Anthony K Akobeng

Summary

Affiliation: Manchester Royal Infirmary
Country: UK

Publications

  1. ncbi Assessing the validity of clinical trials
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    J Pediatr Gastroenterol Nutr 47:277-82. 2008
  2. ncbi Confidence intervals and p-values in clinical decision making
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 97:1004-7. 2008
  3. ncbi Crohn's disease: current treatment options
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester M9 7AA, UK
    Arch Dis Child 93:787-92. 2008
  4. ncbi Communicating the benefits and harms of treatments
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester, UK
    Arch Dis Child 93:710-3. 2008
  5. ncbi Systematic review: tolerable amount of gluten for people with coeliac disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:1044-52. 2008
  6. ncbi Review article: the evidence base for interventions used to maintain remission in Crohn's disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:11-8. 2008
  7. ncbi Understanding diagnostic tests 1: sensitivity, specificity and predictive values
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 96:338-41. 2007
  8. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
  9. ncbi Understanding diagnostic tests 2: likelihood ratios, pre- and post-test probabilities and their use in clinical practice
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester University Hospital, Manchester, UK
    Acta Paediatr 96:487-91. 2007
  10. ncbi Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Manchester, UK
    Clin Nutr 26:51-6. 2007

Detail Information

Publications18

  1. ncbi Assessing the validity of clinical trials
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    J Pediatr Gastroenterol Nutr 47:277-82. 2008
    ..Issues to consider in determining the external validity of a study include the setting of the trial, the study population, the types of interventions used, duration of follow-up, and the types of outcome and how they were assessed...
  2. ncbi Confidence intervals and p-values in clinical decision making
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 97:1004-7. 2008
    ..CONCLUSION: It is good practice for authors of research articles to report CIs with their estimates instead of just p-values as p-values are less informative and convey no information on clinical importance...
  3. ncbi Crohn's disease: current treatment options
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester M9 7AA, UK
    Arch Dis Child 93:787-92. 2008
    ..The available evidence does not support the use of corticosteroids or 5-aminosalicylates as maintenance therapy for CD...
  4. ncbi Communicating the benefits and harms of treatments
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester, UK
    Arch Dis Child 93:710-3. 2008
    ..LHH can be adjusted for individual patients by taking account of their own values and unique circumstances...
  5. ncbi Systematic review: tolerable amount of gluten for people with coeliac disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:1044-52. 2008
    ..The threshold amount of gluten in 'gluten-free' products that can be tolerated by people with coeliac disease is unclear...
  6. ncbi Review article: the evidence base for interventions used to maintain remission in Crohn's disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:11-8. 2008
    ..A number of interventions are currently used in clinical practice to try and maintain remission in Crohn's disease but the evidence base for some of them may be questionable...
  7. ncbi Understanding diagnostic tests 1: sensitivity, specificity and predictive values
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 96:338-41. 2007
    ..Positive and negative predictive values provide estimates of probability of disease but both parameters vary according to disease prevalence...
  8. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
    ..The curve may be used to select optimal cut-off values for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of different tests...
  9. ncbi Understanding diagnostic tests 2: likelihood ratios, pre- and post-test probabilities and their use in clinical practice
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester University Hospital, Manchester, UK
    Acta Paediatr 96:487-91. 2007
    ..The Fagan's nomogram is a useful and convenient graphical tool that allows likelihood ratios to be used in conjunction with a patient's pre-test probability of disease to estimate the post-test probability of disease...
  10. ncbi Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Manchester, UK
    Clin Nutr 26:51-6. 2007
    ..The aim of this study was to determine the effect of exclusive enteral nutrition, which is increasingly being used as primary therapy for CD, on plasma antioxidant concentrations in children with active CD...
  11. ncbi Assessing the population impact of low rates of breast feeding on asthma, coeliac disease and obesity: the use of a new statistical method
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Blackley, Manchester, UK
    Arch Dis Child 92:483-5. 2007
    ..Lack of breast feeding has been reported to be associated with a number of chronic childhood disorders...
  12. ncbi Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester, Manchester, UK
    Arch Dis Child 91:39-43. 2006
    ..Coeliac disease (CD) is a disorder that may depend on genetic, immunological, and environmental factors. Recent observational studies suggest that breast feeding may prevent the development of CD...
  13. ncbi Evidence in practice
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:849-52. 2005
    ..Finally, some of the issues involved in the development of evidence based policies within clinical teams are outlined...
  14. ncbi Understanding systematic reviews and meta-analysis
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:845-8. 2005
    ....
  15. ncbi Understanding randomised controlled trials
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:840-4. 2005
    ..Important terminologies such as randomisation, allocation concealment, blinding, intention to treat, p values, and confidence intervals are explained...
  16. ncbi Principles of evidence based medicine
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:837-40. 2005
    ....
  17. ncbi Understanding measures of treatment effect in clinical trials
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester M9 7AA, UK
    Arch Dis Child 90:54-6. 2005
    ....
  18. ncbi Enteral nutritional supplementation and the maintenance of permission in Crohn's disease
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children's University Hospitals, Booth Hall Children's Hospital, United Kingdom
    J Pediatr Gastroenterol Nutr 34:572-3. 2002