L Smeeth

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study
    Rachael Boggon
    Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, 151 Buckingham Palace Road, London SW1W 9SZ, UK
    BMC Pulm Med 13:32. 2013
  2. pmc Hypertension among adults in a deprived urban area of Peru - undiagnosed and uncontrolled?
    Alisha R Davies
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Res Notes 1:2. 2008
  3. pmc A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
    L Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    BMC Public Health 1:2. 2001
  4. pmc Validation of the diagnosis of autism in general practitioner records
    Eric Fombonne
    McGill University, Montreal Children s Hospital, 4018 St Catherine St West, Montreal, QC, Canada, H3Z 1P2
    BMC Public Health 4:5. 2004
  5. pmc Is the NEI-VFQ-25 a useful tool in identifying visual impairment in an elderly population?
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    BMC Ophthalmol 6:24. 2006
  6. pmc Hospital admissions in older people with visual impairment in Britain
    Jennifer R Evans
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Ophthalmol 8:16. 2008
  7. pmc The prevalence of angina symptoms and association with cardiovascular risk factors, among rural, urban and rural to urban migrant populations in Peru
    M Justin S Zaman
    Division of Medicine, University College London, London, UK
    BMC Cardiovasc Disord 10:50. 2010
  8. pmc The effect on cardiovascular risk factors of migration from rural to urban areas in Peru: PERU MIGRANT Study
    J Jaime Miranda
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Cardiovasc Disord 9:23. 2009
  9. pmc Rate of first recorded diagnosis of autism and other pervasive developmental disorders in United Kingdom general practice, 1988 to 2001
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med 2:39. 2004
  10. ncbi request reprint Risk of myocardial infarction and stroke after acute infection or vaccination
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    N Engl J Med 351:2611-8. 2004

Detail Information

Publications108 found, 100 shown here

  1. pmc Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study
    Rachael Boggon
    Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, 151 Buckingham Palace Road, London SW1W 9SZ, UK
    BMC Pulm Med 13:32. 2013
    ....
  2. pmc Hypertension among adults in a deprived urban area of Peru - undiagnosed and uncontrolled?
    Alisha R Davies
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Res Notes 1:2. 2008
    ..The objectives of this study were to investigate the prevalence of hypertension and levels of awareness, treatment and control in a deprived urban area of Peru...
  3. pmc A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
    L Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    BMC Public Health 1:2. 2001
    ..The rigorous validation of all diagnoses and the collection of additional information by parental questionnaire in this study are essential to minimise the possibility of misleading results...
  4. pmc Validation of the diagnosis of autism in general practitioner records
    Eric Fombonne
    McGill University, Montreal Children s Hospital, 4018 St Catherine St West, Montreal, QC, Canada, H3Z 1P2
    BMC Public Health 4:5. 2004
    ....
  5. pmc Is the NEI-VFQ-25 a useful tool in identifying visual impairment in an elderly population?
    Christopher G Owen
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    BMC Ophthalmol 6:24. 2006
    ..The use of self-report questionnaires to substitute for visual acuity measurement has been limited. We examined the association between visual impairment and self reported visual function in a population sample of older people in the UK...
  6. pmc Hospital admissions in older people with visual impairment in Britain
    Jennifer R Evans
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Ophthalmol 8:16. 2008
    ..We aimed to assess the risk of hospital admission associated with visual impairment in a representative sample of older people living in the community in Britain...
  7. pmc The prevalence of angina symptoms and association with cardiovascular risk factors, among rural, urban and rural to urban migrant populations in Peru
    M Justin S Zaman
    Division of Medicine, University College London, London, UK
    BMC Cardiovasc Disord 10:50. 2010
    ..However, there are few data on the prevalence of angina in developing countries, whilst the understanding the aetiology of angina is complicated by the difficulty in measuring it across differing populations...
  8. pmc The effect on cardiovascular risk factors of migration from rural to urban areas in Peru: PERU MIGRANT Study
    J Jaime Miranda
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Cardiovasc Disord 9:23. 2009
    ..Thus the Peruvian context offers a unique opportunity to test the effects of migration...
  9. pmc Rate of first recorded diagnosis of autism and other pervasive developmental disorders in United Kingdom general practice, 1988 to 2001
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med 2:39. 2004
    ..We investigated time trends in the rates of diagnosis of pervasive developmental disorders...
  10. ncbi request reprint Risk of myocardial infarction and stroke after acute infection or vaccination
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    N Engl J Med 351:2611-8. 2004
    ..There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis that acute infection and vaccination increase the short-term risk of vascular events...
  11. ncbi request reprint The use of primary care databases: case-control and case-only designs
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Fam Pract 23:597-604. 2006
    ..The principles underlying these case-only designs are presented along with examples of their use. The advantages and limitations of the different designs are discussed...
  12. pmc A case control study of age related macular degeneration and use of statins
    L Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 89:1171-5. 2005
    ..The authors assessed the risk of AMD associated with the use of statins...
  13. pmc Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990-2001
    L Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Ann Rheum Dis 65:1093-8. 2006
    ..To investigate time trends, geographical variation, and seasonality in the incidence of diagnosis of polymyalgia rheumatica (PMR) and temporal arteritis (TA) in the United Kingdom...
  14. ncbi request reprint Commentary: we still need observational studies of drugs--they just need to be better
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:1310-1. 2006
  15. pmc Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Br J Clin Pharmacol 67:99-109. 2009
    ..To assess the effect of statins on a range of health outcomes...
  16. ncbi request reprint Community screening for visual impairment in the elderly
    L Smeeth
    London School of Hygiene and Tropical Medicine, Department of Epidemiology, Keppel Street, London, UK WC1E 7HT
    Cochrane Database Syst Rev 3:CD001054. 2006
    ..While the aims of multicomponent screening of older people are broad, any benefit arising from the inclusion of a vision component in the assessment will necessarily be dependent on improving vision...
  17. ncbi request reprint Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting
    Liam Smeeth
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 367:1075-9. 2006
    ..Our aim was to investigate whether acute infections transiently increase the risk of venous thromboembolism...
  18. ncbi request reprint Reduced hearing, ownership, and use of hearing aids in elderly people in the UK--the MRC Trial of the Assessment and Management of Older People in the Community: a cross-sectional survey
    Liam Smeeth
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 359:1466-70. 2002
    ..Reduced hearing in elderly people is important because it is disabling and potentially treatable. We aimed to assess the prevalence of reduced hearing in elderly people and levels of ownership of hearing aids and use...
  19. ncbi request reprint Cataract and the use of statins: a case-control study
    L Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    QJM 96:337-43. 2003
    ..In animal studies, statins have induced cataract formation. Because incident cataract is relatively uncommon, studies in humans have been unable to exclude a clinically important effect...
  20. ncbi request reprint Evaluation of adverse effects of vaccines: the case-control approach
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Vaccine 20:2611-7. 2002
    ..Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered...
  21. ncbi request reprint Intraclass correlation coefficients for cluster randomized trials in primary care: data from the MRC Trial of the Assessment and Management of Older People in the Community
    Liam Smeeth
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Control Clin Trials 23:409-21. 2002
    ....
  22. pmc A population based case-control study of cataract and inhaled corticosteroids
    L Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 87:1247-51. 2003
    ..This study was undertaken to quantify the risk of cataract associated with the use of inhaled corticosteroids and assess whether there is a dose-response relation...
  23. pmc Screening older people for impaired vision in primary care: cluster randomised trial
    Liam Smeeth
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 327:1027. 2003
    ..To determine the effectiveness of screening for visual impairment in people aged 75 or over as part of a multidimensional screening programme...
  24. doi request reprint Evaluating drug toxicity signals: is a hierarchical classification of evidence useful or a hindrance?
    T P Van Staa
    General Practice Research Database, Medicines and Healthcare products Regulatory Agency, London, UK
    Pharmacoepidemiol Drug Saf 17:475-84. 2008
    ..The objective of this study was to evaluate whether causality should remain the only consideration with drug toxicity signals. Cyclooxygenase-2 (Cox-2) inhibitors provided an example...
  25. pmc Randomised comparison of three methods of administering a screening questionnaire to elderly people: findings from the MRC trial of the assessment and management of older people in the community
    L Smeeth
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    BMJ 323:1403-7. 2001
    ..Lower estimates of self reported morbidity were obtained with the nurse interview method and to a lesser extent with the lay interview method than with postal questionnaires...
  26. ncbi request reprint Validity of the Clock-Drawing Test as a screening tool for cognitive impairment in the elderly
    Yuji Nishiwaki
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
    Am J Epidemiol 160:797-807. 2004
    ..The authors conclude that the CDT may have value as a brief face-to-face screening tool for moderate/severe cognitive impairment in an older community population but is relatively poor at detecting milder cognitive impairment...
  27. doi request reprint Socioeconomic position and hypertension: a study of urban civil servants in Ghana
    J Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    J Epidemiol Community Health 63:646-50. 2009
    ..The association of socioeconomic position and cardiovascular disease risk factors in low- and middle-income countries has not been as consistent as that reported from high-income countries...
  28. doi request reprint What is the harm-benefit ratio of Cox-2 inhibitors?
    T P Van Staa
    General Practice Research Database, Medicines and Healthcare products Regulatory Agency, London, UK
    Int J Epidemiol 37:405-13. 2008
    ..Our objective was to determine the balance of potential harm and benefit related to Cox-2 inhibitors' exposure...
  29. ncbi request reprint Effects of ambient temperature on the incidence of myocardial infarction
    K Bhaskaran
    London School of Hygiene and Tropical Medicine, London WC1B 3DP, UK
    Heart 95:1760-9. 2009
    ..While the effects of weather and, in particular, ambient temperature on overall mortality are well documented, the strength of the evidence base for the effects on acute myocardial infarction (MI) are less clear...
  30. pmc Prevalence of visual impairment in people aged 75 years and older in Britain: results from the MRC trial of assessment and management of older people in the community
    J R Evans
    Department of Epidemiology and International Eye Health, Institute of Ophthalmology, London, UK
    Br J Ophthalmol 86:795-800. 2002
    ..To measure the prevalence of visual impairment in a large representative sample of people aged 75 years and over participating in the MRC trial of assessment and management of older people in the community...
  31. ncbi request reprint Hormone replacement therapy and cataract: a population-based case-control study
    F O Aina
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Eye (Lond) 20:417-22. 2006
    ..The aim of this study was to assess the association between hormone replacement therapy and cataract...
  32. ncbi request reprint Geriatric Depression Scale Scores in a representative sample of 14 545 people aged 75 and over in the United Kingdom: results from the MRC Trial of Assessment and Management of Older People in the Community
    David P J Osborn
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Int J Geriatr Psychiatry 17:375-82. 2002
    ..We describe the age and sex distribution of GDS-15 scores in the largest ever UK sample of people aged 75 and over...
  33. ncbi request reprint Cause-specific visual impairment and mortality: results from a population-based study of older people in the United Kingdom
    Manickam Thiagarajan
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    Arch Ophthalmol 123:1397-403. 2005
    ..To assess the association between mortality and cause-specific visual impairment in older people...
  34. ncbi request reprint Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community
    Greta Rait
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Age Ageing 34:242-8. 2005
    ..cognitive impairment is an important part of the diagnostic criteria for dementia. The Mini-Mental State Examination (MMSE) is recommended to test for cognitive impairment and to monitor medication response...
  35. pmc Effect of β blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records
    J K Quint
    Department of Non communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    BMJ 347:f6650. 2013
    ....
  36. pmc Respiratory symptoms in older people and their association with mortality
    J Hewitt
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Thorax 60:331-4. 2005
    ..A study was undertaken to assess the prevalence of reported respiratory symptoms in a population aged over 75 years and their association with mortality...
  37. pmc Constituent country inequalities in myocardial infarction incidence and case fatality in men and women in the United Kingdom, 1996-2005
    A R Davies
    Centre for Population Studies, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Public Health (Oxf) 33:131-8. 2011
    ..Understanding myocardial infarction (MI) incidence and case fatality trends across the four UK constituent countries is of importance following devolution of the government of health-care services...
  38. ncbi request reprint Prevalence, detection, management, and control of hypertension in Ghanaian civil servants
    Juliet Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ethn Dis 18:505-11. 2008
    ..The goal of this study was to determine the prevalence of hypertension and establish the levels of detection, treatment, and control among urban civil servants in Ghana...
  39. pmc The risk of fractures associated with thiazolidinediones: a self-controlled case-series study
    Ian J Douglas
    Non Communicable Disease Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 6:e1000154. 2009
    ..Our objective was to further investigate the risk of fracture associated with thiazolidinedione use...
  40. pmc Performance of oscillometric blood pressure devices in children in resource-poor settings
    Juan Jaime Miranda
    London School of Hygiene and Tropical Medicine, Institute of Child Health, University College London, London, UK
    Eur J Cardiovasc Prev Rehabil 15:362-4. 2008
    ..To compare oscillometric blood pressure devices with mercury sphygmomanometry in children...
  41. pmc The Myocardial Ischaemia National Audit Project (MINAP)
    Emily Herrett
    Department of Epidemiology and Population Health, Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Heart 96:1264-7. 2010
    ..AIMS OF MINAP: To audit the quality of care of patients with acute coronary syndrome and provide a resource for academic research...
  42. pmc Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions
    Anthony Grosso
    Department of Pharmacy, University College London Hospitals NHS Foundation Trust, London, UK
    Br J Clin Pharmacol 66:689-94. 2008
    ..The aim was to assess the potential utility of a more systematic approach to the detection of adverse events that utilizes routinely collected clinical data from a large primary care population...
  43. pmc Exposure to antipsychotics and risk of stroke: self controlled case series study
    Ian J Douglas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 337:a1227. 2008
    ..To investigate the association between use of typical and atypical antipsychotic drugs and incidence of stroke in patients with and without dementia...
  44. pmc An ecological correlation study of late age-related macular degeneration and the complement factor H Y402H polymorphism
    Bareng A S Nonyane
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:2393-402. 2010
    ....
  45. doi request reprint Risk of admission to a nursing home among older people with visual impairment in Great Britain
    Jennifer R Evans
    International Centre for Eye Health, Non Communicable DiseaseEpidemiology Unit, London School of Hygiene and Tropical Medicine, London, England
    Arch Ophthalmol 126:1428-33. 2008
    ..To assess the risk of nursing home admission in a representative sample of older, visually impaired, community-dwelling people 75 years and older living in Great Britain...
  46. pmc Smoking patterns in Ghanaian civil servants: changes over three decades
    Juliet Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Environ Res Public Health 6:200-8. 2009
    ..These figures were dramatically lower than the rates of 32% and 5.9% reported for men and women respectively in the previous study. Knowledge of the health risks associated with smoking may have contributed to the lower rates...
  47. pmc Short term effects of temperature on risk of myocardial infarction in England and Wales: time series regression analysis of the Myocardial Ischaemia National Audit Project (MINAP) registry
    Krishnan Bhaskaran
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 341:c3823. 2010
    ..To examine the short term relation between ambient temperature and risk of myocardial infarction...
  48. doi request reprint Chronic kidney disease and hip fracture-related mortality in older people in the UK
    Dorothea Nitsch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Nephrol Dial Transplant 24:1539-44. 2009
    ..The aim of this study was to examine whether CKD at older ages is associated with hip-fracture-related mortality...
  49. doi request reprint Associations between chronic kidney disease and age-related macular degeneration
    Dorothea Nitsch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Ophthalmic Epidemiol 16:181-6. 2009
    ..Age-related macular degeneration (AMD) and renal impairment are both associated with cardiovascular risk factors and with alterations in the complement pathways. There are few data on the association of AMD with chronic kidney disease...
  50. pmc Hypertensive target organ damage in Ghanaian civil servants with hypertension
    Juliet Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e6672. 2009
    ..Low levels of detection, treatment and control of hypertension have repeatedly been reported from sub Saharan Africa, potentially increasing the likelihood of target organ damage...
  51. pmc Burden of mortality associated with autoimmune diseases among females in the United Kingdom
    Sara L Thomas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Am J Public Health 100:2279-87. 2010
    ..We estimated the collective burden of mortality from autoimmune diseases among females in the United Kingdom and the effects of death certificate coding changes on this estimate...
  52. pmc Frequency of diarrhoea as a predictor of elevated blood pressure in children
    Juan Jaime Miranda
    Noncommunicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Hypertens 27:259-65. 2009
    ..This study aimed to explore whether frequency of diarrhoea is associated with elevated blood pressure in children in a setting with a high incidence of diarrhoeal disease...
  53. pmc Validation and validity of diagnoses in the General Practice Research Database: a systematic review
    Emily Herrett
    Non communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Br J Clin Pharmacol 69:4-14. 2010
    ..To investigate the range of methods used to validate diagnoses in the General Practice Research Database (GPRD), to summarize findings and to assess the quality of these validations...
  54. ncbi request reprint Hypertension in sub-saharan Africa: a systematic review
    Juliet Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Hypertension 50:1012-8. 2007
    ..There is an urgent need to develop strategies to prevent, detect, treat, and control hypertension effectively in the African region...
  55. ncbi request reprint The end of age: but not for the worse off
    Astrid Fletcher
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Age Ageing 31:11-2. 2002
  56. ncbi request reprint Hormone replacement therapy and acute myocardial infarction: a large observational study exploring the influence of age
    Joseph Kim
    Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Int J Epidemiol 35:731-8. 2006
    ....
  57. ncbi request reprint Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, London, UK
    Lancet 366:2026-33. 2005
    ..Guidelines specify that these are the drugs of choice for the treatment of hypertension in patients with renal disease. We sought to determine to what extent this consensus is supported by the available evidence...
  58. ncbi request reprint MMR vaccination and pervasive developmental disorders: a case-control study
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 364:963-9. 2004
    ..We investigated whether MMR vaccination is associated with an increased risk of autism or other pervasive developmental disorders...
  59. ncbi request reprint Performance of a single screening question for depression in a representative sample of 13 670 people aged 75 and over in the UK: results from the MRC trial of assessment and management of older people in the community
    David P J Osborn
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Fam Pract 20:682-4. 2003
    ..A concise, accurate screening question for depression would be an important contribution to the Single Assessment Process for Older People...
  60. ncbi request reprint Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials
    Dorothea Nitsch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Epidemiol 163:397-403. 2006
    ..However, care must be taken, because drawing valid causal inferences from its application depends upon more extensive assumptions than are required in randomized controlled trials...
  61. ncbi request reprint Contribution of changes in incidence and mortality to trends in the prevalence of coronary heart disease in the UK: 1996 2005
    Alisha Ruth Davies
    Department of Epidemiology and Population Health, Centre for Population Studies, London School of Hygiene and Tropical Medicine, 49 51 Bedford Square, London WC1B 3DP, UK
    Eur Heart J 28:2142-7. 2007
    ..To assess how trends in the incidence of coronary heart disease (CHD) and mortality rates among people with CHD have affected the prevalence of CHD in the UK...
  62. ncbi request reprint Age-related macular degeneration and complement activation-related diseases: a population-based case-control study
    Dorothea Nitsch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 115:1904-10. 2008
    ..We aimed to investigate whether other diseases known to be associated with complement activation are associated with AMD...
  63. pmc The use of antidepressants and the risk of haemorrhagic stroke: a nested case control study
    Ian Douglas
    Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Br J Clin Pharmacol 71:116-20. 2011
    ..It is currently unclear whether they increase the risk of haemorrhagic stroke, with conflicting results reported...
  64. pmc A review of population-based studies on hypertension in Ghana
    J Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Ghana Med J 46:4-11. 2012
    ..Epidemiological data on hypertension in Ghana is necessary to guide policy and develop effective interventions...
  65. doi request reprint How accurate are diagnoses for rheumatoid arthritis and juvenile idiopathic arthritis in the general practice research database?
    S L Thomas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Arthritis Rheum 59:1314-21. 2008
    ....
  66. doi request reprint Obesity in urban civil servants in Ghana: association with pre-adult wealth and adult socio-economic status
    J Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Public Health 123:365-70. 2009
    ..To investigate the distribution of obesity and its association with pre-adult wealth and adult socio-economic factors in urban Ghanaian civil servants...
  67. pmc Self management and patient understanding of diabetes in the older person
    J Hewitt
    London School of Hygiene and Tropical Medicine and Portsmouth Hospitals Trust, Queen Alexandra Hospital, Portsmouth, UK
    Diabet Med 28:117-22. 2011
    ..To examine knowledge and management of diabetes by older people...
  68. pmc Oral bisphosphonates and risk of atrial fibrillation and flutter in women: a self-controlled case-series safety analysis
    Anthony Grosso
    Department of Pharmacy, University College London Hospitals NHS Foundation Trust, London, United Kingdom
    PLoS ONE 4:e4720. 2009
    ..Two subsequent population-based case-control studies of patients receiving a more established oral bisphosphonate, alendronic acid, reported conflicting results, possibly due to uncontrolled confounding factors...
  69. ncbi request reprint Effects of air pollution on the incidence of myocardial infarction
    K Bhaskaran
    London School of Hygiene and Tropical Medicine, London WC1B 3DP, UK
    Heart 95:1746-59. 2009
    ..Short-term fluctuations in air pollution have been associated with changes in both overall and cardiovascular mortality...
  70. doi request reprint Invasive dental treatment and risk for vascular events: a self-controlled case series
    Caroline Minassian
    London School of Hygiene and Tropical Medicine, University College London Eastman Dental Institute, and University College London, London, UK
    Ann Intern Med 153:499-506. 2010
    ..However, whether such acute inflammatory effects translate into a short-lived increased risk for vascular events is not known...
  71. pmc Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
    Circulation 121:52-62. 2010
    ..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target...
  72. pmc Bayesian meta-analysis of genetic association studies with different sets of markers
    Claudio Verzilli
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Am J Hum Genet 82:859-72. 2008
    ..The same method could be applied to evidence synthesis of other quantitative traits, whenever the typed SNPs vary among studies, and to assist fine mapping of causal variants...
  73. ncbi request reprint A case-control study of drug risk factors for age-related macular degeneration
    Ian J Douglas
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 114:1164-9. 2007
    ..To investigate the association between age-related macular degeneration (AMD) and exposure to antacids, antithyroids, thyroid hormones, and thiazide diuretics...
  74. ncbi request reprint Factors associated with depression in a representative sample of 14 217 people aged 75 and over in the United Kingdom: results from the MRC trial of assessment and management of older people in the community
    David P J Osborn
    Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Int J Geriatr Psychiatry 18:623-30. 2003
    ..We aimed to assess factors associated with depression in old age, using data from the MRC trial of assessment and management of older people in the community...
  75. doi request reprint Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review
    Charlotte Warren-Gash
    UCL Centre for Infectious Disease Epidemiology, Royal Free Hospital, London, UK
    Lancet Infect Dis 9:601-10. 2009
    ..Further evidence is needed on the effectiveness of influenza vaccines to reduce the risk of cardiac events in people without established vascular disease...
  76. ncbi request reprint Use of electronic healthcare records in large-scale simple randomized trials at the point of care for the documentation of value-based medicine
    T P Van Staa
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands London School of Hygiene and Tropical Medicine, London, UK
    J Intern Med 275:562-9. 2014
    ..In this review, we describe how EHR databases can be used for conducting large-scale simple trials and discuss the advantages and disadvantages of their use. ..
  77. doi request reprint Short-term vascular risk: time to take notice?
    Liam Smeeth
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Nat Rev Cardiol 7:409-11. 2010
    ..Important questions remain, however, before preventative interventions can be offered as a routine part of influenza management...
  78. ncbi request reprint There is no evidence of an inverse relationship between TH2-mediated atopy and TH1-mediated autoimmune disorders: Lack of support for the hygiene hypothesis
    Aziz Sheikh
    Department of Public Health Sciences, St George s Hospital Medical School, London, United Kingdom
    J Allergy Clin Immunol 111:131-5. 2003
    ..The findings of an inverse relationship between T(H)1- and T(H)2-mediated disorders would provide strong empiric support to the hygiene hypothesis...
  79. ncbi request reprint Autoimmune diseases co-occurring within individuals and within families: a systematic review
    Emily C Somers
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 17:202-17. 2006
    ..We reviewed the associations among 4 TH1-associated autoimmune diseases: insulin-dependent diabetes mellitus, autoimmune (Hashimoto) thyroiditis, rheumatoid arthritis, and multiple sclerosis...
  80. pmc Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants
    Paul Bentley
    Imperial College Cerebrovascular Research Unit, Clinical Neurosciences, Charing Cross Hospital, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9136. 2010
    ....
  81. pmc Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts
    Tina Shah
    Centre for Clinical Pharmacology, University College London, London, UK
    Int J Epidemiol 38:217-31. 2009
    ..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events...
  82. pmc A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective cox-2 inhibitors as an example
    Tjeerd Pieter van Staa
    General Practice Research Database, London, United Kingdom
    PLoS Med 6:e1000194. 2009
    ..Selective Cox-2 inhibitors (coxibs) were used as an example...
  83. pmc The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults
    George Peck
    Imperial College Cerebrovascular Research Unit ICCRU, Department of Clinical Neuroscience, Imperial College London and Hammersmith Hospitals, London, UK
    PLoS ONE 3:e3691. 2008
    ..A meta-analysis of all candidate gene association studies of haemorrhagic stroke (including ruptured subarachnoid haemorrhage and amyloid angiopathy-related haemorrhage) was performed, allowing more reliable estimates of risk...
  84. pmc Multilocus Bayesian meta-analysis of gene-disease associations
    Paul J Newcombe
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK
    Am J Hum Genet 84:567-80. 2009
    ..We present results from application of our approach to data on a possible association between PDE4D and ischemic stroke...
  85. pmc Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies
    Michael V Holmes
    Centre for Clinical Pharmacology, University College London, London, United Kingdom
    PLoS ONE 4:e7960. 2009
    ..Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics)...
  86. ncbi request reprint Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories at University College London, London, United Kingdom
    Am J Epidemiol 164:921-35. 2006
    ..The need for large-scale genetic association studies using tagging polymorphisms is warranted to confirm or refute a role of the NOS3 gene in coronary heart disease...
  87. ncbi request reprint Use of inhaled corticosteroids and the risk of fracture
    Richard Hubbard
    Respiratory Medicine, Clinical Sciences Building, Nottingham City Hospital, NG5 1PB, Nottingham, UK
    Chest 130:1082-8. 2006
    ....
  88. pmc Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias
    Norma C Serrano
    Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia
    PLoS Med 3:e520. 2006
    ..However, previous studies of the ACE-I/D variant and preeclampsia have been individually underpowered to detect plausible genotypic risks...
  89. ncbi request reprint Detecting chronic kidney disease in older people; what are the implications?
    Paul J Roderick
    University of Southampton, Public Health Sciences and Medical Statistics, Southampton, UK
    Age Ageing 37:179-86. 2008
    ..However, the significance of identifying CKD in older people is unclear...
  90. ncbi request reprint Autism, bowel inflammation, and measles
    Liam Smeeth
    Lancet 359:2112-3. 2002
  91. ncbi request reprint Incidence of systemic lupus erythematosus in the United Kingdom, 1990-1999
    Emily C Somers
    University of Michigan, Ann Arbor, MI 48109 0358, USA
    Arthritis Rheum 57:612-8. 2007
    ..To estimate the annual incidence of systemic lupus erythematosus (SLE) over a 10-year period in the UK, and to examine age-, sex-, and region-specific rates...
  92. pmc Randomised controlled trials in primary care: scope and application
    Aziz Sheikh
    Department of Primary Health Care and General Practice, Imperial College School of Science, Technology and Medicine, London
    Br J Gen Pract 52:746-51. 2002
    ..This information will, we hope, also prove useful to primary care clinicians attempting to interpret trial findings...
  93. ncbi request reprint Inhaled corticosteroids and hip fracture: a population-based case-control study
    Richard B Hubbard
    Division of Respiratory Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, United Kingdom
    Am J Respir Crit Care Med 166:1563-6. 2002
    ..007). In older subjects, the recent use of inhaled corticosteroids is associated with a dose-related increase in hip fracture...
  94. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  95. ncbi request reprint A comprehensive analysis of adverse obstetric and pediatric complications in women with asthma
    Laila J Tata
    Epidemiology and Public Health, University of Nottingham, Nottingham NG5 1PB, UK
    Am J Respir Crit Care Med 175:991-7. 2007
    ..Previous studies have raised concern that women with asthma have increased risks of adverse obstetric and pediatric complications, but these have generally been underpowered...
  96. ncbi request reprint Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture
    Richard Hubbard
    Division of Respiratory Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, England
    Am J Epidemiol 158:77-84. 2003
    ..The estimates from the case-series analyses were smaller than those from the case-control analyses, suggesting that the case-control method is subject to bias...
  97. ncbi request reprint Homocysteine and stroke: evidence on a causal link from mendelian randomisation
    Juan P Casas
    Centre for Clinical Pharmacology, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, London WC1E 6 JJ, UK
    Lancet 365:224-32. 2005
    ....
  98. ncbi request reprint Non-communicable diseases in low and middle-income countries: a priority or a distraction?
    Shah Ebrahim
    Int J Epidemiol 34:961-6. 2005
  99. pmc Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness
    Christopher G Owen
    Department of Community Health Sciences, St George s Hospital Medical School, London
    Br J Gen Pract 54:451-6. 2004
    ..Evidence for the effectiveness of topical treatments, in providing symptomatic relief from ocular allergy, remains uncertain...