Affiliation: Manchester Metropolitan University
Man A, Slevin M, Petcu E, Fraefel C. The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication. Sci Rep. 2019;9:1260 pubmed publisher
..The microscopy and flow-cytometry data support the hypothesis that CIP is inhibiting HSV-1 replication. ..
Liu D, Zeinolabediny Y, Caccuri F, Ferris G, Fang W, Weston R, et al
. p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation. Lab Invest. 2019;99:180-190 pubmed publisher
..This work provides strong support that p17 may be involved in initiating and/or perpetuating vascular tissue pathophysiology associated with comorbidity in HIV patients. ..
Slevin M, Kumar P, Wang Q, Kumar S, Gaffney J, Grau Olivares M, et al
. New VEGF antagonists as possible therapeutic agents in vascular disease. Expert Opin Investig Drugs. 2008;17:1301-14 pubmed
..Current and future potential clinical therapies are discussed in particular concerning our thoughts on future directives involving adenoviral-mediated gene targeting, nanotechnology and combinational therapies. ..
Slevin M, Krupinski J, Rovira N, Turu M, Luque A, Baldellou M, et al
. Identification of pro-angiogenic markers in blood vessels from stroked-affected brain tissue using laser-capture microdissection. BMC Genomics. 2009;10:113 pubmed publisher
..Therapeutic stimulation of these processes in all areas of damaged tissue might improve morbidity and mortality from stroke. ..
Hussain S, Slevin M, Ahmed N, West D, Choudhary M, Naz H, et al
. Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis. BMC Cell Biol. 2009;10:30 pubmed publisher
..In all cases the concentration of compound 1 which caused 50% inhibition (IC50) was determined. The effect of compound 1 on EGF and VEGF-induced proliferation was also investigated...
Slevin M, Elasbali A, Miguel Turu M, Krupinski J, Badimon L, Gaffney J. Identification of differential protein expression associated with development of unstable human carotid plaques. Am J Pathol. 2006;168:1004-21 pubmed
..We conclude that modulation of novel cell signaling intermediates, such as those described here, could be useful in the therapy of angiogenesis and apoptosis, designed to reduce unstable plaque formation. ..
Slevin M, Krupinski J, Mitsios N, Perikleous C, Cuadrado E, Montaner J, et al
. Leukaemia inhibitory factor is over-expressed by ischaemic brain tissue concomitant with reduced plasma expression following acute stroke. Eur J Neurol. 2008;15:29-37 pubmed
..Increased LIF expression in peri-infarcted regions and sequestration from the peripheral circulation in acute stroke patients are characteristic of the pathobiological response to ischaemia and tissue damage. ..
Slevin M, Matou Nasri S, Turu M, Luque A, Rovira N, Badimon L, et al
. Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro. Brain Pathol. 2010;20:151-65 pubmed publisher
..We propose that mCRP may contribute to the neovascularization process and because of its abundant presence, be important in modulating angiogenesis in both acute stroke and later during neuro-recovery. ..