Sophie E Moore

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi request reprint Early immunological development and mortality from infectious disease in later life
    Sophie E Moore
    MRC Keneba, MRC Laboratories, The Gambia, West Africa
    Proc Nutr Soc 65:311-8. 2006
  2. pmc Maternal protein-energy supplementation does not affect adolescent blood pressure in The Gambia
    Sophie Hawkesworth
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 38:119-27. 2009
  3. pmc Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh
    Sophie E Moore
    MRC Keneba, MRC Laboratories, Banju, The Gambia
    Acta Paediatr 98:1168-75. 2009
  4. ncbi request reprint Landscape analysis of interactions between nutrition and vaccine responses in children
    Mathilde Savy
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    J Nutr 139:2154S-218S. 2009
  5. pmc Thymus development and infant and child mortality in rural Bangladesh
    Sophie E Moore
    MRC International Nutrition Group, Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK, Department of Clinical Trials and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, International Maternal and Child Health, Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden and International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Int J Epidemiol 43:216-23. 2014
  6. pmc Early-life and contemporaneous nutritional and environmental predictors of antibody response to vaccination in young Gambian adults
    Sophie E Moore
    MRC Keneba, Medical Research Council Laboratories, Fajara, Gambia
    Vaccine 30:4842-8. 2012
  7. pmc Birth season and environmental influences on blood leucocyte and lymphocyte subpopulations in rural Gambian infants
    Andrew C Collinson
    1Directorate of Child and Women s Health, Bramble Ward, Royal Devon and Exeter Hospital Wonford, Exeter, UK
    BMC Immunol 9:18. 2008
  8. ncbi request reprint Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight
    Sophie E Moore
    MRC Keneba, Medical Research Council Laboratories, Fajara, P O Box 273, Banjul, Gambia
    Vaccine 26:158-65. 2008
  9. ncbi request reprint Effect of month of vaccine administration on antibody responses in The Gambia and Pakistan
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 11:1529-41. 2006
  10. ncbi request reprint Commentary: patterns in mortality governed by the seasons
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Interventions Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:435-7. 2006

Detail Information

Publications45

  1. ncbi request reprint Early immunological development and mortality from infectious disease in later life
    Sophie E Moore
    MRC Keneba, MRC Laboratories, The Gambia, West Africa
    Proc Nutr Soc 65:311-8. 2006
    ..The present paper will review progress made to date within this field of research...
  2. pmc Maternal protein-energy supplementation does not affect adolescent blood pressure in The Gambia
    Sophie Hawkesworth
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 38:119-27. 2009
    ..Birthweight, and by inference maternal nutrition during pregnancy, is thought to be an important determinant of offspring blood pressure but the evidence base for this in humans is lacking data from randomized controlled trials...
  3. pmc Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh
    Sophie E Moore
    MRC Keneba, MRC Laboratories, Banju, The Gambia
    Acta Paediatr 98:1168-75. 2009
    ..The aim was to assess the impact of nutritional status and environmental exposures on infant thymic development in the rural Matlab region of Bangladesh...
  4. ncbi request reprint Landscape analysis of interactions between nutrition and vaccine responses in children
    Mathilde Savy
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    J Nutr 139:2154S-218S. 2009
    ..This would also help us understand the proposed, but still unproven, negative interactions between VAS and vaccine safety, a resolution of which is urgently required...
  5. pmc Thymus development and infant and child mortality in rural Bangladesh
    Sophie E Moore
    MRC International Nutrition Group, Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK, Department of Clinical Trials and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, International Maternal and Child Health, Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden and International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Int J Epidemiol 43:216-23. 2014
    ..We investigated the association between thymus size (thymic index, TI) in infancy and subsequent infant and child survival in a contemporary South Asian population...
  6. pmc Early-life and contemporaneous nutritional and environmental predictors of antibody response to vaccination in young Gambian adults
    Sophie E Moore
    MRC Keneba, Medical Research Council Laboratories, Fajara, Gambia
    Vaccine 30:4842-8. 2012
    ..The current study does not support the hypothesis that nutritional exposures early in life consistently compromise antibody response to polysaccharide vaccines administered in young adulthood...
  7. pmc Birth season and environmental influences on blood leucocyte and lymphocyte subpopulations in rural Gambian infants
    Andrew C Collinson
    1Directorate of Child and Women s Health, Bramble Ward, Royal Devon and Exeter Hospital Wonford, Exeter, UK
    BMC Immunol 9:18. 2008
    ....
  8. ncbi request reprint Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight
    Sophie E Moore
    MRC Keneba, Medical Research Council Laboratories, Fajara, P O Box 273, Banjul, Gambia
    Vaccine 26:158-65. 2008
    ..No such association was observed in response to a polysaccharide-protein conjugate vaccine indicating an early-life programming effect on the generation of antibodies during a B-cell-dependent immune response...
  9. ncbi request reprint Effect of month of vaccine administration on antibody responses in The Gambia and Pakistan
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 11:1529-41. 2006
    ..To explore the relationship between calendar month of administration and antibody (Ab) response to vaccination in subjects from The Gambia and Pakistan, two countries with distinct patterns of seasonality...
  10. ncbi request reprint Commentary: patterns in mortality governed by the seasons
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Interventions Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:435-7. 2006
  11. ncbi request reprint Glucose, insulin and lipid metabolism in rural Gambians exposed to early malnutrition
    S E Moore
    MRC Keneba, The Gambia, West Africa
    Diabet Med 18:646-53. 2001
    ....
  12. ncbi request reprint Birth weight predicts response to vaccination in adults born in an urban slum in Lahore, Pakistan
    Sophie E Moore
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Am J Clin Nutr 80:453-9. 2004
    ..Evidence is also emerging that some components of immune function may be programmed in early life. However, this evidence is limited and requires confirmation...
  13. ncbi request reprint Comparative analysis of patterns of survival by season of birth in rural Bangladeshi and Gambian populations
    Sophie E Moore
    MRC International Nutrition Group, Public Health Nutrition Unit, London School of Hygiene and Tropical Medicine, 49 51 Bedford Square, London, WC1B 3DP, UK
    Int J Epidemiol 33:137-43. 2004
    ..The current paper uses data from a large demographic survey in the Matlab region of Bangladesh to retest the Gambian-derived hypothesis that early life exposures correlated with season of birth predict later patterns of mortality...
  14. ncbi request reprint Ethnic differences in the relationship between fasting leptin and BMI in children
    S E Moore
    MRC International Nutrition Group, Public Health Nutrition Unit, London School of Hygiene and Tropical Medicine, London, UK
    Int J Obes Relat Metab Disord 28:17-21. 2004
    ..To compare the relationship between fasting serum leptin levels and body mass index (BMI) in children from different ethnic groups...
  15. ncbi request reprint Impact of nutritional status on antibody responses to different vaccines in undernourished Gambian children
    S E Moore
    MRC Keneba, MRC Laboratories, The Gambia
    Acta Paediatr 92:170-6. 2003
    ..To test the efficacy of T-cell-dependent and T-cell-independent vaccines in rural Gambian children suffering from a range of energy/protein and micronutrient deficiencies...
  16. pmc Leptin, malnutrition, and immune response in rural Gambian children
    S E Moore
    MRC Keneba, MRC Laboratories, PO Box 273, Fajara, Banjul, The Gambia
    Arch Dis Child 87:192-7. 2002
    ..In humans leptin influences the differentiation of naïve and memory cells in vitro, and genetic leptin deficiency has been associated with an ill defined susceptibility to infection...
  17. ncbi request reprint Immune function in rural Gambian children is not related to season of birth, birth size, or maternal supplementation status
    S E Moore
    International Nutrition Group, London School of Hygiene and Tropical Medicine, UK
    Am J Clin Nutr 74:840-7. 2001
    ..Excess mortality begins after puberty and has a maximal odds ratio of >10 for deaths between ages 25 and 50 y...
  18. ncbi request reprint Use of stable-isotope techniques to validate infant feeding practices reported by Bangladeshi women receiving breastfeeding counseling
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Interventions Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 85:1075-82. 2007
    ..The World Health Organization recommends exclusive breastfeeding until age 6 mo. Studies relying on mothers' self-reported behaviors have shown that lactation counseling increases both the rate and duration of exclusive breastfeeding...
  19. doi request reprint Effects of exclusive breastfeeding intervention on child growth and body composition: the MINIMat trial, Bangladesh
    Ashraful I Khan
    International Maternal and Child Health, Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Acta Paediatr 102:815-23. 2013
    ..We examined whether randomization to receive EBF counselling (BFC) in rural Bangladeshi women had an impact on childhood growth trajectories and body composition...
  20. pmc Combined food and micronutrient supplements during pregnancy have limited impact on child blood pressure and kidney function in rural Bangladesh
    Sophie Hawkesworth
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    J Nutr 143:728-34. 2013
    ..These marginal associations and small effect sizes suggest limited public health importance in early childhood...
  21. doi request reprint Nutritional supplementation during pregnancy and offspring cardiovascular disease risk in The Gambia
    Sophie Hawkesworth
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 94:1853S-1860S. 2011
    ..Maternal nutritional intake during pregnancy may have important consequences for long-term health in offspring...
  22. pmc DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women
    Paula Dominguez-Salas
    Medical Research Council MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 97:1217-27. 2013
    ..In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season...
  23. pmc Early exposure to toxic metals has a limited effect on blood pressure or kidney function in later childhood, rural Bangladesh
    Sophie Hawkesworth
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 42:176-85. 2013
    ..Chronic exposure to toxic metals such as arsenic and cadmium has been implicated in the development of kidney and cardiovascular diseases but few studies have directly measured exposure during inutero and early child development...
  24. pmc Critical windows for nutritional interventions against stunting
    Andrew M Prentice
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 97:911-8. 2013
    ..The regulation of such growth is complex and may be affected by nutritional interventions imposed many years previously...
  25. pmc Supplemental feeding during pregnancy compared with maternal supplementation during lactation does not affect schooling and cognitive development through late adolescence
    Harold Alderman
    Human Development Network, World Bank, Washington, DC HA, ML, and AT the International Food Policy Research Institute, Washington, DC HA the Medical Research Council MRC, International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom and the MRC Keneba, MRC Unit, Fajara, The Gambia SH, hm, and SEM
    Am J Clin Nutr 99:122-9. 2014
    ..The long-term impact of early malnutrition on human capital outcomes remains unclear, and existing evidence has come largely from observational studies...
  26. doi request reprint Growth faltering in low-income countries
    Andrew M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    World Rev Nutr Diet 106:90-9. 2013
    ....
  27. pmc A randomized trial to investigate the effects of pre-natal and infant nutritional supplementation on infant immune development in rural Gambia: the ENID trial: Early Nutrition and Immune Development
    Sophie E Moore
    MRC Keneba, MRC Unit The Gambia, PO Box 273, Banjul, The Gambia
    BMC Pregnancy Childbirth 12:107. 2012
    ....
  28. pmc Birth weight, season of birth and postnatal growth do not predict levels of systemic inflammation in Gambian adults
    Anna A Richards
    Department of Population Health, Medical Research Council MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E, 7HT, UK
    Am J Hum Biol 25:457-64. 2013
    ..We used repeated measures of a comprehensive set of inflammatory markers to investigate the relationship between early life measures and systemic inflammation in an African population...
  29. pmc Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden
    Pa T Ngom
    Nutrition Programme, MRC Laboratories, The Gambia
    J Biomed Sci 18:41. 2011
    ..Here we report findings on the role of early life stressors as contributors to the onset of T cell immunological defects in later life...
  30. pmc Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children
    Sophie Hawkesworth
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 92:741-7. 2010
    ..Evidence suggests that increased maternal calcium intake during pregnancy may result in lower offspring blood pressure, prompting calls for more robust data in this field, particularly in settings of habitually low calcium intake...
  31. pmc Dietary supplementation of rural Gambian women during pregnancy does not affect body composition in offspring at 11-17 years of age
    Sophie Hawkesworth
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    J Nutr 138:2468-73. 2008
    ..These findings suggest that protein-energy supplements to pregnant women, compared with lactating women, do not affect offspring body composition during adolescence...
  32. ncbi request reprint Fifty-year mortality trends in three rural African villages
    Pura Rayco-Solon
    MRC Keneba, Banjul, The Gambia
    Trop Med Int Health 9:1151-60. 2004
    ..To determine differential improvements in mortality rates according to age, and to discuss differences in neonatal and post-neonatal mortality rates, using longitudinal data from the past 50 years in three rural Gambian villages...
  33. pmc Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development
    Liandré F van der Merwe
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 97:45-57. 2013
    ..Evidence has suggested that supplementary omega-3 (n-3) long-chain PUFAs (LC-PUFAs) might ameliorate this damage by reducing gastrointestinal inflammation. LC-PUFA supplementation may also benefit cognitive development...
  34. ncbi request reprint Low birth weight is associated with altered immune function in rural Bangladeshi children: a birth cohort study
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh
    Am J Clin Nutr 85:845-52. 2007
    ..Recent studies have shown that such exposure early in life may have long-term implications for later immunocompetence and susceptibility to infectious diseases...
  35. ncbi request reprint Maternal malnutrition and the risk of infection in later life
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Nestle Nutr Workshop Ser Pediatr Program 55:153-64; discussion 164-7. 2005
  36. pmc Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
    Paula Dominguez-Salas
    MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene and Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK
    Nat Commun 5:3746. 2014
    ..Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles. ..
  37. pmc Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects
    Paula Dominguez-Salas
    MRC International Nutrition Group, EPH NPHIR, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Proc Nutr Soc 71:154-65. 2012
    ..This may affect gene expression in the offspring. Further research is needed to examine the real impact of maternal nutrient availability on DNA methylation in the developing fetus...
  38. ncbi request reprint Nutritional status and childhood wheezing in rural Bangladesh
    Mohammad Delwer Hossain Hawlader
    1Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    Public Health Nutr 17:1570-7. 2014
    ..To investigate the association between current childhood nutritional status and current wheezing among pre-school children in rural Bangladesh...
  39. doi request reprint Microbes and the malnourished child
    Andrew M Prentice
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WCIE 7HT, UK
    Sci Transl Med 5:180fs11. 2013
    ..New research implicates a dysfunctional gut microbiome in the etiology of severe childhood malnutrition and confirms a role for antibiotics in its treatment...
  40. ncbi request reprint Insights from the developing world: thrifty genotypes and thrifty phenotypes
    Andrew M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Proc Nutr Soc 64:153-61. 2005
    ....
  41. ncbi request reprint Leptin and undernutrition
    Andrew M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, United Kingdom
    Nutr Rev 60:S56-67; discussion S68-84, 85-7. 2002
  42. pmc Observational study of vaccine efficacy 24 years after the start of hepatitis B vaccination in two Gambian villages: no need for a booster dose
    Maimuna Mendy
    Medical Research Council Laboratories, The Gambia, Banjul, The Gambia, West Africa
    PLoS ONE 8:e58029. 2013
    ..To determine the duration of protection from hepatitis B vaccine given in infancy and early childhood and asses risk factors for HBV infection and chronic infection...
  43. pmc Modification of immune function through exposure to dietary aflatoxin in Gambian children
    Paul C Turner
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, University of Leeds, Leeds, United Kingdom
    Environ Health Perspect 111:217-20. 2003
    ..Given the high burden of infection-related mortality in West Africa, further investigation of the immune effects of aflatoxin exposure in children is merited...
  44. pmc Early-life risk factors for adult chronic disease: follow-up of a cohort born during 1964-1978 in an urban slum of Lahore, Pakistan
    Fehmida Jalil
    Department of Social and Preventive Paediatrics, King Edward Medical College and Mayo Hospital, Lahore, Pakistan
    J Health Popul Nutr 26:12-21. 2008
    ..The results suggest that low birthweight may increase later risk of impaired glucose tolerance in urban Pakistani adults. Further research in this area is warranted...
  45. ncbi request reprint Plasma homocysteine, folate and vitamin B(12) compared between rural Gambian and UK adults
    Sophie E Moore
    Medical Research Council, Keneba, The Gambia
    Br J Nutr 96:508-15. 2006
    ..Possible reasons are discussed...