Research Topics
| Heather J WhitakerSummaryAffiliation: Milton Keynes Country: UK Publications
|
Detail Information
Publications
Tutorial in biostatistics: the self-controlled case series methodHeather J Whitaker
Department of Statistics, The Open University, Milton Keynes, MK7 6AA, UK
Stat Med 25:1768-97. 2006..Some brief pointers on the design of case series studies are provided. The data sets, STATA code, and further implementation details in SAS, GENSTAT and GLIM are available from an associated website...- Sample sizes for self-controlled case series studiesPatrick Musonda
Department of Statistics, The Open University, Milton Keynes, UK
Stat Med 25:2618-31. 2006..We extend this method to allow for age effects, which can have a big impact on the sample size needed. This more general sample size formula is also found to perform well in a broad range of situations... - Description of trihalomethane levels in three UK water suppliersHeather Whitaker
Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College School of Medicine at St Mary s, Norfolk Place, London W2 1PG, UK
J Expo Anal Environ Epidemiol 13:17-23. 2003..There was a moderate positive correlation between the THMs most similar in their structure (chloroform and BDCM, BDCM and DBCM, and DBCM and bromoform) and a slight negative correlation between chloroform and bromoform levels... - The methodology of self-controlled case series studiesHeather J Whitaker
Department of Mathematics and Statistics, The Open University, Milton Keynes, MK7 6AA, UK
Stat Methods Med Res 18:7-26. 2009..The efficiency of the self-controlled case series method is compared to the that of cohort and case control studies. Some further extensions, to long or indefinite exposures and to bivariate counts, are described... - Estimation of infectious disease parameters from serological survey data: the impact of regular epidemicsH J Whitaker
Department of Statistics, The Open University, Milton Keynes, UK
Stat Med 23:2429-43. 2004..K. prior to the introduction of the combined measles, mumps, rubella (MMR) vaccine. We conclude that past epidemics have only a marginal effect on estimates, and that standard methods that do not adjust for regular epidemics are valid... - Modelling exposure to disinfection by-products in drinking water for an epidemiological study of adverse birth outcomesHeather Whitaker
Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, UK
J Expo Anal Environ Epidemiol 15:138-46. 2005..We conclude that our modelling approach enabled us to provide robust quarterly estimates of ecological exposure to THMs in a situation where the raw data were too sparse to base exposure assessment on empirical summaries alone... - The relationship between water concentrations and individual uptake of chloroform: a simulation studyHeather J Whitaker
Small Area Health Statistics Unit, Faculty of Medicine, Department of Epidemiology and Public Health, Imperial College, London, United Kingdom
Environ Health Perspect 111:688-94. 2003..6. Mothers who swam regularly received far greater doses than did nonswimmers. Results suggest there will be considerable attenuation in risk estimates and/or power loss in epidemiologic studies if the putative agent is chloroform... - Case series analysis for censored, perturbed, or curtailed post-event exposuresC Paddy Farrington
Department of Mathematics and Statistics, The Open University, Milton Keynes MK7 6AA, UK
Biostatistics 10:3-16. 2009..A computational scheme based on a pseudo-likelihood is proposed to make the computations feasible in complex models. Simulations, a validation study, and 2 applications are described... - Infections with varying contact rates: application to varicellaH J Whitaker
Department of Statistics, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
Biometrics 60:615-23. 2004..We also estimate summary statistics such as time-dependent analogs of the basic reproduction number and critical immunization threshold. We illustrate the methods with data on varicella (chickenpox) in the United Kingdom... - Estimation of effective reproduction numbers for infectious diseases using serological survey dataC P Farrington
Department of Statistics, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
Biostatistics 4:621-32. 2003..We describe semi-parametric and parametric models, and obtain an upper bound on Re when vaccine coverage and efficacy are not known. The methods are illustrated using data on mumps and rubella in England and Wales... - Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series methodM N Hocine
INSERM U780, Universite Paris XI, Villejuif, France
Vaccine 25:5938-43. 2007..We recommend that, when case-control studies of vaccination and adverse events are planned, case series analyses based on the cases are also undertaken when appropriate... - Measures of disassortativeness and their application to directly transmitted infectionsC P Farrington
Department of Mathematics and Statistics, The Open University, Milton Keynes, MK76AA, UK
Biom J 51:387-407. 2009..We explore some of its properties and apply our methods to serological surveys of close contact infections and surveys of self-reported social contacts obtained in several European countries...