Andrew McCaddon

Summary

Country: UK

Publications

  1. ncbi Total serum homocysteine in senile dementia of Alzheimer type
    A McCaddon
    Wrexham Maelor Hospital, North Wales, UK
    Int J Geriatr Psychiatry 13:235-9. 1998
  2. ncbi Functional vitamin B(12) deficiency and Alzheimer disease
    A McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham, UK
    Neurology 58:1395-9. 2002
  3. ncbi The transcobalamin 776C > G polymorphism may be a modifiable genetic risk factor for Alzheimer's disease
    Henrik Zetterberg
    Int Psychogeriatr 17:329-31. 2005
  4. ncbi Homocysteine and cognition--a historical perspective
    Andrew McCaddon
    Wales College of Medicine, Gardden Road Surgery, Rhosllanerchrugog, Wrexham, Wales LL142EN, UK
    J Alzheimers Dis 9:361-80. 2006
  5. ncbi Absence of macrocytic anaemia in Alzheimer's disease
    A McCaddon
    University of Wales College of Medicine, Wrexham, UK
    Clin Lab Haematol 26:259-63. 2004
  6. ncbi Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
    Andrew McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham, UK
    Dement Geriatr Cogn Disord 17:215-21. 2004
  7. ncbi Biological variation of holo-transcobalamin in elderly individuals
    Andrew McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham LL13 7YP, UK
    Clin Chem 49:1542-4. 2003
  8. ncbi Homocysteine and cognitive decline in healthy elderly
    A McCaddon
    University of Wales College of Medicine, Wrexham, LL14 2EN, Wales, UK
    Dement Geriatr Cogn Disord 12:309-13. 2001
  9. ncbi Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease
    A McCaddon
    Gardden Road Surgery, Rhosllanerchrugog, Wrexham, North Wales, UK
    Dement Geriatr Cogn Disord 12:133-7. 2001
  10. pmc Homocysteine and cognitive impairment; a case series in a General Practice setting
    Andrew McCaddon
    Wales College of Medicine, Wrexham, UK
    Nutr J 5:6. 2006

Detail Information

Publications18

  1. ncbi Total serum homocysteine in senile dementia of Alzheimer type
    A McCaddon
    Wrexham Maelor Hospital, North Wales, UK
    Int J Geriatr Psychiatry 13:235-9. 1998
    ..A subsidiary hypothesis was that such deficiencies would be nutritionally independent as determined by retinol binding protein (RBP)...
  2. ncbi Functional vitamin B(12) deficiency and Alzheimer disease
    A McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham, UK
    Neurology 58:1395-9. 2002
    ..Currently available pharmaceutic forms of vitamin B(12) are unlikely to be utilized by neurons under these conditions. Glutathionylcobalamin might be preferential for the treatment of such patients...
  3. ncbi The transcobalamin 776C > G polymorphism may be a modifiable genetic risk factor for Alzheimer's disease
    Henrik Zetterberg
    Int Psychogeriatr 17:329-31. 2005
  4. ncbi Homocysteine and cognition--a historical perspective
    Andrew McCaddon
    Wales College of Medicine, Gardden Road Surgery, Rhosllanerchrugog, Wrexham, Wales LL142EN, UK
    J Alzheimers Dis 9:361-80. 2006
    ..Alternative approaches specifically designed to address this issue are discussed...
  5. ncbi Absence of macrocytic anaemia in Alzheimer's disease
    A McCaddon
    University of Wales College of Medicine, Wrexham, UK
    Clin Lab Haematol 26:259-63. 2004
    ..Our results support previous observations that the neurological and haematological features of B12 and folate deficiency are often unrelated in these patients...
  6. ncbi Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
    Andrew McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham, UK
    Dement Geriatr Cogn Disord 17:215-21. 2004
    ..008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study...
  7. ncbi Biological variation of holo-transcobalamin in elderly individuals
    Andrew McCaddon
    University of Wales College of Medicine, Division of General Practice, Wrexham LL13 7YP, UK
    Clin Chem 49:1542-4. 2003
  8. ncbi Homocysteine and cognitive decline in healthy elderly
    A McCaddon
    University of Wales College of Medicine, Wrexham, LL14 2EN, Wales, UK
    Dement Geriatr Cogn Disord 12:309-13. 2001
    ..Fasting total serum homocysteine appears to be an independent predictor of cognitive decline in healthy elderly and exerts a maximal effect on spatial copying skills...
  9. ncbi Analogues, ageing and aberrant assimilation of vitamin B12 in Alzheimer's disease
    A McCaddon
    Gardden Road Surgery, Rhosllanerchrugog, Wrexham, North Wales, UK
    Dement Geriatr Cogn Disord 12:133-7. 2001
    ..Two disparate mechanisms might exist for the development of cerebral B12 deficiency in Alzheimer's disease, although both imply a disruption of selective B12 assimilation and analogue elimination in such patients...
  10. pmc Homocysteine and cognitive impairment; a case series in a General Practice setting
    Andrew McCaddon
    Wales College of Medicine, Wrexham, UK
    Nutr J 5:6. 2006
    ..This report presents clinical and radiological findings from administering the antioxidant N-acetylcysteine together with B vitamins to cognitively impaired patients with hyperhomocysteinaemia...
  11. ncbi Alzheimer's disease and total plasma aminothiols
    Andrew McCaddon
    University of Wales College of Medicine, Wrexham, UK
    Biol Psychiatry 53:254-60. 2003
    ..We therefore determined total plasma homocysteine, cysteine, and glutathione levels in patients and control subjects and investigated their relationship with cognitive scores...
  12. ncbi Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials
    Christopher C Butler
    Department of General Practice, Cardiff University, Wales, UK
    Fam Pract 23:279-85. 2006
    ..Vitamin B(12) deficiency is common, increasing with age. Most people are treated in primary care with intramuscular vitamin B(12). Several studies have reported equal efficacy of oral administration of vitamin B(12)...
  13. ncbi Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study
    Cherie McCracken
    University Department of Psychiatry, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Am J Clin Nutr 84:1406-11. 2006
    ....
  14. ncbi Co-administration of N-acetylcysteine, vitamin B12 and folate in cognitively impaired hyperhomocysteinaemic patients
    Andrew McCaddon
    Int J Geriatr Psychiatry 20:998-1000. 2005
  15. ncbi Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12
    Andrew McCaddon
    Lancet 360:173. 2002
  16. ncbi Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology
    Alistair Burns
    University of Manchester, Manchester, UK
    J Psychopharmacol 20:732-55. 2006
    ..Patients, their carers, and clinicians deserve to be optimistic in a field which often attracts therapeutic nihilism...
  17. ncbi Methylation and phosphorylation: a tangled relationship?
    Andrew McCaddon
    Clin Chem 53:999-1000. 2007
  18. ncbi The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1590-606. 2007
    ..Treatment with folic acid, B(12) and B(6) lowers tHcy. For secondary and primary prevention from several neuropsychiatric disorders, it seems prudent to actively identify deficient subjects and ensure sufficient vitamin intake...