Claire L Spreadbury

Summary

Affiliation: Manchester Royal Infirmary
Country: UK

Publications

  1. ncbi Point mutations in the DNA- and cNMP-binding domains of the homologue of the cAMP receptor protein (CRP) in Mycobacterium bovis BCG: implications for the inactivation of a global regulator and strain attenuation
    Claire L Spreadbury
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Microbiology 151:547-56. 2005
  2. ncbi Tubercle bacilli generate a novel cell wall-associated pigment after long-term anaerobic culture
    Adam F Cunningham
    Birmingham Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
    FEMS Microbiol Lett 235:191-8. 2004
  3. ncbi Single nucleotide polymorphisms that cause structural changes in the cyclic AMP receptor protein transcriptional regulator of the tuberculosis vaccine strain Mycobacterium bovis BCG alter global gene expression without attenuating growth
    Debbie M Hunt
    Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 76:2227-34. 2008

Collaborators

Detail Information

Publications3

  1. ncbi Point mutations in the DNA- and cNMP-binding domains of the homologue of the cAMP receptor protein (CRP) in Mycobacterium bovis BCG: implications for the inactivation of a global regulator and strain attenuation
    Claire L Spreadbury
    Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Microbiology 151:547-56. 2005
    ..bovis BCG strains. This raises the possibility that a contributing factor to the attenuation of BCG strains may be an inability of this global regulator to control the expression of genes required for in vivo survival and persistence...
  2. ncbi Tubercle bacilli generate a novel cell wall-associated pigment after long-term anaerobic culture
    Adam F Cunningham
    Birmingham Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
    FEMS Microbiol Lett 235:191-8. 2004
    ..We termed this pigment APP1, anaerobically produced pigment 1, the first pigment identified in M. tuberculosis...
  3. ncbi Single nucleotide polymorphisms that cause structural changes in the cyclic AMP receptor protein transcriptional regulator of the tuberculosis vaccine strain Mycobacterium bovis BCG alter global gene expression without attenuating growth
    Debbie M Hunt
    Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 76:2227-34. 2008
    ..However, they may have allowed BCG to grow better under the in vitro-selective conditions used in its derivation from the M. bovis wild type...