Henry C Kitchener

Summary

Affiliation: Manchester Royal Infirmary
Country: UK

Publications

  1. pmc Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
    Andrew E Teschendorff
    Statistical Genomics Group, Paul O Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    Genome Med 4:24. 2012
  2. ncbi request reprint Management of endometrial cancer
    H Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester ARK, United Kingdom
    Eur J Surg Oncol 32:838-43. 2006
  3. pmc HPV testing in routine cervical screening: cross sectional data from the ARTISTIC trial
    H C Kitchener
    Division of Human Development, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 95:56-61. 2006
  4. ncbi request reprint Chapter 7: Achievements and limitations of cervical cytology screening
    Henry C Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester, UK
    Vaccine 24:S3/63-70. 2006
  5. ncbi request reprint The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial
    H C Kitchener
    Division of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom
    Int J Gynecol Cancer 18:743-8. 2008
  6. ncbi request reprint Laparoscopic versus open colposuspension--results of a prospective randomised controlled trial
    H C Kitchener
    Division of Human Development, University of Manchester, Manchester, UK
    BJOG 113:1007-13. 2006
  7. ncbi request reprint Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women
    Henry Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Int J Cancer 121:2484-91. 2007
  8. doi request reprint HPV testing as an adjunct to cytology in the follow up of women treated for cervical intraepithelial neoplasia
    H C Kitchener
    Academic Unit of Obstetrics and Gynaecology, School of Cancer and Imaging Science, University of Manchester, Manchester, UK
    BJOG 115:1001-7. 2008
  9. ncbi request reprint Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination
    Lucy J C Smyth
    Cancer Research UK Immunology Group, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom
    Clin Cancer Res 10:2954-61. 2004
  10. doi request reprint A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: extended follow up in the ARTISTIC trial
    Henry C Kitchener
    School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Eur J Cancer 47:864-71. 2011

Detail Information

Publications45

  1. pmc Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
    Andrew E Teschendorff
    Statistical Genomics Group, Paul O Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    Genome Med 4:24. 2012
    ..We aimed to demonstrate that epigenetic changes in normal cells, collected years in advance of the first signs of morphological transformation, can predict the risk of such transformation...
  2. ncbi request reprint Management of endometrial cancer
    H Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester ARK, United Kingdom
    Eur J Surg Oncol 32:838-43. 2006
    ..To review broadly the diagnosis and treatment of endometrial cancer, concentrating on the evidence base...
  3. pmc HPV testing in routine cervical screening: cross sectional data from the ARTISTIC trial
    H C Kitchener
    Division of Human Development, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 95:56-61. 2006
    ..HPV 16 and HPV 18 are more predictive of underlying disease, but other HPV types account for 30% of high-grade disease...
  4. ncbi request reprint Chapter 7: Achievements and limitations of cervical cytology screening
    Henry C Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester, UK
    Vaccine 24:S3/63-70. 2006
    ..The increasing rate of human papillomavirus (HPV) testing and the prospect of prophylactic vaccination will change the way cervical cytology is used, possibly giving way to HPV testing as the primary test in secondary prevention...
  5. ncbi request reprint The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial
    H C Kitchener
    Division of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom
    Int J Gynecol Cancer 18:743-8. 2008
    ..HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening...
  6. ncbi request reprint Laparoscopic versus open colposuspension--results of a prospective randomised controlled trial
    H C Kitchener
    Division of Human Development, University of Manchester, Manchester, UK
    BJOG 113:1007-13. 2006
    ..To compare the effectiveness and cost effectiveness of open and laparoscopic colposuspension in the treatment of stress urinary incontinence...
  7. ncbi request reprint Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women
    Henry Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Int J Cancer 121:2484-91. 2007
    ..Cytology appears to be sufficient for cervical surveillance, with HPV testing being less specific with poor positive predictive value. There appears to be no additional benefit from routine colposcopy...
  8. doi request reprint HPV testing as an adjunct to cytology in the follow up of women treated for cervical intraepithelial neoplasia
    H C Kitchener
    Academic Unit of Obstetrics and Gynaecology, School of Cancer and Imaging Science, University of Manchester, Manchester, UK
    BJOG 115:1001-7. 2008
    ..To evaluate human papillomavirus (HPV) testing in combination with cytology in the follow up of treated women...
  9. ncbi request reprint Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination
    Lucy J C Smyth
    Cancer Research UK Immunology Group, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom
    Clin Cancer Res 10:2954-61. 2004
    ..The purpose is to study the immunogenicity of heterologous prime-boost human papillomavirus (HPV) oncogene vaccination in patients with anogenital intraepithelial neoplasia (AGIN)...
  10. doi request reprint A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: extended follow up in the ARTISTIC trial
    Henry C Kitchener
    School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Eur J Cancer 47:864-71. 2011
    ..We wished to determine, through a further (third) round of screening in the ARTISTIC trial, the protection provided by a negative baseline HPV screen compared with that of cytology over a 6 year period...
  11. doi request reprint The second to fourth digit ratio (2D:4D) in women with and without human papillomavirus and cervical dysplasia
    Loretta Brabin
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester M13 OJH, United Kingdom
    Am J Hum Biol 20:337-41. 2008
    ..A similar, nonsignificant trend was observed among women with a persistent HPV infection. CONCLUSION: Lower fetal androgen exposure may predispose to persistent HPV and increased risk of CIN...
  12. doi request reprint HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial
    Henry C Kitchener
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
    Lancet Oncol 10:672-82. 2009
    ....
  13. ncbi request reprint Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Cancer Res 63:6032-41. 2003
    ..Local immune infiltration may be a critical factor in potential responsiveness to vaccine therapy in HPV-associated neoplasia and should be carefully monitored in future placebo-controlled trials of immunotherapy for VIN...
  14. ncbi request reprint Human papillomavirus in cervical screening and vaccination
    Emma J Crosbie
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Whitworth Park, Manchester M13 0JH, UK
    Clin Sci (Lond) 110:543-52. 2006
    ..For those generations of women already exposed to high-risk HPV infection, therapeutic vaccines may offer advantages over conventional treatment, although much work still needs to be done...
  15. doi request reprint Human papillomavirus as a target for management, prevention and therapy
    Emma J Crosbie
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, UK
    Int J Hyperthermia 28:478-88. 2012
    ..In this review, the latest evidence supporting HPV as both a biomarker of risk for cervical cancer and a target for prophylactic and therapeutic vaccination is presented...
  16. doi request reprint Body mass index does not influence post-treatment survival in early stage endometrial cancer: results from the MRC ASTEC trial
    Emma J Crosbie
    Gynaecology Oncology Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
    Eur J Cancer 48:853-64. 2012
    ....
  17. pmc A semi-qualitative study of attitudes to vaccinating adolescents against human papillomavirus without parental consent
    Loretta Brabin
    Academic Unit of Obstetrics and Gynaecology, Research Floor, St, Mary s Hospital, Whitworth Park, Manchester, M13 0JH, UK
    BMC Public Health 7:20. 2007
    ..Under-16s in the UK have a right to confidential sexual health care without parental consent. We investigated parents' views on making available HPV vaccination to adolescent minors at sexual health clinics without parental consent...
  18. doi request reprint Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia
    Ursula Winters
    School of Cancer and Imaging, University of Manchester, St Mary s Hospital, Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 14:5292-9. 2008
    ..Indeed, there is evidence that immunosuppressed individuals have higher rates of VIN, suggesting immune control is relevant...
  19. doi request reprint Informing adolescents about human papillomavirus vaccination: what will parents allow?
    Lorraine A Vallely
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, M13 OJH, United Kingdom
    Vaccine 26:2203-10. 2008
    ..Our results indicated that the film's four key messages were acceptable to parents and largely understood by adolescents but these messages will need reinforcing if the full potential of a prophylactic vaccine is to be realised...
  20. ncbi request reprint Five-year follow-up of women with borderline and mildly dyskaryotic cervical smears
    D N Rana
    Manchester Cytology Centre, Manchester Royal Infirmary, Manchester M13 9WW, UK
    Cytopathology 15:263-70. 2004
    ....
  21. doi request reprint Therapy of human papillomavirus-related disease
    Peter L Stern
    Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
    Vaccine 30:F71-82. 2012
    ..This article forms part of a special supplement entitled "Comprehensive Control of HPV Infections and Related Diseases" Vaccine Volume 30, Supplement 5, 2012...
  22. doi request reprint Body mass index, hormone replacement therapy, and endometrial cancer risk: a meta-analysis
    Emma J Crosbie
    Gynaecology Oncology Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
    Cancer Epidemiol Biomarkers Prev 19:3119-30. 2010
    ..Body mass index (BMI) is a risk factor for endometrial cancer. We quantified the risk and investigated whether the association differed by use of hormone replacement therapy (HRT), menopausal status, and histologic type...
  23. ncbi request reprint To stage or not to stage? That is the question: (with apologies to Shakespeare)
    Henry C Kitchener
    University of Manchester, Manchester, UK
    Int J Gynecol Cancer 20:S55-6. 2010
    ..Until new trial evidence is produced to the contrary, routine lymphadenectomy cannot be recommended for endometrial cancer...
  24. doi request reprint Automation-assisted versus manual reading of cervical cytology (MAVARIC): a randomised controlled trial
    Henry C Kitchener
    School of Cancer and enabling Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Lancet Oncol 12:56-64. 2011
    ..In the Manual Assessment Versus Automated Reading In Cytology (MAVARIC) trial, we compared the accuracy of these techniques for the detection of underlying disease...
  25. ncbi request reprint Future acceptance of adolescent human papillomavirus vaccination: a survey of parental attitudes
    Loretta Brabin
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, M13 OJH, UK
    Vaccine 24:3087-94. 2006
    ..It will be important to raise general awareness of the role of HPV in cervical cancer without stigmatizing the vaccine...
  26. pmc Prevalence of type-specific HPV infection by age and grade of cervical cytology: data from the ARTISTIC trial
    A Sargent
    Division of Cancer Studies and Imaging, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 98:1704-9. 2008
    ..In the absence of broader cross-protection, the large majority of low-grade and many high-grade abnormalities may still occur in sexually active vaccinated women...
  27. doi request reprint Human papillomavirus and cervical cancer
    Emma J Crosbie
    Institute of Cancer Sciences, University of Manchester, Oxford Road, Manchester, UK
    Lancet 382:889-99. 2013
    ..If these prevention strategies can be implemented in developing countries, many thousands of lives could be saved. ..
  28. ncbi request reprint Cervarix--a bivalent L1 virus-like particle vaccine for prevention of human papillomavirus type 16- and 18-associated cervical cancer
    Emma J Crosbie
    University of Manchester, Academic Unit of Obstetrics and Gynaecology, St Mary s Hospital, Whitworth Park, Manchester, M13 0JH, UK
    Expert Opin Biol Ther 7:391-6. 2007
    ..The clinical experience of Cervarix and its potential role in reducing the global burden of cervical cancer is discussed...
  29. doi request reprint ARTISTIC: a randomised trial of human papillomavirus (HPV) testing in primary cervical screening
    H C Kitchener
    School of Cancer and Imaging Sciences, University of Manchester, St Mary s Hospital, Manchester, UK
    Health Technol Assess 13:1-150, iii-iv. 2009
    ..CIN3+?; Is HPV testing cost-effective in primary cervical screening?; Is its use associated with adverse psychosocial or psychosexual effects?; and How would it perform as an initial screening test followed by cytology for HPV positivity?..
  30. ncbi request reprint A randomised controlled trial of cytological surveillance versus patient choice between surveillance and colposcopy in managing mildly abnormal cervical smears
    H C Kitchener
    Academic Unit of Obstetrics and Gynaecology, St Mary s Hospital, Manchester, UK
    BJOG 111:63-70. 2004
    ..To determine whether choice of colposcopy or six month cytological surveillance would be beneficial to women with mildly abnormal smears when compared with the national policy of six months surveillance in terms of psychological morbidity...
  31. ncbi request reprint No alteration in NK function or zeta chain expression in NK and T cells of cervical cancer patients
    Toli S Onon
    Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom
    Gynecol Oncol 89:120-8. 2003
    ..To investigate in vitro natural killer (NK) cell activity and expression of signal-transducing zeta chains in patients with cervical cancer...
  32. ncbi request reprint The use of vaccines in the prevention and treatment of cervical cancer
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Clin Oncol (R Coll Radiol) 14:193-200. 2002
    ..A papillomavirus vaccine that prevented HPV infection on the one hand and acted against established disease on the other, would have a profound impact on one of the major cancers affecting women globally...
  33. doi request reprint Endometrial cancer state of the science meeting
    Henry C Kitchener
    UK National Cancer Research Institute and University of Manchester, Manchester, United Kingdom
    Int J Gynecol Cancer 19:134-40. 2009
    ..To identify the most important trials for women with endometrial carcinoma and uterine carcinosarcoma, both those already underway or to be done, for which the Gynecological Cancer Intergroup might facilitate international cooperation...
  34. pmc Biological and hormonal markers of chlamydia, human papillomavirus, and bacterial vaginosis among adolescents attending genitourinary medicine clinics
    L Brabin
    Academic Unit of Obstetrics and Gynaecology and Reproductive Health Care, Research Floor, St Mary s Hospital, Whitworth Park, Manchester M13 0JH, UK
    Sex Transm Infect 81:128-32. 2005
    ..To assess maturity indices, menstrual patterns, hormonal factors, and risk of adolescent genital tract infections...
  35. pmc Factors affecting vaginal pH levels among female adolescents attending genitourinary medicine clinics
    L Brabin
    Academic Unit of Obstetrics and Gynaecology and Reproductive Health Care, Research Floor, St Mary s Hospital, Whitworth Park, Manchester M13 0JH, UK
    Sex Transm Infect 81:483-7. 2005
    ..We assessed hormonal factors and risk of abnormal vaginal pH and bacterial vaginosis (BV) among adolescents attending genitourinary medicine (GUM) clinics...
  36. ncbi request reprint Stage- and CA125-related survival in patients with epithelial ovarian cancer treated at a cancer center
    R E Board
    Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom
    Int J Gynecol Cancer 16:18-24. 2006
    ..Further clinical trials are needed to test whether combinations of surgical, histologic, biochemical, and radiologic parameters can be used to identify a population with such a good prognosis that adjuvant therapy is not required...
  37. ncbi request reprint Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7)
    E J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Vaccine 22:2722-9. 2004
    ..Three patients additionally showed lesion shrinkage or symptom relief, but no direct correlation between clinical and immunological responses was seen...
  38. ncbi request reprint Immunological and viral factors associated with the response of vulval intraepithelial neoplasia to photodynamic therapy
    E S Abdel-Hady
    University of Manchester, Academic Department of Obstetrics and Gynaecology and Reproductive Health Care, St. Mary's Hospital, United Kingdom
    Cancer Res 61:192-6. 2001
    ..0001). These data clearly support the contention that high-risk HPV infection and lack of cell-mediated immunity may play a role in the observed poor response of lower genital lesions to topical PDT...
  39. ncbi request reprint The IL-10 -1082G polymorphism is associated with clearance of HPV infection
    F Farzaneh
    Academic Unit of Obstetrics and Gynaecology, St Mary s Hospital, Manchester, UK
    BJOG 113:961-4. 2006
    ..028 [95% CI 0.001-0.66], P= 0.001). This preliminary study suggests that higher levels of IL-10 may prevent cervical neoplasia through their role in eliminating HPV...
  40. ncbi request reprint A report on the current status of European research on the use of human papillomavirus testing for primary cervical cancer screening
    Philip Davies
    European Cervical Cancer Association, 68 cours Albert Thomas, Lyon, France
    Int J Cancer 118:791-6. 2006
    ..Our study reviews the randomized controlled trials that are currently being conducted in Europe to establish the performance of HPV testing as a primary cervical cancer screening test...
  41. ncbi request reprint Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer
    Andreas M Kaufmann
    Frauenklinik, Friedrich Schiller University of Jena, 07743 Jena, Germany
    Clin Cancer Res 8:3676-85. 2002
    ....
  42. ncbi request reprint Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    J Gen Virol 84:2089-97. 2003
    ..In spite of previous studies showing the immunogenicity of E2 in eliciting primary T-cell responses in vitro, there was a low prevalence of E2 responses in the VIN patients and controls (2/18 vs 0/17)...
  43. ncbi request reprint Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial
    Jorma Paavonen
    University of Helsinki, Department of Obstetrics and Gynaecology, Helsinki, Finland
    Lancet 369:2161-70. 2007
    ....
  44. ncbi request reprint Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom
    Cancer Res 63:400-3. 2003
    ..Such factors are important to the development of HPV vaccines for treatment of cervical and vulval neoplasia...
  45. ncbi request reprint Cervical regeneration after diathermy excision of cervical intraepithelial neoplasia as assessed by transvaginal sonography
    Evangelos Paraskevaidis
    Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, Greece
    Eur J Obstet Gynecol Reprod Biol 102:88-91. 2002
    ..To evaluate regeneration in cervical craters following large loop excision of the transformation zone (LLETZ) and to investigate possible differential healing patterns depending on the cone's size...