E M Riley

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. doi request reprint Immune mechanisms in malaria: new insights in vaccine development
    Eleanor M Riley
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 19:168-78. 2013
  2. pmc Developmental allometry and paediatric malaria
    Erica M W Billig
    Fogarty International Center, National Institutes of Health, Building 16, Bethesda, MD 20892, USA
    Malar J 11:64. 2012
  3. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
  4. doi request reprint Wild mice provide insights into natural killer cell maturation and memory
    Eleanor M Riley
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Ecol 20:4827-9. 2011
  5. pmc The relevance of non-human primate and rodent malaria models for humans
    Jean Langhorne
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Malar J 10:23. 2011
  6. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
  7. pmc Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity
    Geoffrey S Williams
    Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Malar J 8:168. 2009
  8. ncbi request reprint Do maternally acquired antibodies protect infants from malaria infection?
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 23:51-9. 2001
  9. pmc Lack of association between maternal antibody and protection of African infants from malaria infection
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5856-63. 2000
  10. ncbi request reprint Regulating immunity to malaria
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 28:35-49. 2006

Collaborators

  • Q D Bickle
  • V Ann Stewart
  • D J Conway
  • R F Anders
  • D McGuinness
  • S E Cox
  • K Yeboah-Antwi
  • L Schofield
  • M A Wozniak
  • J A Todd
  • C S Boutlis
  • Alphaxard Manjurano
  • Patrick H Corran
  • Erica M W Billig
  • Jean Langhorne
  • Hugh Reyburn
  • Chris Drakeley
  • Geoffrey S Williams
  • Jackie Cook
  • C J Drakeley
  • J E Tongren
  • K Artavanis-Tsakonas
  • D Dodoo
  • B D Akanmori
  • M S Rhee
  • Wendy P O'Meara
  • F Ellis McKenzie
  • Patrick Duffy
  • Tedson Lukindo
  • Mary Galinski
  • Monique Stins
  • Taane G Clark
  • Pierre Buffet
  • Erica Pasini
  • John Harty
  • Sarah Joseph
  • Didier Leroy
  • Maria M Mota
  • Michael Good
  • Laurent Renia
  • Lucy Okell
  • Raimos Olomi
  • Cally Roper
  • D M Okenu
  • Chris J Drakeley
  • George Mtove
  • Laveta Stewart
  • Clement Mweya
  • Azra C Ghani
  • Tarekegn Abeku
  • Jamie Griffin
  • Jonathan Cox
  • Teun Bousema
  • Caroline Lynch
  • Heleen Leendertse
  • W M M Nkya
  • P G Coleman
  • I Carneiro
  • P H Corran
  • H Reyburn
  • J Lusingu
  • A Manjurano
  • S L R McDonald
  • M M Lemnge
  • R Malima
  • J Cox
  • F M Omer
  • K A Koram
  • M Waterfall
  • D E Lanar
  • P U Agomo
  • J R Daugherty
  • A Barbosa

Detail Information

Publications21

  1. doi request reprint Immune mechanisms in malaria: new insights in vaccine development
    Eleanor M Riley
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 19:168-78. 2013
    ..We argue that rational design of more effective malaria vaccines will be accelerated by a better understanding of the immune effector mechanisms involved in parasite regulation, control and elimination...
  2. pmc Developmental allometry and paediatric malaria
    Erica M W Billig
    Fogarty International Center, National Institutes of Health, Building 16, Bethesda, MD 20892, USA
    Malar J 11:64. 2012
    ..Here, scattered items of evidence have been collected from a variety of disciplines, aiming to suggest possible research paths for investigating exposure-independent age differences affecting clinical outcomes of malaria infection...
  3. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
    ..The PCR prevalence was then compared against other measures of transmission intensity collected in the same area...
  4. doi request reprint Wild mice provide insights into natural killer cell maturation and memory
    Eleanor M Riley
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Ecol 20:4827-9. 2011
    ..2011) in this issue of Molecular Ecology, studies in wild animal populations-especially free-living M. musculus-represent a valuable bridge between studies in humans and livestock and studies of captive animals...
  5. pmc The relevance of non-human primate and rodent malaria models for humans
    Jean Langhorne
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Malar J 10:23. 2011
    ..The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material...
  6. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
    ..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
  7. pmc Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity
    Geoffrey S Williams
    Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Malar J 8:168. 2009
    ..RDTs are now widely used for the diagnosis of malaria and estimation of parasite rates, and this method represents a further use for these devices in malaria control...
  8. ncbi request reprint Do maternally acquired antibodies protect infants from malaria infection?
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 23:51-9. 2001
    ....
  9. pmc Lack of association between maternal antibody and protection of African infants from malaria infection
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5856-63. 2000
    ..However, all five children who experienced high-density infections (>100 parasites/microl of blood) were seronegative for MSP-1(19) at the time of infection...
  10. ncbi request reprint Regulating immunity to malaria
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Parasite Immunol 28:35-49. 2006
    ..A detailed understanding of the interplay between these different immunoregulatory processes may facilitate the rationale design of vaccines and novel therapeutics...
  11. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
  12. pmc Analysis of human antibodies to erythrocyte binding antigen 175 of Plasmodium falciparum
    D M Okenu
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Infect Immun 68:5559-66. 2000
    ..However, there was a trend indicating that individuals with high levels of IgG to region II may have some protection...
  13. ncbi request reprint Is T-cell priming required for initiation of pathology in malaria infections?
    E M Riley
    Dept of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT
    Immunol Today 20:228-33. 1999
    ..Here, Eleanor Riley proposes that T-cell priming is required for amplification of the inflammatory response to malaria and that this explains patterns of clinical malaria in both endemic and non-endemic populations...
  14. pmc Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation
    S E Cox
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine LSHTM, London, UK
    Clin Exp Immunol 144:392-400. 2006
    ....
  15. pmc The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology
    K Artavanis-Tsakonas
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Clin Exp Immunol 133:145-52. 2003
    ..We conclude by proposing a model of antimalarial immunity which integrates both the immunological and epidemiological data collected to date...
  16. ncbi request reprint The London School of Hygiene and Tropical Medicine: a new century of malaria research
    E M Riley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Mem Inst Oswaldo Cruz 95:25-32. 2000
    ..Sustainable malaria control may require the deployment of a highly effective vaccine, but there is much that can be done in the meantime to reduce the burden of disease...
  17. ncbi request reprint Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination
    C S Boutlis
    International Health Program, Infectious Diseases Division, Menzies School of Health Research, P O Box 41096, 0811 Casuarina, NT, Australia
    Curr Top Microbiol Immunol 297:145-85. 2005
    ..P. falciparum GPIs are potentially amenable to specific therapeutic inhibition and vaccination; more needs to be known about their dual roles in malaria pathogenesis and protection for these strategies to succeed...
  18. pmc Changes in cytokine production associated with acquired immunity to Plasmodium falciparum malaria
    M S Rhee
    Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Clin Exp Immunol 126:503-10. 2001
    ....
  19. pmc Does apolipoprotein E polymorphism influence susceptibility to malaria?
    M A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 40:348-51. 2003
    ..Parasite densities, all of which were low, did not differ significantly. This effect, although based on small numbers, suggests that APOE epsilon 2 may be a risk factor for early infection...
  20. pmc Apolipoprotein E polymorphisms and risk of malaria
    M A Wozniak
    Department of Optometry and Neuroscience, UMIST, Manchester, UK
    J Med Genet 41:145-6. 2004
  21. ncbi request reprint Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria
    D Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    J Infect Dis 185:971-9. 2002
    ..These data contradict data from cross-sectional clinical studies and indicate a need for detailed analysis of the relationship between cellular immunity to malaria and resistance to disease...