint Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases
    Susan Gilchrist
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Chromosome Res 12:505-16. 2004
    ..We conclude that the distinctive nuclear localization of centromeric domains is independent of histone acetylation...
  21. ncbi request reprint The role of chromatin structure in regulating the expression of clustered genes
    Duncan Sproul
    Chromosomes and Gene Expression Section, Medical Research Council Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Nat Rev Genet 6:775-81. 2005
    ..Can unravelling the mechanisms of gene regulation at these gene clusters help us to understand how other genes are controlled? Moreover, can it explain why there is clustering of apparently unrelated genes in mammalian genomes?..
  22. pmc Changes in chromatin structure during processing of wax-embedded tissue sections
    Elizabeth Kerr
    Breakthrough Breast Cancer Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK
    Chromosome Res 18:677-88. 2010
    ....
  23. ncbi request reprint 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus
    Heidi G E Sutherland
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Exp Cell Res 294:94-105. 2004
    ..Furthermore, 3D3/lyric is also found in the nucleolus and is therefore a rare example of a protein that suggests a possible connection between this compartment and the endoplasmic reticulum...
  24. doi request reprint Transcription and the nuclear periphery: edge of darkness?
    Emmanuelle Deniaud
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    Curr Opin Genet Dev 19:187-91. 2009
    ..Moreover, the nuclear periphery itself is heterogeneous, with microdomains of differing compositions, associating with different genomic regions and probably having differential effects on genome function...
  25. doi request reprint Genome architecture: domain organization of interphase chromosomes
    Wendy A Bickmore
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH42XU, UK
    Cell 152:1270-84. 2013
    ....
  26. pmc Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations
    Heidi G Sutherland
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Mol Cell Biol 26:7201-10. 2006
    ..The latter phenotypes suggest a role for Psip1 in the control of Hox expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 in myeloid leukemias...
  27. pmc Formation of facultative heterochromatin in the absence of HP1
    Nick Gilbert
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    EMBO J 22:5540-50. 2003
    ..To our knowledge, this is the first report of cell types that lack HP1s and that have gross changes in the levels of histone modifications...
  28. ncbi request reprint Nuclear re-organisation of the Hoxb complex during mouse embryonic development
    Séverine Chambeyron
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Development 132:2215-23. 2005
    ..In early development nuclear re-organisation is coupled to Hoxb expression, but does not anticipate it...
  29. ncbi request reprint Considering nuclear compartmentalization in the light of nuclear dynamics
    Jonathan R Chubb
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Cell 112:403-6. 2003
    ..However, nuclear proteins have now been shown to be highly mobile. This review considers the formation and function of nuclear compartments in a situation in which proteins are rapidly moving through the nuclear volume...
  30. pmc Chromatin structure and evolution in the human genome
    James G D Prendergast
    Colon Cancer Genetics Group, Division of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    BMC Evol Biol 7:72. 2007
    ..Using the results of a recent genome-wide analysis of open and closed human chromatin structures we have investigated the global association between divergence, selection and chromatin structure for the first time...
  31. pmc Porin new light onto chromatin and nuclear organization
    Lee E Finlan
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, UK
    Genome Biol 9:222. 2008
    ..These associations are modulated by levels of global histone acetylation and highlight the dynamic nature of chromatin organization in the nucleus...
  32. pmc Altered protein dynamics of disease-associated lamin A mutants
    Susan Gilchrist
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    BMC Cell Biol 5:46. 2004
    ..To investigate this we have used photobleaching in human cells to analyse the dynamics of wild-type and mutant lamin A protein at the nuclear periphery...
  33. pmc Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes
    Graham Dellaire
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    Mol Cell Biol 22:5141-56. 2002
    ....
  34. ncbi request reprint Does radial nuclear organisation influence DNA damage?
    Elodie Gazave
    MRC Human Genetics Unit, Crewe Road, Edinburgh, EH4 2XU, UK
    Chromosome Res 13:377-88. 2005
    ..We suggest that features of the chromatin structure, or base composition, of sequences in the nuclear centre make them more susceptible to damage...
  35. doi request reprint Transcription factories: gene expression in unions?
    Heidi Sutherland
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh EH4 2XU, UK
    Nat Rev Genet 10:457-66. 2009
    ..The transcription factory model has implications for the regulation of transcription initiation and elongation, for the organization of genes in the genome, for the co-regulation of genes and for genome instability...
  36. ncbi request reprint Chromatin motion is constrained by association with nuclear compartments in human cells
    Jonathan R Chubb
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Curr Biol 12:439-45. 2002
    ..In comparison with many nuclear proteins, the movement of chromatin in nuclei appears to be generally constrained. These restrictions on motion are proposed to reflect the attachment of chromatin to immobile nuclear substructures...
  37. pmc Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing
    Madapura M Pradeepa
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 8:e1002717. 2012
    ..We propose that Psip1/p52, through its binding to both chromatin and splicing factors, might act to modulate splicing...
  38. doi request reprint Bone marrow stem cells contribute to alcohol liver fibrosis in humans
    Evangelos Dalakas
    Department of Hepatology, University of Edinburgh, Edinburgh, UK
    Stem Cells Dev 19:1417-25. 2010
    ..Alcohol liver injury mobilizes CD34(+) stem cells into the circulation and recruits them into the liver. These BMSCs contribute to the hepatic myofibroblast population but not to parenchymal lineages and do not promote hepatocyte repair...
  39. ncbi request reprint Does looping and clustering in the nucleus regulate gene expression?
    Séverine Chambeyron
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    Curr Opin Cell Biol 16:256-62. 2004
    ..Nuclear compartments may also be involved in the post-translational modification of proteins by sumoylation and ubiquitylation...
  40. doi request reprint Enhancers: from developmental genetics to the genetics of common human disease
    Iain Williamson
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh, UK
    Dev Cell 21:17-9. 2011
    ..Can the insights into gene control, provided by the study of these enhancers, help us understand the functional significance of sequence variation associated with common/complex human disease and quantitative traits?..
  41. ncbi request reprint The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1
    Inga Thomson
    Medical Research Council, Human Genetics Unit, Edinburgh EH4 2XU, United Kingdom
    Curr Biol 14:166-72. 2004
    ..We conclude that the organization of chromatin in the nucleus is not passed down precisely from one cell to its descendents but is more plastic and becomes refined during early G1...
  42. ncbi request reprint Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase
    Jonathan R Chubb
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA
    Dev Biol 292:519-32. 2006
    ..Microarray analysis of the set1 mutants reveals genomic clustering of mis-expressed genes, suggesting a requirement for Set1 in the regulation of chromatin-mediated events at gene clusters...
  43. pmc Spatial organization of active and inactive genes and noncoding DNA within chromosome territories
    Nicola L Mahy
    Medical Research Council Human Genetics Unit, Edinburgh EH4 2XU, United Kingdom
    J Cell Biol 157:579-89. 2002
    ....
  44. pmc Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy
    Christina F Chakarova
    Institute of Ophthalmology, University College London, London, UK
    Am J Hum Genet 81:1098-103. 2007
    ....
  45. pmc Chromosome territory reorganization in a human disease with altered DNA methylation
    Maria R Matarazzo
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, Via P Castellino 111, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 104:16546-51. 2007
    ....
  46. pmc The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
    Angela Taddei
    Institut Curie, Research Section, UMR 218 du CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Rep 6:520-4. 2005
    ..Here, we discuss the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome...
  47. pmc G9a histone methyltransferase contributes to imprinting in the mouse placenta
    Alexandre Wagschal
    Institute of Molecular Genetics, CNRS UMR 5535, and University of Montpellier, 1919, route de Mende, 34293 Montpellier, France
    Mol Cell Biol 28:1104-13. 2008
    ..These findings provide the first evidence for the involvement of an HMT and suggest that histone methylation contributes to imprinted gene repression in the trophoblast...