Julian Peto

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi request reprint Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer
    Christina Fleischmann
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom
    Int J Cancer 109:554-8. 2004
  2. ncbi request reprint Lack of evidence on diets for obesity for children: a systematic review
    Lorna J Gibson
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:1544-52. 2006
  3. pmc Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study
    C Rake
    Institute of Cancer Research, Sutton, Surrey, UK
    Br J Cancer 100:1175-83. 2009
  4. pmc That lung cancer incidence falls in ex-smokers: misconceptions 2
    J Peto
    London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Br J Cancer 104:389. 2011
  5. pmc That the effects of smoking should be measured in pack-years: misconceptions 4
    J Peto
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Br J Cancer 107:406-7. 2012
  6. ncbi request reprint The cervical cancer epidemic that screening has prevented in the UK
    Julian Peto
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 364:249-56. 2004
  7. pmc Cervical HPV infection and neoplasia in a large population-based prospective study: the Manchester cohort
    J Peto
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Cancer 91:942-53. 2004
  8. ncbi request reprint CYP3A variation, premenopausal estrone levels, and breast cancer risk
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 104:657-69. 2012
  9. doi request reprint Association of genetic variants at 8q24 with breast cancer risk
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:702-5. 2008
  10. doi request reprint No breast cancer association for transforming growth factor-beta pathway colorectal cancer single nucleotide polymorphisms
    Lorna Gibson
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:1934-6. 2009

Detail Information

Publications47

  1. ncbi request reprint Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer
    Christina Fleischmann
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom
    Int J Cancer 109:554-8. 2004
    ..No biallelic mutations were detected among 354 controls. These results confirm that biallelic MYH mutations confer susceptibility to colorectal cancer but are unlikely to account for more than 3% of early-onset colorectal cancer...
  2. ncbi request reprint Lack of evidence on diets for obesity for children: a systematic review
    Lorna J Gibson
    Cancer Research UK Epidemiology and Genetics Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:1544-52. 2006
    ..A low-fat energy-restricted diet is the conventional therapy for obesity, but alternative dietary interventions have been proposed in recent years...
  3. pmc Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study
    C Rake
    Institute of Cancer Research, Sutton, Surrey, UK
    Br J Cancer 100:1175-83. 2009
    ..Approximately half of the male cases were construction workers, and only four had worked for more than 5 years in asbestos product manufacture...
  4. pmc That lung cancer incidence falls in ex-smokers: misconceptions 2
    J Peto
    London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Br J Cancer 104:389. 2011
    ..We hope that this series will prove instructive to cancer researchers in other disciplines as well as to students of epidemiology. Adrian L Harris and Leo Kinlen...
  5. pmc That the effects of smoking should be measured in pack-years: misconceptions 4
    J Peto
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Br J Cancer 107:406-7. 2012
    ..This is mathematically unnecessary and scientifically unhelpful...
  6. ncbi request reprint The cervical cancer epidemic that screening has prevented in the UK
    Julian Peto
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 364:249-56. 2004
    ..Recent reports suggest that the reduction in mortality achieved by the UK national cervical screening programme is too small to justify its financial and psychosocial costs, except perhaps in a few high-risk women...
  7. pmc Cervical HPV infection and neoplasia in a large population-based prospective study: the Manchester cohort
    J Peto
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Cancer 91:942-53. 2004
    ..Persistence of oncogenic HPV may be more sensitive and specific than cytology for early detection of CIN3 and invasive cancer...
  8. ncbi request reprint CYP3A variation, premenopausal estrone levels, and breast cancer risk
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 104:657-69. 2012
    ..Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in premenopausal women...
  9. doi request reprint Association of genetic variants at 8q24 with breast cancer risk
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:702-5. 2008
    ..25-fold increased risk of prostate cancer, with no effect for the two other variants, indicates that the effects of the risk alleles clustered at 8q24 are cancer site specific...
  10. doi request reprint No breast cancer association for transforming growth factor-beta pathway colorectal cancer single nucleotide polymorphisms
    Lorna Gibson
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:1934-6. 2009
    ..94 or >1.08. One or more of these variants may be associated with a very small OR for breast cancer, but our data suggest that the effects of these alleles are cancer site-specific...
  11. pmc Genome-wide association studies identify four ER negative-specific breast cancer risk loci
    Montserrat Garcia-Closas
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK 2 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK 3
    Nat Genet 45:392-8, 398e1-2. 2013
    ..0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers...
  12. ncbi request reprint Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Hum Mol Genet 16:1051-7. 2007
    ..A risk score incorporating a suitably weighted sum of all potentially functional variants in these and a few other candidate genes may provide clinically useful identification of women at high genetic risk...
  13. doi request reprint Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  14. doi request reprint Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer
    Alan M Pittman
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Hum Mol Genet 17:3720-7. 2008
    ..The absence of exonic mutations in any of the transcripts (FLJ45803, LOC120376, C11orf53 and POU2AF1) mapping to this region makes the association likely to be a consequence of non-coding effects on gene expression...
  15. pmc Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
    Tom Treasure
    Department of Mathematics, Clinical Operational Research Unit, University College London, London, UK
    Lancet Oncol 12:763-72. 2011
    ..We aimed to assess the clinical outcomes of patients who were randomly assigned to EPP or no EPP in the context of trimodal therapy in the Mesothelioma and Radical Surgery (MARS) feasibility study...
  16. ncbi request reprint Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk
    Olivia Fletcher
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    J Natl Cancer Inst 98:1014-8. 2006
    ..001). This heterogeneity could reflect either population-specific linkage disequilibrium with a functional variant or artifacts such as population stratification or publication bias...
  17. pmc Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    James M Flanagan
    CR UK Viral Oncology Group, UCL Cancer Institute, London, UK
    Hum Mol Genet 18:1332-42. 2009
    ..ACCESSION NUMBERS: The microarray data and associated .BED and .WIG files can be accessed through Gene Expression Omnibus accession number: GSE14603...
  18. pmc Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases
    Frank Dudbridge
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:262-72. 2012
    ..This can be explained by incomplete linkage disequilibrium between the tested marker and the underlying causal variant...
  19. ncbi request reprint The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:449-55. 2006
    ....
  20. ncbi request reprint Lifetime risks of common cancers among retinoblastoma survivors
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Natl Cancer Inst 96:357-63. 2004
    ..However, their risks for the epithelial cancers that commonly occur after age 50 years are not known...
  21. doi request reprint Premenopausal mammographic density in relation to cyclic variations in endogenous sex hormone levels, prolactin, and insulin-like growth factors
    Kate Walker
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, and The Academic Department of Biochemistry, The Royal Marsden Hospital, London, UK
    Cancer Res 69:6490-9. 2009
    ..Most of these hormone-density associations were attenuated with further adjustment for BMI...
  22. ncbi request reprint A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
    Peter Broderick
    Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK
    Nat Genet 39:1315-7. 2007
    ..Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12))...
  23. ncbi request reprint Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study
    Nichola Johnson
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lancet 366:1554-7. 2005
    ..Our aim was to measure the risk of breast cancer in relatives of women with bilateral breast cancer who were carriers of this allele...
  24. ncbi request reprint Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives
    Emily L Webb
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK
    Hum Mol Genet 15:3263-71. 2006
    ..shtml in order to facilitate the identification of low penetrance CRC susceptibility alleles through pooled analyses...
  25. pmc 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium
    Helen Warren
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:1783-91. 2012
    ..Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686)...
  26. doi request reprint Sexual behavior and HPV infection in British women, by postal questionnaires and telephone interviews
    Maribel Almonte
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Med Virol 83:1238-46. 2011
    ..4, 95% CI: 1.7-11.2) was stronger than that of earlier (> 5 years ago) partners (OR for 2+ earlier partners: 2.2, 95% CI: 0.7-6.7) suggesting that most incident HPV infections are newly acquired rather than recurrent...
  27. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
    ..To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients...
  28. pmc Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
    Elise Ruark
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Nat Genet 45:686-9. 2013
    ..3, is required for the regulation of germ cell development. Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation...
  29. pmc Certified causes of death in patients with mesothelioma in South East England
    Catherine Okello
    King s College London, Thames Cancer Registry, London, UK
    BMC Cancer 9:28. 2009
    ..We examine certified causes of death of patients who have been diagnosed with mesothelioma, and assess the validity of death certification data as a proxy for mesothelioma incidence...
  30. ncbi request reprint Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2-19. 2005
    ..Further large studies, or combined analysis of data from existing studies, are needed to quantify these effects more precisely...
  31. ncbi request reprint The search for low-penetrance cancer susceptibility alleles
    Richard S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
    Oncogene 23:6471-6. 2004
    ..Cancer patients with affected relatives are considerably more informative than unselected cases for such studies...
  32. pmc A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
    Afshan Siddiq
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    Hum Mol Genet 21:5373-84. 2012
    ..Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci...
  33. doi request reprint The Mesothelioma and Radical surgery randomized controlled trial: the Mars feasibility study
    Tom Treasure
    Guy s and St Thomas Hospital, London, UK
    J Thorac Oncol 4:1254-8. 2009
    ..The question was whether randomization to surgery versus no surgery would be possible...
  34. ncbi request reprint Breast cancer susceptibility-A new look at an old model
    Julian Peto
    Institute of Cancer Research, Sutton, Surrey SM2 5NG, London, UK
    Cancer Cell 1:411-2. 2002
    ....
  35. ncbi request reprint Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies
    Paul Appleby
    Cancer Research UK Epidemiology Unit, Oxford, UK
    Lancet 370:1609-21. 2007
    ..Information from 24 studies worldwide is pooled here to investigate the association between cervical carcinoma and pattern of oral contraceptive use...
  36. doi request reprint Current CD4 cell count and the short-term risk of AIDS and death before the availability of effective antiretroviral therapy in HIV-infected children and adults
    David Dunn
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    J Infect Dis 197:398-404. 2008
    ..Currently, there are no comparable estimates of the short-term risk of disease progression in the absence of effective antiretroviral therapy for human immunodeficiency virus (HIV)-infected adults and children...
  37. ncbi request reprint Oral contraceptives and cervical cancer
    Amy Berrington
    Lancet 360:410. 2002
  38. ncbi request reprint The future of association studies of common cancers
    Richard S Houlston
    Hum Genet 112:434-5. 2003
  39. doi request reprint Breast cancer onset in twins and women with bilateral disease
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 26:4086-91. 2008
    ..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration...
  40. ncbi request reprint Cervical cancer and use of hormonal contraceptives: a systematic review
    Jennifer S Smith
    International Agency for Research on Cancer, Lyon, France
    Lancet 361:1159-67. 2003
    ..Human papillomavirus (HPV) is believed to be the most important cause of cervical cancer. Recent studies suggest that long duration use of oral contraceptives increases the risk of cervical cancer in HPV positive women...
  41. doi request reprint Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy
    Claire Palles
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Hum Mol Genet 17:1457-64. 2008
    ..Targeting ECRs appears to be a useful strategy for identifying a subset of potentially functional non-coding regulatory SNPs...
  42. ncbi request reprint ESR1 gene amplification in breast cancer: a common phenomenon?
    Jorge S Reis-Filho
    Nat Genet 40:809-10; author reply 810-2. 2008
  43. ncbi request reprint Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations
    Hanne Meijers-Heijboer
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 31:55-9. 2002
    ....
  44. doi request reprint Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Natl Cancer Inst 100:437-42. 2008
    ..10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001)...
  45. ncbi request reprint Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium
    Marjanka K Schmidt
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 67:9584-90. 2007
    ..This suggests that any effect of these two variants would be very small and possibly confined to subgroups that were not assessed in our present study...
  46. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...