E M Riley

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Pathog 4:e1000004. 2008
  2. pmc Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax
    Jiraprapa Wipasa
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    PLoS Pathog 6:e1000770. 2010
  3. pmc Short-lived IFN-γ effector responses, but long-lived IL-10 memory responses, to malaria in an area of low malaria endemicity
    Jiraprapa Wipasa
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    PLoS Pathog 7:e1001281. 2011
  4. pmc Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule
    Fakhreldin M Omer
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    J Exp Med 198:1817-27. 2003
  5. pmc Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
    Aubrey J Cunnington
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 18:120-7. 2012
  6. pmc Activation of Natural Killer Cells during Microbial Infections
    Amir Horowitz
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine London, UK
    Front Immunol 2:88. 2011
  7. doi request reprint Immune mechanisms in malaria: new insights in vaccine development
    Eleanor M Riley
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 19:168-78. 2013
  8. pmc Developmental allometry and paediatric malaria
    Erica M W Billig
    Fogarty International Center, National Institutes of Health, Building 16, Bethesda, MD 20892, USA
    Malar J 11:64. 2012
  9. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
  10. doi request reprint Wild mice provide insights into natural killer cell maturation and memory
    Eleanor M Riley
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Ecol 20:4827-9. 2011

Collaborators

Detail Information

Publications29

  1. pmc IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Pathog 4:e1000004. 2008
    ..In summary, we have identified a population of induced Foxp3- regulatory (Tr1) T cells, characterised by production of IL-10 and down regulation of IL-7Ralpha, that modulates the inflammatory response to malaria...
  2. pmc Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax
    Jiraprapa Wipasa
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    PLoS Pathog 6:e1000770. 2010
    ..We conclude that infrequent malaria infections are capable of inducing long-lived antibody and memory B cell responses...
  3. pmc Short-lived IFN-γ effector responses, but long-lived IL-10 memory responses, to malaria in an area of low malaria endemicity
    Jiraprapa Wipasa
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    PLoS Pathog 7:e1001281. 2011
    ..The observations have clear implications for understanding the immunoepidemiology of naturally acquired malaria infections and for malaria vaccine development...
  4. pmc Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule
    Fakhreldin M Omer
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    J Exp Med 198:1817-27. 2003
    ..Activation of LatTGF-beta represents a novel mechanism for direct modulation of the host response by malaria parasites...
  5. pmc Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
    Aubrey J Cunnington
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 18:120-7. 2012
    ..typhimurium by hemolysis. Thus, a mechanism of tolerance to one infection, malaria, impairs resistance to another, NTS. Furthermore, HO inhibitors may be useful adjunctive therapy for NTS infection in the context of hemolysis...
  6. pmc Activation of Natural Killer Cells during Microbial Infections
    Amir Horowitz
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine London, UK
    Front Immunol 2:88. 2011
    ..We also consider two emerging themes of NK cell-pathogen interactions, namely their contribution to adaptive immune responses and their potential to take on regulatory and immunomodulatory functions...
  7. doi request reprint Immune mechanisms in malaria: new insights in vaccine development
    Eleanor M Riley
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 19:168-78. 2013
    ..We argue that rational design of more effective malaria vaccines will be accelerated by a better understanding of the immune effector mechanisms involved in parasite regulation, control and elimination...
  8. pmc Developmental allometry and paediatric malaria
    Erica M W Billig
    Fogarty International Center, National Institutes of Health, Building 16, Bethesda, MD 20892, USA
    Malar J 11:64. 2012
    ..Here, scattered items of evidence have been collected from a variety of disciplines, aiming to suggest possible research paths for investigating exposure-independent age differences affecting clinical outcomes of malaria infection...
  9. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
    ..The PCR prevalence was then compared against other measures of transmission intensity collected in the same area...
  10. doi request reprint Wild mice provide insights into natural killer cell maturation and memory
    Eleanor M Riley
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Ecol 20:4827-9. 2011
    ..2011) in this issue of Molecular Ecology, studies in wild animal populations-especially free-living M. musculus-represent a valuable bridge between studies in humans and livestock and studies of captive animals...
  11. pmc The relevance of non-human primate and rodent malaria models for humans
    Jean Langhorne
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Malar J 10:23. 2011
    ..The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material...
  12. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
    ..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
  13. pmc Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity
    Geoffrey S Williams
    Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Malar J 8:168. 2009
    ..RDTs are now widely used for the diagnosis of malaria and estimation of parasite rates, and this method represents a further use for these devices in malaria control...
  14. ncbi request reprint Regulating immunity to malaria
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 28:35-49. 2006
    ..A detailed understanding of the interplay between these different immunoregulatory processes may facilitate the rationale design of vaccines and novel therapeutics...
  15. pmc Lack of association between maternal antibody and protection of African infants from malaria infection
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5856-63. 2000
    ..However, all five children who experienced high-density infections (>100 parasites/microl of blood) were seronegative for MSP-1(19) at the time of infection...
  16. ncbi request reprint Do maternally acquired antibodies protect infants from malaria infection?
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 23:51-9. 2001
    ....
  17. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
  18. pmc Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation
    S E Cox
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine LSHTM, London, UK
    Clin Exp Immunol 144:392-400. 2006
    ....
  19. ncbi request reprint Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda
    C Proietti
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 35:164-73. 2013
    ..These findings indicate that continued malaria infections are required to maintain antibody titres in an area of intense malaria transmission...
  20. pmc Analysis of human antibodies to erythrocyte binding antigen 175 of Plasmodium falciparum
    D M Okenu
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5559-66. 2000
    ..However, there was a trend indicating that individuals with high levels of IgG to region II may have some protection...
  21. ncbi request reprint Is T-cell priming required for initiation of pathology in malaria infections?
    E M Riley
    Dept of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT
    Immunol Today 20:228-33. 1999
    ..Here, Eleanor Riley proposes that T-cell priming is required for amplification of the inflammatory response to malaria and that this explains patterns of clinical malaria in both endemic and non-endemic populations...
  22. pmc The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology
    K Artavanis-Tsakonas
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Clin Exp Immunol 133:145-52. 2003
    ..We conclude by proposing a model of antimalarial immunity which integrates both the immunological and epidemiological data collected to date...
  23. ncbi request reprint The London School of Hygiene and Tropical Medicine: a new century of malaria research
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Mem Inst Oswaldo Cruz 95:25-32. 2000
    ..Sustainable malaria control may require the deployment of a highly effective vaccine, but there is much that can be done in the meantime to reduce the burden of disease...
  24. ncbi request reprint Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination
    C S Boutlis
    International Health Program, Infectious Diseases Division, Menzies School of Health Research, P O Box 41096, 0811 Casuarina, NT, Australia
    Curr Top Microbiol Immunol 297:145-85. 2005
    ..P. falciparum GPIs are potentially amenable to specific therapeutic inhibition and vaccination; more needs to be known about their dual roles in malaria pathogenesis and protection for these strategies to succeed...
  25. pmc Does apolipoprotein E polymorphism influence susceptibility to malaria?
    M A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 40:348-51. 2003
    ..Parasite densities, all of which were low, did not differ significantly. This effect, although based on small numbers, suggests that APOE epsilon 2 may be a risk factor for early infection...
  26. pmc Changes in cytokine production associated with acquired immunity to Plasmodium falciparum malaria
    M S Rhee
    Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Clin Exp Immunol 126:503-10. 2001
    ....
  27. pmc Apolipoprotein E polymorphisms and risk of malaria
    M A Wozniak
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 41:145-6. 2004
  28. ncbi request reprint Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria
    D Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    J Infect Dis 185:971-9. 2002
    ..These data contradict data from cross-sectional clinical studies and indicate a need for detailed analysis of the relationship between cellular immunity to malaria and resistance to disease...