P Perel

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial
    Yashbir Dewan
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Trials 13:87. 2012
  2. pmc Predicting intracranial hemorrhage after traumatic brain injury in low and middle-income countries: a prognostic model based on a large, multi-center, international cohort
    Saleena Subaiya
    Department of Emergency Medicine, New York Presbyterian, New York, NY, USA
    BMC Emerg Med 12:17. 2012
  3. doi request reprint Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 2:CD000567. 2013
  4. doi request reprint Tranexamic acid for reducing mortality in emergency and urgent surgery
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 1:CD010245. 2013
  5. doi request reprint CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial
    P Perel
    London School of Hygiene and Tropical Medicine, London, UK
    Health Technol Assess 16:iii-xii, 1-54. 2012
  6. pmc Predicting early death in patients with traumatic bleeding: development and validation of prognostic model
    Pablo Perel
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    BMJ 345:e5166. 2012
  7. pmc Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    Katharine Ker
    Clinical Trials Unit, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Emerg Med 12:3. 2012
  8. doi request reprint Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
  9. pmc Between-centre differences and treatment effects in randomized controlled trials: a case study in traumatic brain injury
    Hester F Lingsma
    Department of Public Health, Erasmus MC, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Trials 12:201. 2011
  10. pmc The added value of ordinal analysis in clinical trials: an example in traumatic brain injury
    Bob Roozenbeek
    Department of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium
    Crit Care 15:R127. 2011

Detail Information

Publications30

  1. pmc CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial
    Yashbir Dewan
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Trials 13:87. 2012
    ....
  2. pmc Predicting intracranial hemorrhage after traumatic brain injury in low and middle-income countries: a prognostic model based on a large, multi-center, international cohort
    Saleena Subaiya
    Department of Emergency Medicine, New York Presbyterian, New York, NY, USA
    BMC Emerg Med 12:17. 2012
    ..Diagnostic capabilities and treatment options for intracranial hemorrhage are limited in LMIC as there are fewer computed tomography (CT) scanners and neurosurgeons per patient as in high-income countries...
  3. doi request reprint Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 2:CD000567. 2013
    ..Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid, and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids...
  4. doi request reprint Tranexamic acid for reducing mortality in emergency and urgent surgery
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 1:CD010245. 2013
    ..Tranexamic acid has been shown to reduce the need for a blood transfusion in adult patients undergoing elective surgery but its effects in patients undergoing emergency or urgent surgery is unclear.  ..
  5. doi request reprint CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial
    P Perel
    London School of Hygiene and Tropical Medicine, London, UK
    Health Technol Assess 16:iii-xii, 1-54. 2012
    ..These findings raise the possibility that it might also be effective in traumatic brain injury (TBI)...
  6. pmc Predicting early death in patients with traumatic bleeding: development and validation of prognostic model
    Pablo Perel
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    BMJ 345:e5166. 2012
    ..To develop and validate a prognostic model for early death in patients with traumatic bleeding...
  7. pmc Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    Katharine Ker
    Clinical Trials Unit, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Emerg Med 12:3. 2012
    ..Based on data from the CRASH-2 trial, global mortality data and a systematic literature review, we estimated the number of premature deaths that might be averted every year worldwide through the use of TXA...
  8. doi request reprint Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
    ..Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids...
  9. pmc Between-centre differences and treatment effects in randomized controlled trials: a case study in traumatic brain injury
    Hester F Lingsma
    Department of Public Health, Erasmus MC, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Trials 12:201. 2011
    ..The aim of this study was to assess the influence of between-centre differences in outcome on the estimated treatment effect in a large RCT in TBI...
  10. pmc The added value of ordinal analysis in clinical trials: an example in traumatic brain injury
    Bob Roozenbeek
    Department of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium
    Crit Care 15:R127. 2011
    ..The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial...
  11. pmc Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation
    Carla Guerriero
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Cost Eff Resour Alloc 8:1. 2010
    ..In countries where there is a blood shortage, TXA would be a cost effective way to reduce mortality. In countries where there is no blood shortage, TXA would reduce healthcare costs and avert blood borne infections...
  12. pmc Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients
    Pablo Perel
    London School of Hygiene and Tropical Medicine, London WC1B 3DP
    BMJ 336:425-9. 2008
    ..To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury...
  13. pmc Road safety in low- and middle-income countries: a neglected research area
    P Perel
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Inj Prev 13:227. 2007
  14. pmc Use of the Oxford Handicap Scale at hospital discharge to predict Glasgow Outcome Scale at 6 months in patients with traumatic brain injury
    Pablo Perel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Med Res Methodol 8:72. 2008
    ..The objectives of this study were to evaluate the association and predictive validity between a simple disability scale at hospital discharge, the Oxford Handicap Scale (OHS), and the GOS at 6 months among TBI patients...
  15. pmc Comparison of treatment effects between animal experiments and clinical trials: systematic review
    Pablo Perel
    Crash Trials Coordinating Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 334:197. 2007
    ..To examine concordance between treatment effects in animal experiments and clinical trials. Study design Systematic review...
  16. pmc Intracranial bleeding in patients with traumatic brain injury: a prognostic study
    Pablo Perel
    Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, London, UK
    BMC Emerg Med 9:15. 2009
    ..We analysed data from the Trauma Audit & Research Network (TARN), a large European trauma registry, to evaluate the association between the size of IB and mortality in patients with TBI...
  17. pmc Systematic review of prognostic models in traumatic brain injury
    Pablo Perel
    Nutrition and Public Health Intervention Research Unit, Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med Inform Decis Mak 6:38. 2006
    ..Two reviewers independently examined titles, abstracts and assessed whether each met the pre-defined inclusion criteria...
  18. pmc Noncommunicable diseases and injuries in Latin America and the Caribbean: time for action
    Pablo Perel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 3:e344. 2006
  19. doi request reprint The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients
    I Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London, UK
    Health Technol Assess 17:1-79. 2013
    ..In addition, the effort of tranexamic acid on the risk of vascular occlusive events was assessed...
  20. doi request reprint Development and validation of a prognostic model to predict death in patients with traumatic bleeding, and evaluation of the effect of tranexamic acid on mortality according to baseline risk: a secondary analysis of a randomised controlled trial
    P Perel
    London School of Hygiene and Tropical Medicine, London, UK
    Health Technol Assess 17:1-45, v-vi. 2013
    ....
  21. doi request reprint The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial
    Ian Roberts
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 377:1096-101, 1101.e1-2. 2011
    ..Tranexamic acid significantly reduced all-cause mortality. Because tranexamic acid is thought to exert its effect through inhibition of fibrinolysis, we undertook exploratory analyses of its effect on death due to bleeding...
  22. doi request reprint How effective are some common treatments for traumatic brain injury?
    Katharine Ker
    Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
    BMJ 337:a865. 2008
  23. doi request reprint Patient outcome after traumatic brain injury in high-, middle- and low-income countries: analysis of data on 8927 patients in 46 countries
    Mary J De Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Int J Epidemiol 38:452-8. 2009
    ..Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. The burden of TBI is greatest in low- and middle-income countries (LAMIC), yet little is known about patient outcomes in these settings...
  24. doi request reprint Beta-2 receptor antagonists for traumatic brain injury: a systematic review of controlled trials in animal models
    K Ker
    NPHIRU, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    CNS Neurosci Ther 15:52-64. 2009
    ..However, the poor methodological quality of the included studies and presence of small study effects may have influenced these findings...
  25. doi request reprint Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
    Haleema Shakur
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Lancet 376:23-32. 2010
    ..We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients...
  26. pmc Relation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journals
    Pablo Perel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e1696. 2008
    ..We analyzed the relationship between the global burden of disease and Randomized Clinical Trials (RCTs) conducted in Latin America that were published in the five leading medical journals...
  27. pmc Research on preventing road traffic injuries in developing countries is needed
    Pablo Perel
    BMJ 328:895. 2004
  28. ncbi request reprint Prognosis following head injury: a survey of doctors from developing and developed countries
    Pablo Perel
    J Eval Clin Pract 13:464-5. 2007
  29. ncbi request reprint Household wealth and the metabolic syndrome in the Whitehall II study
    Pablo Perel
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, U K
    Diabetes Care 29:2694-700. 2006
    ..The metabolic syndrome is more common in socially disadvantaged groups. Inequalities in household wealth are currently widening and may contribute to the increasing prevalence of the metabolic syndrome...
  30. pmc Evidence-based medicine in Iberoamerica: problems and possible solutions
    Zulma Ortiz
    PLoS Med 2:e277. 2005