I G Roberts

..In addition, the effort of tranexamic acid on the risk of vascular occlusive events was assessed...

..Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma...

..However, barbiturates also reduce blood pressure and may, therefore, adversely effect cerebral perfusion pressure...

..To assess the extent to which current protocols for treatment with tranexamic acid maximise benefits to patients...

..Based on data from the CRASH-2 trial, global mortality data and a systematic literature review, we estimated the number of premature deaths that might be averted every year worldwide through the use of TXA...

..The aim of this study was to assess the influence of between-centre differences in outcome on the estimated treatment effect in a large RCT in TBI...

..We compare the carbon emissions from two international clinical trials in order to identify where emissions reductions can be made...

..We evaluated the safety and effectiveness of the non-peptide bradykinin B2 receptor antagonist Anatibant in the treatment of patients with traumatic brain injury. During the course of the trial, funding was withdrawn by the sponsor...

..A study with 15,000 women will have over 90% power to detect a 25% reduction from 4% to 3% in the primary endpoint of mortality or hysterectomy...

..The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial...

..In countries where there is a blood shortage, TXA would be a cost effective way to reduce mortality. In countries where there is no blood shortage, TXA would reduce healthcare costs and avert blood borne infections...

..Anti-fibrinolytic agents have been proposed as a treatment for post partum haemorrhage. We conducted a systematic review to assess the effectiveness and safety of anti-fibrinolytic agents in post partum bleeding...

..The objectives of this study were to evaluate the association and predictive validity between a simple disability scale at hospital discharge, the Oxford Handicap Scale (OHS), and the GOS at 6 months among TBI patients...

..Two reviewers independently examined titles, abstracts and assessed whether each met the pre-defined inclusion criteria...

..We analysed data from the Trauma Audit & Research Network (TARN), a large European trauma registry, to evaluate the association between the size of IB and mortality in patients with TBI...

..However, some commentators are sceptical. The authors examined road safety policy documents to assess the extent of any bias...

..The trial is currently recruiting, and new collaborators are welcome to join the trial (see www.crash.lshtm.ac.uk)...

..Health professionals have an urgent responsibility to ensure that the health benefits of environmental policies are understood by the public and by policymakers...

....

..This might encourage more walking and cycling and also has the potential to reduce social class gradients in injury mortality...

..To test the application of statistical methods to detect data fabrication in a clinical trial...

..To conduct a pilot randomised controlled trial of mobile phone-based smoking cessation support intervention for the UK population...

....

..Two reviewers should screen records for eligibility, whenever possible, in order to maximize ascertainment of relevant trials...

....

..To examine concordance between treatment effects in animal experiments and clinical trials. Study design Systematic review...

..To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury...

..This study is to identify predictors of loss to follow-up among adults with head injury...

..To assess the effectiveness of interventions to improve the microbial quality of drinking water for preventing diarrhoea...

..Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. The burden of TBI is greatest in low- and middle-income countries (LAMIC), yet little is known about patient outcomes in these settings...

..There exists the potential for a global contraction and convergence in use of fossil-fuel energy for transport to benefit health and achieve sustainability...

..Intersectoral research and concerted action, both nationally and internationally, will be required...

..We estimate the impact on greenhouse gas emissions of increases in the population distribution of body mass index (BMI)...

..To examine socioeconomic inequalities in rates of death from injury in children in England and Wales...

..CONCLUSIONS: Many local authorities offer smoke alarm provision to their public-sector households. Whether this represents an effective and cost-effective use of resources requires further investigation...

..If a new follow-up questionnaire is to be designed, it should be made as short as possible without compromising the data collection requirements of the trial...

..To discover what types of scientific misconduct are most likely to influence the results of a clinical trial...

..To assess the effects of providing daycare facilities for young children on the health and welfare of disadvantaged families...

..To identify methods to increase response to postal questionnaires...

..Although the results are compatible with a small reduction in the occurrence of traffic crashes, this may be due to selection biases or bias in the included trials...

..To quantify the increase in mailed questionnaire response attributable to a monetary incentive...

..CONCLUSIONS: Nearly half of the alarms installed were not working when tested 15 months later. Type of alarm and power source are important determinants of whether a household had a working alarm...

..To establish a register of randomized controlled trials of interventions in the prehospital care of trauma patients...

..We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients...

..To explore sex workers' accounts of condom use and their recommendations about how condoms might be improved...

..Our objective was to systematically review randomized, controlled trials of fluid resuscitation in animal models of uncontrolled hemorrhage and to explore potential sources of heterogeneity...

..In 2001 in the US, there were 383 500 home fires, resulting in 3110 deaths, 15,200 injuries and dollar 5.5 billion in direct property damage...

..To quantify the effectiveness of safety education of pedestrians...

..22) or time since injury (p=0.05). INTERPRETATION: Our results show there is no reduction in mortality with methylprednisolone in the 2 weeks after head injury. The cause of the rise in risk of death within 2 weeks is unclear...

..To measure the effect of giving out free smoke alarms on rates of fires and rates of fire related injury in a deprived multiethnic urban population...

....

..The goal is to establish a reproducible and clinically effective classification which will gain worldwide acceptance for use in clinical practice and research...

..These results lend support to our earlier conclusion that corticosteroids should not be used routinely in the treatment of head injury...

....