S Missailidis

Summary

Affiliation: Milton Keynes
Country: UK

Publications

  1. ncbi request reprint Update: aptamers as novel radiopharmaceuticals: their applications and future prospects in diagnosis and therapy
    Sotiris Missailidis
    Department of Chemistry, The Open University, Walton Hall, Milton Keynes, UK
    Cancer Biother Radiopharm 22:453-68. 2007
  2. ncbi request reprint Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer
    K Eszter Borbas
    Chemistry Department, The Open University, Milton Keynes, UK
    Bioconjug Chem 18:1205-12. 2007
  3. doi request reprint Aptamers as inhibitors of target proteins
    S Missailidis
    The Open University, Department of Chemistry and Analytical Sciences, Walton Hall, Milton Keynes, MK7 6AA, UK
    Expert Opin Ther Pat 19:1073-82. 2009
  4. pmc Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1)
    Suzanne C Simmons
    Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom
    PLoS ONE 7:e37938. 2012
  5. ncbi request reprint Antitumor polycyclic acridines. Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design
    Sotiris Missailidis
    Cancer Research Laboratories, School of Pharmaceutical Sciences, School of Clinical Laboratory Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Oncol Res 13:175-89. 2002
  6. ncbi request reprint Selection of aptamers with high affinity and high specificity against C595, an anti-MUC1 IgG3 monoclonal antibody, for antibody targeting
    Sotiris Missailidis
    Chemistry Department, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
    J Immunol Methods 296:45-62. 2005
  7. ncbi request reprint Antitumor polycyclic acridines. Part 16. Triplex DNA as a target for DNA-binding polycyclic acridine derivatives
    Sotiris Missailidis
    Cancer Research UK Experimental Cancer Chemotherapy Research Group, Centre for Bio molecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
    Oncol Res 15:95-105. 2005
  8. ncbi request reprint DNA aptamers against the MUC1 tumour marker: design of aptamer-antibody sandwich ELISA for the early diagnosis of epithelial tumours
    C S M Ferreira
    Chemistry Department, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Anal Bioanal Chem 390:1039-50. 2008
  9. ncbi request reprint Design of ligands for the purification of anti-MUC1 antibodies by peptide epitope affinity chromatography
    A Murray
    Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, United Kingdom
    J Pept Res 52:375-83. 1998
  10. doi request reprint Modification of thiol functionalized aptamers by conjugation of synthetic polymers
    Chiara Da Pieve
    Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, UK
    Bioconjug Chem 21:169-74. 2010

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Update: aptamers as novel radiopharmaceuticals: their applications and future prospects in diagnosis and therapy
    Sotiris Missailidis
    Department of Chemistry, The Open University, Walton Hall, Milton Keynes, UK
    Cancer Biother Radiopharm 22:453-68. 2007
    ....
  2. ncbi request reprint Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer
    K Eszter Borbas
    Chemistry Department, The Open University, Milton Keynes, UK
    Bioconjug Chem 18:1205-12. 2007
    ..Such multi-aptamer complexes have increased retention of the complex in circulation, without affecting the lack of immunogenicity of the complex or altering its superior tumor penetration properties...
  3. doi request reprint Aptamers as inhibitors of target proteins
    S Missailidis
    The Open University, Department of Chemistry and Analytical Sciences, Walton Hall, Milton Keynes, MK7 6AA, UK
    Expert Opin Ther Pat 19:1073-82. 2009
    ..Yet, their great potential is keeping aptamers at the research forefront, with one aptamer in the clinic and various at different stages of clinical trials...
  4. pmc Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1)
    Suzanne C Simmons
    Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, Buckinghamshire, United Kingdom
    PLoS ONE 7:e37938. 2012
    ..These reagents may serve as useful tools to explore the functional role of the enzyme and in the future development of diagnostic assays or therapeutic reagents...
  5. ncbi request reprint Antitumor polycyclic acridines. Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design
    Sotiris Missailidis
    Cancer Research Laboratories, School of Pharmaceutical Sciences, School of Clinical Laboratory Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Oncol Res 13:175-89. 2002
    ....
  6. ncbi request reprint Selection of aptamers with high affinity and high specificity against C595, an anti-MUC1 IgG3 monoclonal antibody, for antibody targeting
    Sotiris Missailidis
    Chemistry Department, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
    J Immunol Methods 296:45-62. 2005
    ....
  7. ncbi request reprint Antitumor polycyclic acridines. Part 16. Triplex DNA as a target for DNA-binding polycyclic acridine derivatives
    Sotiris Missailidis
    Cancer Research UK Experimental Cancer Chemotherapy Research Group, Centre for Bio molecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
    Oncol Res 15:95-105. 2005
    ..Furthermore, structure/affinity analysis gives insights into the structural features that optimize affinity and selectivity for triplex DNA, and may play a role in their profile of antitumor activity...
  8. ncbi request reprint DNA aptamers against the MUC1 tumour marker: design of aptamer-antibody sandwich ELISA for the early diagnosis of epithelial tumours
    C S M Ferreira
    Chemistry Department, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Anal Bioanal Chem 390:1039-50. 2008
    ..Our results aim towards the formation of new diagnostic assays against this tumour marker for the early diagnosis of primary or metastatic disease in breast, bladder and other epithelial tumours...
  9. ncbi request reprint Design of ligands for the purification of anti-MUC1 antibodies by peptide epitope affinity chromatography
    A Murray
    Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, United Kingdom
    J Pept Res 52:375-83. 1998
    ..In conclusion, RNET analysis is useful in the rational design of peptide ligands so that the performance of affinity matrices may be regulated...
  10. doi request reprint Modification of thiol functionalized aptamers by conjugation of synthetic polymers
    Chiara Da Pieve
    Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, UK
    Bioconjug Chem 21:169-74. 2010
    ..This work demonstrates an alternative approach to PEGylation of aptamers, and that the effect of PEG on the affinity for the target varies according to the structure and conformation of the synthetic polymer...
  11. doi request reprint Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents
    Mai Kim Cheng
    Cancer Research UK Experimental Cancer Chemotherapy Research Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, UK
    J Med Chem 51:963-75. 2008
    ..82). Quantification of relative quadruplex and duplex binding affinity constants puts some of these ligands among the most selective quadruplex DNA interactive agents reported to date...
  12. ncbi request reprint Purification of anti-MUC1 antibodies by peptide mimotope affinity chromatography using peptides derived from a polyvalent phage display library
    Richard G Smith
    University of Nottingham, Cancer Research Laboratories, School of Pharmaceutical Sciences, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 766:13-26. 2002
    ..75 x 10(6)) than the epitope peptide (K(A)=0.16 x 10(6)). Circular dichroism showed that the novel peptide had a more highly ordered structure at 4 degrees C and room temperature, than the epitope peptide...
  13. doi request reprint Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis
    C A C Hyde
    Department of Chemistry and Analytical Sciences, The Open University, Walton Hall, Milton Keynes, MK5 7AS, UK
    Int Immunopharmacol 9:701-15. 2009
    ....
  14. ncbi request reprint Structure-activity studies of the binding of the flavonoid scaffold to DNA
    Patricia A Ragazzon
    Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, MK7 6AA, U K
    Anticancer Res 29:2285-93. 2009
    ..Flavonoids have been shown to have a wide variety of biological activities and proven to be good scaffolds for the design of DNA-binding agents as anticancer therapeutics...
  15. ncbi request reprint The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development
    Patricia A Ragazzon
    Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, MK7 6AA, U K
    Anticancer Res 29:2273-83. 2009
    ..The physical properties and sequence specificity observed in the interactions between a group of flavonoids with proven antitumour activity and various nucleic acid structures are summarised...
  16. ncbi request reprint Radiolabelled aptamers for tumour imaging and therapy
    A C Perkins
    Academic Medical Physics, Queen s Medical Centre, The University of Nottingham, Nottingham, UK
    Q J Nucl Med Mol Imaging 51:292-6. 2007
    ..In this way, a balance can be achieved between the rapid renal clearance and adequate tumour uptake required for diagnostic imaging and targeted therapy...
  17. ncbi request reprint Targeting the hedgehog pathway: the development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway
    A Gould
    Department of Chemistry and Analytical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Mini Rev Med Chem 11:200-13. 2011
    ..Finally, combination chemotherapy - incorporating a Hedgehog pathway inhibitor as well as another drug - is discussed from the perspective of drug resistance and effects on cancer stem cells...
  18. ncbi request reprint DNA aptamers that bind to MUC1 tumour marker: design and characterization of MUC1-binding single-stranded DNA aptamers
    C S M Ferreira
    Chemistry Department, The Open University, Milton Keynes, MK7 6AA, UK
    Tumour Biol 27:289-301. 2006
    ....
  19. ncbi request reprint Characterization of antibody-antigen interactions by fluorescence spectroscopy
    Sotiris Missailidis
    Department of Chemistry, The Open University, Milton Keynes, UK
    Methods Mol Biol 248:431-41. 2004
  20. ncbi request reprint A novel methodological approach for the analysis of host-ligand interactions
    Daniela Strat
    Dage Precision Industries Ltd, 1 Davey Close, Colchester, Essex, CO1 2XL, UK
    Chemphyschem 8:270-8. 2007
    ..The binding constants and the number of binding sites derived from the model remained consistent across the different techniques used. The different wavelengths at which the measurements were made maintained the coherence of the results...
  21. ncbi request reprint Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold
    Stefano Alcaro
    Dipartimento di Scienze Farmacobiologiche Università degli Studi Magna Graecia di Catanzaro, Complesso Nini Barbieri, 88021 Roccelletta di Borgia CZ, Italy
    Bioorg Med Chem Lett 17:2509-14. 2007
    ....