Ajith K Siriwardena

Summary

Affiliation: Manchester Royal Infirmary
Country: UK

Publications

  1. pmc Pro/con debate: antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics
    Philippe Eggimann
    Department of Intensive Care Medicine and Burn Unit, Interdisciplinary Department for Support and Technics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care 10:229. 2006
  2. pmc Contemporary management of infected necrosis complicating severe acute pancreatitis
    Saurabh Jamdar
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    Crit Care 10:101. 2006
  3. pmc Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis
    Ajith K Siriwardena
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Gut 56:1439-44. 2007
  4. ncbi request reprint Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer
    H P P Siriwardana
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Br J Surg 93:662-73. 2006
  5. ncbi request reprint Evaluation of the Manchester classification system for chronic pancreatitis
    Anil Bagul
    Hepatobiliary Surgical Unit, Manchester Royal Infirmary Manchester, United Kingdom
    JOP 7:390-6. 2006
  6. ncbi request reprint Sequential endovascular repair and pancreaticoduodenectomy for abdominal aortic aneurysm copresenting with periampullary cancer
    Aali J Sheen
    Hepatobiliary Unit, Manchester Royal Infirmary, Manchester, UK
    Ann Vasc Surg 20:114-6. 2006
  7. doi request reprint Recombinant human activated protein C (Xigris) attenuates murine cerulein-induced acute pancreatitis via regulation of nuclear factor κB and apoptotic pathways
    Benoy I Babu
    Academic Hepato pancreato biliary Surgery Unit, University of Manchester, Manchester Biomedical Research Centre, Manchester Royal Infirmary, Manchester, UK
    Pancreas 41:619-28. 2012
  8. doi request reprint Green tea polyphenols ameliorate pancreatic injury in cerulein-induced murine acute pancreatitis
    Benoy I Babu
    Manchester Royal Infirmary, Manchester, United Kingdom
    Pancreas 38:954-67. 2009
  9. doi request reprint Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy
    Melissa Oliveira-Cunha
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, UK
    Pancreas 39:171-4. 2010
  10. ncbi request reprint Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy
    Harsha R Hathurusinghe
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9 WL, UK
    Ann Surg Oncol 14:2714-20. 2007

Collaborators

  • Saurabh Jamdar
  • Melissa Oliveira-Cunha
  • Emanuela Mazzon
  • Salvatore Cuzzocrea
  • Richard J Byers
  • J M Mason
  • Helen C Hancock
  • Ian Paterson
  • Irene Paterniti
  • H Paul Redmond
  • Jonathan G Hardman
  • Ravindra S Date
  • Benoy I Babu
  • Giuseppe Malleo
  • Santhalingam Jegatheeswaran
  • Kolitha S Goonetilleke
  • Benoy Idicula Babu
  • Nehal S Shah
  • Tiziana Genovese
  • Aali J Sheen
  • Anil Bagul
  • Srinivasan Balachandra
  • Harsha R Hathurusinghe
  • Rosanna Di Paola
  • Charles J Miranda
  • Concetta Crisafulli
  • Alistair J Makin
  • Samy R Mohamed
  • Paul J Barrow
  • H P P Siriwardana
  • Philippe Eggimann
  • Kant J Shah
  • Ioannis T Virlos
  • Ray F McMahon
  • H P Priyantha Siriwardana
  • Nicolas K K King
  • Garth C Beattie
  • Luisa Riccardi
  • Maria Galuppo
  • Stephen H Lee
  • Jane M Eddleston
  • Sarah O'Shea
  • Rocco Caminiti
  • Sorrell Burden
  • Priyantha Siriwardana
  • Michael W France
  • Nicholas K King
  • Tommaso Centorrino
  • Carmelo Muià
  • Jee Low
  • James Boylan
  • Sudeep Pushpakom
  • Michael G Walker
  • William Newman
  • Mohamed Baguneid
  • Kassiani Skordilis
  • Simon Ellenbogen
  • H Priyantha Siriwardana
  • Christoph Thiemerman
  • Jill Biggins
  • John Denton
  • Yeliz Cemal
  • Doris Redhead

Detail Information

Publications45

  1. pmc Pro/con debate: antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics
    Philippe Eggimann
    Department of Intensive Care Medicine and Burn Unit, Interdisciplinary Department for Support and Technics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care 10:229. 2006
    ..In this issue of Critical Care, two expert groups debate the merits of antifungal prophylaxis in patients with acute necrotizing pancreatitis who are receiving antibiotics...
  2. pmc Contemporary management of infected necrosis complicating severe acute pancreatitis
    Saurabh Jamdar
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    Crit Care 10:101. 2006
    ..Early surgical intervention is unhelpful; surgery is indicated when there is strong evidence for infection of necrotic tissue, with the current trend being toward 'less drastic' surgical interventions...
  3. pmc Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis
    Ajith K Siriwardena
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Gut 56:1439-44. 2007
    ..Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis...
  4. ncbi request reprint Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer
    H P P Siriwardana
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Br J Surg 93:662-73. 2006
    ..There is no consensus about which patients benefit from portal-superior mesenteric vein resection...
  5. ncbi request reprint Evaluation of the Manchester classification system for chronic pancreatitis
    Anil Bagul
    Hepatobiliary Surgical Unit, Manchester Royal Infirmary Manchester, United Kingdom
    JOP 7:390-6. 2006
    ..Classifications of chronic pancreatitis based on either histologic (Marseilles) or endoscopic (Cambridge) criteria are not widely used...
  6. ncbi request reprint Sequential endovascular repair and pancreaticoduodenectomy for abdominal aortic aneurysm copresenting with periampullary cancer
    Aali J Sheen
    Hepatobiliary Unit, Manchester Royal Infirmary, Manchester, UK
    Ann Vasc Surg 20:114-6. 2006
    ..Use of the endovascular approach avoided the need for two major operative interventions...
  7. doi request reprint Recombinant human activated protein C (Xigris) attenuates murine cerulein-induced acute pancreatitis via regulation of nuclear factor κB and apoptotic pathways
    Benoy I Babu
    Academic Hepato pancreato biliary Surgery Unit, University of Manchester, Manchester Biomedical Research Centre, Manchester Royal Infirmary, Manchester, UK
    Pancreas 41:619-28. 2012
    ..Exploiting this knowledge, we used human recombinant activated protein C (Xigris; Eli Lilly, Indianapolis, Ind) known to preserve microvascular patency, in evaluating the role of Xigris in experimental AP...
  8. doi request reprint Green tea polyphenols ameliorate pancreatic injury in cerulein-induced murine acute pancreatitis
    Benoy I Babu
    Manchester Royal Infirmary, Manchester, United Kingdom
    Pancreas 38:954-67. 2009
    ..This study investigates the effect of GTPs in a cerulein-induced murine model of acute pancreatitis (AP)...
  9. doi request reprint Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy
    Melissa Oliveira-Cunha
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, UK
    Pancreas 39:171-4. 2010
    ..The aim of this work was to explore the feasibility of measurement of gene expression in RNA isolated from ductal juice...
  10. ncbi request reprint Current status of tumor M2 pyruvate kinase (tumor M2-PK) as a biomarker of gastrointestinal malignancy
    Harsha R Hathurusinghe
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9 WL, UK
    Ann Surg Oncol 14:2714-20. 2007
    ..This study undertakes a systematic review of the current literature on tumor M2-PK as a diagnostic tool and provides an overview of the current usage and scope of this emerging biomarker...
  11. doi request reprint Open pancreatic necrosectomy in the multidisciplinary management of postinflammatory necrosis
    Benoy I Babu
    Hepatobiliary Surgical Unit, Department of Radiology, Manchester Royal Infirmary, Manchester, United Kingdom
    Ann Surg 251:783-6. 2010
    ..To examine clinical outcome in a consecutive cohort of patients undergoing open necrosectomy for postinflammatory necrosis...
  12. ncbi request reprint Radiofrequency ablation of the pancreas. I: Definition of optimal thermal kinetic parameters and the effect of simulated portal venous circulation in an ex-vivo porcine model
    Ravindra S Date
    Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 6:581-7. 2005
    ..Radiofrequency ablation of pancreatic tumours carries a risk of injury to important structures such as the bile duct and duodenum. We have recently developed an ex-vivo model of radiofrequency ablation of the porcine pancreas...
  13. ncbi request reprint Intravenous selenium modulates L-arginine-induced experimental acute pancreatitis
    Jonathan Hardman
    HPB Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 6:431-7. 2005
    ..As the principal co-factor for glutathione, selenium is a key constituent of multiple antioxidant preparations...
  14. doi request reprint The performance of organ dysfunction scores for the early prediction and management of severity in acute pancreatitis: an exploratory phase diagnostic study
    James M Mason
    Regional Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, United Kingdom
    Pancreas 39:1104-8. 2010
    ..To evaluate contemporary organ dysfunction scoring systems for early prediction of severity in acute pancreatitis (AP)...
  15. doi request reprint Antioxidant therapy does not reduce pain in patients with chronic pancreatitis: the ANTICIPATE study
    Ajith K Siriwardena
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, United Kingdom
    Gastroenterology 143:655-63.e1. 2012
    ..We investigated whether antioxidant therapy reduces pain and improves quality of life in patients with chronic pancreatitis...
  16. ncbi request reprint Differential kinetics of plasma CD105 and transforming growth factor beta expression early in human acute pancreatitis
    Saurabh Jamdar
    Department of Surgery, Manchester Royal Infirmary, University of Manchester, Manchester, UK
    Pancreas 32:152-8. 2006
    ..The importance of this interaction during the critical early phases of acute pancreatitis is unknown. This study explores patterns of expression of CD105 and TGF-beta in plasma during human acute pancreatitis...
  17. pmc Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy
    Nehal S Shah
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    World J Gastroenterol 16:4066-71. 2010
    ..To undertake a baseline study comparing quality of life (QoL) in patients with chronic pancreatitis (CP) on Antox to those with CP, matched for disease duration, who were not on this medication...
  18. doi request reprint Recombinant human activated protein C as a disease modifier in severe acute pancreatitis: systematic review of current evidence
    Charles J Miranda
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Pancreatology 12:119-23. 2012
    ....
  19. ncbi request reprint Nutritional and anthropometric assessment of the scope for dietary optimization during staging prior to pancreaticoduodenectomy
    Kolitha S Goonetilleke
    Hepatobiliary Surgical Unit, Manchester Royal Infirmary Manchester, United Kingdom
    JOP 9:415-21. 2008
    ..Although several studies have examined peri-operative nutritional supplementation in patients undergoing pancreaticoduodenectomy all provided support at various timepoints with a variety of protocols...
  20. ncbi request reprint Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis
    Srinivasan Balachandra
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, England
    Surgery 138:913-23. 2005
    ..The effects of the tyrosine kinase inhibitors, tyrphostin AG126 and AG556 in a murine model of acute pancreatitis are investigated...
  21. doi request reprint Functional protein C levels during the early phase of clinical acute pancreatitis
    Benoy Idicula Babu
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester M13 9WL, United Kingdom
    Pancreas 39:1077-81. 2010
    ..However, little is known of the pathophysiological characteristics of endogenous protein C early in the disease course of AP. This study undertakes an evaluation of protein C levels in AP...
  22. doi request reprint EGFR and KRAS mutational analysis and their correlation to survival in pancreatic and periampullary cancer
    Melissa Oliveira-Cunha
    Hepatobiliary Surgery Unit, University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
    Pancreas 41:428-34. 2012
    ..The aim of this study was to determine the incidence of KRAS and EGFR mutations in pancreatic and periampullary cancers and their relationship with survival...
  23. pmc Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitis
    Saurabh Jamdar
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    Crit Care 9:321-2. 2005
    ..Modulation of the coagulation cascade, although probably essential to the mode of action of drotrecogin alfa, can lead to an increased risk of bleeding...
  24. ncbi request reprint Current status of laparoscopic biliary bypass in the management of non-resectable peri-ampullary cancer
    Ravindra S Date
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    Pancreatology 5:325-9. 2005
    ..However, the evidence base for selection of laparoscopic bypass is limited and the aim of this report is to scrutinize the available evidence in order to assess the current role of this procedure...
  25. ncbi request reprint Quantitative analysis of plasma DNA in severe acute pancreatitis
    Anil Bagul
    HPB Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 7:602-7. 2006
    ..Severe acute pancreatitis is characterized by inflammation but may also be associated with accelerated apoptotic and necrotic pathways...
  26. ncbi request reprint Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis
    Kolitha S Goonetilleke
    Hepato Pancreato Biliary Unit, Manchester Royal Infirmary, Manchester, United Kingdom
    Pancreas 34:318-24. 2007
    ....
  27. ncbi request reprint Radiofrequency ablation of the pancreas. II: Intra-operative ablation of non-resectable pancreatic cancer. A description of technique and initial outcome
    Ravindra S Date
    Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 6:588-92. 2005
    ..Our group has reported the development of a porcine pancreatic model of radiofrequency ablation of the pancreas. This brief report details the application of this technique to clinical practice...
  28. doi request reprint Understanding the colonic complications of pancreatitis
    Samy R Mohamed
    Hepatobiliary Surgical Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    Pancreatology 8:153-8. 2008
    ..As any individual unit will have only limited experience, this study aims to provide a structured, systematic appraisal of published experience to identify any consistent trends and disease patterns that may help in practical management...
  29. doi request reprint The liver-first approach to the management of colorectal cancer with synchronous hepatic metastases: a systematic review
    Santhalingam Jegatheeswaran
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, England
    JAMA Surg 148:385-91. 2013
    ..To our knowledge, this is the first systematic review of the liver-first approach to the management of patients with colorectal cancer with synchronous liver metastases...
  30. ncbi request reprint Outcome of hepaticojejunostomy without access loop for repair of iatrogenic bile duct injury at laparoscopic cholecystectomy
    Paul J Barrow
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    J Hepatobiliary Pancreat Surg 14:374-6. 2007
    ..Reasoning that percutaneous access can be achieved transhepatically in patients with stenosis, this study reports the outcome of a policy of biliary repair without the use of a jejunal access loop...
  31. pmc Experimental and clinical evidence for modification of hepatic ischaemia-reperfusion injury by N-acetylcysteine during major liver surgery
    Santhalingam Jegatheeswaran
    Hepatobiliary Surgery Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    HPB (Oxford) 13:71-8. 2011
    ..The present study is a detailed overview of the experimental and clinical evidence for the use of NAC as a pharmaco-protection agent in patients undergoing major liver surgery or transplantation...
  32. doi request reprint Poly(A) cDNA real-time PCR for indicator gene measurement in cancer
    Melissa Oliveira-Cunha
    Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Manchester, UK
    Methods Mol Biol 630:13-32. 2010
    ....
  33. doi request reprint Practical strategies for case selection in minimally invasive necrosectomy
    Benoy Idicula Babu
    Hepatobiliary Surgical Unit, Manchester Royal Infirmary, Manchester, UK
    Pancreatology 9:9-12. 2009
    ..Minimally invasive necrosectomy is an umbrella term encapsulating the retroperitoneal, endoscopic and laparoscopic approaches. However, current evidence is unclear in terms of which approach to select in any particular setting...
  34. ncbi request reprint Systematic appraisal of the management of the major vascular complications of pancreatitis
    Srinivasan Balachandra
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester M13 9RN, United Kingdom
    Am J Surg 190:489-95. 2005
    ..This study is a systematic appraisal of the management of major vascular complications of pancreatitis conducted by collating individual patient-episode data from published literature...
  35. ncbi request reprint Variance in elective surgery for chronic pancreatitis
    Nehal S Shah
    Hepatobiliary Surgical Unit, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 10:30-6. 2009
    ..Baseline assessment data are limited and thus patients in different centres may be presenting at different stages of their illness...
  36. ncbi request reprint Duodenal duplication cyst with profound elevation of intracystic carbohydrate antigen (CA 19-9) and carcinoembryonic antigen (CEA): a rare but important differential in the diagnosis of cystic tumours of the pancreas
    Kant J Shah
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 7:200-4. 2006
    ..Pre-operative confirmation of diagnosis can be difficult. This case reports an adult duodenal duplication cyst presenting with grossly elevated intra-lesional levels of tumour markers...
  37. ncbi request reprint European survey of surgical strategies for the management of severe acute pancreatitis
    Nicolas K K King
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Am J Gastroenterol 99:719-28. 2004
    ..This study is the first pan-European survey of surgical strategies for the management of severe acute pancreatitis...
  38. pmc Systematic appraisal of the role of metallic endobiliary stents in the treatment of benign bile duct stricture
    H P Priyantha Siriwardana
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, UK
    Ann Surg 242:10-9. 2005
    ..To carry out a systematic appraisal of the current status of the use of metallic endobiliary stents in the treatment of benign biliary strictures...
  39. ncbi request reprint Pathways of care for patients with suspected cancer of the pancreas: a tiered questionnaire-based survey of medical personnel across a single United kingdom Calman-Hine cancer network
    Ioannis T Virlos
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    JOP 6:13-25. 2005
    ....
  40. ncbi request reprint Development and validation of an experimental model for the assessment of radiofrequency ablation of pancreatic parenchyma
    Ravindra S Date
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    Pancreas 30:266-71. 2005
    ..The aim of this study was to develop and validate an ex vivo model for the assessment of radiofrequency (RF) ablation of the pancreas...
  41. ncbi request reprint Laparoscopic biliary bypass and current management algorithms for the palliation of malignant obstructive jaundice
    Ravindra S Date
    Ann Surg Oncol 11:815-7. 2004
  42. ncbi request reprint Etanercept attenuates the development of cerulein-induced acute pancreatitis in mice: a comparison with TNF-alpha genetic deletion
    Giuseppe Malleo
    Department of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Shock 27:542-51. 2007
    ..TNF-alpha receptor 1 gene deletion and Etanercept administration ameliorate the course of experimental acute pancreatitis in a similar degree. Future studies on clinical applications of Etanercept in pancreatitis seem promising...
  43. ncbi request reprint Evidence for a central role for selective mesenteric angiography in the management of the major vascular complications of pancreatitis
    Garth C Beattie
    Department of Surgical and Clinical Sciences, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Am J Surg 185:96-102. 2003
    ....
  44. ncbi request reprint Role of tumor necrosis factor-alpha in acute pancreatitis: from biological basis to clinical evidence
    Giuseppe Malleo
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria Gazzi, 98100 Messina, Italy
    Shock 28:130-40. 2007
    ....
  45. ncbi request reprint Radiofrequency ablation for locally advanced cancer of the pancreas
    Ajith K Siriwardena
    JOP 7:1-4. 2006