Affiliation: National Institute for Medical Research
- ENU mutagenesis, a way forward to understand gene functionAbraham Acevedo-Arozena
MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
Annu Rev Genomics Hum Genet 9:49-69. 2008..N-ethyl-N-nitrosourea (ENU) mutagenesis has been widely used for both approaches to generate mouse mutants. Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders...