C J Sutherland

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc ama1 genes of sympatric Plasmodium vivax and P. falciparum from Venezuela differ significantly in genetic diversity and recombination frequency
    Rosalynn L Ord
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e3366. 2008
  2. pmc Plasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyte
    Maha Saeed
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e2280. 2008
  3. pmc Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients
    Timothy Robinson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e23204. 2011
  4. pmc Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes
    Samana Schwank
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e14470. 2010
  5. pmc Clinical evaluation of a loop-mediated amplification kit for diagnosis of imported malaria
    Spencer D Polley
    Department of Clinical Parasitology, Walk in Clinic, Hospital for Tropical Diseases, University London Colleges NHS Foundation Trust, Mortimer Market, London WC1E 6JB, UK
    J Infect Dis 208:637-44. 2013
  6. pmc Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers
    Donelly A van Schalkwyk
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 12:320. 2013
  7. pmc Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies
    Amrish Baidjoe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Malar J 12:272. 2013
  8. pmc Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan
    Nahla B Gadalla
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 12:255. 2013
  9. pmc Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
    Jacklin F Mosha
    National Institute for Medical Research, NIMR, Mwanza Medical Research Centre, Mwanza, Tanzania
    Malar J 12:221. 2013
  10. pmc Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal
    Aminata C Lo
    Service of Parasitology, Faculty of Medicine, University Cheikh Anta Diop, Dakar, Senegal
    Malar J 12:137. 2013

Detail Information

Publications60

  1. pmc ama1 genes of sympatric Plasmodium vivax and P. falciparum from Venezuela differ significantly in genetic diversity and recombination frequency
    Rosalynn L Ord
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e3366. 2008
    ..falciparum collected in the Venezuelan Amazon...
  2. pmc Plasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyte
    Maha Saeed
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e2280. 2008
    ..In contrast, few studies have examined the surface of the gametocyte-infected erythrocyte...
  3. pmc Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients
    Timothy Robinson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e23204. 2011
    ..falciparum taken directly from malaria patients provides high quality data useful for drug resistance studies, genomic structural analyses and population genetics, and also robustly represents clonal multiplicity...
  4. pmc Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes
    Samana Schwank
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e14470. 2010
    ..Measuring the impact of anti-gametocyte drugs on sexual commitment of immature gametocyte stages in vitro is not currently possible as male and female parasites cannot be distinguished by morphology alone prior to stage IV...
  5. pmc Clinical evaluation of a loop-mediated amplification kit for diagnosis of imported malaria
    Spencer D Polley
    Department of Clinical Parasitology, Walk in Clinic, Hospital for Tropical Diseases, University London Colleges NHS Foundation Trust, Mortimer Market, London WC1E 6JB, UK
    J Infect Dis 208:637-44. 2013
    ..We determined the diagnostic accuracy of a new loop-mediated amplification (LAMP) kit in febrile returned travelers...
  6. pmc Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers
    Donelly A van Schalkwyk
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 12:320. 2013
    ..This study sought to establish in continuous culture a series of recent Plasmodium falciparum isolates to represent the current parasite populations in Africa, all of which are now exposed to artemisinin combination therapy...
  7. pmc Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies
    Amrish Baidjoe
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Malar J 12:272. 2013
    ..Filter paper blood spots are commonly used a source of both DNA and antibodies. To enhance the operational practicability of malaria surveys, a method is presented for combined DNA extraction and antibody elution...
  8. pmc Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan
    Nahla B Gadalla
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 12:255. 2013
    ..In this study, an evaluation of the efficacy and prevalence of drug resistance alleles (pfcrt, pfmdr1, pfdhfr and pfdhps) eight years after the adoption of AS/SP in eastern Sudan is reported...
  9. pmc Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
    Jacklin F Mosha
    National Institute for Medical Research, NIMR, Mwanza Medical Research Centre, Mwanza, Tanzania
    Malar J 12:221. 2013
    ..Data from a cross-sectional survey conducted in north-western Tanzania were used to examine the spatial distribution of Plasmodium falciparum and the relationship between household exposure and parasite density...
  10. pmc Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal
    Aminata C Lo
    Service of Parasitology, Faculty of Medicine, University Cheikh Anta Diop, Dakar, Senegal
    Malar J 12:137. 2013
    ..Here are report the effect of SMC delivery on the prevalence of markers of resistance to SP and AQ...
  11. pmc Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes
    Steven B Mwakalinga
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Malar J 11:429. 2012
    ..A particular type B RIFIN, PF13_0006, has previously been shown to be strongly transcribed in the asexual and sexual stages of P. falciparum in vitro...
  12. pmc Filter paper collection of Plasmodium falciparum mRNA for detecting low-density gametocytes
    Sophie Jones
    Department of Immunology and Infection Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 11:266. 2012
    ..Filter papers can be used for collecting RNA samples, but rigorous testing of their capacity to withstand adverse storage conditions has not been fully explored...
  13. pmc A Poisson hierarchical modelling approach to detecting copy number variation in sequence coverage data
    Nuno Sepúlveda
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Genomics 14:128. 2013
    ....
  14. pmc Increased sensitivity for detecting malaria parasites in human umbilical cord blood using scaled-up DNA preparation
    Spencer D Polley
    Department of Clinical Parasitology, Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK
    Malar J 11:62. 2012
    ..This paper details the screening of cord blood units from malaria serology positive mothers to detect malaria parasite DNA using a highly sensitive nested PCR...
  15. pmc Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance
    Khalid B Beshir
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel St, London, WC1E 7HT, UK
    Malar J 9:312. 2010
    ....
  16. pmc Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum
    Christian W Wang
    Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Malar J 9:147. 2010
    ..Sexual stage parasite surface proteins are of interest as candidate target antigens for transmission blocking vaccines...
  17. pmc World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria
    Christopher V Plowe
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 6:121. 2007
    ....
  18. pmc Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance
    Neal Alexander
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 6:9. 2007
    ..Intermittent preventive treatment (IPT) is a promising intervention for malaria control, although there are concerns about its impact on drug resistance...
  19. pmc Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:125. 2008
    ..The size of this effect is estimated in symptomatic P. falciparum infections...
  20. pmc Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum
    Nahla B Gadalla
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Malar J 9:74. 2010
    ....
  21. pmc Assessing agreement between malaria slide density readings
    Neal Alexander
    Tropical Epidemiology Group, Department of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:4. 2010
    ..The current paper seeks a procedure which avoids the disadvantages of these current options and whose parameter values are more clearly justified...
  22. pmc Sympatric Plasmodium falciparum isolates from Venezuela have structured var gene repertoires
    Adriana Tami
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
    Malar J 2:7. 2003
    ..Studies to date have compared var repertoires of natural isolates from various geographical locations but have not addressed any within-population structure that may exist among repertoires...
  23. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  24. pmc Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates
    Sabelo V Dlamini
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Malar J 9:68. 2010
    ..However, despite recent drug policy changes to adopt the more effective artemisinin-based combination (ACT) in Africa and in the Southern African region, in 2007 Swaziland still relied on CQ as first-line anti-malarial drug...
  25. pmc Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:136. 2010
    ..Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients...
  26. pmc Establishment of the 1st World Health Organization International Standard for Plasmodium falciparum DNA for nucleic acid amplification technique (NAT)-based assays
    David J Padley
    National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
    Malar J 7:139. 2008
    ....
  27. pmc Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities
    Mary Chiaka Oguike
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, LSHTM, UK
    Int J Parasitol 41:677-83. 2011
    ..Malaria elimination programmes in Africa need to include strategies for control of P. o. curtisi and P. o. wallikeri...
  28. pmc How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions?
    Colin J Sutherland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 6:161. 2007
    ....
  29. ncbi Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally
    Colin J Sutherland
    Health Protection Agency Malaria Reference Laboratory, Immunology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 201:1544-50. 2010
    ..Dimorphism in defined genes has led to P. ovale parasites being divided into classic and variant types. We hypothesized that these dimorphs represent distinct parasite species...
  30. pmc Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases?
    Colin J Sutherland
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Parasitology 138:1459-68. 2011
    ..This approach is suitable for qualitatively and quantitatively different burdens of malaria, and should be supported by a programme of routine surveillance for emerging resistance...
  31. pmc Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether
    Colin J Sutherland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    PLoS Med 2:e92. 2005
    ..Thus, drug combinations must be identified which minimise gametocyte emergence in treated cases, and so prevent selective transmission of parasites resistant to any of the partner drugs...
  32. doi Surface antigens of Plasmodium falciparum gametocytes--a new class of transmission-blocking vaccine targets?
    Colin J Sutherland
    HPA Malaria Reference Laboratory, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Mol Biochem Parasitol 166:93-8. 2009
    ..The next steps for development of anti-gametocyte transmission-blocking vaccines for P. falciparum and the other human malaria species are considered...
  33. pmc Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom
    Colin J Sutherland
    HPA Parasite Reference Laboratory, Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market Centre, Capper St, London WC1E 6JB, United Kingdom
    Antimicrob Agents Chemother 53:3405-10. 2009
    ..Parasites with novel pfdhps haplotypes are circulating in West Africa. The response of these parasites to chemotherapy needs to be evaluated...
  34. ncbi Genetic complexity of Plasmodium falciparum gametocytes isolated from the peripheral blood of treated Gambian children
    Colin J Sutherland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Am J Trop Med Hyg 66:700-5. 2002
    ..3 genotypes occurred in these gametocyte-only isolates, and many of these were shown to be infective to mosquitoes. Thus, meiotic recombination between different genotypes is predicted to be a common event in this study area...
  35. ncbi Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis
    Colin J Sutherland
    Hospital for Tropical Diseases, London, UK
    J Antimicrob Chemother 59:1197-9. 2007
    ..We sought to identify chloroquine-resistant Plasmodium falciparum parasites among 66 travellers who presented in the UK with malaria...
  36. pmc A challenge for the development of malaria vaccines: polymorphic target antigens
    Colin Sutherland
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 4:e116. 2007
  37. ncbi The addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children delays, but does not prevent treatment failure
    Colin J Sutherland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 69:19-25. 2003
    ..Chloroquine plus artesunate is not sufficiently efficacious to justify its introduction as a replacement for chloroquine monotherapy in The Gambia...
  38. ncbi Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes
    Colin J Sutherland
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 67:578-85. 2002
    ..83 x 10(-4)), and were infective to Anopheles mosquitoes. Therapeutic success may thus be accompanied by public health failure as cured children pass resistance genes on to mosquitoes at an enhanced rate...
  39. pmc Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil
    Colin J Sutherland
    Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market, Capper St, London, WC1E 6AU, UK
    Malar J 7:240. 2008
    ..Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for treatment of acute malaria cases in European hospitals and clinics...
  40. pmc Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes
    Rachel L Hallett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 48:3940-3. 2004
    ..Thus, combination therapy overcomes the transmission advantage enjoyed by drug-resistant parasites...
  41. pmc Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria
    G S Humphreys
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 51:991-7. 2007
    ..25; 95% confidence interval, 4.17 to 1441; P, <0.001). We conclude that AL and AQ exert opposite within-host selective effects on the Pfmdr1 gene of P. falciparum...
  42. ncbi Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens
    Gareth D Weedall
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Int J Parasitol 37:77-85. 2007
    ..Overall, the results predict more allele-specific immunity to TRAP than to CSP and should be considered in design and efficacy testing of vaccine candidates based on these antigens...
  43. pmc Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes
    Sarah Sharp
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Eukaryot Cell 5:1206-14. 2006
    ..We also provide evidence that for both asexual parasites and gametocytes, var and stevor transcription patterns are not linked to each other...
  44. pmc Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, WC1E 7HT, UK
    Infect Immun 72:6597-602. 2004
    ..STEVOR variants are therefore likely to perform different functions in each stage of the parasites life cycle in which they occur...
  45. pmc Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76
    Khalid Beshir
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 54:3714-6. 2010
    ..We provide in vivo data to support the in vitro correlation between pfcrt SVMNT and increased resistance to the metabolite of amodiaquine...
  46. ncbi Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites
    Rosalynn Ord
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    J Infect Dis 196:1613-9. 2007
    ..Observations in natural Plasmodium falciparum populations after removal of failing drugs suggest that there is a fitness cost of drug resistance...
  47. ncbi High sequence diversity and evidence of balancing selection in the Pvmsp3alpha gene of Plasmodium vivax in the Venezuelan Amazon
    Rosalynn Ord
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Mol Biochem Parasitol 144:86-93. 2005
    ..Our findings support the use of Pvmsp3alpha genotyping as a tool for monitoring interventions aimed at control of P. vivax...
  48. ncbi Improved synchronous production of Plasmodium falciparum gametocytes in vitro
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 154:119-23. 2007
    ..The protocol described lends itself to large scale culturing and harvesting of synchronous parasites suitable for biochemical assays, northern blots, flow cytometry, microarrays and proteomic analysis...
  49. ncbi Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes
    Christopher J Drakeley
    Joint Malaria Programme, Moshi, Tanzania
    Trop Med Int Health 9:53-61. 2004
    ..We assessed the effect on Plasmodium falciparum transmissibility of the addition of AS to chloroquine (CQ) in an area of The Gambia where resistance to CQ is increasing...
  50. ncbi Vaccination for vivax malaria: targeting the invaders
    Spencer D Polley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E7HT, UK
    Trends Parasitol 20:99-102. 2004
    ..vivax, given the constraints imposed by the use of primate models and the cost of producing suitable material for human trials...
  51. pmc Mitochondrial DNA targets increase sensitivity of malaria detection using loop-mediated isothermal amplification
    Spencer D Polley
    Department of Clinical Parasitology, Hospital for Tropical Diseases, London Hospitals University College NHS Foundation Trust, Mortimer Market, Capper Street, London WC1E 6JB, United Kingdom
    J Clin Microbiol 48:2866-71. 2010
    ....
  52. pmc Determination of the processes driving the acquisition of immunity to malaria using a mathematical transmission model
    Joao A N Filipe
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Comput Biol 3:e255. 2007
    ..Understanding the effector mechanisms underlying these two immune functions will assist in the design of transmission-reducing interventions against malaria...
  53. pmc Loss of population levels of immunity to malaria as a result of exposure-reducing interventions: consequences for interpretation of disease trends
    Azra C Ghani
    Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, United Kingdom
    PLoS ONE 4:e4383. 2009
    ..The development of appropriate monitoring of these interventions requires an understanding of the timescales of their effect...
  54. pmc Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine
    Nahla B Gadalla
    Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan
    Antimicrob Agents Chemother 55:5408-11. 2011
    ..One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up...
  55. ncbi Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum
    J Teun Bousema
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 193:1151-9. 2006
    ....
  56. pmc Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children
    Margaret Pinder
    MRC Laboratories, P O Box 273, Banjul, The Gambia
    Infect Immun 74:2887-93. 2006
    ..550 and -0.590 and P values of 0.002 and 0.001, respectively). The results validate the use of this approach to identify antigens that are associated with protection from malaria...
  57. pmc Cluster of falciparum malaria cases in UK airport
    Alison J Rodger
    Northwick Park Hospital, Harrow, UK
    Emerg Infect Dis 14:1284-6. 2008
    ..Molecular genotyping analysis indicated that all had been exposed to different parasites. The travelers' use of chemoprophylaxis was poor; their perception of risk was limited...
  58. ncbi Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children
    Larissa Meerman
    Department of Medical Microbiology, St Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 192:1651-7. 2005
    ..We conclude that, in this setting, poor access to the hospital and a high prevalence of chloroquine-resistant parasites lead to a delay of adequate treatment for young children with malaria, who may then develop SMA...
  59. pmc Plasmodium malariae in Haitian refugees, Jamaica
    John F Lindo
    University of the West Indies, Kingston, Jamaica
    Emerg Infect Dis 13:931-3. 2007
    ..malariae. PCR confirmed the P. malariae and P. falciparum but not P. vivax infections. DNA sequencing and rRNA gene sequences showed transmission of P. malariae. This report confirms that P. malariae is still being transmitted in Haiti...