Research Topics
| Helen WeissSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
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Detail Information
Publications
Validation of brief screening tools for depressive and alcohol use disorders among TB and HIV patients in primary care in ZambiaNathaniel Chishinga
Zambia AIDS Related TB Project, School of Medicine, Ridgeway Campus, Lusaka, Zambia
BMC Psychiatry 11:75. 2011....
An overview of the global epidemiology of HIV/AIDSH A Weiss
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, UK
Lepr Rev 72:92-8. 2001....- Spousal sexual violence and poverty are risk factors for sexually transmitted infections in women: a longitudinal study of women in Goa, IndiaH A Weiss
Department of Epidemiology and Population Health, Keppel Street, London, WC1E 7HT, UK
Sex Transm Infect 84:133-9. 2008..To describe factors associated with incident sexually transmitted infections (STI) in a population-based sample of women in Goa, India... 
Circumcision among adolescent boys in rural northwestern TanzaniaHelen A Weiss
Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 13:1054-61. 2008..Modelling the impact of circumcision on HIV transmission, and planning service expansion, relies on self-reported circumcision status. We investigated the validity of self-reported status...- Male circumcision as a preventive measure against HIV and other sexually transmitted diseasesHelen A Weiss
Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
Curr Opin Infect Dis 20:66-72. 2007..Male circumcision is one of several potential approaches. This review summarizes recent evidence for the potential of male circumcision to prevent HIV and other sexually transmitted infections... - Episodic therapy for genital herpes in sub-saharan Africa: a pooled analysis from three randomized controlled trialsHelen A Weiss
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 6:e22601. 2011..The aim of this paper is to assess whether the variation in impact of acyclovir on ulcer healing in these trials can be explained by differences in the characteristics of the study populations... - Male circumcision and risk of HIV infection in women: a systematic review and meta-analysisHelen A Weiss
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet Infect Dis 9:669-77. 2009..Rigorous monitoring is essential to ensure that any adverse effects on women are detected and minimised... - Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysisH A Weiss
MRC Tropical Epidemiology Group, Infectious Disease Epidemiology Unit, Keppel Street, London WC1E 7HT, UK
Sex Transm Infect 82:101-9; discussion 110. 2006..Our objective was to conduct a systematic review and meta-analyses of the associations between male circumcision and infection with herpes simplex virus type 2 (HSV-2), Treponema pallidum, or Haemophilus ducreyi... - Complications of circumcision in male neonates, infants and children: a systematic reviewHelen A Weiss
MRC Tropical Epidemiology Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
BMC Urol 10:2. 2010..The aim of this paper is to summarize the literature on frequency of adverse events following pediatric circumcision, with a focus on developing countries... - Epidemiology of herpes simplex virus type 2 infection in the developing worldHelen Weiss
London School of Hygiene and Tropical Medicine, London, UK
Herpes 11:24A-35A. 2004..Where possible, the aetiology of GUD should be evaluated using polymerase chain reaction (PCR), while recognizing that co-pathogens can exist in a lesion. GUD management should incorporate HIV testing and antiherpetic treatment... - The epidemiology of HSV-2 infection and its association with HIV infection in four urban African populationsH A Weiss
London School of Hygiene and Tropical Medicine, UK
AIDS 15:S97-108. 2001..To estimate age- and sex-specific herpes simplex virus type-2 (HSV-2) prevalence in urban African adult populations and to identify factors associated with infection... - Male circumcision for HIV prevention: current research and programmatic issuesHelen A Weiss
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
AIDS 24:S61-9. 2010.... - Gender disadvantage and reproductive health risk factors for common mental disorders in women: a community survey in IndiaVikram Patel
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, England
Arch Gen Psychiatry 63:404-13. 2006..Gender disadvantage and reproductive health are major determinants of women's health in developing countries... - Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomesDeborah Watson-Jones
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Infect Dis 186:948-57. 2002..4-1.4) or low-titer active syphilis (OR, 0.95; 95% CI, 0.6-1.5), compared with seronegative women. Single-dose treatment is effective in preventing adverse pregnancy outcomes attributable to maternal syphilis... - Risk factors for common mental disorders in women. Population-based longitudinal studyVikram Patel
London School of Hygiene and Tropical Medicine, London, UK
Br J Psychiatry 189:547-55. 2006..The determinants of common mental disorders in women have not been described in longitudinal studies from a low-income country... - Long-term impact of acyclovir suppressive therapy on genital and plasma HIV RNA in Tanzanian women: a randomized controlled trialClare Tanton
London School of Hygiene and Tropical Medicine, London, United Kingdom
J Infect Dis 201:1285-97. 2010..Herpes simplex virus (HSV) suppressive therapy reduces genital and plasma human immunodeficiency virus type 1 (HIV-1) RNA over periods up to 3 months, but the long-term effect is unknown... - Long-term biological and behavioural impact of an adolescent sexual health intervention in Tanzania: follow-up survey of the community-based MEMA kwa Vijana TrialAoife M Doyle
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 7:e1000287. 2010..A further impact evaluation survey in 2007/8 ( approximately 9 years post-intervention) tested this hypothesis... - Chronic fatigue in developing countries: population based survey of women in IndiaVikram Patel
London School of Hygiene and Tropical Medicine, London WC1E 7HT
BMJ 330:1190. 2005..To describe the prevalence of and risk factors for chronic fatigue in a developing country; in particular, to determine the association of anaemia, mental health, and gender disadvantage factors with chronic fatigue... - Epidemiology. Understanding HIV epidemic trends in AfricaRichard Hayes
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Science 311:620-1. 2006 - Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studiesEsther E Freeman
Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, UK
AIDS 20:73-83. 2006..To estimate the sex-specific effect of herpes simplex virus type 2 (HSV-2) on the acquisition of HIV infection... - Socio-cultural, psychosexual and biomedical factors associated with genital symptoms experienced by men in rural IndiaMeenakshi Gautham
London School of Hygiene and Tropical Medicine, UK
Trop Med Int Health 13:384-95. 2008..STI treatment guidelines for urethral symptoms should be revised and be based on epidemiological data... - Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan AfricaEsther E Freeman
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
Vaccine 27:940-6. 2009..Over 20 years, in most scenarios fewer than 100 vaccinations were required to avert one HIV infection. HSV2 vaccines could have a substantial impact on HIV incidence. Intensified efforts are needed to develop an effective HSV2 vaccine... - Male circumcision for HIV prevention in sub-Saharan Africa: who, what and when?Richard G White
London School of Hygiene and Tropical Medicine, London, UK
AIDS 22:1841-50. 2008..We explore how the population-level impact of circumcision varies by target age group, coverage, time-to-scale-up, level of risk compensation and circumcision of HIV infected men... - Effect of HIV-1 and antiretroviral therapy on herpes simplex virus type 2: a prospective study in African womenP Mayaud
Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E7HT, UK
Sex Transm Infect 84:332-7. 2008.... - Prevalence of, and risk factors for Kaposi's sarcoma-associated herpesvirus infection among blood donors in Brazil: a multi-center serosurveyMaria Claudia Nascimento
Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Med Virol 80:1202-10. 2008..KSHV seroprevalence is high among Brazilian blood donors, particularly from the Amazon region. This study supports the co-existence of sexual and non-sexual routes of KSHV transmission in this population... - Risk factors for HIV incidence in women participating in an HSV suppressive treatment trial in TanzaniaDeborah Watson-Jones
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
AIDS 23:415-22. 2009..Risk factors for HIV incidence were examined in the context of 3-monthly follow-up visits offering both voluntary counselling and testing and care for sexually transmitted infections... - Design of epidemiological studies measuring genital and plasma HIV-1 outcomes: lessons from a randomised controlled trialNatasha L Larke
Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 14:267-75. 2009..We set out to determine whether the variability of genital HIV-1 RNA over time necessitates design adjustments in studies measuring genital shedding to account for this variability... - Seroprevalence of Kaposi sarcoma-associated herpesvirus and other serologic markers in the Brazilian AmazonMaria C Nascimento
Universidade de Sao Paulo, Sao Paulo, Brazil
Emerg Infect Dis 15:663-7. 2009..High KSHV seroprevalence in children and inverse association with herpes simplex virus type 2 indicates predominant nonsexual transmission among Amerindians... - Measurement and predictors of adherence in a trial of HSV suppressive therapy in TanzaniaDeborah Watson-Jones
London School of Hygiene and Tropical Medicine, London, UK
Contemp Clin Trials 30:504-12. 2009..Use of biomarkers may alert investigators to adherence problems... - Performance of commercial herpes simplex virus type-2 antibody tests using serum samples from Sub-Saharan Africa: a systematic review and meta-analysisSamuel Biraro
Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
Sex Transm Dis 38:140-7. 2011..Several commercial type-specific serologic tests are available for herpes simplex virus type 2 (HSV-2). Poor specificity of some tests has been reported on samples from sub-Saharan Africa... - Impact of acyclovir on genital and plasma HIV-1 RNA, genital herpes simplex virus type 2 DNA, and ulcer healing among HIV-1-infected African women with herpes ulcers: a randomized placebo-controlled trialPhilippe Mayaud
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
J Infect Dis 200:216-26. 2009..Little is known about the impact of episodic treatment of herpes on human immunodeficiency virus type 1 (HIV-1)... - Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal studyAndrea J Low
London School of Hygiene and Tropical Medicine, London, UK
BMC Infect Dis 11:20. 2011..We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology... - Effectiveness of an intervention led by lay health counsellors for depressive and anxiety disorders in primary care in Goa, India (MANAS): a cluster randomised controlled trialVikram Patel
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet 376:2086-95. 2010..The MANAS trial aimed to test the effectiveness of an intervention led by lay health counsellors in primary care settings to improve outcomes of people with these disorders... - Modelling the interactions between herpes simplex virus type 2 and HIV: implications for the HIV epidemic in southern IndiaAnna M Foss
Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK
Sex Transm Infect 87:22-7. 2011.... - Effect of herpes simplex suppression on incidence of HIV among women in TanzaniaDeborah Watson-Jones
London School of Hygiene and Tropical Medicine, London
N Engl J Med 358:1560-71. 2008..This study tested the hypothesis that HSV-2 suppressive therapy reduces the risk of HIV acquisition... - Biological and behavioural impact of an adolescent sexual health intervention in Tanzania: a community-randomized trialDavid A Ross
London School of Hygiene and Tropical Medicine, London, UK
AIDS 21:1943-55. 2007..The impact of a multicomponent intervention programme on the sexual health of adolescents was assessed in rural Tanzania... - Conjunctival transcriptome in scarring trachomaMatthew J Burton
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Infect Immun 79:499-511. 2011.... - Genital human papillomavirus genotypes in northwestern TanzaniaPhilippe Mayaud
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
J Clin Microbiol 41:4451-3. 2003..A multivalent vaccine for HPV-16, -18, -31, -33, and -35 would be necessary to prevent 50% of the neoplasia in this population... - Molecular characterization of Kaposi's sarcoma associated herpesvirus (KSHV) from patients with AIDS-associated Kaposi's sarcoma in Sao Paulo, BrazilMaria C Nascimento
Instituto de Infectologia Emílio Ribas Hospital, Sao Paulo, Brazil
J Clin Virol 33:52-9. 2005..The molecular epidemiology of KSHV is related closely to ethnicity and geographical location of studied populations. There is little epidemiological and molecular information about KSHV strains circulating in Brazil... - Prevalence of severe mental and neurological disorders in Mozambique: a population-based surveyVikram Patel
London School of Hygiene and Tropical Medicine, London, UK
Lancet 370:1055-60. 2007..We aimed to assess the prevalence of seizure disorders, psychoses, and mental retardation in urban and rural Mozambique... - Common genital complaints in women: the contribution of psychosocial and infectious factors in a population-based cohort study in Goa, IndiaVikram Patel
London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Int J Epidemiol 35:1478-85. 2006..Method Population-based cohort study in Goa, India. Out of 3000 randomly selected women, 2494 women participated. The outcome was an incident case of the complaint of abnormal vaginal discharge at 6 months (T1) and 12 months (T2) review... - Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: preparing for an HSV-2 intervention trialDeborah Watson-Jones
London School of Hygiene and Tropical Medicine, London, England
J Acquir Immune Defic Syndr 46:631-42. 2007..To determine prevalence of and risk factors for herpes simplex virus type 2 (HSV-2) and HIV among women being screened for a randomized, controlled trial of HSV suppressive therapy in northwestern Tanzania... - Non-traditional lifestyles and prevalence of mental disorders in adolescents in Goa, IndiaAravind Pillai
London School of Hygiene and Tropical Medicine, UK
Br J Psychiatry 192:45-51. 2008..We conducted an epidemiological study in the state of Goa to describe the current prevalence of mental disorders and its correlates among adolescents aged between 12 and 16 years... - Differing spectrum of HIV-associated ophthalmic disease among patients starting antiretroviral therapy in India and South AfricaSophia Pathai
Department of Clinical Research, London School of Hygiene and Tropical Medicine, UK
Trop Med Int Health 16:356-9. 2011..This difference persisted after adjusting for confounding factors (adjusted odds ratio=11.32, 95% confidence interval: 2.67-48.13), confirming a marked geographical difference in the prevalence of HIV-associated retinal disease... - Syphilis in pregnancy in Tanzania. I. Impact of maternal syphilis on outcome of pregnancyDeborah Watson-Jones
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Infect Dis 186:940-7. 2002..Syphilis continues to be a major cause of pregnancy loss and adverse pregnancy outcome among women who do not receive antenatal syphilis screening and treatment... - A qualitative study of participant adherence in a randomized controlled trial of herpes suppressive therapy for HIV prevention in TanzaniaMary L Plummer
London School of Hygiene and Tropical Medicine, London, UK
AIDS Care 22:499-508. 2010..Methodological research is also needed to improve adherence measures... - Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescentsDean B Everett
London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 12:1323-6. 2007..To determine the specificity of the Abbott Murex HIV antigen/antibody combination enzyme immunoassay (EIA) for the diagnosis of HIV infection in Tanzania... - Why do women complain of vaginal discharge? A population survey of infectious and pyschosocial risk factors in a South Asian communityVikram Patel
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Int J Epidemiol 34:853-62. 2005..Although presumed to be caused by reproductive tract infections (RTIs), the association between the complaint and the presence of RTIs is weak. This study aimed to investigate the risk factors of the complaint of vaginal discharge... - Serum IgG3 to the Plasmodium falciparum merozoite surface protein 2 is strongly associated with a reduced prospective risk of malariaWolfram G Metzger
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Parasite Immunol 25:307-12. 2003..Importantly, this effect remained significant after adjusting for a simultaneous strong protective association of antibodies to another antigen (MSP1 block 2) which itself remained highly significant... - Evaluation of a community-based rehabilitation model for chronic schizophrenia in rural IndiaSudipto Chatterjee
Latrobe Regional Hospital, Traralgon Victoria, Australia
Br J Psychiatry 182:57-62. 2003..Although the subjects in the CBR group were more socially disadvantaged, they had significantly better retention in treatment. CONCLUSIONS: The CBR model is a feasible model of care for chronic schizophrenia in resource-poor settings... - Male circumcision for HIV prevention: from evidence to action?Helen A Weiss
AIDS 22:567-74. 2008 - Increased condom use at sexual debut in the general population of Slovenia and association with subsequent condom useIrena Klavs
AIDS STD HAI Unit, Communicable Diseases Department, Institute of Public Health of the Republic of Slovenia, Ljubljana, Slovenia
AIDS 19:1215-23. 2005..To describe the extent of condom use at first heterosexual intercourse (FHI) in the general population of Slovenia, identify associated factors and assess the association with subsequent use... - Performance of HerpeSelect and Kalon assays in detection of antibodies to herpes simplex virus type 2Jerome Legoff
Universite Paris Descartes, Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743, Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Hopital Europeen Georges Pompidou, Paris, France
J Clin Microbiol 46:1914-8. 2008..Low index values obtained with the HerpeSelect assay may correspond to true HSV-2 infection, in particular to nonprimary first episodes of genital HSV-2 infection, and need to be interpreted in the context of clinical history... - Adverse birth outcomes in United Republic of Tanzania--impact and prevention of maternal risk factorsDeborah Watson Jones
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, England
Bull World Health Organ 85:9-18. 2007..To determine risk factors for poor birth outcome and their population attributable fractions... - Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levelsN Nagot
Centre Muraz, Burkina Faso
J Infect Dis 198:241-9. 2008.... - Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodesJerome Legoff
Université Paris Descartes Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 Immunologie Humaine, Centre de Recherches Biomedicales des Cordeliers, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
AIDS 21:1569-78. 2007..To investigate correlates of herpes simplex virus type 2 (HSV-2) DNA and HIV-1 RNA among women with genital ulcer disease (GUD)... - Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virusNicolas Nagot
Centre Muraz, Bobo Dioulasso, Burkina Faso
N Engl J Med 356:790-9. 2007..Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility... - Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trialAbdoulaye Ouedraogo
Centre Muraz, Bobo-Dioulasso, Burkina Faso
AIDS 20:2305-13. 2006..71 log10 copies/ml, 95% CI -1.27, -0.14). CONCLUSION: HSV-2 facilitates residual genital HIV-1 replication among dually infected women taking HAART despite HIV-1 suppression at the systemic level... - Response to Ronald Gray, Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda ( 2000, 14:2371-2381)Daniel T Halperin
AIDS 16:810-2; author reply 809-10. 2002 - Delay in motor development of twins in Africa: a prospective cohort studyTessa Goetghebuer
University Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
Twin Res 6:279-84. 2003..In conclusion, our data suggest that twinning is an independent risk factor for developmental delay in early life in The Gambia, and that genetic factors contribute strongly to certain motor development outcomes... - Performance of commercially available enzyme immunoassays for detection of antibodies against herpes simplex virus type 2 in African populationsEddy van Dyck
Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium
J Clin Microbiol 42:2961-5. 2004..7%; specificity, 92.6%) tests. It cannot be assumed that enzyme immunoassays for the detection of HSV-2 infection that perform well in industrialized countries will perform equally well in other populations... - Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infantsArnaud Marchant
Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
J Infect Dis 193:1598-605. 2006..CONCLUSIONS: Genetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturation...