Philippa C Matthews

Summary

Country: UK

Publications

  1. ncbi request reprint Teicoplanin levels in bone and joint infections: are standard doses subtherapeutic?
    Philippa C Matthews
    Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Headington, Oxford, OX3 9DU, UK
    J Infect 55:408-13. 2007
  2. pmc Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
  3. pmc HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
  4. doi request reprint Increased teicoplanin doses are associated with improved serum levels but not drug toxicity
    Philippa C Matthews
    Oxford Bone Infection Unit, Oxford University Hospitals NHS Trust, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7HE, UK Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, South Parks Road, Oxford OX1 3SY, UK Electronic address
    J Infect 68:43-9. 2014
  5. pmc Co-operative additive effects between HLA alleles in control of HIV-1
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e47799. 2012
  6. pmc HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering
    Philippa C Matthews
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    J Virol 83:4605-15. 2009
  7. pmc Acute necrotizing sinusitis caused by Staphylococcus lugdunensis
    Philippa C Matthews
    Department of Microbiology and Infectious Diseases, John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Headington, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 49:2740-2. 2011
  8. doi request reprint Muscle hemorrhage in a paraplegic adult with neurofibromatosis type 1 and an associated vasculopathy
    Philippa C Matthews
    Department of Infectious Diseases and Microbiology, Oxford Radcliffe Hospitals, Oxford, UK
    Am J Med Genet A 146:2424-6. 2008
  9. ncbi request reprint Outpatient parenteral antimicrobial therapy (OPAT): is it safe for selected patients to self-administer at home? A retrospective analysis of a large cohort over 13 years
    Philippa C Matthews
    Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    J Antimicrob Chemother 60:356-62. 2007
  10. ncbi request reprint Clinical management of diabetic foot infection: diagnostics, therapeutics and the future
    Philippa C Matthews
    Bone Infection Unit, Nuffield Orthopaedic Centre NHS Trust, Windmill Road, Headington, Oxford OX3 7LD, UK
    Expert Rev Anti Infect Ther 5:117-27. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Teicoplanin levels in bone and joint infections: are standard doses subtherapeutic?
    Philippa C Matthews
    Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Headington, Oxford, OX3 9DU, UK
    J Infect 55:408-13. 2007
    ..We investigated how dose regimen and patient characteristics impact on trough teicoplanin levels in patients with musculoskeletal infection, in order to help standardise teicoplanin use...
  2. pmc Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
    ..The significance of these results is in highlighting the rationale for an HIV vaccine that can induce these broad responses...
  3. pmc HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
    ..In addition, these studies identify a factor contributing to different HIV disease outcomes in individuals expressing HLA-B*5703...
  4. doi request reprint Increased teicoplanin doses are associated with improved serum levels but not drug toxicity
    Philippa C Matthews
    Oxford Bone Infection Unit, Oxford University Hospitals NHS Trust, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7HE, UK Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, South Parks Road, Oxford OX1 3SY, UK Electronic address
    J Infect 68:43-9. 2014
    ..We set out to investigate the impact of this dose increase on drug levels and potential side-effects...
  5. pmc Co-operative additive effects between HLA alleles in control of HIV-1
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e47799. 2012
    ..We here investigate the extent to which HLA alleles--irrespective of linkage disequilibrium--function co-operatively...
  6. pmc HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering
    Philippa C Matthews
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    J Virol 83:4605-15. 2009
    ..In conclusion, these data highlight the fact that HLA can be a strong selection force for both intra- and interclade HIV evolution at a population level...
  7. pmc Acute necrotizing sinusitis caused by Staphylococcus lugdunensis
    Philippa C Matthews
    Department of Microbiology and Infectious Diseases, John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Headington, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 49:2740-2. 2011
    ..The severity of necrosis demonstrates the potential for destructive pathology mimicking Staphylococcus aureus disease...
  8. doi request reprint Muscle hemorrhage in a paraplegic adult with neurofibromatosis type 1 and an associated vasculopathy
    Philippa C Matthews
    Department of Infectious Diseases and Microbiology, Oxford Radcliffe Hospitals, Oxford, UK
    Am J Med Genet A 146:2424-6. 2008
  9. ncbi request reprint Outpatient parenteral antimicrobial therapy (OPAT): is it safe for selected patients to self-administer at home? A retrospective analysis of a large cohort over 13 years
    Philippa C Matthews
    Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    J Antimicrob Chemother 60:356-62. 2007
    ..To distinguish between healthcare professional OPAT and self-administered OPAT, we have coined the terms H-OPAT and S-OPAT, respectively...
  10. ncbi request reprint Clinical management of diabetic foot infection: diagnostics, therapeutics and the future
    Philippa C Matthews
    Bone Infection Unit, Nuffield Orthopaedic Centre NHS Trust, Windmill Road, Headington, Oxford OX3 7LD, UK
    Expert Rev Anti Infect Ther 5:117-27. 2007
    ..We discuss this complex group of infections with a particular emphasis on medical management of osteomyelitis, while also highlighting the importance of a broad multidisciplinary approach to eradicating infection...
  11. doi request reprint Native hip joint septic arthritis in 20 adults: delayed presentation beyond three weeks predicts need for excision arthroplasty
    Philippa C Matthews
    Bone Infection Unit, Nuffield Orthopaedic Centre NHS Trust, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Infect 57:185-90. 2008
    ..We set out to study the natural history and bacteriology of the disease in this group, with a particular focus on patients requiring excision arthroplasty (EA)...
  12. pmc Additive contribution of HLA class I alleles in the immune control of HIV-1 infection
    Alasdair Leslie
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    J Virol 84:9879-88. 2010
    ..Taken together, these data suggest that although individual HLA alleles, particularly HLA-B, can have a strong impact, HIV control overall is likely to be influenced by the additive effect of some or all of the other HLA alleles present...
  13. pmc HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control
    Henrik N Kloverpris
    Department of Paediatrics, University of Oxford, Peter Medawar Building, Oxford, United Kingdom
    J Virol 86:919-29. 2012
    ..These findings are consistent with HLA class I alleles mediating effective immune control of HIV through the number of p24 Gag-specific CD8(+) T-cell responses generated that can drive significant selection pressure on the virus...
  14. ncbi request reprint HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome
    Henrik N Kløverpris
    1 Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    AIDS Res Hum Retroviruses 30:468-75. 2014
    ..These data support earlier studies suggesting that increased breadth of the Gag-specific CD8(+) T cell response may contribute to improved HIV immune control irrespective of the particular HLA molecules expressed. ..
  15. pmc The hypervariable HIV-1 capsid protein residues comprise HLA-driven CD8+ T-cell escape mutations and covarying HLA-independent polymorphisms
    Hayley Crawford
    Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 85:1384-90. 2011
    ..Our results demonstrate complex patterns of adaptation of HIV under immune selection pressure, the understanding of which should aid vaccine design...
  16. pmc Nef-specific CD8+ T cell responses contribute to HIV-1 immune control
    Emily Adland
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e73117. 2013
    ..These data suggest that a re-evaluation of the potential use of Nef in HIV T-cell vaccine candidates would be justified. ..
  17. pmc Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    J Virol 86:12643-54. 2012
    ..This distinction is of direct relevance to development of vaccines designed to optimize the anti-HIV CD8(+) T-cell response in all individuals, irrespective of HLA type...
  18. doi request reprint HLA-mediated control of HIV and HIV adaptation to HLA
    Rebecca P Payne
    Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    Adv Parasitol 68:1-20. 2009
    ....
  19. pmc Misdiagnosing melioidosis
    Andrew J Brent
    Emerg Infect Dis 13:349-51. 2007
  20. ncbi request reprint HIV testing for adult patients with Streptococcus pneumoniae bacteraemia
    Philippa C Matthews
    Clin Med 6:512. 2006