- Point mutations in the DNA- and cNMP-binding domains of the homologue of the cAMP receptor protein (CRP) in Mycobacterium bovis BCG: implications for the inactivation of a global regulator and strain attenuationClaire L Spreadbury
Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
Microbiology 151:547-56. 2005..bovis BCG strains. This raises the possibility that a contributing factor to the attenuation of BCG strains may be an inability of this global regulator to control the expression of genes required for in vivo survival and persistence...
- Tubercle bacilli generate a novel cell wall-associated pigment after long-term anaerobic cultureAdam F Cunningham
Birmingham Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
FEMS Microbiol Lett 235:191-8. 2004..We termed this pigment APP1, anaerobically produced pigment 1, the first pigment identified in M. tuberculosis...
- Single nucleotide polymorphisms that cause structural changes in the cyclic AMP receptor protein transcriptional regulator of the tuberculosis vaccine strain Mycobacterium bovis BCG alter global gene expression without attenuating growthDebbie M Hunt
Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
Infect Immun 76:2227-34. 2008..However, they may have allowed BCG to grow better under the in vitro-selective conditions used in its derivation from the M. bovis wild type...