Pal Miheller

Summary

Country: UK

Publications

  1. doi request reprint [Hungarian data on inflammatory bowel diseases: analytical data on ulcerative colistis]
    Pal Miheller
    Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Budapest
    Orv Hetil 153:702-12. 2012
  2. ncbi request reprint [Molecular biology background of inflammatory bowel disease]
    Pal Miheller
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 147:1395-403. 2006
  3. ncbi request reprint International Falk Foundation 164th Falk Symposium
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Szentkiralyi u 46, H 1088, Hungary
    Expert Rev Gastroenterol Hepatol 2:523-4. 2008
  4. ncbi request reprint Infliximab therapy improves the bone metabolism in fistulizing Crohn's disease
    Pal Miheller
    Semmelweis University, Second Department of Internal Medicine, Budapest, Hungary
    Dig Dis 24:201-6. 2006
  5. ncbi request reprint Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyvitamin D on bone pathology and disease activity in Crohn's disease patients
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 15:1656-62. 2009
  6. pmc Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Gastroenterol 9:66. 2009
  7. ncbi request reprint Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy
    Pal Miheller
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 13:1379-84. 2007
  8. doi request reprint Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a Hungarian IBD cohort
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 15:365-74. 2009
  9. ncbi request reprint [Improvement of bone metabolism after infliximab therapy in Crohn's disease]
    Pal Miheller
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 146:1477-80. 2005
  10. ncbi request reprint New serological markers for inflammatory bowel disease are associated with earlier age at onset, complicated disease behavior, risk for surgery, and NOD2/CARD15 genotype in a Hungarian IBD cohort
    Maria Papp
    2nd Department of Medicine, University of Debrecen, Debrecen, Hungary
    Am J Gastroenterol 103:665-81. 2008

Collaborators

Detail Information

Publications39

  1. doi request reprint [Hungarian data on inflammatory bowel diseases: analytical data on ulcerative colistis]
    Pal Miheller
    Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Budapest
    Orv Hetil 153:702-12. 2012
    ..In Hungary, a registry for patients with inflammatory bowel disease has already been set up, which makes it possible for clinicians to collect prospective data on their patients...
  2. ncbi request reprint [Molecular biology background of inflammatory bowel disease]
    Pal Miheller
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 147:1395-403. 2006
    ..It seems that these alterations are secondary, and don't play a major role in the pathogenesis of inflammatory bowel disease...
  3. ncbi request reprint International Falk Foundation 164th Falk Symposium
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Szentkiralyi u 46, H 1088, Hungary
    Expert Rev Gastroenterol Hepatol 2:523-4. 2008
    ....
  4. ncbi request reprint Infliximab therapy improves the bone metabolism in fistulizing Crohn's disease
    Pal Miheller
    Semmelweis University, Second Department of Internal Medicine, Budapest, Hungary
    Dig Dis 24:201-6. 2006
    ..Limited data exist about the effect of anti-TNF-alpha infliximab on bone metabolism in inflammatory-type Crohn's disease (CD)...
  5. ncbi request reprint Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyvitamin D on bone pathology and disease activity in Crohn's disease patients
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 15:1656-62. 2009
    ..Our work is a prospective study to compare the effects of aVD and pVD on bone metabolism and the clinical course of CD...
  6. pmc Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Gastroenterol 9:66. 2009
    ..Our objective in this study is to report the nationwide, multicenter experience with IFX induction therapy for CD in Hungary...
  7. ncbi request reprint Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy
    Pal Miheller
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 13:1379-84. 2007
    ..Long-term infliximab (IFX) maintenance therapy improves the patients' bone mineral density. The effect of IFX on bone metabolism has not yet been clarified. Our aim was to evaluate IFX effects on bone pathology in CD patients...
  8. doi request reprint Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a Hungarian IBD cohort
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 15:365-74. 2009
    ..Our aim was to determine the accuracy of PAB and GAB autoantibodies as well as to study relevant phenotype-serotype associations...
  9. ncbi request reprint [Improvement of bone metabolism after infliximab therapy in Crohn's disease]
    Pal Miheller
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 146:1477-80. 2005
    ..Only few data are present about the effect of infliximab on bone metabolism...
  10. ncbi request reprint New serological markers for inflammatory bowel disease are associated with earlier age at onset, complicated disease behavior, risk for surgery, and NOD2/CARD15 genotype in a Hungarian IBD cohort
    Maria Papp
    2nd Department of Medicine, University of Debrecen, Debrecen, Hungary
    Am J Gastroenterol 103:665-81. 2008
    ....
  11. doi request reprint Matrix metalloproteinase-9 expression in the normal mucosa-adenoma-dysplasia-adenocarcinoma sequence of the colon
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, 1088 Szentkirályi str 46, Budapest, Hungary
    Pathol Oncol Res 14:31-7. 2008
    ..We demonstrate a significantly higher expression of MMP-9 in adenoma with high grade dysplasia-CRC sequence as compared to normal tissue. The over-expression of MMP-9 strongly suggests its association with colorectal carcinogenesis...
  12. pmc Low bone mass in microscopic colitis
    Katalin Lorinczy
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Gastroenterol 11:58. 2011
    ..Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis...
  13. doi request reprint The 3'UTR NFKBIA variant is associated with extensive colitis in Hungarian IBD patients
    Tamas Szamosi
    1st Department of Medicine, Semmelweis University, Koranyi st 2 A, 1083, Budapest, Hungary
    Dig Dis Sci 54:351-9. 2009
    ..The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or disease phenotype in Hungarian inflammatory bowel disease (IBD) patients...
  14. doi request reprint Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral centre
    Dorottya Kocsis
    Semmelweis University, 2nd Dept Med, Budapest, Hungary
    Eur J Intern Med 24:461-7. 2013
    ..The aim of this study is to evaluate the experience of a single coeliac centre over a 15-year-long study period (between November of 1997 and September of 2011)...
  15. ncbi request reprint [Insulin-like growth factor receptor, hepatocyte-derived growth factor receptor and telomerase expression in ulcerative colitis]
    Ferenc Sipos
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Magyar Tudományos Akadémia, Budapest
    Orv Hetil 147:1835-41. 2006
    ..Aim of the study was to describe the expression alterations of regenerative signal receptors and cell aging inhibitory systems within colonic crypts considering the histological activity of the disease...
  16. doi request reprint [Prevalence of gastric polypoid lesions at an endoscopic facility]
    Agnes Anna Csontos
    Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Szentkirályi u 46 1088
    Orv Hetil 154:770-4. 2013
    ..The prevalence of gastric polyps is unknown in Hungary...
  17. doi request reprint The behavior of matrix metalloproteinase-9 in lymphocytic colitis, collagenous colitis and ulcerative colitis
    Gabor Lakatos
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Pathol Oncol Res 18:85-91. 2012
    ..In contrast, the mucosal up-regulation of MMP-9 correlated with the severity of inflammation in UC. The increased MMP-9 expression could contribute to the severity of mucosal damage in active UC...
  18. doi request reprint The impact of matrix metalloproteinases and their tissue inhibitors in inflammatory bowel diseases
    Gabor Lakatos
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Dig Dis 30:289-95. 2012
    ....
  19. doi request reprint Effect of proton-pump inhibitor therapy on serum chromogranin a level
    Istvan Pregun
    2nd Department of Medicine, Semmelweis University, and Gastroenterology and Endocrinology Unit, Hungarian Academy of Sciences, Budapest, Hungary pregunistvan yahoo com
    Digestion 84:22-8. 2011
    ..Aims: To analyze the effect of ultra-short-term and diverse dose of PPI therapy on serum CgA and gastrin levels and evaluate the effect of PPI treatment cessation...
  20. ncbi request reprint Methotrexate: should we start using it in clinical practice?
    Pal Miheller
    1st Department of Medicine, Semmelweis University, H 1083 Budapest, Koranyi S 2A, Hungary
    Curr Drug Targets 14:1480-9. 2013
    ..This review summarizes current knowledge on the efficacy and side effects of methotrexate, and tries to reevaluate the drug in the current IBD armamentarium. ..
  21. ncbi request reprint [Osteoporosis associated with inflammatory bowel diseases]
    Pal Miheller
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 145:1045-51. 2004
    ..The authors provide an algorithm for the therapy of metabolic bone disease in inflammatory bowel disease...
  22. doi request reprint Association of adherence to therapy and complementary and alternative medicine use with demographic factors and disease phenotype in patients with inflammatory bowel disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    J Crohns Colitis 4:283-90. 2010
    ..Furthermore, a significant number of IBD patients fail to comply with treatment. The aim of our study was to evaluate the prevalence of non-adherence and the use of CAM in Hungarian patients with IBD...
  23. doi request reprint [Epidemiology, predictors and clinical aspects of loss of response to biological therapy]
    Katalin Lorinczy
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 153:163-73. 2012
    ..In clinical practice, meticulous complex assessment of clinical symptoms, confirmation of active disease by endoscopic or radiological imaging, and excluding complications remain necessary...
  24. doi request reprint ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients
    P L Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Dig Liver Dis 40:867-73. 2008
    ..The aims of this study were to investigate the association and examine genotype-phenotype relationships in a Hungarian IBD cohort...
  25. ncbi request reprint [Novel therapeutic approaches in the treatment of irritable bowel syndrome]
    Istvan Pregun
    Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Budapest
    Orv Hetil 148:923-8. 2007
    ..Albeit nowadays several drugs (alosetron, tegaserod) have been registered in a few countries for the treatment of irritable bowel syndrome, further large clinical trials are required related to the new chemical entities...
  26. doi request reprint Anti-TNF trough levels and detection of antibodies to anti-TNF in inflammatory bowel disease: are they ready for everyday clinical use?
    Pal Miheller
    Semmelweis University, 2nd Department of Medicine, H1088 Budapest, Szentkiralyi u 46, Hungary
    Expert Opin Biol Ther 12:179-92. 2012
    ..Some patients, however, experience lack- or loss of response (LOR) to treatment, and management of such patients is often empirical...
  27. ncbi request reprint Carcinogenesis in inflammatory bowel disease
    Laszlo Herszenyi
    Semmelweis University, Second Department of Medicine, Hungarian Academy of Science, Clinical Gastroenterology Unit, Budapest, Hungary
    Dig Dis 25:267-9. 2007
    ..There is no clear evidence that surveillance colonoscopy prolongs survival in patients with extensive colitis. Newer endoscopic and molecular techniques are being assessed for their effectiveness in augmenting conventional surveillance...
  28. pmc Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature
    Orsolya Galamb
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Dis Markers 25:1-16. 2008
    ..Our results provide further insight into the pathophysiological background of colonic diseases. The results set up data warehouse which can be mined further...
  29. ncbi request reprint [Acromegaly associated with McCune-Albright syndrome]
    Miklos Toth
    AOK II Belgyógyászati Klinika, Semmelweis Egyetem, Budapest
    Orv Hetil 143:1070-3. 2002
    ....
  30. doi request reprint Recommendations for identifying Crohn's disease patients with poor prognosis
    Pal Miheller
    Second Department of Medicine, Semmelweis University, H 1083 Budapest, Hungary
    Expert Rev Clin Immunol 9:65-75; quiz 76. 2013
    ..This review summarizes the available evidence and will hopefully assist clinicians when choosing a treatment strategy in everyday practice...
  31. ncbi request reprint Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
    Maria Papp
    2nd Department of Medicine, University of Debrecen, Debrecen, Hungary
    Inflamm Bowel Dis 13:984-92. 2007
    ..Since limited data are available from Eastern Europe, we assessed the above antibodies in Hungarian IBD patients...
  32. doi request reprint Nutritional influences in selected gastrointestinal diseases
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Dig Dis 29:154-65. 2011
    ..g. recall bias, heterogeneity between collected data, lack of correction for covariates, difficulties in double blinding)...
  33. ncbi request reprint Have biologics changed the natural history of Crohn's disease?
    Michael D Mandel
    First Department of Medicine, Semmelweis University, Budapest, Hungary
    Dig Dis 32:351-9. 2014
    ..2014 S. Karger AG, Basel. ..
  34. ncbi request reprint Probiotics in the Management of Crohn's disease and Ulcerative Colitis
    Katalin Mullner
    Semmelweis University, 2nd Department of Internal Medicine, H 1088, Budapest, Szentkiralyi u 46, Hungary
    Curr Pharm Des 20:4556-60. 2014
    ..Small number of comparable protocols and lack of standardization encumber the analysis of study results. ..
  35. doi request reprint Thiopurines in Crohn's disease, is there something new?
    Pal Miheller
    Semmelweis University, 2nd Department of Medicine, Budapest, Koranyi, Hungary
    Expert Opin Drug Metab Toxicol 6:1505-14. 2010
    ..Major complications occur in patients with low thiopurine-S-methyltransferase (TPMT) enzyme activity; however, the clinical relevance of these tests remains conflictive...
  36. doi request reprint Chemoprevention of colorectal cancer: feasibility in everyday practice?
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Hungarian Academy of Science, Budapest, Hungary
    Eur J Cancer Prev 17:502-14. 2008
    ..The usefulness of selenium, folate, calcium, and vitamin D awaits further evaluation. Chemoprevention cannot yet be accepted as standard medical practice. Use of chemopreventive agents cannot be a substitute for colorectal surveillance...
  37. doi request reprint Clinical aspects of mucosal healing in inflammatory bowel diseases: what is it and what is the real value for the everyday practice?
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, H 1083 Budapest, Hungary
    Expert Rev Clin Immunol 9:871-82. 2013
    ..This review summarizes the available evidence in order to assist clinicians when assessing the mucosal status in the everyday practice. ..
  38. ncbi request reprint [Is the successful eradication of Helicobacter pylori sufficient for the healing of peptic ulcer?]
    Istvan Pregun
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika
    Orv Hetil 147:435-9. 2006
    ..There are less data available concerning gastric ulcer: successful eradication is also essential to ulcer healing and to avoid relapse, however it seems that post-eradication PPI therapy might be beneficial...
  39. ncbi request reprint Automated virtual microscopy of gastric biopsies
    Levente Ficsor
    2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Cytometry B Clin Cytom 70:423-31. 2006
    ..Our objective was to classify gastritis and adenocarcinoma based on cytometric parameters. We hypothesized that automated virtual microscopy using this novel classification can reliably diagnose gastritis and adenocarcinoma...