T J Aitman

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
  2. pmc Complete cardiac regeneration in a mouse model of myocardial infarction
    Bernhard Johannes Haubner
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Aging (Albany NY) 4:966-77. 2012
  3. pmc Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains
    K Maratou
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Genes Immun 12:78-89. 2011
  4. pmc Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat
    Santosh S Atanur
    Physiological Genomic and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK
    Cell 154:691-703. 2013
  5. pmc Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages
    Richard P Hull
    MRC Clinical Sciences Centre, Imperial College London, HammersmithHospital, Du Cane Road W12 0NN, London, UK
    BMC Genomics 14:92. 2013
  6. pmc Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel
    Marieke Simonis
    Genome Biology Group, Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Genome Biol 13:r31. 2012
  7. pmc EMAAS: an extensible grid-based rich internet application for microarray data analysis and management
    G Barton
    Division of Molecular Biosciences, Faculty of Natural Sciences, Centre for Bioinformatics, Imperial College, London, UK
    BMC Bioinformatics 9:493. 2008
  8. pmc MiMiR--an integrated platform for microarray data sharing, mining and analysis
    Chris Tomlinson
    Microarray Centre, MRC Clinical Sciences Centre and Imperial College, Hammersmith Hospital, London, UK
    BMC Bioinformatics 9:379. 2008
  9. doi request reprint The future of model organisms in human disease research
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre, Imperial College, London, UK
    Nat Rev Genet 12:575-82. 2011
  10. ncbi request reprint Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
    Timothy J Aitman
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nature 439:851-5. 2006

Detail Information

Publications43

  1. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
    ..Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity...
  2. pmc Complete cardiac regeneration in a mouse model of myocardial infarction
    Bernhard Johannes Haubner
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Aging (Albany NY) 4:966-77. 2012
    ..This novel model system provides the unique opportunity to uncover molecular and cellular pathways that can induce cardiac regeneration after ischemic injury, findings that one day could be translated to human heart attack patients...
  3. pmc Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains
    K Maratou
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    Genes Immun 12:78-89. 2011
    ....
  4. pmc Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat
    Santosh S Atanur
    Physiological Genomic and Medicine Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK
    Cell 154:691-703. 2013
    ..These data represent a step change in resources available for evolutionary analysis of complex traits in disease models...
  5. pmc Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages
    Richard P Hull
    MRC Clinical Sciences Centre, Imperial College London, HammersmithHospital, Du Cane Road W12 0NN, London, UK
    BMC Genomics 14:92. 2013
    ..JunD is over-expressed in WKY BMDMs and its silencing reduces Fc receptor-mediated oxidative burst in these cells...
  6. pmc Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel
    Marieke Simonis
    Genome Biology Group, Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Genome Biol 13:r31. 2012
    ..Recombinant inbred panels are powerful tools to study the cis and trans effects of genetic variation on molecular phenotypes such as gene expression...
  7. pmc EMAAS: an extensible grid-based rich internet application for microarray data analysis and management
    G Barton
    Division of Molecular Biosciences, Faculty of Natural Sciences, Centre for Bioinformatics, Imperial College, London, UK
    BMC Bioinformatics 9:493. 2008
    ..Our aim was to develop a distributed e-support system for microarray data analysis and management...
  8. pmc MiMiR--an integrated platform for microarray data sharing, mining and analysis
    Chris Tomlinson
    Microarray Centre, MRC Clinical Sciences Centre and Imperial College, Hammersmith Hospital, London, UK
    BMC Bioinformatics 9:379. 2008
    ..Here we present new software components and enhancements to the original infrastructure that increase accessibility, utility and opportunities for large scale mining of experimental and clinical data...
  9. doi request reprint The future of model organisms in human disease research
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre, Imperial College, London, UK
    Nat Rev Genet 12:575-82. 2011
    ..Furthermore, disease modelling can be done with increasing effectiveness using human cells. Where does this leave non-human models of disease?..
  10. ncbi request reprint Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
    Timothy J Aitman
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nature 439:851-5. 2006
    ....
  11. doi request reprint Progress and prospects in rat genetics: a community view
    Timothy J Aitman
    Medical Research Council Clinical Sciences Centre and Imperial College London, Du Cane Road, London W12 0NN, UK
    Nat Genet 40:516-22. 2008
    ..Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research...
  12. ncbi request reprint Malaria susceptibility and CD36 mutation
    T J Aitman
    MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, UK
    Nature 405:1015-6. 2000
  13. ncbi request reprint Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    T J Aitman
    MRC Clinical Sciences Centre, and Division of National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nat Genet 21:76-83. 1999
    ..We conclude that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes...
  14. ncbi request reprint Leptin receptor gene variation and obesity: lack of association in a white British male population
    T Gotoda
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Hum Mol Genet 6:869-76. 1997
    ..In these subjects, there was no evidence for a significant effect of the common variants on obesity or obesity-related phenotypes. These results suggest that mutations in the leptin receptor gene are not a common cause of human obesity...
  15. doi request reprint Copy number variation of Fc gamma receptor genes and disease predisposition
    M Fanciulli
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, UK
    Cytogenet Genome Res 123:161-8. 2008
    ..This review will explore copy number variation at the Fc gamma receptor cluster and its relevance in the pathogenesis of common human diseases...
  16. ncbi request reprint Finding genes that underlie complex traits
    Anne M Glazier
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, DuCane Road, London W12 0NN, UK
    Science 298:2345-9. 2002
    ..These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field...
  17. ncbi request reprint A gene harvest revealing the archeology and complexity of human disease
    Enrico Petretto
    Faculty of Medicine, Imperial College, London W12 0NN, UK
    Nat Genet 39:1299-301. 2007
    ..nature.com/ng/meetings/genomics) co-sponsored by the Wellcome Trust, held at the Wellcome Trust Hinxton Conference Centre July 7-10, 2007 and co-organized by Tim Aitman, David Altshuler and Eddy Rubin...
  18. pmc Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Genet 40:546-52. 2008
    ..Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis...
  19. pmc Heritability and tissue specificity of expression quantitative trait loci
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    PLoS Genet 2:e172. 2006
    ..We delineate the effects of genetic architecture on variation in gene expression and show the sensitivity of this experimental design to tissue sampling variability in large-scale eQTL studies...
  20. ncbi request reprint Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism
    Anne M Glazier
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Mamm Genome 13:108-13. 2002
    ..This demonstrates that chromosomal deletions caused by unequal recombination can be a cause of quantitative or complex mammalian phenotypes...
  21. ncbi request reprint Radiation hybrid mapping of 70 rat genes from a data set of differentially expressed genes
    Caroline A Wallace
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Mamm Genome 13:194-7. 2002
    ..The data provide new map locations for rat genes and will aid efforts to advance the rat genome map. The data may also be used to prioritize candidate QTL genes in SHR and other rat strains on the basis of their map location...
  22. doi request reprint Gene copy number variation and common human disease
    M Fanciulli
    Imperial College London, Hammersmith Hospital, London, W12 0NN, UK
    Clin Genet 77:201-13. 2010
    ....
  23. ncbi request reprint Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia
    T J Aitman
    Molecular Medicine Group, Hammersmith Hospital, London, England
    Arterioscler Thromb Vasc Biol 17:748-54. 1997
    ..Direct study of this defect may facilitate genetic analysis of this disorder...
  24. pmc The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance
    Santosh S Atanur
    Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Genome Res 20:791-803. 2010
    ....
  25. pmc Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
    Jacques Behmoaras
    Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Genet 40:553-9. 2008
    ....
  26. ncbi request reprint Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats
    T J Aitman
    Molecular Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Nat Genet 16:197-201. 1997
    ....
  27. pmc Copy number variation in the human genome and its implication in autoimmunity
    H Schaschl
    Imperial College London, Faculty of Medicine, Section of Molecular Genetics and Rheumatology, Hammersmith Campus, London, UK
    Clin Exp Immunol 156:12-6. 2009
    ....
  28. pmc Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis
    Jacques Behmoaras
    Department of Renal Medicine, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom
    J Am Soc Nephrol 21:1136-44. 2010
    ..Taken together, these results demonstrate that a genetic influence on macrophage activation, rather than number, determines glomerular damage in immune-mediated glomerulonephritis...
  29. pmc Genome-wide co-expression analysis in multiple tissues
    Ian C Grieve
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 3:e4033. 2008
    ..Our results demonstrate the power of an integrative, systematic approach to the analysis of a large gene expression dataset to uncover underlying structure, and inform future eQTL studies...
  30. ncbi request reprint Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene
    John Reynolds
    Renal Section, Division of Medicine, MRC Clinical Sciences Centre and Imperial College Genetics and Genomics Research Institute, Imperial College, Hammersmith Hospital, London, UK
    Exp Nephrol 10:402-7. 2002
    ..No significant linkage was detected. These results exclude Col4a3 as a recessive susceptibility gene for EAG in the BC1 progeny...
  31. pmc Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus
    David L Morris
    Section of Rheumatology, Hammersmith Hospital, Imperial College London, London, UK
    Eur J Hum Genet 18:1027-31. 2010
    ....
  32. ncbi request reprint Glycomics investigation into insulin action
    Simon Parry
    Division of Molecular Biosciences, Imperial College, London, South Kensington, UK
    Biochim Biophys Acta 1760:652-68. 2006
    ..A fat-fed versus carbohydrate-fed mouse insulin resistant model was analysed to test the consequences of chronic insulin resistance. Muscle and liver N-glycosylation profiles from these mice are reported...
  33. pmc Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins
    Catherine A Martin
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK
    Protein Sci 16:2531-41. 2007
    ....
  34. doi request reprint Genetic mapping and positional cloning
    Timothy J Aitman
    Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Section of Molecular Genetics and Rheumatology, Imperial College, Hammersmith Hospital, London, UK
    Methods Mol Biol 597:13-32. 2010
    ..In this review, we will consider different strategies that are being used in the successful positional cloning of rat complex trait genes in the context of recent progress in rodent and human genetics...
  35. pmc Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci
    Sophie Bernichtein
    Department of Reproductive Biology, Physiological Genomics and Medicine Group, Medical Research Council, Clinical Sciences Center, Faculty of Medicine, Imperial College London, London, UK
    Endocrinology 149:651-61. 2008
    ..These findings may have relevance to the human pathogenesis of macronodular adrenal hyperplasia and adrenocortical tumors in postmenopausal women and why some of them develop obesity...
  36. ncbi request reprint eQTL Explorer: integrated mining of combined genetic linkage and expression experiments
    Michael Mueller
    MRC Clinical Sciences Centre, Imperial College London, W12 0NN, UK
    Bioinformatics 22:509-11. 2006
    ..eQTL Explorer provides a new and powerful tool to interrogate these very large and complex datasets...
  37. ncbi request reprint Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature
    Brian R Curtis
    Platelet and Neutrophil Immunology Lab, Blood Center of Southeastern Wisconsin, Milwaukee 53233, USA
    Transfusion 42:1173-9. 2002
    ..A subset of these individuals is at risk for immunization against CD36, but the magnitude of this problem and its significance in transfusion medicine have not yet been clarified...
  38. ncbi request reprint Gene expression profiling in hypertension research: a critical perspective
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences and The Center for Integrated Genomics, Prague, Czech Republic
    Hypertension 41:3-8. 2003
    ..In this review, we offer a critical perspective on the use of gene expression profiling in hypertension research and discuss some emerging strategies for taking this technology beyond the limits of correlational and descriptive studies...
  39. ncbi request reprint A novel role for CD36 in VLDL-enhanced platelet activation
    Nicola A Englyst
    Endocrinology and Metabolism Unit, University of Southampton, Southhampton General Hospital, Tremona Road, Southampton SO16 6YD, U K
    Diabetes 52:1248-55. 2003
    ..These data suggest that platelet Cd36 has a key role in VLDL-induced collagen-mediated platelet aggregation, possibly contributing to atherothrombosis associated with increased VLDL levels...
  40. ncbi request reprint Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertension 51:148-53. 2008
    ....
  41. doi request reprint Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic
    Nat Genet 40:952-4. 2008
    ....
  42. ncbi request reprint Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
    Norbert Hubner
    Max Delbruck Center for Molecular Medicine, Berlin Buch 13125, Germany
    Nat Genet 37:243-53. 2005
    ....
  43. ncbi request reprint The rat comes clean
    Caroline A Wallace
    Nat Genet 36:441-2. 2004