Affiliation: National Institute for Medical Research
- ENU mutagenesis, a way forward to understand gene functionAbraham Acevedo-Arozena
MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
Annu Rev Genomics Hum Genet 9:49-69. 2008..N-ethyl-N-nitrosourea (ENU) mutagenesis has been widely used for both approaches to generate mouse mutants. Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders...
- Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory diseaseHilda Tateossian
MRC Mammalian Genetics Unit, Harwell, UK
Hum Mol Genet 22:2553-65. 2013..The identification and characterization of the Tgif mutant supports the role of TGFβ signalling in the development of chronic OM and provides an important candidate gene for genetic studies in the human population...
- Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD miceSilvia Corrochano
MRC Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom
PLoS ONE 9:e105595. 2014..Interestingly, Igf-1r deficiency had no discernible effects on downstream mTOR signalling in HD mice. These results do not support a broad beneficial effect of diminishing the IIS pathway in HD pathology in a mammalian system. ..