Anthony K Akobeng

Summary

Affiliation: Manchester Royal Infirmary
Country: UK

Publications

  1. ncbi request reprint Assessing the validity of clinical trials
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    J Pediatr Gastroenterol Nutr 47:277-82. 2008
  2. ncbi request reprint Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
  3. doi request reprint Communicating the benefits and harms of treatments
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester, UK
    Arch Dis Child 93:710-3. 2008
  4. ncbi request reprint Systematic review: tolerable amount of gluten for people with coeliac disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:1044-52. 2008
  5. ncbi request reprint Review article: the evidence base for interventions used to maintain remission in Crohn's disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:11-8. 2008
  6. ncbi request reprint Understanding diagnostic tests 1: sensitivity, specificity and predictive values
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 96:338-41. 2007
  7. ncbi request reprint Confidence intervals and p-values in clinical decision making
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 97:1004-7. 2008
  8. ncbi request reprint Understanding diagnostic tests 2: likelihood ratios, pre- and post-test probabilities and their use in clinical practice
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester University Hospital, Manchester, UK
    Acta Paediatr 96:487-91. 2007
  9. ncbi request reprint Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Manchester, UK
    Clin Nutr 26:51-6. 2007
  10. pmc Assessing the population impact of low rates of breast feeding on asthma, coeliac disease and obesity: the use of a new statistical method
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Blackley, Manchester, UK
    Arch Dis Child 92:483-5. 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Assessing the validity of clinical trials
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    J Pediatr Gastroenterol Nutr 47:277-82. 2008
    ..Issues to consider in determining the external validity of a study include the setting of the trial, the study population, the types of interventions used, duration of follow-up, and the types of outcome and how they were assessed...
  2. ncbi request reprint Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
    ..In this paper, the author explains how the ROC curve can be used to select optimal cut-off points for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of tests...
  3. doi request reprint Communicating the benefits and harms of treatments
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester, UK
    Arch Dis Child 93:710-3. 2008
    ..LHH can be adjusted for individual patients by taking account of their own values and unique circumstances...
  4. ncbi request reprint Systematic review: tolerable amount of gluten for people with coeliac disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:1044-52. 2008
    ..The threshold amount of gluten in 'gluten-free' products that can be tolerated by people with coeliac disease is unclear...
  5. ncbi request reprint Review article: the evidence base for interventions used to maintain remission in Crohn's disease
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Aliment Pharmacol Ther 27:11-8. 2008
    ..A number of interventions are currently used in clinical practice to try and maintain remission in Crohn's disease but the evidence base for some of them may be questionable...
  6. ncbi request reprint Understanding diagnostic tests 1: sensitivity, specificity and predictive values
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 96:338-41. 2007
    ..It would therefore be wrong for predictive values determined for one population to be applied to another population with a different prevalence of disease...
  7. ncbi request reprint Confidence intervals and p-values in clinical decision making
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester and Manchester Children s University Hospitals, Manchester, UK
    Acta Paediatr 97:1004-7. 2008
    ..The p-value is often used to express the probability that the observed differences between study groups are due to chance. p-values provide no information on the clinical importance of results...
  8. ncbi request reprint Understanding diagnostic tests 2: likelihood ratios, pre- and post-test probabilities and their use in clinical practice
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester University Hospital, Manchester, UK
    Acta Paediatr 96:487-91. 2007
    ..The Fagan's nomogram is a graphical tool which, in routine clinical practice, allows one to combine the likelihood ratio of a test with a patient's pre-test probability of disease to estimate post-test probability...
  9. ncbi request reprint Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Manchester, UK
    Clin Nutr 26:51-6. 2007
    ..The aim of this study was to determine the effect of exclusive enteral nutrition, which is increasingly being used as primary therapy for CD, on plasma antioxidant concentrations in children with active CD...
  10. pmc Assessing the population impact of low rates of breast feeding on asthma, coeliac disease and obesity: the use of a new statistical method
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Blackley, Manchester, UK
    Arch Dis Child 92:483-5. 2007
    ..Lack of breast feeding has been reported to be associated with a number of chronic childhood disorders...
  11. pmc Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies
    A K Akobeng
    Department of Paediatric Gastroenterology, Booth Hall Children s Hospital, Central Manchester, Manchester, UK
    Arch Dis Child 91:39-43. 2006
    ..Coeliac disease (CD) is a disorder that may depend on genetic, immunological, and environmental factors. Recent observational studies suggest that breast feeding may prevent the development of CD...
  12. pmc Evidence in practice
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:849-52. 2005
    ..Finally, some of the issues involved in the development of evidence based policies within clinical teams are outlined...
  13. pmc Understanding systematic reviews and meta-analysis
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:845-8. 2005
    ....
  14. pmc Understanding randomised controlled trials
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:840-4. 2005
    ..Important terminologies such as randomisation, allocation concealment, blinding, intention to treat, p values, and confidence intervals are explained...
  15. pmc Principles of evidence based medicine
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester, M9 7AA, UK
    Arch Dis Child 90:837-40. 2005
    ....
  16. pmc Understanding measures of treatment effect in clinical trials
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Charlestown Road, Blackley, Manchester M9 7AA, UK
    Arch Dis Child 90:54-6. 2005
    ....
  17. ncbi request reprint Crohn's disease: current treatment options
    A K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Charlestown Road, Blackley, Manchester M9 7AA, UK
    Arch Dis Child 93:787-92. 2008
    ..The available evidence does not support the use of corticosteroids or 5-aminosalicylates as maintenance therapy for CD...
  18. doi request reprint Cochrane Review: Osmotic and stimulant laxatives for the management of childhood constipation (Review)
    Morris Gordon
    Royal Manchester Children s Hospital, Manchester, UK
    Evid Based Child Health 8:57-109. 2013
    ..Despite the widespread use of osmotic and stimulant laxatives by health professionals to manage constipation in children, there has been a long standing paucity of high quality evidence to support this practice...
  19. doi request reprint Osmotic and stimulant laxatives for the management of childhood constipation
    Morris Gordon
    RoyalManchester Children sHospital, Manchester, UK
    Cochrane Database Syst Rev 7:CD009118. 2012
    ..Despite the widespread use of osmotic and stimulant laxatives by health professionals to manage constipation in children, there has been a long standing paucity of high quality evidence to support this practice...
  20. ncbi request reprint Inverted appendix mistaken for a polyp during colonoscopy and leading to intussusception
    Ashok D Ram
    Department of Paediatric Surgery, Central Manchester and Manchester Children s University Hospitals, UK
    J Cyst Fibros 4:203-4. 2005
    ..However, histopathological examination suggested it was a segment of inverted appendix. The remnant of the inverted appendix was subsequently found to be associated with an intussusception...
  21. ncbi request reprint Oral 5-aminosalicylic acid for maintenance of surgically-induced remission in Crohn's disease
    Morris Gordon
    Royal Manchester Children s Hospital, Oxford Road, Manchester, UK, M13 9WL
    Cochrane Database Syst Rev 1:CD008414. 2011
    ..A recent Cochrane review found that 5-ASAs are not effective for the maintenance of medically-induced remission in CD, but their role in the maintenance of surgically-induced remission is unclear...
  22. ncbi request reprint Enteral nutritional supplementation and the maintenance of permission in Crohn's disease
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, United Kingdom
    J Pediatr Gastroenterol Nutr 34:572-3. 2002