D N J Lockwood

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi request reprint Leprosy
    Warwick J Britton
    Centenary Institute of Cancer Medicine and Cell Biology and Department of Medicine, University of Sydney, NSW 2006, Australia
    Lancet 363:1209-19. 2004
  2. pmc Two randomized controlled clinical trials to study the effectiveness of prednisolone treatment in preventing and restoring clinical nerve function loss in leprosy: the TENLEP study protocols
    Inge Wagenaar
    Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Neurol 12:159. 2012
  3. pmc Comparing the clinical and histological diagnosis of leprosy and leprosy reactions in the INFIR cohort of Indian patients with multibacillary leprosy
    Diana N J Lockwood
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 6:e1702. 2012
  4. ncbi request reprint The diagnosis of leprosy is delayed in the United Kingdom
    D N Lockwood
    Hospital for Tropical Diseases, Mortimer Market, Capper Street, London WC1E 6AU, UK
    QJM 94:207-12. 2001
  5. ncbi request reprint Classifying leprosy patients--searching for the perfect solution?
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 78:317-20. 2007
  6. doi request reprint The histological diagnosis of leprosy type 1 reactions: identification of key variables and an analysis of the process of histological diagnosis
    D N J Lockwood
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    J Clin Pathol 61:595-600. 2008
  7. ncbi request reprint Commentary: leprosy and poverty
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
    Int J Epidemiol 33:269-70. 2004
  8. doi request reprint Human immunodeficiency virus and leprosy: an update
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, UK
    Dermatol Clin 29:125-8. 2011
  9. pmc Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort
    Diana N J Lockwood
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1327. 2011
  10. ncbi request reprint The detection of Mycobacterium leprae protein and carbohydrate antigens in skin and nerve from leprosy patients with type 1 (reversal) reactions
    Diana N J Lockwood
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Am J Trop Med Hyg 66:409-15. 2002

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Leprosy
    Warwick J Britton
    Centenary Institute of Cancer Medicine and Cell Biology and Department of Medicine, University of Sydney, NSW 2006, Australia
    Lancet 363:1209-19. 2004
    ..Thus, leprosy control activities must be maintained for decades to interrupt transmission of infection...
  2. pmc Two randomized controlled clinical trials to study the effectiveness of prednisolone treatment in preventing and restoring clinical nerve function loss in leprosy: the TENLEP study protocols
    Inge Wagenaar
    Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Neurol 12:159. 2012
    ....
  3. pmc Comparing the clinical and histological diagnosis of leprosy and leprosy reactions in the INFIR cohort of Indian patients with multibacillary leprosy
    Diana N J Lockwood
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 6:e1702. 2012
    ..The aim was to study correlations between clinical and histological diagnosis of reactions...
  4. ncbi request reprint The diagnosis of leprosy is delayed in the United Kingdom
    D N Lockwood
    Hospital for Tropical Diseases, Mortimer Market, Capper Street, London WC1E 6AU, UK
    QJM 94:207-12. 2001
    ..Leprosy can be difficult to diagnose outside endemic areas. Increased awareness amongst general practitioners and hospital specialists would lead to more rapid diagnosis, thus minimizing damage and disability...
  5. ncbi request reprint Classifying leprosy patients--searching for the perfect solution?
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 78:317-20. 2007
  6. doi request reprint The histological diagnosis of leprosy type 1 reactions: identification of key variables and an analysis of the process of histological diagnosis
    D N J Lockwood
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    J Clin Pathol 61:595-600. 2008
    ..Type 1 leprosy reactions (T1R) are a major inflammatory complication of leprosy affecting 30% of patients with borderline leprosy, but there has been no diagnostic evaluation of the histological diagnosis of this entity...
  7. ncbi request reprint Commentary: leprosy and poverty
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK
    Int J Epidemiol 33:269-70. 2004
  8. doi request reprint Human immunodeficiency virus and leprosy: an update
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, UK
    Dermatol Clin 29:125-8. 2011
    ..With regular new discoveries about the interaction of leprosy and HIV, the need to maintain research in this field is of considerable importance...
  9. pmc Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort
    Diana N J Lockwood
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1327. 2011
    ..This study characterised the cellular infiltrate in skin and nerve biopsies using light microscopic and immunohistochemical techniques to identify any association of cytokine markers, nerve and cell markers with leprosy reactions...
  10. ncbi request reprint The detection of Mycobacterium leprae protein and carbohydrate antigens in skin and nerve from leprosy patients with type 1 (reversal) reactions
    Diana N J Lockwood
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Am J Trop Med Hyg 66:409-15. 2002
    ..LAM also stained strongly and persisted after treatment. The possible roles of LAM and 65 kd in the cellular events of type 1 reactions are discussed...
  11. pmc Leprosy elimination-a virtual phenomenon or a reality?
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 324:1516-8. 2002
  12. pmc Leprosy: too complex a disease for a simple elimination paradigm
    Diana N J Lockwood
    London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 83:230-5. 2005
    ..It is also critical that broad-based research into this challenging disease continues until the problems are truly solved...
  13. pmc Single nucleotide polymorphism analysis of European archaeological M. leprae DNA
    Claire L Watson
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 4:e7547. 2009
    ..leprae ancient DNA (aDNA) from medieval bones and single nucleotide polymorphism (SNP) typed the DNA, this provides insight into the pattern of leprosy transmission in Europe and may assist in the understanding of M. leprae evolution...
  14. pmc Development and validation of a severity scale for leprosy type 1 reactions
    Stephen L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 2:e351. 2008
    ..To develop a valid and reliable quantitative measure of leprosy Type 1 reactions...
  15. doi request reprint Leprosy occurring as immune reconstitution syndrome
    Patricia D Deps
    Department of Social Medicine, Federal University of Espirito Santo, Vitoria ES, Brazil
    Trans R Soc Trop Med Hyg 102:966-8. 2008
    ..Although pathogenic mechanisms are still unclear, it is likely that leprosy-associated IRIS will be increasingly reported in those countries endemic for both diseases and as access to HAART becomes more widely available...
  16. pmc Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactions
    Anna K Andersson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E HTM, United Kingdom
    Infect Immun 73:3725-33. 2005
    ..This in vivo well-controlled study of the immunosuppressive effects of prednisolone showed that the drug does not switch off cytokine responses effectively...
  17. ncbi request reprint Clinical outcomes in a randomized controlled study comparing azathioprine and prednisolone versus prednisolone alone in the treatment of severe leprosy type 1 reactions in Nepal
    Sharon N S Marlowe
    London School of Hygiene and Tropical Medicine, Keppel Street, London W1CE 7HT, UK
    Trans R Soc Trop Med Hyg 98:602-9. 2004
    ....
  18. ncbi request reprint Leprosy: current diagnostic and treatment approaches
    Andrew P Ustianowski
    Hospital for Tropical Diseases, London, UK
    Curr Opin Infect Dis 16:421-7. 2003
    ..Leprosy remains an important problem globally and leprosy patients may present to physicians outside leprosy endemic areas. We review the recent biological and clinical advances in leprosy...
  19. ncbi request reprint Detection of IL-13, IL-10, and IL-6 in the leprosy skin lesions of patients during prednisolone treatment for type 1 (T1R) reactions
    Sara E Atkinson
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Int J Lepr Other Mycobact Dis 72:27-34. 2004
    ..Interestingly, some cytokine activity within the lesions was observed after 6 months of treatment...
  20. pmc Expression of CC and CXC chemokines and chemokine receptors in human leprosy skin lesions
    A A Kirkaldy
    Clinical Research Unit, Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Clin Exp Immunol 134:447-53. 2003
    ..These results suggest that the chemokines and their receptors, which are known to chemoattract T lymphocytes and macrophages, are involved in assembling the cellular infiltrate found in lesions across the leprosy spectrum...
  21. pmc Microsatellite mapping of Mycobacterium leprae populations in infected humans
    Saroj K Young
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    J Clin Microbiol 42:4931-6. 2004
    ..Comparison of skin and nerve lesions suggests that the evolution of disease within an individual involves the expansion of multiple distinct subpopulations of M. leprae...
  22. pmc Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India
    Saroj K Young
    Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 2:e214. 2008
    ..Genotypic tests that allow tracking of individual bacterial strains would strengthen epidemiological studies and contribute to our understanding of the disease...
  23. ncbi request reprint Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India
    Leonor Pocaterra
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 74:868-79. 2006
    ..Improved strategies for treatment and management of these reactions need to be developed...
  24. doi request reprint Towards understanding the pathology of erythema nodosum leprosum
    I P Kahawita
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trans R Soc Trop Med Hyg 102:329-37. 2008
    ..Co-stimulatory molecules such as B7-1 have also been studied but further work is needed to draw strong conclusions. We also highlight potential areas for future research...
  25. ncbi request reprint The clinical and immunological features of leprosy
    S L Walker
    Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Br Med Bull 77:103-21. 2006
    ..It is important that the manifestations of the condition are recognized as early as possible so that early nerve damage can be identified and treated rapidly...
  26. ncbi request reprint Leprosy type 1 (reversal) reactions and their management
    Stephen L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 79:372-86. 2008
    ..Searches were complete to the end of November 2008...
  27. doi request reprint The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions
    S L Walker
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Br J Dermatol 167:29-35. 2012
    ..Genetic studies have suggested that polymorphisms in toll-like receptors (TLRs) may affect the susceptibility of an individual with leprosy to developing Type 1 reactions...
  28. ncbi request reprint New world mucosal and cutaneous leishmaniasis: an emerging health problem among British travellers
    S D Lawn
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
    QJM 97:781-8. 2004
    ..Mucosal leishmaniasis (ML) is an important complication of new world cutaneous leishmaniasis (CL) caused by species of the Leishmania Viannia subgenus. Previous reports of ML among travellers to Latin America are few...
  29. ncbi request reprint Alteration of the cortisol-cortisone shuttle in leprosy type 1 reactions in leprosy patients in Hyderabad, India
    Anna K Andersson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Immunol Lett 109:72-5. 2007
    ..However in leprosy reactions this local response is insufficient and exogenous steroids are required to control inflammation...
  30. pmc Changing pattern of visceral leishmaniasis, United Kingdom, 1985-2004
    Aeesha N J Malik
    Hospital for Tropical Diseases, London WC1E 6AU, United Kingdom
    Emerg Infect Dis 12:1257-9. 2006
    ..Diagnosis was often delayed. Treatment with liposomal amphotericin B has improved prognosis. Visceral leishmaniasis should be made a reportable disease...
  31. ncbi request reprint Interactions between HIV infection and leprosy: a paradox
    Andrew P Ustianowski
    The Hospital for Tropical Diseases, London, UK
    Lancet Infect Dis 6:350-60. 2006
    ..The interactions between leprosy and HIV have been little studied and further research on the clinical, pathological, and management aspects of this coinfection is warranted...
  32. ncbi request reprint Impacts of the diagnosis of leprosy and of visible impairments amongst people affected by leprosy in Cebu, the Philippines
    Noriko Boku
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 81:111-20. 2010
    ..To quantify the impact of the diagnosis of leprosy and of visible impairments in people affected by leprosy...
  33. ncbi request reprint Response to ciclosporin treatment in Ethiopian and Nepali patients with severe leprosy Type 1 reactions
    S N S Marlowe
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Trans R Soc Trop Med Hyg 101:1004-12. 2007
    ..This suggests that Cn monotherapy is an effective treatment for severe T1R with few adverse effects. A dose of 5 mg/kg/day seems efficacious in Nepalis, but a higher dose may be required in Ethiopian patients...
  34. ncbi request reprint The role of thalidomide in the management of erythema nodosum leprosum
    Steven L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, UK
    Lepr Rev 78:197-215. 2007
    ..iii. A well designed trial comparing thalidomide with prednisolone. iv. The development of a safe and effective alternative to both steroids and thalidomide...
  35. ncbi request reprint Leprosy--a changing picture but a continuing challenge
    Diana N J Lockwood
    Trop Doct 35:65-7. 2005
  36. ncbi request reprint Antigenic trigger for type 1 reaction in leprosy
    Robert J Wilkinson
    Division of Medicine, Wellcome Trust Centre for Research Clinical Tropical Medicine, Imperial College London, 2nd Floor Wright Fleming Institute, Norfolk Place, London W2 1PG, UK
    J Infect 50:242-3. 2005
    ....
  37. ncbi request reprint Histopathological and clinical findings in leprosy patients with chronic neuropathic pain: a study from Hyderabad, India
    Caroline Lund
    Department of Neurology, Sentralsykehuset i Vestfold, Tønsberg, Norway
    Lepr Rev 78:369-80. 2007
    ..The reason why some leprosy patients develop it is unknown. In this study we evaluated the role of ongoing inflammation and small-fibre neuropathy as possible contributing factors for neuropathic pain...
  38. ncbi request reprint The INFIR Cohort Study: assessment of sensory and motor neuropathy in leprosy at baseline
    Wim H van Brakel
    Lepr Rev 76:277-95. 2005
    ..To compare different method(s) to detect peripheral neuropathy in leprosy and to study the validity of the monofilament test (MF) and the voluntary muscle test (VMT) as standard tests of nerve function...
  39. pmc Leprosy after starting antiretroviral treatment
    Stephen D Lawn
    BMJ 334:217-8. 2007
  40. ncbi request reprint A scale to assess the severity of leprosy reactions
    Wim H van Brakel
    Lepr Rev 78:161-4. 2007
  41. ncbi request reprint Neuropathic pain in leprosy
    Maija Haanpää
    Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Lepr Rev 75:7-18. 2004
    ..In this article the concept, clinical features and diagnosis of neuropathic pain are reviewed. The possible pathophysiological mechanisms, treatment challenges and research needs in this area are discussed...
  42. pmc Treatment of leprosy
    Diana N J Lockwood
    BMJ 328:1447-8. 2004
  43. ncbi request reprint Editor's choice June 2008
    Diana N J Lockwood
    Lepr Rev 79:123. 2008
  44. ncbi request reprint The INFIR Cohort Study: investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in north India
    Wim H van Brakel
    Royal Tropical Institute, Leprosy Unit, Amsterdam, The Netherlands
    Lepr Rev 76:14-34. 2005
    ..Patients with skin lesions overlying peripheral nerve trunks should be carefully monitored for development of sensory or motor impairment...