Elisabeth A Innes

Summary

Affiliation: Moredun Research Institute
Country: UK

Publications

  1. ncbi request reprint Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ, UK
    Parasitology 133:S145-68. 2006
  2. ncbi request reprint Comparative host-parasite relationships in ovine toxoplasmosis and bovine neosporosis and strategies for vaccination
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ, United Kingdom
    Vaccine 25:5495-503. 2007
  3. ncbi request reprint The host-parasite relationship in pregnant cattle infected with Neospora caninum
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh, EH26 OPZ, UK
    Parasitology 134:1903-10. 2007
  4. ncbi request reprint Neospora caninum emerges from the shadow of Toxoplasma gondii
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 0PZ, UK
    Trends Parasitol 23:43-4; discussion 44-5. 2007
  5. ncbi request reprint Veterinary vaccines against Toxoplasma gondii
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh
    Mem Inst Oswaldo Cruz 104:246-51. 2009
  6. doi request reprint A brief history and overview of Toxoplasma gondii
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh, UK
    Zoonoses Public Health 57:1-7. 2010
  7. doi request reprint Ovine toxoplasmosis
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ
    Parasitology 136:1887-94. 2009
  8. doi request reprint Developing vaccines to control protozoan parasites in ruminants: dead or alive?
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ, United Kingdom
    Vet Parasitol 180:155-63. 2011
  9. ncbi request reprint The host-parasite relationship in bovine neosporosis
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 OPZ, UK
    Vet Immunol Immunopathol 108:29-36. 2005
  10. ncbi request reprint Toxoplasma gondii and ovine toxoplasmosis: new aspects of an old story
    David Buxton
    Moredun Research Institute, Edinburgh, Scotland, United Kingdom
    Vet Parasitol 149:25-8. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ, UK
    Parasitology 133:S145-68. 2006
    ..This paper discusses current vaccination strategies to help combat infections with Eimeria, Toxoplasma and Neospora and recent research looking towards developing new vaccine targets and approaches...
  2. ncbi request reprint Comparative host-parasite relationships in ovine toxoplasmosis and bovine neosporosis and strategies for vaccination
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ, United Kingdom
    Vaccine 25:5495-503. 2007
    ....
  3. ncbi request reprint The host-parasite relationship in pregnant cattle infected with Neospora caninum
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh, EH26 OPZ, UK
    Parasitology 134:1903-10. 2007
    ....
  4. ncbi request reprint Neospora caninum emerges from the shadow of Toxoplasma gondii
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 0PZ, UK
    Trends Parasitol 23:43-4; discussion 44-5. 2007
    ..However, a recurring theme in the recent review by Hemphill et al. is not the similarities but the striking differences between the two parasites...
  5. ncbi request reprint Veterinary vaccines against Toxoplasma gondii
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh
    Mem Inst Oswaldo Cruz 104:246-51. 2009
    ..In this paper we will discuss some of the history, challenges and progress in the development of veterinary vaccines against T. gondii...
  6. doi request reprint A brief history and overview of Toxoplasma gondii
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh, UK
    Zoonoses Public Health 57:1-7. 2010
    ....
  7. doi request reprint Ovine toxoplasmosis
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ
    Parasitology 136:1887-94. 2009
    ..A live vaccine, Toxovax is the only commercially available vaccine worldwide to protect against congenital toxoplasmosis...
  8. doi request reprint Developing vaccines to control protozoan parasites in ruminants: dead or alive?
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Edinburgh EH26 OPZ, United Kingdom
    Vet Parasitol 180:155-63. 2011
    ....
  9. ncbi request reprint The host-parasite relationship in bovine neosporosis
    Elisabeth A Innes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 OPZ, UK
    Vet Immunol Immunopathol 108:29-36. 2005
    ..caninum. This is likely to involve a fine balancing act with the immune system that will allow intervention in a manner that will tip the host-parasite balance in favour of the host without compromising the pregnancy...
  10. ncbi request reprint Toxoplasma gondii and ovine toxoplasmosis: new aspects of an old story
    David Buxton
    Moredun Research Institute, Edinburgh, Scotland, United Kingdom
    Vet Parasitol 149:25-8. 2007
    ..gondii with a tendency for samples from certain genetic lines of Charollais sheep more likely to be positive than samples from other lines, suggesting that some sheep have a particular genetic susceptibility to T. gondii...
  11. pmc Development of maternal and foetal immune responses in cattle following experimental challenge with Neospora caninum at day 210 of gestation
    Paul M Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian, EH26 0PZ, Scotland, United Kingdom
    Vet Res 44:91. 2013
    ..Our results show that vertical transmission of the parasite occurred in all infected dams, with their foetuses showing effective Neospora-specific cell mediated, humoral and innate immune responses...
  12. ncbi request reprint Maternal and fetal immune responses of cattle inoculated with Neospora caninum at mid-gestation
    P M Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Edinburgh, Scotland EH26 0PZ, UK
    J Comp Pathol 130:81-91. 2004
    ..At day 42 pi, specific cell-mediated immune responses were not apparent; however, N. caninum-specific fetal IgG and IgM antibodies were detected...
  13. ncbi request reprint Immunity to experimental neosporosis in pregnant sheep
    D Buxton
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, UK
    Parasite Immunol 23:85-91. 2001
    ..caninum during pregnancy killed all the fetuses while inoculation before pregnancy did not cause any mortality but did provide a degree of protection against subsequent challenge with Neospora during pregnancy...
  14. ncbi request reprint Intranasal immunisation with Toxoplasma gondii tachyzoite antigen encapsulated into PLG microspheres induces humoral and cell-mediated immunity in sheep
    A C Stanley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    Vaccine 22:3929-41. 2004
    ..These studies show that intra-nasal delivery has the potential to be an effective route for mucosal immunisation in sheep...
  15. ncbi request reprint Immune responses to Neospora caninum and prospects for vaccination
    Elisabeth A Innes
    Dept of Parasitology, Moredun Research Institute, Pentlands Science Park, Edinburgh, UK
    Trends Parasitol 18:497-504. 2002
    ..So, is vaccination a feasible option to control the disease? This article discusses some of these issues and reports on the progress towards a vaccine for neosporosis...
  16. ncbi request reprint A previous infection with Toxoplasma gondii does not protect against a challenge with Neospora caninum in pregnant sheep
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, UK
    Parasite Immunol 23:121-32. 2001
    ..Vaccination prior to pregnancy with Toxovax did protect against foetal death following oral challenge at 90 days with 2000 T. gondii oocysts which caused 100% foetal death in a control challenge group...
  17. doi request reprint Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
    Germán J Cantón
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    Vet Res 45:11. 2014
    ..This distinctive cellular immune response may explain the milder clinical outcome observed when animals are infected in later gestation. ..
  18. pmc Maternal and foetal immune responses of cattle following an experimental challenge with Neospora caninum at day 70 of gestation
    Paul M Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian, EH26 0PZ, Scotland, United Kingdom
    Vet Res 43:38. 2012
    ..This study shows that the generation of robust peripheral and local maternal CMI responses (lymphoproliferation, IFN-γ) may inhibit the vertical transmission of the parasite...
  19. ncbi request reprint Prevalence of antibodies to Toxoplasmagondii and Neosporacaninum in red foxes (Vulpesvulpes) from around the UK
    Clare M Hamilton
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 OPZ, UK
    Vet Parasitol 130:169-73. 2005
    ..The results of this study indicate that red foxes of the UK have more exposure to T. gondii than to N. caninum in their environment...
  20. ncbi request reprint Seroprevalence of Neospora caninum infection in dairy and beef cattle in Paraguay
    Takeshi Osawa
    Moredun Research Institute, International Research Centre, Pentland Science Park, Bush Loan, Penicuik EH26 OPZ, UK
    Vet Parasitol 110:17-23. 2002
    ..In conclusion, N. caninum infection is present among Paraguayan beef and dairy cattle, and it may be an important cause of bovine abortion in Paraguay...
  21. ncbi request reprint Neosporosis and bovine abortion in Scotland
    D Buxton
    Moredun Research Institute, Edinburgh
    Vet Rec 141:649-51. 1997
    ..9 per cent of aborted fetuses had antibody to the parasite shows that vertical transmission from dam to fetus is relatively common and may be an important cause of fetal loss in cattle in Scotland...
  22. ncbi request reprint Serological analysis of calves experimentally infected with Neospora caninum: a 1-year study
    S W Maley
    Moredun Research Institute, International Research Centre, Pentlands Science Park, Edinburgh EH26 0PZ, UK
    Vet Parasitol 96:1-9. 2001
    ....
  23. ncbi request reprint Protection against vertical transmission in bovine neosporosis
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 OPZ, UK
    Int J Parasitol 31:1523-34. 2001
    ..These results suggest that the immune response generated in the dams in group 2 prior to pregnancy had protected against vertical transmission of the parasite following challenge at mid-gestation...
  24. ncbi request reprint The pathogenesis of neosporosis in pregnant cattle: inoculation at mid-gestation
    S W Maley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, EH26 0PZ, UK
    J Comp Pathol 129:186-95. 2003
    ....
  25. ncbi request reprint Placental pathology associated with fetal death in cattle inoculated with Neospora caninum by two different routes in early pregnancy
    C Macaldowie
    Division of Virology, Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 OPZ, UK
    J Comp Pathol 131:142-56. 2004
    ..Of the two inoculation routes, the intravenous induced the more acute placental lesions and greater mortality...
  26. pmc High rate of transplacental infection and transmission of Neospora caninum following experimental challenge of cattle at day 210 of gestation
    Julio Benavides
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, EH26 0PZ, United Kingdom
    Vet Res 43:83. 2012
    ..This suggests that a change in the maternal immune response plays a crucial role in limiting the initial infection during the last term of pregnancy...
  27. pmc Increased Toxoplasma gondii positivity relative to age in 125 Scottish sheep flocks; evidence of frequent acquired infection
    Frank Katzer
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, EH26 0PZ, UK
    Vet Res 42:121. 2011
    ..gondii infection. Only 24.7% of farmers used the vaccine and the vaccine did not significantly affect the within flock seroprevalence for T. gondii. The implications for food safety and human infection are discussed...
  28. ncbi request reprint Ovine toxoplasmosis: transmission, clinical outcome and control
    D Buxton
    Moredun Research Institute, Edinburgh, Scotland, UK
    Parassitologia 49:219-21. 2007
    ..If this were so it raises the question of whether the vaccine could be used to make meat safer for human consumption...
  29. ncbi request reprint Long-term passage of tachyzoites in tissue culture can attenuate virulence of Neospora caninum in vivo
    P M Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland, UK
    Parasitology 133:421-32. 2006
    ..These results would suggest that it is possible to attenuate the virulence of N. caninum tachyzoites in mice through prolonged in vitro passage...
  30. ncbi request reprint Characterization of the immune response in the placenta of cattle experimentally infected with Neospora caninum in early gestation
    S W Maley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, EH26 0PZ, Ireland
    J Comp Pathol 135:130-41. 2006
    ..It is possible that a pro-inflammatory Th-1 response early in gestation protects the dam by eliminating the parasite; however, it may lead to destruction of the placental tissues themselves and thus be incompatible with fetal survival...
  31. ncbi request reprint Inoculation of Balb/c mice with live attenuated tachyzoites protects against a lethal challenge of Neospora caninum
    P M Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland, UK
    Parasitology 135:13-21. 2008
    ..However, more severe pathology developed in mice initially inoculated with virulent parasites following a secondary challenge, compared to mice initially inoculated with attenuated parasites...
  32. doi request reprint The development of immune responses in Balb/c mice following inoculation with attenuated or virulent Neospora caninum tachyzoites
    P M Bartley
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, UK
    Parasite Immunol 31:392-401. 2009
    ..All mice in group 2 were protected following challenge on day 48 p.i. whereas naïve control mice succumbed to the challenge. No mice from group 1 (virulent) survived beyond day 24 p.i. so they were not included in the challenge...
  33. ncbi request reprint Neosporosis. Aspects of epidemiology and host immune response
    E A Innes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh, EH26 OPZ, United Kingdom
    Ann N Y Acad Sci 916:93-101. 2000
    ..CD4+ T-cells, interferon gamma and macrophages have all been found to significantly inhibit multiplication of N. caninum tachyzoites. The nature of a protective immune response and its modulation in the pregnant animal is discussed...
  34. ncbi request reprint Genetic and biological diversity among isolates of Neospora caninum
    A Schock
    Moredun Research Institute, Pentland Science Park, Penicuik, Edinburgh, UK
    Parasitology 123:13-23. 2001
    ..The genetic and biological diversity observed in this study may have important implications for our understanding of the pathology and epidemiology of neosporosis...
  35. pmc Selection of Neospora caninum antigens stimulating bovine CD4+ve T cell responses through immuno-potency screening and proteomic approaches
    Mara S Rocchi
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian, EH26 0PZ, UK
    Vet Res 42:91. 2011
    ....
  36. doi request reprint Detection of Cryptosporidium in miniaturised fluidic devices
    Helen Bridle
    University of Edinburgh, King s Buildings, Edinburgh, United Kingdom
    Water Res 46:1641-61. 2012
    ..Finally, conclusions are drawn with regard to the most promising methods and directions of future research...