Pradyumna Kumar Mishra

Summary

Country: UK

Publications

  1. ncbi request reprint Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
    P K Mishra
    Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Genet Mol Res 8:129-43. 2009
  2. doi request reprint Mitochondrial Oxidative Stress-Induced Epigenetic Modif ications in Pancreatic Epithelial Cells
    Pradyumna Kumar Mishra
    Translational Research Lab, School of Biological Sciences, Dr Hari Singh Gour Central University, Sagar, Madhya Pradesh, India Email
    Int J Toxicol 33:116-29. 2014
  3. pmc A pragmatic & translational approach of human biomonitoring to methyl isocyanate exposure in Bhopal
    Pradyumna Kumar Mishra
    Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India
    Indian J Med Res 135:479-84. 2012
  4. doi request reprint In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris
    Pradyumna Kumar Mishra
    Research Wing, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Br J Nutr 106:1154-68. 2011
  5. doi request reprint Molecular surveillance of hepatitis and tuberculosis infections in a cohort exposed to methyl isocyanate
    Pradyumna K Mishra
    Research Wing, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Int J Occup Med Environ Health 24:94-101. 2011
  6. doi request reprint Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: a study from Central India
    P K Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Indian J Med Microbiol 28:358-62. 2010
  7. ncbi request reprint Molecular detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues and biopsies of gastrointestinal specimens using real-time polymerase chain reaction system
    Pradyumna Kumar Mishra
    Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Turk J Gastroenterol 21:129-34. 2010
  8. doi request reprint Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas
    P K Mishra
    Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Genet Mol Res 8:1202-10. 2009
  9. doi request reprint Bhopal Gas Tragedy: review of clinical and experimental findings after 25 years
    Pradyumna K Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Int J Occup Med Environ Health 22:193-202. 2009
  10. doi request reprint Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cells
    Pradyumna K Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Free Radic Res 43:718-28. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
    P K Mishra
    Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Genet Mol Res 8:129-43. 2009
    ..This information could be useful in the design of new approaches for risk assessment of potential industrial disasters...
  2. doi request reprint Mitochondrial Oxidative Stress-Induced Epigenetic Modif ications in Pancreatic Epithelial Cells
    Pradyumna Kumar Mishra
    Translational Research Lab, School of Biological Sciences, Dr Hari Singh Gour Central University, Sagar, Madhya Pradesh, India Email
    Int J Toxicol 33:116-29. 2014
    ..Further, identification and characterization of molecular switches that affect these epigenomic signatures and targets thereof will be imperative to understand the complex role of redox-regulatory network in pancreatic milieu. ..
  3. pmc A pragmatic & translational approach of human biomonitoring to methyl isocyanate exposure in Bhopal
    Pradyumna Kumar Mishra
    Division of Translational Research, Tata Memorial Centre, ACTREC, Navi Mumbai, India
    Indian J Med Res 135:479-84. 2012
    ..The investigative strategy might also be helpful in identification of biomarkers with potential for translational research...
  4. doi request reprint In vitro and in vivo evaluation of the anticarcinogenic and cancer chemopreventive potential of a flavonoid-rich fraction from a traditional Indian herb Selaginella bryopteris
    Pradyumna Kumar Mishra
    Research Wing, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Br J Nutr 106:1154-68. 2011
    ..Results from the present study provide evidence of anticarcinogenic and chemopreventive activities of S. bryopteris hitherto unreported and reaffirm the nutritional significance of flavonoids in cancer prevention...
  5. doi request reprint Molecular surveillance of hepatitis and tuberculosis infections in a cohort exposed to methyl isocyanate
    Pradyumna K Mishra
    Research Wing, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Int J Occup Med Environ Health 24:94-101. 2011
    ..We have performed a molecular surveillance study to characterize hepatitis and tuberculosis infections amongst the first and the second generation of survivors exposed to MIC...
  6. doi request reprint Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: a study from Central India
    P K Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Indian J Med Microbiol 28:358-62. 2010
    ..Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients...
  7. ncbi request reprint Molecular detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues and biopsies of gastrointestinal specimens using real-time polymerase chain reaction system
    Pradyumna Kumar Mishra
    Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Turk J Gastroenterol 21:129-34. 2010
    ..We aimed to perform the molecular detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues and biopsies of gastrointestinal specimens using real-time polymerase chain reaction system...
  8. doi request reprint Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas
    P K Mishra
    Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Genet Mol Res 8:1202-10. 2009
    ..Hence, these proteins may be useful as markers to identify premalignant lesions that are likely to progress into malignant adenocarcinoma...
  9. doi request reprint Bhopal Gas Tragedy: review of clinical and experimental findings after 25 years
    Pradyumna K Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Int J Occup Med Environ Health 22:193-202. 2009
    ....
  10. doi request reprint Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cells
    Pradyumna K Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Free Radic Res 43:718-28. 2009
    ..Thus, endogenous oxidative stress resulted in aberrant expression of p53, p21, cyclin E and CDK2 proteins, suggestive of deregulated cell cycle, chromosomal aberrations, centromeric amplification, aneuploidy and genomic instability...
  11. doi request reprint Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells
    Pradyumna Kumar Mishra
    Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal 462 038, Madhya Pradesh, India
    Environ Mol Mutagen 50:328-36. 2009
    ....
  12. doi request reprint Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates
    Pradyumna Kumar Mishra
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Cell Biol Int 33:675-83. 2009
    ..Analysis through ISSR PCR demonstrated increased microsatellite instability. The results imply that isocyanates can cause genomic instability in colonocytes...
  13. doi request reprint Regulation of isocyanate-induced apoptosis, oxidative stress, and inflammation in cultured human neutrophils: isocyanate-induced neutrophils apoptosis
    P K Mishra
    Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal 462 038, India
    Cell Biol Toxicol 26:279-91. 2010
    ....
  14. doi request reprint Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes
    Pradyumna Kumar Mishra
    Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal 462 038, India pkm
    J Biochem Mol Toxicol 22:429-40. 2008
    ..We anticipate these data along with other studies reported in the literature would help to design better approaches in risk assessment of occupational and accidental exposure to isocyanates...
  15. ncbi request reprint Molecular characterization of isocyanate-induced male germ-line genomic instability
    Gorantla Venkata Raghuram
    Department of Research, Bhopal Memorial Hospital and Research Centre, Bhokal, India
    J Environ Pathol Toxicol Oncol 29:213-34. 2010
    ..We envisage that understanding the interplay between environmental toxin-induced signaling and predisposition to testicular cancers would spur identification of meaningful targets for useful therapeutic translational modalities...
  16. doi request reprint Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cells
    Gorantla Venkata Raghuram
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Reprod Toxicol 30:377-86. 2010
    ..These results indicate that isocyanate exposure alters ovarian epithelial cell proliferation and might lead to ovarian dysfunction and carcinogenesis...
  17. doi request reprint Comparative evaluation of hepatitis B surface antigen-loaded elastic liposomes and ethosomes for human dendritic cell uptake and immune response
    Dinesh Mishra
    Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar, India
    Nanomedicine 6:110-8. 2010
    ..These properties of ethosomes coupled with their skin-navigating potential, make it an attractive vehicle for development of a transcutaneous vaccine against hepatitis B in preference to elastic liposomes...
  18. doi request reprint Evaluation of cytotoxicity and anticarcinogenic potential of Mentha leaf extracts
    Deepika Jain
    Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Int J Toxicol 30:225-36. 2011
    ....
  19. ncbi request reprint Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: a study after two decades
    Arpit Bhargava
    Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India
    Ind Health 48:204-8. 2010
    ..A toxin induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns...
  20. doi request reprint Dendritic cell engineering for tumor immunotherapy: from biology to clinical translation
    Arpit Bhargava
    Division of Translational Research, Tata Memorial Centre, ACTREC, India
    Immunotherapy 4:703-18. 2012
    ..It also showcases certain practical intricacies in order to explore novel strategies for providing new impetus to DC-based cancer vaccination...
  21. doi request reprint Engineered dendritic cells for gastrointestinal tumor immunotherapy: opportunities in translational research
    Arpit Bhargava
    Division of Translational Research, Tata Memorial Centre, ACTREC, Navi, Mumbai, India
    J Drug Target 21:126-36. 2013
    ..It also showcases the necessity of exploring nano-engineered strategies for improving the clinical utility of DC-vaccination for GI tract malignancies to overcome immune tolerance...
  22. pmc Diagnosis of gastrointestinal tuberculosis: Using cytomorphological, microbiological, immunological and molecular techniques - A study from Central India
    Pradyumna Kumar Mishra
    Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, India Department of Research and Training, Bhopal Memorial Hospital and Research Centre, Bhopal, India
    Indian J Clin Biochem 25:158-63. 2010
    ..A combinatorial diagnostic approach for rapid detection and characterization of GITB might provide specific therapeutic strategies for prevention and treatment of the infection in future...
  23. doi request reprint Novel approach for quantification of hepatitis C virus in liver cirrhosis using real-time reverse transcriptase PCR
    Kewal Krishan Maudar
    Department of Surgical Gastroenterology, Bhopal Memorial Hospital and Research Center, Karond, Raisen Bypass Road, Bhopal, 462 038, Madhya Pradesh, India
    J Gastrointest Surg 16:142-6; discussion 146-7. 2012
    ..As HCV replicates in the liver cells, detection and localization of HCV RNA in liver tissue are vital for diagnosis...
  24. ncbi request reprint Nucleic acids in circulation: are they harmful to the host?
    Indraneel Mittra
    Department of Translational Research, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, India
    J Biosci 37:301-12. 2012
    ..In this review we raise the question as to whether circulating nucleic acids may have damaging effects on the host and be implicated in ageing and diverse acute and chronic human pathologies...
  25. ncbi request reprint Evaluation of uptake and generation of immune response by murine dendritic cells pulsed with hepatitis B surface antigen-loaded elastic liposomes
    Dinesh Mishra
    Department of Pharmaceutical Sciences, Dr H S Gour University, Sagar, India
    Vaccine 25:6939-44. 2007
    ..The property of elastic liposomes to traverse and target the immunological milieu of the skin makes it an attractive vehicle for development of a transcutaneous vaccine against hepatitis B virus...
  26. pmc Clinical presentation, etiology, and survival in adult acute encephalitis syndrome in rural Central India
    Rajnish Joshi
    Department of Medicine, All India Institute of Medical Sciences, Bhopal, India
    Clin Neurol Neurosurg 115:1753-61. 2013
    ..We conducted hospital-based surveillance for sporadic adult-AES in rural Central India in order to describe its incidence, spatial and temporal distribution, clinical profile, etiology and predictors of mortality...