Hugh Reyburn

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. doi request reprint Malaria overdiagnosis: is patient pressure the problem?
    Clare I R Chandler
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, 51 Bedford Square, London, WC1B 3DP, UK
    Health Policy Plan 23:170-8. 2008
  2. pmc WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study
    Behzad Nadjm
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 340:c1350. 2010
  3. pmc Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    Thiranut Ramutton
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:276. 2012
  4. pmc A rapid assessment of the quality of neonatal healthcare in Kilimanjaro region, northeast Tanzania
    Bernard Mbwele
    Kilimanjaro Clinical Research Institute, Moshi, Tanzania
    BMC Pediatr 12:182. 2012
  5. pmc Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
    Kathryn Maitland
    Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK
    BMC Med 11:68. 2013
  6. pmc Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    Malar J 10:320. 2011
  7. pmc Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds PO Box 43640 00100, Nairobi, Kenya
    Malar J 8:4. 2009
  8. pmc Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity
    Geoffrey S Williams
    Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Malar J 8:168. 2009
  9. pmc Knowledge of malaria influences the use of insecticide treated nets but not intermittent presumptive treatment by pregnant women in Tanzania
    Rhoida Y Nganda
    Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
    Malar J 3:42. 2004
  10. pmc Quality of paediatric blood transfusions in two district hospitals in Tanzania: a cross-sectional hospital based study
    Dominic Mosha
    Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
    BMC Pediatr 9:51. 2009

Collaborators

Detail Information

Publications41

  1. doi request reprint Malaria overdiagnosis: is patient pressure the problem?
    Clare I R Chandler
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, 51 Bedford Square, London, WC1B 3DP, UK
    Health Policy Plan 23:170-8. 2008
    ..However, little is known about what drives the overuse of antimalarials. We conducted this study to explore to what extent current prescribing behaviour in hospitals is driven by patient demand...
  2. pmc WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study
    Behzad Nadjm
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 340:c1350. 2010
    ..To assess the performance of WHO's "Guidelines for care at the first-referral level in developing countries" in an area of intense malaria transmission and identify bacterial infections in children with and without malaria...
  3. pmc Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    Thiranut Ramutton
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:276. 2012
    ..The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These issues potentially confound the interpretation of PFHRP2 measurements...
  4. pmc A rapid assessment of the quality of neonatal healthcare in Kilimanjaro region, northeast Tanzania
    Bernard Mbwele
    Kilimanjaro Clinical Research Institute, Moshi, Tanzania
    BMC Pediatr 12:182. 2012
    ..The objective of this study was to assess the quality of neonatal care in the district hospitals of the Kilimanjaro region of Tanzania...
  5. pmc Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
    Kathryn Maitland
    Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK
    BMC Med 11:68. 2013
    ..We hypothesize that boluses may cause excess deaths from neurological or respiratory events relating to fluid overload...
  6. pmc Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    Malar J 10:320. 2011
    ..The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed...
  7. pmc Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds PO Box 43640 00100, Nairobi, Kenya
    Malar J 8:4. 2009
    ....
  8. pmc Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity
    Geoffrey S Williams
    Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    Malar J 8:168. 2009
    ..RDTs are now widely used for the diagnosis of malaria and estimation of parasite rates, and this method represents a further use for these devices in malaria control...
  9. pmc Knowledge of malaria influences the use of insecticide treated nets but not intermittent presumptive treatment by pregnant women in Tanzania
    Rhoida Y Nganda
    Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
    Malar J 3:42. 2004
    ..This study explores the determinants of uptake for both ITNs and IPTp-SP by pregnant women and the role that individual knowledge and socio-economic status has to play for each...
  10. pmc Quality of paediatric blood transfusions in two district hospitals in Tanzania: a cross-sectional hospital based study
    Dominic Mosha
    Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania
    BMC Pediatr 9:51. 2009
    ..The current study describes the quality of paediatric BT delivered in two district hospitals in north-east Tanzania in order to identify areas for quality assurance and improvement in the administration of BT...
  11. pmc Evaluation of the Widal tube agglutination test for the diagnosis of typhoid fever among children admitted to a rural hdospital in Tanzania and a comparison with previous studies
    Benedikt Ley
    International Vaccine Institute, Seoul, Korea
    BMC Infect Dis 10:180. 2010
    ..typhi). However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its reliability...
  12. pmc Clinical assessment and treatment in paediatric wards in the north-east of the United Republic of Tanzania
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 86:132-9. 2008
    ..We assessed paediatric care in the 13 public hospitals in the north-east of the United Republic of Tanzania to determine if diagnoses and treatments were consistent with current guidelines for care...
  13. pmc Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial
    Hugh Reyburn
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 334:403. 2007
    ..To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in guiding treatment decisions for febrile patients...
  14. pmc Treatment guided by rapid diagnostic tests for malaria in Tanzanian children: safety and alternative bacterial diagnoses
    George Mtove
    1National Institute for Medical Research, Amani Centre, Muheza, Tanga, Tanzania
    Malar J 10:290. 2011
    ..However, there is limited evidence of the safety of this policy in routine outpatient settings in Africa...
  15. pmc The contribution of microscopy to targeting antimalarial treatment in a low transmission area of Tanzania
    Hugh Reyburn
    Dept of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel St, London WCIE 7HT, UK
    Malar J 5:4. 2006
    ..This study aimed to explore why malaria slides are requested and how their results guide treatment decisions in an area of low transmission of P. falciparum...
  16. pmc Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 329:1212. 2004
    ..To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission...
  17. ncbi request reprint Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London, England
    JAMA 293:1461-70. 2005
    ..An understanding of the relationships among the level of exposure to Plasmodium falciparum, age, and severity of malaria can provide evidence of whether this is likely...
  18. doi request reprint The importance of context in malaria diagnosis and treatment decisions - a quantitative analysis of observed clinical encounters in Tanzania
    Clare I R Chandler
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:1131-42. 2008
    ..To gain a better understanding of the decision-making context in the diagnosis of malaria in order to inform behaviour change strategies, using quantitative methods...
  19. ncbi request reprint Assessment of children for acute respiratory infections in hospital outpatients in Tanzania: what drives good practice?
    Clare I R Chandler
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 79:925-32. 2008
    ..Although respiratory examinations are relatively more common in those with cough or difficulty breathing, the absolute rates are low and related to non-clinical and clinical factors...
  20. doi request reprint Severe febrile illness in adult hospital admissions in Tanzania: a prospective study in an area of high malaria transmission
    Behzad Nadjm
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trans R Soc Trop Med Hyg 106:688-95. 2012
    ..Adults with severe febrile illness should be tested for malaria and HIV using rapid, sensitive tests. Early antibiotic use should be promoted. Improved diagnostics for invasive bacterial disease are needed...
  21. pmc Equity and coverage of insecticide-treated bed nets in an area of intense transmission of Plasmodium falciparum in Tanzania
    Jubilate Bernard
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 8:65. 2009
    ..Tanzania has been a leader in social marketing but it is still not clear if this can result in high and equitable levels of coverage...
  22. pmc Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania
    Alphaxard Manjurano
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Malar J 10:370. 2011
    ..The PCR prevalence was then compared against other measures of transmission intensity collected in the same area...
  23. pmc Candidate human genetic polymorphisms and severe malaria in a Tanzanian population
    Alphaxard Manjurano
    Joint Malaria Programme, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    PLoS ONE 7:e47463. 2012
    ..Further studies are required to test the generality of these associations and to understand their functional consequences...
  24. ncbi request reprint The cost-effectiveness of parasitologic diagnosis for malaria-suspected patients in an era of combination therapy
    Yoel Lubell
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    Am J Trop Med Hyg 77:128-32. 2007
    ..Cost-effectiveness would be worse if prescribers do not comply with test results. The cost of this additional benefit may be higher than many countries can afford without external assistance or lower RDT prices...
  25. doi request reprint Patient costs for paediatric hospital admissions in Tanzania: a neglected burden?
    Priyanka Saksena
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Health Policy Plan 25:328-33. 2010
    ..However, little is known about out-of-pocket costs that may be incurred by families in seeking care for sick children. We conducted this study to identify the magnitude of these costs in relation to family income...
  26. pmc Blood glucose as a predictor of mortality in children admitted to the hospital with febrile illness in Tanzania
    Behzad Nadjm
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 89:232-7. 2013
    ..7%, specificity = 75.2%). A cutoff for admission blood glucose of < 5 mmol/L represents a simple and clinically useful predictor of mortality in children admitted with severe febrile illness to hospital in resource-poor settings...
  27. pmc Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey
    Yoel Lubell
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e17439. 2011
    ..However, data on these key parameters are lacking and assumptions are frequently made based on expert opinion. Widely diverse opinions can lead to conflicting outcomes in models they inform...
  28. doi request reprint Motivation, money and respect: a mixed-method study of Tanzanian non-physician clinicians
    Clare I R Chandler
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK
    Soc Sci Med 68:2078-88. 2009
    ..As well as improvements to organisational management, we put forward the case for the professionalization of non-physician clinicians...
  29. ncbi request reprint The effect of altitude on parasite density case definitions for malaria in northeastern Tanzania
    Clare I R Chandler
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 11:1178-84. 2006
    ..This study examines appropriate case definitions from parasitological surveys conducted over a broad range of transmission intensities, using altitude as a proxy for transmission intensity...
  30. pmc Guidelines and mindlines: why do clinical staff over-diagnose malaria in Tanzania? A qualitative study
    Clare I R Chandler
    London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Malar J 7:53. 2008
    ..An understanding of the reasons behind malaria over-diagnosis is urgently needed to inform strategies for better targeting of antimalarials...
  31. ncbi request reprint DEET mosquito repellent provides personal protection against malaria: a household randomized trial in an Afghan refugee camp in Pakistan
    Mark Rowland
    HealthNet International, Peshawar, Pakistan
    Trop Med Int Health 9:335-42. 2004
    ..There is a case for giving repellents more prominence in public health as a preventive measure in regions where vectors bite in the early evening or in emergency situations such as epidemics or newly established refugee camps...
  32. doi request reprint Out with the old, in with the new: the utility of rapid diagnostic tests for malaria diagnosis in Africa
    Chris Drakeley
    Joint Malaria Programme, Moshi, Tanzania
    Trans R Soc Trop Med Hyg 103:333-7. 2009
    ..Here we review what is known and what new evidence is needed to maximise the utility of RDTs in Africa...
  33. ncbi request reprint Epidemiology of anthroponotic cutaneous leishmaniasis in Afghan refugee camps in northwest Pakistan
    Jan Kolaczinski
    HealthNet International, University Town, Peshawar, Pakistan
    Trans R Soc Trop Med Hyg 98:373-8. 2004
    ..Based on the evidence from this study an intervention strategy was formulated for all camps with reported ACL cases. This includes targeting of active cases with insecticide-treated nets, sold at a highly subsidised price...
  34. pmc The impact of response to the results of diagnostic tests for malaria: cost-benefit analysis
    Yoel Lubell
    Health Economics and Financing Programme, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 336:202-5. 2008
    ..This study tested the impact of clinicians' response to rapid diagnostic test or microscopy results on the costs and benefits of testing at different levels of malaria transmission and in different age groups...
  35. ncbi request reprint Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern Tanzania
    Chris J Drakeley
    Joint Malaria Programme, Moshi, Tanzania
    J Infect Dis 191:1589-98. 2005
    ..Estimates based on entomological factors lack precision and are not cost-effective to obtain. We tested altitude and rainfall measurements as correlates of transmission intensity in different ecological settings...
  36. pmc Timing of intermittent preventive treatment for malaria during pregnancy and the implications of current policy on early uptake in north-east Tanzania
    Katherine Anders
    London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Malar J 7:79. 2008
    ..This study investigated the timing of delivery of IPTp to pregnant women attending antenatal clinics (ANC), and the potential determinants of timely uptake...
  37. pmc Conflicting priorities: evaluation of an intervention to improve nurse-parent relationships on a Tanzanian paediatric ward
    Rachel N Manongi
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Hum Resour Health 7:50. 2009
    ..Development of awareness and empathy was not enough to provide care that was satisfactory to clients in the context of working conditions that were unsatisfactory to nurses...
  38. ncbi request reprint The prolonged epidemic of anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: 'bringing down the neighbourhood'
    Hugh Reyburn
    HealthNet International, Kabul, Afghanistan
    Trans R Soc Trop Med Hyg 97:170-6. 2003
    ..As population movement is clearly a contributing factor to its transmission, this threat is very real...
  39. pmc Malaria diagnosis and treatment: one size does not fit all
    Chris Drakeley
    PLoS Med 2:e156; author reply e165. 2005
  40. pmc Global initiatives for improving hospital care for children: state of the art and future prospects
    Harry Campbell
    Public Health Sciences, Institute of Genomics and Molecular Medicine, College of Medicine and Vet Medicine University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    Pediatrics 121:e984-92. 2008
    ..The challenges remain to bring these and other strategies to scale and to support research into their use, impact, and sustainability in different environments...
  41. pmc Treating severe malaria
    Christopher J M Whitty
    BMJ 330:317-8. 2005