M Slevin

Summary

Affiliation: Manchester Metropolitan University
Country: UK

Publications

  1. ncbi request reprint Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses
    Mark Slevin
    Department of Biological Sciences, Manchester Metropolitan University, Manchester M1 5GD, UK
    J Biol Chem 277:41046-59. 2002
  2. pmc Human and mouse brain-derived endothelial cells require high levels of growth factors medium for their isolation, in vitro maintenance and survival
    Stefania Elena Navone
    Laboratory of Cellular Neurobiology, Cerebrovascular Diseases Unit, IRCCS Foundation Neurological Institute C, Besta, Via Celoria 11, Milan, 20133, Italy
    Vasc Cell 5:10. 2013
  3. pmc Bisphosphonate-related osteonecrosis of jaw (BRONJ): diagnostic criteria and possible pathogenic mechanisms of an unexpected anti-angiogenic side effect
    Dileep Sharma
    Department of Anatomy and Doctoral School, University of Medicine and Pharmacy Targu Mures, Targu Mures, 540000, Romania
    Vasc Cell 5:1. 2013
  4. pmc Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1
    Jerzy Krupinski
    Cerebrovascular Diseases, Department of Neurology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain
    Vasc Cell 4:20. 2012
  5. pmc Unique vascular protective properties of natural products: supplements or future main-line drugs with significant anti-atherosclerotic potential?
    Mark Slevin
    Centro de Investigación Cardiovascular CSIC ICCC Hospital de la Santa Creu i Sant Pau, Pavelló del Convent Sant Antoni Maria Claret, 167 08025, Barcelona, Spain
    Vasc Cell 4:9. 2012
  6. pmc Prostate carcinoma metastatic to the skin as an extrammamary Paget's disease
    Eugen Bogdan Petcu
    Griffith University School of Medicine, Gold Coast Campus, Griffith University, Southport, Qld 4222, Australia
    Diagn Pathol 7:106. 2012
  7. pmc Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?
    Eugen B Petcu
    Griffith University School of Medicine, Gold Coast Campus, Griffith University, Griffith, Qld 4222, Australia
    Diagn Pathol 7:78. 2012
  8. pmc Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective
    Garry McDowell
    Faculty of Health, Edge Hill University, Ormskirk, UK
    Vasc Cell 3:8. 2011
  9. pmc A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion
    Nick Mitsios
    School of Biology, Chemistry and Health Science, John Dalton Building, Manchester Metropolitan University, Chester Street, Manchester, UK
    BMC Neurosci 8:93. 2007
  10. pmc Cheiradone: a vascular endothelial cell growth factor receptor antagonist
    Sajjad Hussain
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Chester St, Manchester M1 5GD, UK
    BMC Cell Biol 9:7. 2008

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses
    Mark Slevin
    Department of Biological Sciences, Manchester Metropolitan University, Manchester M1 5GD, UK
    J Biol Chem 277:41046-59. 2002
    ..However, the specific Src kinase inhibitor PP2 inhibited Gbeta subunit co-precipitation with PLCgamma1, suggesting a possible role for Src in activation of PLCgamma1 and interaction between two distinct o-HA-induced signaling pathways...
  2. pmc Human and mouse brain-derived endothelial cells require high levels of growth factors medium for their isolation, in vitro maintenance and survival
    Stefania Elena Navone
    Laboratory of Cellular Neurobiology, Cerebrovascular Diseases Unit, IRCCS Foundation Neurological Institute C, Besta, Via Celoria 11, Milan, 20133, Italy
    Vasc Cell 5:10. 2013
    ..Our goal was to study the efficiency of our pending patent medium, Endothelial Proliferation Medium (EndoPM), on the isolation and purification of human and murine BMVECs...
  3. pmc Bisphosphonate-related osteonecrosis of jaw (BRONJ): diagnostic criteria and possible pathogenic mechanisms of an unexpected anti-angiogenic side effect
    Dileep Sharma
    Department of Anatomy and Doctoral School, University of Medicine and Pharmacy Targu Mures, Targu Mures, 540000, Romania
    Vasc Cell 5:1. 2013
    ..In addition, based on our own experience we describe the histopathological criteria for diagnosis of BRONJ and the possible pathways which may lead to this frustrating pathological condition...
  4. pmc Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1
    Jerzy Krupinski
    Cerebrovascular Diseases, Department of Neurology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain
    Vasc Cell 4:20. 2012
    ..abstract:..
  5. pmc Unique vascular protective properties of natural products: supplements or future main-line drugs with significant anti-atherosclerotic potential?
    Mark Slevin
    Centro de Investigación Cardiovascular CSIC ICCC Hospital de la Santa Creu i Sant Pau, Pavelló del Convent Sant Antoni Maria Claret, 167 08025, Barcelona, Spain
    Vasc Cell 4:9. 2012
    ....
  6. pmc Prostate carcinoma metastatic to the skin as an extrammamary Paget's disease
    Eugen Bogdan Petcu
    Griffith University School of Medicine, Gold Coast Campus, Griffith University, Southport, Qld 4222, Australia
    Diagn Pathol 7:106. 2012
    ..The inguinal metastases were sessile and 'keratotic.' The tumour displayed solid, glandular areas as well as a polypoid region suggestive of extramammary Paget's disease were identified...
  7. pmc Bisphosphonate-related osteonecrosis of jaw (BRONJ): an anti-angiogenic side-effect?
    Eugen B Petcu
    Griffith University School of Medicine, Gold Coast Campus, Griffith University, Griffith, Qld 4222, Australia
    Diagn Pathol 7:78. 2012
    ..Considering the differential diagnosis which includes various primary and secondary cancers, a correct histopathological diagnosis is very important. The morphological criteria for diagnosis of BRONJ are highlighted in this material...
  8. pmc Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective
    Garry McDowell
    Faculty of Health, Edge Hill University, Ormskirk, UK
    Vasc Cell 3:8. 2011
    ..To date however, no formal clinical evaluation has been reported as to the clinical utility of nab-paclitaxel, or any of the nano preparations discussed, for the suppression of coronary in stent restenosis...
  9. pmc A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion
    Nick Mitsios
    School of Biology, Chemistry and Health Science, John Dalton Building, Manchester Metropolitan University, Chester Street, Manchester, UK
    BMC Neurosci 8:93. 2007
    ..We have used microarrays to investigate the changes in gene expression at various times after middle cerebral artery occlusion in human and rat brain...
  10. pmc Cheiradone: a vascular endothelial cell growth factor receptor antagonist
    Sajjad Hussain
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Chester St, Manchester M1 5GD, UK
    BMC Cell Biol 9:7. 2008
    ..In all cases, the concentration of cheiradone which caused 50% inhibition (IC50) was determined. The effect of cheiradone on the binding of growth factors to their receptors was also investigated...
  11. pmc Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis
    Sajjad Hussain
    School of Chemistry, Biology and Health Sciences, Manchester Metropolitan University, Chester St, Manchester, UK
    BMC Cell Biol 10:30. 2009
    ..In all cases the concentration of compound 1 which caused 50% inhibition (IC50) was determined. The effect of compound 1 on EGF and VEGF-induced proliferation was also investigated...
  12. pmc C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression
    Marta M Turu
    Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
    BMC Cell Biol 9:47. 2008
    ..Although CRP is known to induce a pro-inflammatory phenotype in endothelial cells (EC) a direct role on modulation of angiogenesis has not been established...
  13. ncbi request reprint Leukaemia inhibitory factor is over-expressed by ischaemic brain tissue concomitant with reduced plasma expression following acute stroke
    M Slevin
    The Department of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Eur J Neurol 15:29-37. 2008
    ..Increased LIF expression in peri-infarcted regions and sequestration from the peripheral circulation in acute stroke patients are characteristic of the pathobiological response to ischaemia and tissue damage...
  14. ncbi request reprint Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways
    Mark Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Matrix Biol 26:58-68. 2007
    ..We review the role of o-HA in modulation of angiogenesis during tissue injury, and vascular disease, focusing on receptor-mediated signal transduction pathways that have been evaluated...
  15. ncbi request reprint Dynamin and perforin are associated with neovascularisation in advanced carotid plaques
    Mark Slevin
    ICCC, St Pau Hospital, Barcelona, Spain
    Front Biosci 13:6515-9. 2008
    ..Over-expression of these proteins may contribute to plaque destabilisation by increasing cellular apoptosis in vulnerable atherosclerotic plaques...
  16. ncbi request reprint Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential
    Mark Slevin
    Department of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester M1 5GD, U K
    Clin Sci (Lond) 111:171-83. 2006
    ....
  17. doi request reprint Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro
    Mark Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Brain Pathol 20:151-65. 2010
    ..We propose that mCRP may contribute to the neovascularization process and because of its abundant presence, be important in modulating angiogenesis in both acute stroke and later during neuro-recovery...
  18. ncbi request reprint Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells
    M Slevin
    Department of Biological Sciences, Manchester Metropolitan University, England
    Int J Cancer 82:412-23. 1999
    ..The results suggest that circulating gangliosides may have a role in regulating solid-tumour growth by modulating angiogenesis...
  19. pmc Identification of pro-angiogenic markers in blood vessels from stroked-affected brain tissue using laser-capture microdissection
    Mark Slevin
    SBCHS, Manchester Metropolitan University, Manchester, UK
    BMC Genomics 10:113. 2009
    ..Angiogenesis is critical for the development of new microvessels and leads to re-formation of collateral circulation, reperfusion, enhanced neuronal survival and improved recovery...
  20. pmc Identification of differential protein expression associated with development of unstable human carotid plaques
    Mark Slevin
    Department of Biological Sciences, Manchester Metropolitan University, Manchester, United Kingdom
    Am J Pathol 168:1004-21. 2006
    ..We conclude that modulation of novel cell signaling intermediates, such as those described here, could be useful in the therapy of angiogenesis and apoptosis, designed to reduce unstable plaque formation...
  21. ncbi request reprint Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke
    M Slevin
    Department of Biological Sciences, Manchester Metropolitan University, UK
    Stroke 31:1863-70. 2000
    ....
  22. doi request reprint Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis
    M Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Mol Biosyst 6:444-50. 2010
    ....
  23. ncbi request reprint New VEGF antagonists as possible therapeutic agents in vascular disease
    M Slevin
    Manchester Metropolitan University, School of Biology, Chemistry and Health Science, Manchester, M1 5GD, UK
    Expert Opin Investig Drugs 17:1301-14. 2008
    ..In this review we provide the reader with an analysis of the importance of VEGF in modulating the angiogenic process in vascular diseases...
  24. ncbi request reprint A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular/cerebrovascular disease?
    M Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United Kingdom
    Histol Histopathol 24:1473-8. 2009
    ....
  25. doi request reprint B-cell translocation gene 2 is over-expressed in peri-infarct neurons after ischaemic stroke
    M Slevin
    Department of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Pathobiology 76:129-35. 2009
    ..Our previous microarray studies identified increased expression of a novel protein, the B-cell translocation gene 2 (BTG2), in infarcted regions...
  26. ncbi request reprint Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin
    S Matou-Nasri
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester M1 5GD, UK
    Int J Oncol 35:761-73. 2009
    ..The data presented here extend our understanding of key stages of the processes of o-HA-induced angiogenesis which may have relevance to tumour progression...
  27. doi request reprint Identification of a 'snapshot' of co-expressed angiogenic markers in laser-dissected vessels from unstable carotid plaques with targeted arrays
    M Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester M1 5GD, UK
    J Vasc Res 47:323-35. 2010
    ....
  28. doi request reprint Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis
    S Hussain
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Chester St, Manchester, M1 5GD, UK
    Angiogenesis 11:245-56. 2008
    ..Since angiogenesis is essential for tumour development we conclude that these compounds may have potential as anti-tumour agents...
  29. doi request reprint A comparative study of carotid atherosclerotic plaque microvessel density and angiogenic growth factor expression in symptomatic versus asymptomatic patients
    M Chowdhury
    Department of Vascular and Endovascular Surgery, Manchester Royal Infirmary, Manchester, UK
    Eur J Vasc Endovasc Surg 39:388-95. 2010
    ..A challenge facing clinicians is identifying patients with asymptomatic carotid disease at risk of plaque instability. We hypothesise that locally released angiogenic growth factors contribute to plaque instability...
  30. ncbi request reprint Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: possible relevance to wound healing in diabetes
    Y Duraisamy
    Department of Biological Sciences, Manchester Metropolitan University, Chester St, Manchester M1 5GD, UK
    Angiogenesis 4:277-88. 2001
    ..These results could help to explain the mechanism behind impaired wound healing in patients with diabetes mellitus...
  31. ncbi request reprint The cooperative transforming effects of PAX3-FKHR and IGF-II on mouse myoblasts
    W Wang
    Department of Biological Sciences, Manchester Metropolitan University, Manchester M1 5GD, UK
    Int J Oncol 27:1087-96. 2005
    ..Our results suggest that high expression of PAX3-FKHR and IGF-II in ARMS synergistically play a key role in oncogenesis and tumour progression of ARMS...
  32. ncbi request reprint Gene activation and protein expression following ischaemic stroke: strategies towards neuroprotection
    M Slevin
    Biological Sciences Department, Manchester Metropolitan University, Chester St, Manchester, UK
    J Cell Mol Med 9:85-102. 2005
    ..We have highlighted the complexities of cellular regulation and demonstrated a requirement for detailed studies examining cell specific protective mechanisms after stroke in humans...
  33. doi request reprint Atherothrombosis and plaque heterology: different location or a unique disease?
    M Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Pathobiology 75:209-25. 2008
    ..Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture...
  34. ncbi request reprint Pathophysiology of acute ischaemic stroke: an analysis of common signalling mechanisms and identification of new molecular targets
    N Mitsios
    Department of Biological Sciences, Manchester Metropolitan University, Manchester, UK
    Pathobiology 73:159-75. 2006
    ....
  35. ncbi request reprint Overexpression of hypoxia/inflammatory markers in atherosclerotic carotid plaques
    Ana Luque
    Department of Neurology, Stroke Unit, University Hospital of Bellvitge and IDIBELL, Barcelona, Spain
    Front Biosci 13:6483-90. 2008
    ..Dynamic changes in the non-occluding plaques may explain some of the clinical events in patients with low to moderate carotid stenosis...
  36. ncbi request reprint Time-course phosphorylation of the mitogen activated protein (MAP) kinase group of signalling proteins and related molecules following middle cerebral artery occlusion (MCAO) in rats
    J Krupinski
    Department of Neurology, Hospital Princeps d Espanya, Ciutat Sanitaria I Universitaria de Belvitge, Barcelona, Spain
    Neuropathol Appl Neurobiol 29:144-58. 2003
    ..Therapeutic manipulation of phosphorylation/activation of these and other important signalling intermediates might form the basis of an appropriate treatment to maximize revascularization and neuronal protection after ischaemic stroke...
  37. doi request reprint Brain natriuretic peptide is associated with worsening and mortality in acute stroke patients but adds no prognostic value to clinical predictors of outcome
    J Montaner
    Neurovascular Research Laboratory, Vall d Hebron University Hospital Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cerebrovasc Dis 34:240-5. 2012
    ..Although the prognostic role of natriuretic peptides has been studied in heart failure and coronary diseases, the value of brain natriuretic peptide (BNP) is less known within the field of strokes...
  38. ncbi request reprint Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia
    J Krupinski
    Cardiovascular Research Center, IIBB CSIC HSCSP UAB, St Pau Hospital, Barcelona, Spain
    Neurochem Res 30:1067-73. 2005
    ..The effects of CDP-choline on intracellular mechanisms of signal transduction, suggests that this molecule may play a key role in recovery after ischaemic stroke...
  39. ncbi request reprint Angiogenesis and inflammation in carotid atherosclerosis
    Jerzy Krupinski
    Department of Neurology, Stroke Unit, University Hospital of Bellvitge and IDIBELL, Barcelona, Spain
    Front Biosci 13:6472-82. 2008
    ..The purpose of the review is to bring new insights into complicated pathophysiology of carotid atherosclerosis...
  40. doi request reprint Therapeutic applications of hyaluronan
    John Gaffney
    School of Biology, Chemistry and Health Sciences, Manchester Metropolitan University, Chester St, Manchester, UK M1 5GD
    Mol Biosyst 6:437-43. 2010
    ..In this review we discuss some of the recent therapeutic applications of hyaluronan in tissue repair, as a drug delivery system and the synthesis, application and delivery of hyaluronan nanoparticles to target drugs to sites of disease...
  41. ncbi request reprint Changes in hyaluronan production and metabolism following ischaemic stroke in man
    Ahmed Al'Qteishat
    Department of Biology, Chemistry and Health Science, Manchester Metropolitan University, Liverpool, UK
    Brain 129:2158-76. 2006
    ....
  42. doi request reprint Cyclin-dependent kinase-5 targeting for ischaemic stroke
    Mark Slevin
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester M1 5GD, United Kingdom
    Curr Opin Pharmacol 9:119-24. 2009
    ..Therefore its cell-specific pharmacological or genetic modulation using novel nanotechnology-based delivery systems could be of benefit when considering future stroke therapies...
  43. doi request reprint Increased PrPC expression correlates with endoglin (CD105) positive microvessels in advanced carotid lesions
    Jerzy Krupinski
    Department of Neurology, Stroke Unit, University Hospital of Bellvitge HUB, Fundacio IDIBELL, Barcelona, Spain
    Acta Neuropathol 116:537-45. 2008
    ..We conclude that PrP(C) is expressed in carotid specimens and may be associated with neovessel growth or survival in these plaques. Our results suggest a role for PrP(C) in modulating neovessel formation in complicated plaques...
  44. ncbi request reprint CD105 inhibits transforming growth factor-beta-Smad3 signalling
    Baoqiang Guo
    Laboratory Medicine Academic Group, Medical School, University of Manchester, Manchester, UK
    Anticancer Res 24:1337-45. 2004
    ..CD105 resulted in high phosphorylation of JNK1, which is able to activate c-Jun. c-Jun is known to inhibit Smad3 transcriptional activity on CAGA sites, suggesting that CD105 may also inhibit Smad3 signalling through JNK1...
  45. ncbi request reprint Endogenous expression of C-reactive protein is increased in active (ulcerated noncomplicated) human carotid artery plaques
    Jerzy Krupinski
    Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Stroke 37:1200-4. 2006
    ..Our aim was to analyze the presence of CRP in human advanced carotid artery plaques with differential anatomo-pathological characteristics and to assess local expression of CRP and other proinflammatory genes in these lesions...
  46. ncbi request reprint Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke
    Jerzy Krupinski
    Department of Neurology, Stroke Unit, Hospital Universitari de Bellvitge, Feixa Llarga s n 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Curr Cardiol Rep 10:25-30. 2008
    ..Whether a reduction of CRP levels could be beneficial to stroke patients remains to be clarified. More studies are needed before CRP becomes a routine part of the evaluation of stroke patients...
  47. doi request reprint Changes in contractile properties of skinned single rat soleus and diaphragm fibres after chronic hypoxia
    Hans Degens
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, John Dalton Building, Oxford Road, Manchester, M1 5GD, UK
    Pflugers Arch 460:863-73. 2010
    ..These effects are similar in the soleus and diaphragm muscle, but more pronounced in type IIa than I fibres...
  48. doi request reprint An investigation of the kinetic and anti-angiogenic properties of plant glycoside inhibitors of thymidine phosphorylase
    S Hussain
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    J Asian Nat Prod Res 11:159-67. 2009
    ..Compound 1 may have potential as an anti-angiogenic and anti-tumor agent...
  49. ncbi request reprint Overexpression of CD105 in rat myoblasts: role of CD105 in cell attachment, spreading and survival
    Baoqiang Guo
    Laboratory Medicine Academic Group, The Medical School, University of Manchester, Manchester, M13 9PT, UK
    Int J Oncol 25:285-91. 2004
    ..From this preliminary study, we conclude that in addition to acting as a transforming growth factor-beta receptor, CD105 has an important role in cell adhesion, migration and survival...
  50. ncbi request reprint Expression of basic fibroblast growth factor mRNA and protein in the human brain following ischaemic stroke
    Razao Issa
    Biological Sciences Department, Manchester Metropolitan University, Manchester, UK
    Angiogenesis 8:53-62. 2005
    ..We suggest that up-regulation of FGF-2 is one of the mechanisms that leads to angiogenesis and neuro-protection in the penumbra region after acute stroke in man...
  51. ncbi request reprint Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke
    Nicholas Mitsios
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Brain Pathol 17:11-23. 2007
    ..These results provide new evidence for a role of Cdk5 in the events associated with response to ischemic injury in humans...
  52. ncbi request reprint Comparison of protective effects of aspirin, D-penicillamine and vitamin E against high glucose-mediated toxicity in cultured endothelial cells
    Jing Zhang
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Oxford Road, Manchester M1 5GD, UK
    Biochim Biophys Acta 1762:551-7. 2006
    ..Our studies suggest that compounds, such as vitamin E, with combined antiglycation and antioxidant properties offer maximum therapeutic potential in protection against high glucose and AGE-mediated cellular toxicity...
  53. ncbi request reprint Aminosalicylic acid reduces the antiproliferative effect of hyperglycaemia, advanced glycation endproducts and glycated basic fibroblast growth factor in cultured bovine aortic endothelial cells: comparison with aminoguanidine
    Yasotha Duraisamy
    Department of Biological Sciences, Manchester Metropolitan University, Chester Street, Manchester, UK
    Mol Cell Biochem 246:143-53. 2003
    ..Compounds like aminoguanidine and, in particular, aminosalicylic acid protect endothelial cells against glucose-mediated toxicity and may therefore have therapeutic potential...
  54. ncbi request reprint Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemia
    Jerzy Krupinski
    Department of Neurology, Hospital Universitario de Bellvitge, Barcelona, Spain
    Neuroreport 14:1171-6. 2003
    ..This normal growth pattern might be essential in future therapies involving induction of vascularization and neuroprotection to enhance long-term survival of the penumbra...
  55. ncbi request reprint D-dimer local expression is increased in symptomatic patients undergoing carotid endarterectomy
    Jerzy Krupinski
    Cardiovascular Research Center, IIBB CSIC HSCSP UAB, Barcelona, Spain
    Int J Cardiol 116:174-9. 2007
    ..We hypothesized that symptomatic patients with advanced, unstable carotid plaques have increased local intraplaque and circulating levels of fibrin-fibrinogen related products...
  56. ncbi request reprint Investigation of downstream target genes of PAX3c, PAX3e and PAX3g isoforms in melanocytes by microarray analysis
    Qiuyu Wang
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United Kingdom
    Int J Cancer 120:1223-31. 2007
    ..Thus, our data reveal that PAX3 isoforms regulate distinct but overlapping sets of genes in melanocytes in vitro...
  57. ncbi request reprint Cellular prion protein is increased in the plasma and peri-infarcted brain tissue after acute stroke
    Nicholas Mitsios
    School of Biology, Chemistry and Health Science, John Dalton Building, Manchester Metropolitan University, Manchester, United Kingdom
    J Neurosci Res 85:602-11. 2007
    ..Increased cellular expression in peri-infarcted regions may influence hypoxia-induced cell damage, although the effects on EC survival and angiogenesis remain to be elucidated...
  58. pmc Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis
    Jerzy Krupinski
    Department of Neurology, Stroke Unit, University Hospital of Bellvitge HUB, Fundacio IDIBELL, Barcelona, Spain
    Vasc Health Risk Manag 3:405-12. 2007
    ..Increased procoagulant activity in diabetic patients may be linked to increased mural remodeling...
  59. ncbi request reprint Hyaluronan expression following middle cerebral artery occlusion in the rat
    Ahmed Al Qteishat
    The School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK
    Neuroreport 17:1111-4. 2006
    ..Hyaluronan synthesis and degradation in the stroke hemisphere might have an impact on neuronal survival, angiogenesis and general tissue remodelling after stroke...
  60. doi request reprint Modulation of endothelium and endothelial progenitor cell function by low-density lipoproteins: implication for vascular repair, angiogenesis and vasculogenesis
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Pathobiology 76:11-22. 2009
    ..This review is focused on the central role of the cholesterol pathway in the biology of the endothelium and EPCs...
  61. doi request reprint Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
    Eloy Cuadrado
    Neurovascular Research Laboratory, Neurovascular Unit, Department of Neurology, Universitat Autonoma de Barcelona, Institut de Recerca, Hospital Vall d Hebron, Barcelona, Spain
    J Proteome Res 8:3191-7. 2009
    ..These findings demonstrate a selective cell-dependent MMP secretion, opening the possibility of selectively targeting specific MMPs for neuroprotection or vasculoprotection following stroke...
  62. ncbi request reprint The normal cellular prion protein and its possible role in angiogenesis
    Marta Turu
    Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
    Front Biosci 13:6491-500. 2008
    ..Moreover, PrPc plays an important role in the immune response. Here, we review the multiple functions of PrPc with a special attention to its recently reported role in angiogenesis...
  63. ncbi request reprint Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
    M Angels M Angels Font
    Department of Neurology, University Hospital of Bellvitge HUB, Fundacio IDIBELL, Barcelona, Spain
    Front Biosci (Landmark Ed) 14:3352-60. 2009
    ..This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis...
  64. doi request reprint C-reactive protein isoforms differ in their effects on thrombus growth
    Blanca Molins
    Cardiovascular Research Center, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 28:2239-46. 2008
    ..We studied the impact of native (natCRP) and modified CRP (mCRP) isoforms on platelet adhesion and thrombus growth under arterial flow...
  65. ncbi request reprint Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue
    Nicholas Mitsios
    Department of Biological Sciences, Manchester Metropolitan University, Chester St, Manchester M1 5GD, UK
    Cell Biochem Biophys 47:73-86. 2007
    ..It is tempting to suggest that further studies of apoptotic proteins in human stroke may lead to identification of novel targets for drug discovery...
  66. ncbi request reprint Blood-borne tissue factor activity predicts major cerebrovascular events in patients undergoing carotid endarterectomy: results from a 1-year follow-up study
    Jerzy Krupinski
    Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
    Cerebrovasc Dis 25:32-9. 2008
    ..The aim of this study was to assess whether the expression of TF in carotid plaques from patients undergoing carotid endarterectomy (CEA) or/and blood-borne ('circulating') TF activity could predict future vascular complications...
  67. doi request reprint Pax genes in embryogenesis and oncogenesis
    Qiuyu Wang
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, and Department of Pathology Sciences, Christie Hospital, Manchester, United Kingdom
    J Cell Mol Med 12:2281-94. 2008
    ....
  68. ncbi request reprint PAX3 and PAX3-FKHR promote rhabdomyosarcoma cell survival through downregulation of PTEN
    Hong Gui Li
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester M1 5GD, United Kingdom
    Cancer Lett 253:215-23. 2007
    ..These results indicate that the involvement of PAX3 and PAX3-FKHR in rhabdomyosarcoma tumourigenesis may be through downregulation of PTEN tumour suppressor gene, affecting the PTEN/AKT survival pathway...
  69. ncbi request reprint Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes in vitro
    Qiuyu Wang
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United Kingdom
    Cancer Res 66:8574-80. 2006
    ..PAX3h increased cell proliferation, migration, survival, and transformation. These functional studies have advanced our understanding of the effects of PAX3 isoforms in melanocytes and their potential contribution in tumorigenesis...
  70. ncbi request reprint CD105 (endoglin), apoptosis, and stroke
    Baoqiang Guo
    Stroke 35:e94-5. 2004
  71. ncbi request reprint Hyaluronan, angiogenesis and malignant disease
    Mark Slevin
    Int J Cancer 109:793-4; author reply 795-6. 2004