Luis Aragon

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase
    Felix Machin
    Cell Cycle Group, Clinical Sciences Centre, Medical Research Council, Imperial College London, London W12 0NN, England, UK
    J Cell Biol 168:209-19. 2005
  2. pmc Transcription of ribosomal genes can cause nondisjunction
    Felix Machin
    Cell Cycle Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK
    J Cell Biol 173:893-903. 2006
  3. pmc The Smc5-Smc6 complex is required to remove chromosome junctions in meiosis
    Sarah Farmer
    Cell Cycle Group, Medical Research Council Clinical Sciences Centre, Imperial College, London, United Kingdom
    PLoS ONE 6:e20948. 2011
  4. pmc Rtt107 phosphorylation promotes localisation to DNA double-stranded breaks (DSBs) and recombinational repair between sister chromatids
    Pranav Ullal
    Cell Cycle Group, Medical Research Council, Clinical Sciences Centre, Imperial College, London, United Kingdom
    PLoS ONE 6:e20152. 2011
  5. pmc Can eukaryotic cells monitor the presence of unreplicated DNA?
    Jordi Torres-Rosell
    Dept, Ciències Mèdiques Bàsiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Cell Div 2:19. 2007
  6. doi request reprint Ribosomal genes: safety in numbers
    Luis Aragon
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Curr Biol 20:R368-70. 2010
  7. ncbi request reprint A double lock on sister chromatids by cohesin
    Luis Aragon
    Cell Cycle Group, Medical Research Council MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Mol Cell 44:5-6. 2011
  8. pmc Sumoylation: a new wrestler in the DNA repair ring
    Luis Aragon
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Proc Natl Acad Sci U S A 102:4661-2. 2005
  9. ncbi request reprint Cdc14 and the temporal coordination between mitotic exit and chromosome segregation
    Jordi Torres-Rosell
    Cell Cycle Group, Clinical Sciences Centre, Medical Research Council, Imperial College London, London, UK
    Cell Cycle 4:109-12. 2005
  10. doi request reprint The unnamed complex: what do we know about Smc5-Smc6?
    Giacomo De Piccoli
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK
    Chromosome Res 17:251-63. 2009

Collaborators

Detail Information

Publications25

  1. pmc Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase
    Felix Machin
    Cell Cycle Group, Clinical Sciences Centre, Medical Research Council, Imperial College London, London W12 0NN, England, UK
    J Cell Biol 168:209-19. 2005
    ..These results demonstrate that chromosome resolution is not simply a consequence of compacting chromosome arms and that overall rDNA compaction is necessary to mediate the segregation of the long arm of chromosome XII...
  2. pmc Transcription of ribosomal genes can cause nondisjunction
    Felix Machin
    Cell Cycle Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK
    J Cell Biol 173:893-903. 2006
    ..In addition, our study uncovers an unexpected role for the replication barrier protein Fob1 in rDNA segregation that is independent of Cdc14. These findings demonstrate that highly transcribed loci can cause chromosome nondisjunction...
  3. pmc The Smc5-Smc6 complex is required to remove chromosome junctions in meiosis
    Sarah Farmer
    Cell Cycle Group, Medical Research Council Clinical Sciences Centre, Imperial College, London, United Kingdom
    PLoS ONE 6:e20948. 2011
    ..These results demonstrate that, as in mitosis, Smc5-Smc6 is required to ensure proper chromosome segregation during meiosis by preventing aberrant recombination intermediates between homologous chromosomes...
  4. pmc Rtt107 phosphorylation promotes localisation to DNA double-stranded breaks (DSBs) and recombinational repair between sister chromatids
    Pranav Ullal
    Cell Cycle Group, Medical Research Council, Clinical Sciences Centre, Imperial College, London, United Kingdom
    PLoS ONE 6:e20152. 2011
    ..We demonstrate that Rtt107 has an effect on the efficiency of sister chromatid recombination (SCR) and propose that its recruitment to DSBs, together with the Smc5-Smc6 complex is important for repair through the SCR pathway...
  5. pmc Can eukaryotic cells monitor the presence of unreplicated DNA?
    Jordi Torres-Rosell
    Dept, Ciències Mèdiques Bàsiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Cell Div 2:19. 2007
    ..Therefore, these results strongly suggest that normal yeast cells do not contain a DNA replication-completion checkpoint...
  6. doi request reprint Ribosomal genes: safety in numbers
    Luis Aragon
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Curr Biol 20:R368-70. 2010
    ....
  7. ncbi request reprint A double lock on sister chromatids by cohesin
    Luis Aragon
    Cell Cycle Group, Medical Research Council MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Mol Cell 44:5-6. 2011
    ..In this issue of Molecular Cell, Farcas et al. (2011) demonstrate that intertwining between sister chromatids at metaphase is much more significant than previously thought and, remarkably, show that it depends on cohesin...
  8. pmc Sumoylation: a new wrestler in the DNA repair ring
    Luis Aragon
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Proc Natl Acad Sci U S A 102:4661-2. 2005
  9. ncbi request reprint Cdc14 and the temporal coordination between mitotic exit and chromosome segregation
    Jordi Torres-Rosell
    Cell Cycle Group, Clinical Sciences Centre, Medical Research Council, Imperial College London, London, UK
    Cell Cycle 4:109-12. 2005
    ..Future studies will be targeted towards unravelling the nature of the additional segregation requirements for repetitive regions and the specifics of its cell cycle control...
  10. doi request reprint The unnamed complex: what do we know about Smc5-Smc6?
    Giacomo De Piccoli
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK
    Chromosome Res 17:251-63. 2009
    ..In this review we summarize our present understanding of this enigmatic protein complex...
  11. ncbi request reprint Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network
    Jordi Torres-Rosell
    Cell Cycle Group, Clinical Sciences Center, Medical Research Council, Imperial College London, London, UK
    Cell Cycle 3:496-502. 2004
    ..Inactivation of FEAR delays nucleolar segregation until late anaphase, demonstrating that one function of the FEAR network is to promote segregation of repetitive nucleolar chromatin during mid-anaphase...
  12. ncbi request reprint Anaphase onset before complete DNA replication with intact checkpoint responses
    Jordi Torres-Rosell
    Cell Cycle Group, Medical Research Council MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Science 315:1411-5. 2007
    ..We propose that the completion of replication is not under the surveillance of known checkpoints...
  13. doi request reprint Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin
    Alexandra McAleenan
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK
    Nature 493:250-4. 2013
    ..We conclude that post-replicative DNA repair involves cohesin dissociation by separase to promote accessibility to repair factors during the coordinated cellular response to restore DNA integrity...
  14. ncbi request reprint The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus
    Jordi Torres-Rosell
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 9:923-31. 2007
    ..Our study also suggests a key role of sumoylation for nucleolar dynamics, perhaps in the compartmentalization of nuclear activities...
  15. ncbi request reprint Condensin regulates rDNA silencing by modulating nucleolar Sir2p
    Felix Machin
    Cell Cycle Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom
    Curr Biol 14:125-30. 2004
    ..Our data reveal the implication of yeast condensin in the arrangement of rDNA repeats into a heterochromatic-like structure that is important for the correct delineation of silencing domains in the nucleus...
  16. doi request reprint Cdc14 inhibits transcription by RNA polymerase I during anaphase
    Andres Clemente-Blanco
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK
    Nature 458:219-22. 2009
    ..We conclude that budding yeast, like most eukaryotes, inhibit Pol I transcription before segregation as a prerequisite for chromosome condensation and faithful genome separation...
  17. ncbi request reprint SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions
    Jordi Torres-Rosell
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 7:412-9. 2005
    ..These results point towards a role for the Smc5-Smc6 complex in preventing the formation of sister chromatid junctions, thereby ensuring the correct partitioning of chromosomes during anaphase...
  18. doi request reprint SUMOylation of the α-kleisin subunit of cohesin is required for DNA damage-induced cohesion
    Alexandra McAleenan
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK
    Curr Biol 22:1564-75. 2012
    ..At the molecular level, cohesion establishment involves two defined events, a chromatin binding step and a chromatid entrapment event driven by posttranslational modifications on cohesin subunits...
  19. ncbi request reprint Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae
    Jordi Torres-Rosell
    Medical Research Council, Clinical Sciences Centre, Imperial College London, London, UK
    Cell Cycle 4:868-72. 2005
    ..Here, we present results further supporting the importance of Smc5-Smc6 in maintaining the integrity of the repetitive ribosomal DNA (rDNA) locus, the largest repetitive region of the budding yeast genome...
  20. ncbi request reprint Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination
    Giacomo De Piccoli
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 8:1032-4. 2006
    ..Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events...
  21. pmc Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription
    Andres Clemente-Blanco
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Cell Biol 13:1450-6. 2011
    ..Finally, telomere segregation defects in cdc14 mutants(4) correlate with the presence of subtelomeric Y' elements and can be rescued by transcriptional inhibition of RNA polymerase II...
  22. doi request reprint Condensin, cohesin and the control of chromatin states
    Luis Aragon
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Curr Opin Genet Dev 23:204-11. 2013
    ..Here we look at the emerging role of these complexes in regulating chromatin structure and gene expression and reflect on how these activities could be linked with chromosome topology...
  23. ncbi request reprint Cis-interactions between non-coding ribosomal spacers dependent on RNAP-II separate RNAP-I and RNAP-III transcription domains
    Maria Mayan
    MRC Clinical Sciences Centre, Imperial College, London, UK
    Cell Cycle 9:4328-37. 2010
    ..We conclude that stalled RNAP-II plays an active role in the cis-organisation of ribosomal repeats providing domains of polymerase specificity in the nucleolar transcription environment...
  24. doi request reprint Cohesins functionally associate with CTCF on mammalian chromosome arms
    Vania Parelho
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell 132:422-33. 2008
    ..Recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because CTCF binding is sensitive to DNA methylation, allows cohesin positioning to integrate DNA sequence and epigenetic state...
  25. pmc A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation
    Vlad C Seitan
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Nature 476:467-71. 2011
    ....