R J Aitken

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint The extragenomic action of progesterone on human spermatozoa: evidence for a ubiquitous response that is rapidly down-regulated
    R J Aitken
    MRC Reproductive Biology Unit, Edinburgh, Scotland
    Endocrinology 137:3999-4009. 1996
  2. ncbi request reprint On the cellular mechanisms by which the bicarbonate ion mediates the extragenomic action of progesterone on human spermatozoa
    R J Aitken
    MRC Reproductive Biology Unit, Edinburgh, Scotland
    Biol Reprod 58:186-96. 1998
  3. ncbi request reprint Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa
    R J Aitken
    MRC Reproductive Biology Unit, Edinburgh EH3 9EW, United Kingdom
    Biol Reprod 59:1037-46. 1998
  4. ncbi request reprint Impact of epididymal maturation on the tyrosine phosphorylation patterns exhibited by rat spermatozoa
    B Lewis
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh EH3 9EW, United Kingdom
    Biol Reprod 64:1545-56. 2001
  5. ncbi request reprint A redox-regulated tyrosine phosphorylation cascade in rat spermatozoa
    B Lewis
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, University of Edinburgh, Scotland
    J Androl 22:611-22. 2001
  6. ncbi request reprint DNA integrity in human spermatozoa: relationships with semen quality
    D S Irvine
    Centre for Reproductive Biology, Edinburgh, Scotland
    J Androl 21:33-44. 2000
  7. ncbi request reprint Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa
    P Vernet
    MRC Reproductive Biology Unit, Edinburgh EH3 9ET, Scotland, UK
    Biol Reprod 65:1102-13. 2001
  8. ncbi request reprint Immunocontraception with zona pellucida proteins
    M Paterson
    MRC Reproductive Biology Unit, Edinburgh, UK
    Cells Tissues Organs 166:228-32. 2000
  9. ncbi request reprint Impact of a deep saturation dive on semen quality
    R J Aitken
    MRC Reproductive Biology Unit, 37 Chalmers Street, Edinburgh EH3 9ET, Scotland
    Int J Androl 23:116-20. 2000

Collaborators

Detail Information

Publications9

  1. ncbi request reprint The extragenomic action of progesterone on human spermatozoa: evidence for a ubiquitous response that is rapidly down-regulated
    R J Aitken
    MRC Reproductive Biology Unit, Edinburgh, Scotland
    Endocrinology 137:3999-4009. 1996
    ..There are implications in these results for our understanding of the extragenomic action of progesterone on human spermatozoa and the clinical manipulation of this system for the assessment and suppression of human sperm function...
  2. ncbi request reprint On the cellular mechanisms by which the bicarbonate ion mediates the extragenomic action of progesterone on human spermatozoa
    R J Aitken
    MRC Reproductive Biology Unit, Edinburgh, Scotland
    Biol Reprod 58:186-96. 1998
    ....
  3. ncbi request reprint Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa
    R J Aitken
    MRC Reproductive Biology Unit, Edinburgh EH3 9EW, United Kingdom
    Biol Reprod 59:1037-46. 1998
    ..These results may have long-term implications for the safety of assisted conception procedures in cases associated with oxidative stress...
  4. ncbi request reprint Impact of epididymal maturation on the tyrosine phosphorylation patterns exhibited by rat spermatozoa
    B Lewis
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh EH3 9EW, United Kingdom
    Biol Reprod 64:1545-56. 2001
    ..These findings help to clarify the biochemical changes associated with the functional maturation of spermatozoa during epididymal transit...
  5. ncbi request reprint A redox-regulated tyrosine phosphorylation cascade in rat spermatozoa
    B Lewis
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, University of Edinburgh, Scotland
    J Androl 22:611-22. 2001
    ....
  6. ncbi request reprint DNA integrity in human spermatozoa: relationships with semen quality
    D S Irvine
    Centre for Reproductive Biology, Edinburgh, Scotland
    J Androl 21:33-44. 2000
    ..We conclude that a significant proportion of infertile men have elevated levels of DNA damage in their ejaculated spermatozoa...
  7. ncbi request reprint Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa
    P Vernet
    MRC Reproductive Biology Unit, Edinburgh EH3 9ET, Scotland, UK
    Biol Reprod 65:1102-13. 2001
    ..Reverse transcription-polymerase chain reaction analysis indicated that the sperm NAD(P)H oxidoreductase complex is quite distinct from the equivalent leukocyte system...
  8. ncbi request reprint Immunocontraception with zona pellucida proteins
    M Paterson
    MRC Reproductive Biology Unit, Edinburgh, UK
    Cells Tissues Organs 166:228-32. 2000
    ..Thus, considerable research is still required to identify a combination of ZP3 epitopes that will induce infertility free of any unwanted side effects...
  9. ncbi request reprint Impact of a deep saturation dive on semen quality
    R J Aitken
    MRC Reproductive Biology Unit, 37 Chalmers Street, Edinburgh EH3 9ET, Scotland
    Int J Androl 23:116-20. 2000
    ..These studies indicate, for the first time, that the severe hyperbaric conditions associated with deep saturation dives have a profound effect on male reproductive function...