Research Topics
| C M PondSummaryAffiliation: Milton Keynes Country: UK Publications
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Detail Information
Publications
The source of fatty acids incorporated into proliferating lymphoid cells in immune-stimulated lymph nodesCaroline M Pond
Department of Biological Sciences, The Open University, Milton Keynes, MK7 6AA, UK
Br J Nutr 89:375-83. 2003..Such local interactions show that specialised adipocytes can act as an interface between whole-body and cellular nutrition, and may explain why mammalian adipose tissue is partitioned into a few large and many small depots...
Paracrine interactions of mammalian adipose tissueCaroline M Pond
Department of Biological Sciences, The Open University, Milton Keynes, MK7 6AA, United Kingdom
J Exp Zool A Comp Exp Biol 295:99-110. 2003..Skeletal and cardiac muscle may also have paracrine relationships with anatomically associated adipose tissue, but interactions between contiguous tissues have not been demonstrated directly...
Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndromeCaroline M Pond
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Trends Immunol 24:13-8. 2003....
Adipose tissue, the immune system and exercise fatigue: how activated lymphocytes compete for lipidsC M Pond
Department of Biological Sciences, The Open University, Milton Keynes, MK7 6AA, U K
Biochem Soc Trans 30:270-5. 2002..The concept of paracrine interactions between certain adipocytes and "user" tissue may account for the widespread contiguity between these tissues in vivo...
The activation of the adipose tissue associated with lymph nodes during the early stages of an immune responseCaroline M Pond
Department of Biological Sciences, The Open University, Milton Keynes, MK7 6AA, UK
Cytokine 17:131-9. 2002..Signals spread from lymph nodes to surrounding adipocytes, but the time courses of activation of adipocytes and their maximum responses differ between the mesenteric and popliteal depots...
Long-term changes in adipose tissue in human diseaseC M Pond
Department of Biological Sciences, The Open University, Milton Keynes, UK
Proc Nutr Soc 60:365-74. 2001..These concepts suggest hypotheses about HARS and the anomalous development of mesenteric adipose tissue in Crohn's disease that could form the basis for further investigations...
Adipose tissue and the immune systemCaroline M Pond
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Prostaglandins Leukot Essent Fatty Acids 73:17-30. 2005..The partitioning of adipose tissue in many depots, some specialised for local, paracrine interactions with other tissues, is a fundamental feature of mammals...
In vivo evidence for the involvement of the adipose tissue surrounding lymph nodes in immune responsesC M Pond
Department of Biology, The Open University, Milton Keynes, UK
Immunol Lett 63:159-67. 1998..We conclude that the adipocytes surrounding lymph nodes are actively involved in local, transient immune responses. Their participation may explain why most major lymph nodes are embedded in adipose tissue...
Changes in lymphokine receptor expression and fatty acid composition of phospholipids and triacylglycerols in rat adipocytes associated with lymph nodes following a transient immune challengeJ D Priddle
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Cell Biol Int 27:23-9. 2003..These data are consistent with paracrine interactions between perinodal adipocytes and activated lymphoid cells...
The effects of dietary lipids on adrenergically-stimulated lipolysis in perinodal adipose tissue following prolonged activation of a single lymph nodeChristine A Mattacks
Department of Biological Sciences, The Open University, Milton Keys, Bucks, UK
Br J Nutr 87:375-82. 2002..These results are consistent with the hypothesis that perinodal adipocytes interact with adjacent lymphoid cells during immune responses...
Immunofluorescent localisation of tumour necrosis factor-alpha receptors on the popliteal lymph node and the surrounding adipose tissue following a simulated immune challengeH A MacQueen
Department of Biology, The Open University, Milton Keynes, UK
J Anat 192:223-31. 1998....
Vascularisation in adipose depots surrounding immune-stimulated lymph nodesH A MacQueen
Department of Biology, The Open University, Milton Keynes, UK
J Anat 194:33-8. 1999..These data support the hypothesis that perinodal adipose tissue is involved in peripheral immune responses...
Site-specific differences in the action of NRTI drugs on adipose tissue incubated in vitro with lymphoid cells, and their interaction with dietary lipidsChristine A Mattacks
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Comp Biochem Physiol C Toxicol Pharmacol 135:11-29. 2003..Local interactions, and hence the selective hypertrophy of node-containing adipose depots, may be curtailed by dietary manipulation...
The effects of dietary lipids on dendritic cells in perinodal adipose tissue during chronic mild inflammationChristine A Mattacks
Department of Biological Sciences, The Open University, Milton Keynes MK7 6AA, UK
Br J Nutr 91:883-92. 2004..These data show that dietary lipids modulate the number of dendritic cells in lymphoid tissue-containing adipose depots and support the hypothesis that perinodal adipose tissue interacts locally with lymphoid cells...
The cellular structure and lipid/protein composition of adipose tissue surrounding chronically stimulated lymph nodes in ratsChristine A Mattacks
Department of Biological Sciences, The Open University, Milton Keynes, UK
J Anat 202:551-61. 2003..These findings suggest a mechanism for the selective hypertrophy of lymphoid-containing adipose depots in the HIV-associated adipose redistribution syndrome...
Site-specific differences in fatty acid composition of dendritic cells and associated adipose tissue in popliteal depot, mesentery, and omentum and their modulation by chronic inflammation and dietary lipidsChristine A Mattacks
Department of Biological Sciences, The Open University, Milton Keynes, United Kingdom
Lymphat Res Biol 2:107-29. 2004..These findings demonstrated functional bases for the anatomical associations between adipose and lymphoid tissues and may be a mechanism by which dietary lipids modulate the immune system...
Changes in adipocytes and dendritic cells in lymph node containing adipose depots during and after many weeks of mild inflammationDawn Sadler
Department of Biological Sciences, The Open University, Milton Keynes, UK
J Anat 207:769-81. 2005..It would be useful for further study of molecular mechanisms in inflammation-induced local hypertrophy of adipose tissue and development of specific therapies that avoid interference with whole-body lipid metabolism...
Perinodal adipose tissue and fatty acid composition of lymphoid tissues in patients with and without Crohn's disease and their implications for the etiology and treatment of CDEdward D A Westcott
Antigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, Harrow HA1 3UJ, UK
Ann N Y Acad Sci 1072:395-400. 2006..But these site-specific properties are absent in Crohn's disease, causing anomalies in composition of lymphoid cell fatty acids, which may explain the efficacy of elemental diets containing oils rich in n-6 polyunsaturates...
Different "weight" of cardiac and general adiposity in predicting left ventricle morphologyGianluca Iacobellis
Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
Obesity (Silver Spring) 14:1679-84. 2006..Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues...
