Erik Arstad

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer
    Erik Arstad
    Hammersmith Imanet Ltd, Cyclotron Building, Du Cane Road, W12 ONN, London, UK
    Bioorg Med Chem 14:4712-7. 2006
  2. ncbi Towards NR2B receptor selective imaging agents for PET-synthesis and evaluation of N-[11C]-(2-methoxy)benzyl (E)-styrene-, 2-naphthyl- and 4-trifluoromethoxyphenylamidine
    Erik Arstad
    Hammersmith Imanet Ltd, Cyclotron Building, Du Cane Road, London W12 ONN, UK
    Bioorg Med Chem 14:6307-13. 2006
  3. ncbi Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study
    James M Stone
    Institute of Psychiatry, King s College London, London, UK
    Psychopharmacology (Berl) 197:401-8. 2008
  4. ncbi Methods for 18F-labeling of RGD peptides: comparison of aminooxy [18F]fluorobenzaldehyde condensation with 'click labeling' using 2-[18F]fluoroethylazide, and S-alkylation with [18F]fluoropropanethiol
    Matthias Glaser
    GE Healthcare, Medical Diagnostics Discovery, Hammersmith Imanet Ltd, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Amino Acids 37:717-24. 2009
  5. ncbi "Click labeling" with 2-[18f]fluoroethylazide for positron emission tomography
    Matthias Glaser
    Hammersmith Imanet Ltd, Cyclotron Building, Du Cane Road, London W12 ONN, UK
    Bioconjug Chem 18:989-93. 2007

Detail Information

Publications5

  1. ncbi Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer
    Erik Arstad
    Hammersmith Imanet Ltd, Cyclotron Building, Du Cane Road, W12 ONN, London, UK
    Bioorg Med Chem 14:4712-7. 2006
    ..8+/-1.8 nM. We conclude that the low receptor density labelled with this compound, its rapid clearance from the CNS and low specific binding makes it unsuitable as an in vivo PET imaging agent for AMPA receptors...
  2. ncbi Towards NR2B receptor selective imaging agents for PET-synthesis and evaluation of N-[11C]-(2-methoxy)benzyl (E)-styrene-, 2-naphthyl- and 4-trifluoromethoxyphenylamidine
    Erik Arstad
    Hammersmith Imanet Ltd, Cyclotron Building, Du Cane Road, London W12 ONN, UK
    Bioorg Med Chem 14:6307-13. 2006
    ..However, the metabolism of the compounds tested was too rapid to allow for in vivo imaging...
  3. ncbi Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study
    James M Stone
    Institute of Psychiatry, King s College London, London, UK
    Psychopharmacology (Berl) 197:401-8. 2008
    ..Ketamine induces effects resembling both positive and negative psychotic symptoms of schizophrenia. These are thought to arise through its action as an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor...
  4. ncbi Methods for 18F-labeling of RGD peptides: comparison of aminooxy [18F]fluorobenzaldehyde condensation with 'click labeling' using 2-[18F]fluoroethylazide, and S-alkylation with [18F]fluoropropanethiol
    Matthias Glaser
    GE Healthcare, Medical Diagnostics Discovery, Hammersmith Imanet Ltd, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Amino Acids 37:717-24. 2009
    ....
  5. ncbi "Click labeling" with 2-[18f]fluoroethylazide for positron emission tomography
    Matthias Glaser
    Hammersmith Imanet Ltd, Cyclotron Building, Du Cane Road, London W12 ONN, UK
    Bioconjug Chem 18:989-93. 2007
    ..Using the method described, a model peptide was obtained in 92.3 +/- 0.3% (n = 3) radiochemical yield (decay-corrected) after purification by semipreparative HPLC...