Research Topics
Species | Pradyumna Kumar MishraSummaryCountry: UK Publications
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Detail Information
Publications
Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblastsP K Mishra
Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, India
Genet Mol Res 8:129-43. 2009..This information could be useful in the design of new approaches for risk assessment of potential industrial disasters...
A pragmatic & translational approach of human biomonitoring to methyl isocyanate exposure in BhopalPradyumna Kumar Mishra
Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India
Indian J Med Res 135:479-84. 2012..The investigative strategy might also be helpful in identification of biomarkers with potential for translational research...
Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: a study from Central IndiaP K Mishra
Bhopal Memorial Hospital and Research Centre, Bhopal, India
Indian J Med Microbiol 28:358-62. 2010..Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients...- Molecular detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues and biopsies of gastrointestinal specimens using real-time polymerase chain reaction systemPradyumna Kumar Mishra
Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
Turk J Gastroenterol 21:129-34. 2010..We aimed to perform the molecular detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues and biopsies of gastrointestinal specimens using real-time polymerase chain reaction system... - In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopterisPradyumna Kumar Mishra
Research Wing, Bhopal Memorial Hospital and Research Centre, Bhopal, India
Br J Nutr 106:1154-68. 2011..Results from the present study provide evidence of anticarcinogenic and chemopreventive activities of S. bryopteris hitherto unreported and reaffirm the nutritional significance of flavonoids in cancer prevention... - Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomasP K Mishra
Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
Genet Mol Res 8:1202-10. 2009..Hence, these proteins may be useful as markers to identify premalignant lesions that are likely to progress into malignant adenocarcinoma... - Bhopal Gas Tragedy: review of clinical and experimental findings after 25 yearsPradyumna K Mishra
Bhopal Memorial Hospital and Research Centre, Bhopal, India
Int J Occup Med Environ Health 22:193-202. 2009.... - Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cellsPradyumna K Mishra
Bhopal Memorial Hospital and Research Centre, Bhopal, India
Free Radic Res 43:718-28. 2009..Thus, endogenous oxidative stress resulted in aberrant expression of p53, p21, cyclin E and CDK2 proteins, suggestive of deregulated cell cycle, chromosomal aberrations, centromeric amplification, aneuploidy and genomic instability... - Regulation of isocyanate-induced apoptosis, oxidative stress, and inflammation in cultured human neutrophils: isocyanate-induced neutrophils apoptosisP K Mishra
Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal 462 038, India
Cell Biol Toxicol 26:279-91. 2010.... - Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanatesPradyumna Kumar Mishra
Bhopal Memorial Hospital and Research Centre, Bhopal, India
Cell Biol Int 33:675-83. 2009..Analysis through ISSR PCR demonstrated increased microsatellite instability. The results imply that isocyanates can cause genomic instability in colonocytes... - Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cellsPradyumna Kumar Mishra
Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal 462 038, Madhya Pradesh, India
Environ Mol Mutagen 50:328-36. 2009.... - Molecular surveillance of hepatitis and tuberculosis infections in a cohort exposed to methyl isocyanatePradyumna K Mishra
Research Wing, Bhopal Memorial Hospital and Research Centre, Bhopal, India
Int J Occup Med Environ Health 24:94-101. 2011..We have performed a molecular surveillance study to characterize hepatitis and tuberculosis infections amongst the first and the second generation of survivors exposed to MIC... - Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytesPradyumna Kumar Mishra
Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal 462 038, India pkm
J Biochem Mol Toxicol 22:429-40. 2008..We anticipate these data along with other studies reported in the literature would help to design better approaches in risk assessment of occupational and accidental exposure to isocyanates... - Molecular characterization of isocyanate-induced male germ-line genomic instabilityGorantla Venkata Raghuram
Department of Research, Bhopal Memorial Hospital and Research Centre, Bhokal, India
J Environ Pathol Toxicol Oncol 29:213-34. 2010..We envisage that understanding the interplay between environmental toxin-induced signaling and predisposition to testicular cancers would spur identification of meaningful targets for useful therapeutic translational modalities... - Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cellsGorantla Venkata Raghuram
Bhopal Memorial Hospital and Research Centre, Bhopal, India
Reprod Toxicol 30:377-86. 2010..These results indicate that isocyanate exposure alters ovarian epithelial cell proliferation and might lead to ovarian dysfunction and carcinogenesis... - Evaluation of cytotoxicity and anticarcinogenic potential of Mentha leaf extractsDeepika Jain
Bhopal Memorial Hospital and Research Centre, Bhopal, India
Int J Toxicol 30:225-36. 2011.... - Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: a study after two decadesArpit Bhargava
Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India
Ind Health 48:204-8. 2010..A toxin induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns... - Diagnosis of gastrointestinal tuberculosis: Using cytomorphological, microbiological, immunological and molecular techniques - A study from Central IndiaPradyumna Kumar Mishra
Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, India Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
Indian J Clin Biochem 25:158-63. 2010..A combinatorial diagnostic approach for rapid detection and characterization of GITB might provide specific therapeutic strategies for prevention and treatment of the infection in future... - Novel approach for quantification of hepatitis C virus in liver cirrhosis using real-time reverse transcriptase PCRKewal Krishan Maudar
Department of Surgical Gastroenterology, Bhopal Memorial Hospital and Research Center, Karond, Raisen Bypass Road, Bhopal, 462 038, Madhya Pradesh, India
J Gastrointest Surg 16:142-6; discussion 146-7. 2012..As HCV replicates in the liver cells, detection and localization of HCV RNA in liver tissue are vital for diagnosis... - Engineered dendritic cells for gastrointestinal tumor immunotherapy: opportunities in translational researchArpit Bhargava
Division of Translational Research, Tata Memorial Centre, ACTREC, Navi, Mumbai, India
J Drug Target 21:126-36. 2013..It also showcases the necessity of exploring nano-engineered strategies for improving the clinical utility of DC-vaccination for GI tract malignancies to overcome immune tolerance... - Dendritic cell engineering for tumor immunotherapy: from biology to clinical translationArpit Bhargava
Division of Translational Research, Tata Memorial Centre, ACTREC, India
Immunotherapy 4:703-18. 2012..It also showcases certain practical intricacies in order to explore novel strategies for providing new impetus to DC-based cancer vaccination... - Nucleic acids in circulation: are they harmful to the host?Indraneel Mittra
Department of Translational Research, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, India
J Biosci 37:301-12. 2012..In this review we raise the question as to whether circulating nucleic acids may have damaging effects on the host and be implicated in ageing and diverse acute and chronic human pathologies...