Affiliation: London School of Hygiene and Tropical Medicine
Wilkinson S, Meyer D, Kelly J. Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity. Biochem J. 2000;352 Pt 3:755-61 pubmed
..With lower-affinity substrates such as t-butyl hydroperoxide, the rate-limiting step is the reduction of the oxidant. The data presented here identify a new arm of the T. cruzi oxidative defence system. ..
Wilkinson S, Prathalingam S, Taylor M, Horn D, Kelly J. Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proc Natl Acad Sci U S A. 2005;102:11645-50 pubmed publisher
..It is implicit, therefore, that bloodstream-form trypanosomes also possess a capacity for ascorbate transport...