Colin R Goding

Summary

Affiliation: Marie Curie Research Institute
Country: UK

Publications

  1. ncbi Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage
    C R Goding
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted Surrey, RH8 OTL, UK
    Genes Dev 14:1712-28. 2000
  2. pmc The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma
    K K C Li
    Department of Biology, HK University of Science and Technology, Kowloon, HK, China
    Br J Cancer 89:1072-8. 2003
  3. ncbi Melanocytes: the new Black
    Colin R Goding
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Int J Biochem Cell Biol 39:275-9. 2007
  4. doi Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7788-94. 2008
  5. pmc The Brn-2 transcription factor links activated BRAF to melanoma proliferation
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 24:2923-31. 2004
  6. doi Tbx3 represses E-cadherin expression and enhances melanoma invasiveness
    Mercedes Rodriguez
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7872-81. 2008
  7. ncbi T-box factors: targeting to chromatin and interaction with the histone H3 N-terminal tail
    Florence Demay
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    Pigment Cell Res 20:279-87. 2007
  8. pmc Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
  9. ncbi Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
  10. ncbi Cell cycle regulation of the T-box transcription factor tbx2
    Bilada Bilican
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK
    Exp Cell Res 312:2358-66. 2006

Collaborators

Detail Information

Publications41

  1. ncbi Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage
    C R Goding
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted Surrey, RH8 OTL, UK
    Genes Dev 14:1712-28. 2000
  2. pmc The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma
    K K C Li
    Department of Biology, HK University of Science and Technology, Kowloon, HK, China
    Br J Cancer 89:1072-8. 2003
    ..Thus, our results indicate that Mitf-M promoter activation may require an appropriate chromosomal context in CCS cells or alternatively that the Mitf-M promoter is not directly activated by EWS/ATF1...
  3. ncbi Melanocytes: the new Black
    Colin R Goding
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Int J Biochem Cell Biol 39:275-9. 2007
    ....
  4. doi Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7788-94. 2008
    ..Remarkably, in melanoma biopsies, Mitf and Brn-2 each mark a distinct subpopulation of melanoma cells, providing a striking illustration of melanoma tumor heterogeneity with implications for melanoma therapy...
  5. pmc The Brn-2 transcription factor links activated BRAF to melanoma proliferation
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 24:2923-31. 2004
    ..The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation...
  6. doi Tbx3 represses E-cadherin expression and enhances melanoma invasiveness
    Mercedes Rodriguez
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7872-81. 2008
    ....
  7. ncbi T-box factors: targeting to chromatin and interaction with the histone H3 N-terminal tail
    Florence Demay
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    Pigment Cell Res 20:279-87. 2007
    ..Taken together our results suggest that Tbx2, and most likely other members of the T-box family, are able to target chromatin and may indicate a role for the T-box factors in epigenetic reprogramming events...
  8. pmc Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
    ..The results imply variations in the repertoire of environmental cues that determine Mitf activity will dictate the differentiation, proliferative, and invasive/migratory potential of melanoma cells through a dynamic epigenetic mechanism...
  9. ncbi Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
    ..The mutation of genes associated with melanoma, such as INK4a or BRAF that would affect either Mitf cooperation with Rb1 or Mitf stability respectively, would impair Mitf-mediated cell cycle control...
  10. ncbi Cell cycle regulation of the T-box transcription factor tbx2
    Bilada Bilican
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK
    Exp Cell Res 312:2358-66. 2006
    ..The results are consistent with Tbx2 playing a role in cell cycle progression and organization of subnuclear compartments...
  11. ncbi The transcription network regulating melanocyte development and melanoma
    Keith W Vance
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    Pigment Cell Res 17:318-25. 2004
    ....
  12. ncbi Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas
    Keith W Vance
    Signaling and Development Laboratory, Marie Curie Research Institute, Surrey, United Kingdom
    Cancer Res 65:2260-8. 2005
    ..The results suggest that the activity of endogenous Tbx2 is critically required to maintain proliferation and suppress senescence in melanomas...
  13. doi Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis
    Marco Pontecorvi
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Gene Expr Patterns 8:411-7. 2008
    ....
  14. pmc The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression
    M D Galibert
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted RH8 0TL, UK
    EMBO J 20:5022-31. 2001
    ....
  15. ncbi Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor
    M D Galibert
    Unité d Immunogénétique, Institut National de la Sante et de la Recherche Medical, U276, Institut Pasteur, Paris, France
    J Immunol 159:6176-83. 1997
    ..The implications of USF-1 phosphorylation for C4 complement gene expression and transcription regulation are discussed...
  16. pmc Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 24:2915-22. 2004
    ..These results, together with the observation that BRAF signaling also induces Brn-2 expression, reveal that Brn-2 is a focus for the convergence of two key melanoma-associated signaling pathways that are linked to cell proliferation...
  17. ncbi The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
    S Carreira
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey RH8 OTL, United Kingdom
    J Biol Chem 275:21920-7. 2000
    ....
  18. pmc Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo
    I Aksan
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 18:6930-8. 1998
    ....
  19. pmc Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
    S Carreira
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 18:5099-108. 1998
    ....
  20. ncbi C-myc and the yeast transcription factor PHO4 share a common CACGTG-binding motif
    F Fisher
    Marie Curie Research Institute, Oxted, Surrey, UK
    Oncogene 6:1099-104. 1991
    ..From these data it is clear that the myc basic region confers specific binding to the sequence CACGTG...
  21. ncbi The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression
    T Eisen
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey, UK
    Oncogene 11:2157-64. 1995
    ..The potential role of Brn-2/N-Oct3 in melanocyte differentiation and gene expression is discussed...
  22. pmc The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulation
    P S Jayaraman
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    EMBO J 13:2192-9. 1994
    ..The possibility that repression of PHO4 by PHO80 may represent a general mechanism of transcription control, including regulation of the cell-type-specific transcription activation domain of c-Jun, is discussed...
  23. pmc The transcription factor, the Cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal
    K Hirst
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey, UK
    EMBO J 13:5410-20. 1994
    ....
  24. ncbi Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex
    Jean Luc Moreau
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, United Kingdom
    Mol Cell 11:1609-20. 2003
    ..The results point to a promoter-specific Isw1p-dependent mechanism for targeted regulation of basal transcription by displacement of TBP from a promoter...
  25. ncbi Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor
    Sharon Prince
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    Cancer Res 64:1669-74. 2004
    ....
  26. pmc Single amino acid substitutions alter helix-loop-helix protein specificity for bases flanking the core CANNTG motif
    F Fisher
    Marie Curie Research Institute, Oxted, Surrey, UK
    EMBO J 11:4103-9. 1992
    ..The significance of these data for DNA-binding and transcription regulation by the bHLH family of transcription factors is discussed...
  27. pmc Transcription and cancer
    P M Cox
    Transcriptional Control Laboratory, Marie Curie Cancer Research, Oxted, Surrey, UK
    Br J Cancer 63:651-62. 1991
    ..Current research is starting to elucidate which of the elements of this complicated system are important in neoplasia...
  28. pmc Requirements for chromatin modulation and transcription activation by the Pho4 acidic activation domain
    P C McAndrew
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 18:5818-27. 1998
    ..The implications for transcription activation by Pho4 are discussed...
  29. pmc Positive and negative elements regulate a melanocyte-specific promoter
    P Lowings
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    Mol Cell Biol 12:3653-62. 1992
    ..The possible mechanisms underlying melanocyte-specific gene expression are discussed...
  30. pmc Multiple transcription factors interact with the adenovirus-2 EII-late promoter: evidence for a novel CCAAT recognition factor
    C R Goding
    Marie Curie Research Institute, Oxted, Surrey, UK
    Nucleic Acids Res 15:7761-80. 1987
    ..Finally, an additional factor recognising the consensus GGGGGGNT has been detected...
  31. pmc The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006
    ..Our results reveal a novel mechanism by which Wnt signaling and beta-catenin activate gene expression, with significant implications for our understanding of both melanocyte development and melanoma...
  32. ncbi UV-mediated regulation of the anti-senescence factor Tbx2
    Amaal Abrahams
    Divisions of Medical Biochemistry and Cell Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    J Biol Chem 283:2223-30. 2008
    ....
  33. doi TBX3 and its splice variant TBX3 + exon 2a are functionally similar
    Willem M H Hoogaars
    Center for Heart Failure Research, Academic Medical Centre, Amsterdam, The Netherlands
    Pigment Cell Melanoma Res 21:379-87. 2008
    ..The results suggest that in the assays used, Tbx3 and Tbx3 + 2a are functionally equivalent and that like Tbx2, Tbx3 may also function as an anti-senescence factor in melanoma...
  34. ncbi Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf
    Mayuko Kumasaka
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan
    Dev Dyn 234:523-34. 2005
    ..We also observed an induction of ectopic RPE and extended RPE by overexpression of XlMitfalpha-M and possible interactions between XlMitfalpha and several eye-related genes essential for normal eye development...
  35. ncbi UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
    Sébastien Corre
    CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculte de Medecine, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    J Biol Chem 279:51226-33. 2004
    ..The results define USF-1 as a critical UV-responsive activator of genes implicated in protection from solar radiation...
  36. ncbi Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells
    Ichiro Yajima
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aramaki Aza Aoba, Aoba ku, Sendai, Miyagi 980 8578, Japan
    Mech Dev 120:1489-504. 2003
    ....
  37. ncbi Beta-catenin in the melanocyte lineage
    Lionel Larue
    Developmental Genetics of Melanocytes, CNRS Institut Curie, Orsay Cedex, France
    Pigment Cell Res 16:312-7. 2003
    ..Here, we review the known beta-catenin interacting factors and targets involved in the development and transformation of melanocytes and in particular its role in the expression of the crucial gene of melanocyte development, Mitf...
  38. ncbi Melanoma senescence: HDAC1 in focus
    Colin R Goding
    Pigment Cell Res 20:336-8. 2007
  39. ncbi DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)
    Tuba Erdemir
    Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey
    J Cell Sci 115:207-16. 2002
    ..These results suggest that one role for C1D may be to regulate TRAX/Translin complex formation...
  40. ncbi Precise nucleosome positioning and the TATA box dictate requirements for the histone H4 tail and the bromodomain factor Bdf1
    Carlos Martinez-Campa
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Mol Cell 15:69-81. 2004
    ..We propose that nucleosome positioning at the nucleotide level provides a subtle, but highly effective, mechanism for gene regulation...
  41. pmc Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
    Veronique Delmas
    Developmental Genetics of Melanocytes, UMR 146, Centre National de Recherche Scientifique Institut Curie, 91405 Orsay Cedex, France
    Genes Dev 21:2923-35. 2007
    ..The results reveal that synergy between the Wnt and mitogen-activated protein (MAP) kinase pathways may represent an important mechanism underpinning the genesis of melanoma, a highly aggressive and increasingly common disease...