K P Murphy
Affiliation: Milton Keynes
- Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutationK P Murphy
Department of Pharmacology, Centre for Brain Repair, Parke Davis Neuroscience Research, Department of Experimental Psychology, University of Cambridge, CB2 1QJ, United Kingdom
J Neurosci 20:5115-23. 2000..The temporal and regional changes in synaptic plasticity within the hippocampus mirror the appearance of neuronal intranuclear inclusions, suggesting a relationship between polyglutamine aggregation and dysfunction...
- Bi-directional changes in synaptic plasticity induced at corticostriatal synapses in vitroJ P Spencer
Department of Biological Sciences, The Open University, Milton Keynes, UK
Exp Brain Res 135:497-503. 2000..Our observation that it is indeed possible to induce LTP at corticostriatal synapses under physiological conditions in vitro has implications for the normal function and control of the basal ganglia in motor learning and cognition...