Nasser Al Shanti

Summary

Affiliation: Manchester Metropolitan University
Country: UK

Publications

  1. ncbi request reprint Inhibition of alpha nascent polypeptide associated complex protein may induce proliferation, differentiation and enhance the cytotoxic activity of human CD8+ T cells
    Nasser Al-Shanti
    Institute for Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Stoke on Trent, England
    J Clin Immunol 26:457-64. 2006
  2. doi request reprint A semi-automated programme for tracking myoblast migration following mechanical damage: manipulation by chemical inhibitors
    Nasser Al-Shanti
    School of Healthcare Science, Institute for Biomedical Research into Human Movement and Health IRM, MMU, Oxford Road, Manchester, UK
    Cell Physiol Biochem 27:625-36. 2011
  3. doi request reprint Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, John Dalton Building, Oxford Road, Manchester, M1 5GD, UK
    Biol Rev Camb Philos Soc 84:637-52. 2009
  4. pmc Two-Step versus One-Step RNA-to-CT 2-Step and One-Step RNA-to-CT 1-Step: validity, sensitivity, and efficiency
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, M1 5GD, United Kingdom
    J Biomol Tech 20:172-9. 2009
  5. doi request reprint PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Hassall Road, Alsager, Cheshire ST7 2HL, England, UK
    J Endocrinol 198:243-52. 2008
  6. doi request reprint Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Cheshire, England, UK
    Growth Factors 26:61-73. 2008
  7. ncbi request reprint Human purified CD8+ T cells: Ex vivo expansion model to generate a maximum yield of functional cytotoxic cells
    Nasser Al-Shanti
    Institute for Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Stoke on Trent, England
    Immunol Invest 36:85-104. 2007
  8. doi request reprint Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3
    Nasser Al-Shanti
    School of Healthcare Science, Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Oxford Road, Manchester, M1 5GD, England, UK
    J Cell Biochem 113:923-33. 2012
  9. doi request reprint C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d
    Amarjit Saini
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, M1 5GD, UK
    Cell Physiol Biochem 25:253-62. 2010
  10. doi request reprint Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism
    Amarjit Saini
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Cheshire, UK
    Growth Factors 26:239-53. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Inhibition of alpha nascent polypeptide associated complex protein may induce proliferation, differentiation and enhance the cytotoxic activity of human CD8+ T cells
    Nasser Al-Shanti
    Institute for Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Stoke on Trent, England
    J Clin Immunol 26:457-64. 2006
    ..Taken together, our results demonstrated that inhibition of alpha NAC protein induced not only cell proliferation but also differentiation and cytotoxic activity of CD8(+) T cells...
  2. doi request reprint A semi-automated programme for tracking myoblast migration following mechanical damage: manipulation by chemical inhibitors
    Nasser Al-Shanti
    School of Healthcare Science, Institute for Biomedical Research into Human Movement and Health IRM, MMU, Oxford Road, Manchester, UK
    Cell Physiol Biochem 27:625-36. 2011
    ..We hypothesised that damaged skeletal myoblasts would elicit a mesenchymal-like migratory response, which could be precisely tracked and subsequently manipulated...
  3. doi request reprint Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, John Dalton Building, Oxford Road, Manchester, M1 5GD, UK
    Biol Rev Camb Philos Soc 84:637-52. 2009
    ..4) How calcineurin transmits signals to the nucleus through the dephosphorylation and translocation of NFAT from the cytoplasm to the nucleus...
  4. pmc Two-Step versus One-Step RNA-to-CT 2-Step and One-Step RNA-to-CT 1-Step: validity, sensitivity, and efficiency
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, M1 5GD, United Kingdom
    J Biomol Tech 20:172-9. 2009
    ..This is the first study to demonstrate that the RNA-to-C(T) 2-Step kit is not reliable to be performed as a one-step reaction but as a two-step reaction, is even more sensitive than the newly launched RNA-to-C(T) 1-Step kit...
  5. doi request reprint PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Hassall Road, Alsager, Cheshire ST7 2HL, England, UK
    J Endocrinol 198:243-52. 2008
    ..7+/-5.7%). These findings uncover a previously unconsidered positive effect of PD98059 on C2 myoblast differentiation and identify the pathway(s) underlying PD-induced C2 myoblast differentiation...
  6. doi request reprint Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Cheshire, England, UK
    Growth Factors 26:61-73. 2008
    ..Our data suggest that in the presence of TNF-alpha/IL-6 functions positively and potentially also cooperatively with the IGF system to achieve the maximal beneficial effect on skeletal myoblast numbers...
  7. ncbi request reprint Human purified CD8+ T cells: Ex vivo expansion model to generate a maximum yield of functional cytotoxic cells
    Nasser Al-Shanti
    Institute for Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Stoke on Trent, England
    Immunol Invest 36:85-104. 2007
    ..In conclusion, we have developed a reliable, simple method that uses minimal cell numbers to generate a high yield of functional cytotoxic CD8+ T cells, which can be used for the development of cellular immunotherapies...
  8. doi request reprint Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3
    Nasser Al-Shanti
    School of Healthcare Science, Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Oxford Road, Manchester, M1 5GD, England, UK
    J Cell Biochem 113:923-33. 2012
    ..These data may suggest that IL-6 exerts its inhibitory effects on IGF-1 signalling pathways (ERK1/2 and Akt) through blocking its receptor substrate IRS-1 by SOCS-3...
  9. doi request reprint C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d
    Amarjit Saini
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, M1 5GD, UK
    Cell Physiol Biochem 25:253-62. 2010
    ..Adra1d knockdown resulted in significantly higher levels of cell death under all incubations suggesting Adra1d expression is essential for skeletal muscle cell survival...
  10. doi request reprint Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism
    Amarjit Saini
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Cheshire, UK
    Growth Factors 26:239-53. 2008
    ....
  11. ncbi request reprint Waste management - cytokines, growth factors and cachexia
    Amarjit Saini
    Institute for Biophysical and Clinical Research into Human Movement, Department of Exercise and Sport Science, Manchester Metropolitan University, Hassall Road, Alsager, Cheshire ST7 2HL, England, UK
    Cytokine Growth Factor Rev 17:475-86. 2006
    ....
  12. doi request reprint Powerful signals for weak muscles
    Amarjit Saini
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, United Kingdom
    Ageing Res Rev 8:251-67. 2009
    ....
  13. doi request reprint C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing?
    Adam P Sharples
    Faculty of Science and Engineering, Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, UK
    J Cell Physiol 225:240-50. 2010
    ..This investigation provides insight into regulators of altered basal hypertrophy and TNF-induced atrophy, providing a model for future investigation into therapeutic initiatives for ageing/wasting disorders...