Ulrich E Schaible

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Malnutrition and infection: complex mechanisms and global impacts
    Ulrich E Schaible
    London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Immunology Unit, London, United Kingdom
    PLoS Med 4:e115. 2007
  2. doi request reprint Escape of Mycobacterium tuberculosis from oxidative killing by neutrophils
    Björn Corleis
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Cell Microbiol 14:1109-21. 2012
  3. pmc Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis
    Susanne Herbst
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 6:e19105. 2011
  4. pmc A role for IL-18 in protective immunity against Mycobacterium tuberculosis
    Bianca E Schneider
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases Immunology, London, UK
    Eur J Immunol 40:396-405. 2010
  5. pmc New challenges in studying nutrition-disease interactions in the developing world
    Andrew M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Clin Invest 118:1322-9. 2008
  6. doi request reprint Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 38:680-94. 2008
  7. ncbi request reprint CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion
    Martin J Raftery
    Institute of Virology, Charite Medical School, Humboldt University Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Immunol 177:6207-14. 2006
  8. ncbi request reprint Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 24:105-17. 2006
  9. ncbi request reprint 100th anniversary of Robert Koch's Nobel Prize for the discovery of the tubercle bacillus
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Trends Microbiol 13:469-75. 2005
  10. ncbi request reprint Antigen presentation and recognition in bacterial infections
    Stefan He Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Curr Opin Immunol 17:79-87. 2005

Collaborators

Detail Information

Publications17

  1. pmc Malnutrition and infection: complex mechanisms and global impacts
    Ulrich E Schaible
    London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Immunology Unit, London, United Kingdom
    PLoS Med 4:e115. 2007
  2. doi request reprint Escape of Mycobacterium tuberculosis from oxidative killing by neutrophils
    Björn Corleis
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Cell Microbiol 14:1109-21. 2012
    ..We conclude that this virulence function is instrumental for M. tuberculosis to escape killing by neutrophils and contributes to pathogenesis in tuberculosis...
  3. pmc Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis
    Susanne Herbst
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 6:e19105. 2011
    ..In line with the finding that drug-induced apoptosis kills intracellular mycobacteria in the absence of NO, we identified NO-mediated apoptosis as a new defense mechanism of activated macrophages against M. tuberculosis...
  4. pmc A role for IL-18 in protective immunity against Mycobacterium tuberculosis
    Bianca E Schneider
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases Immunology, London, UK
    Eur J Immunol 40:396-405. 2010
    ..Thus, IL-18 plays a decisive role in protective immunity against tuberculosis...
  5. pmc New challenges in studying nutrition-disease interactions in the developing world
    Andrew M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Clin Invest 118:1322-9. 2008
    ..In this Personal Perspective, we highlight some of these gaps and make some proposals as to how improved research methods and technologies can be brought to bear on the problems of undernourished children in the developing world...
  6. doi request reprint Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 38:680-94. 2008
    ..Rather, MyD88, but not TLR2, TLR4 and TLR9, is critical for triggering macrophage effector mechanisms central to anti-mycobacterial defense...
  7. ncbi request reprint CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion
    Martin J Raftery
    Institute of Virology, Charite Medical School, Humboldt University Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Immunol 177:6207-14. 2006
    ..Thus, we demonstrate both the existence of a CD1 pathway allowing human DC to react to viral infection, as well as its blockage by a human herpesvirus...
  8. ncbi request reprint Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis
    Florian Winau
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Immunity 24:105-17. 2006
    ..tuberculosis infection. Taken together, we propose the detour pathway to represent a genuine immunological mechanism mediating crosspriming of CD8 T cells in vivo and protection against tuberculosis...
  9. ncbi request reprint 100th anniversary of Robert Koch's Nobel Prize for the discovery of the tubercle bacillus
    Stefan H E Kaufmann
    Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Trends Microbiol 13:469-75. 2005
    ..Despite great efforts, however, Koch failed to conquer tuberculosis, which still causes enormous health problems worldwide 100 years after his Nobel award...
  10. ncbi request reprint Antigen presentation and recognition in bacterial infections
    Stefan He Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Curr Opin Immunol 17:79-87. 2005
    ..Although several such mechanisms have been described in viral systems, few have thus far been elucidated in bacterial infections...
  11. pmc Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells
    Karsten Fischer
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 101:10685-90. 2004
    ..This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d...
  12. ncbi request reprint Apoptosis paves the detour path for CD8 T cell activation against intracellular bacteria
    Florian Winau
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstr 21 22, D 10117 Berlin, Germany
    Cell Microbiol 6:599-607. 2004
    ..This important new function of cell death in antibacterial immunity requires consideration for rational vaccine design...
  13. ncbi request reprint Saposin C is required for lipid presentation by human CD1b
    Florian Winau
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Immunol 5:169-74. 2004
    ..We propose a model in which SAP-C exposes lipid antigens from intralysosomal membranes for loading onto CD1b. Thus, SAP-C represents a missing link in antigen presentation of lipids through CD1b to human T cells...
  14. ncbi request reprint Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
    Ulrich E Schaible
    Max Planck Institute for Infection Biology, Department of Immunology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Med 9:1039-46. 2003
    ....
  15. pmc A dangerous liaison between two major killers: Mycobacterium tuberculosis and HIV target dendritic cells through DC-SIGN
    Stefan H E Kaufmann
    Department of Immunology, Max Planck Institute for Infection Biology, D 10117 Berlin, Germany
    J Exp Med 197:1-5. 2003
  16. pmc Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis
    Ulrich E Schaible
    Max Planck Institute for Infection Biology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    J Exp Med 196:1507-13. 2002
    ..Our data establish: (a) defective iron metabolism explains the increased susceptibility of beta2m-KO mice over MHC-I-KO mice, and (b) iron overload represents an exacerbating cofactor for tuberculosis...
  17. ncbi request reprint IL-4 and T cells are required for the generation of IgG1 isotype antibodies against cardiolipin
    Karsten Fischer
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 168:2689-94. 2002
    ..1(+) T cells. We conclude that IgG1 production to CL depends on T cell help and IL-4, which can be provided by different T cell populations. This is the first report that IL-4 is indispensable for the induction of IgG1 Abs to lipid Ags...