Abraham Acevedo-Arozena

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi request reprint ENU mutagenesis, a way forward to understand gene function
    Abraham Acevedo-Arozena
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Annu Rev Genomics Hum Genet 9:49-69. 2008
  2. pmc Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease
    Hilda Tateossian
    MRC Mammalian Genetics Unit, Harwell, UK
    Hum Mol Genet 22:2553-65. 2013
  3. doi request reprint Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice
    Silvia Corrochano
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom
    PLoS ONE 9:e105595. 2014

Collaborators

Detail Information

Publications3

  1. ncbi request reprint ENU mutagenesis, a way forward to understand gene function
    Abraham Acevedo-Arozena
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Annu Rev Genomics Hum Genet 9:49-69. 2008
    ..N-ethyl-N-nitrosourea (ENU) mutagenesis has been widely used for both approaches to generate mouse mutants. Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders...
  2. pmc Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease
    Hilda Tateossian
    MRC Mammalian Genetics Unit, Harwell, UK
    Hum Mol Genet 22:2553-65. 2013
    ..The identification and characterization of the Tgif mutant supports the role of TGFβ signalling in the development of chronic OM and provides an important candidate gene for genetic studies in the human population...
  3. doi request reprint Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice
    Silvia Corrochano
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, United Kingdom
    PLoS ONE 9:e105595. 2014
    ..Interestingly, Igf-1r deficiency had no discernible effects on downstream mTOR signalling in HD mice. These results do not support a broad beneficial effect of diminishing the IIS pathway in HD pathology in a mammalian system. ..