T Leslie

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi Rapid diagnostic tests to improve treatment of malaria and other febrile illnesses: patient randomised effectiveness trial in primary care clinics in Afghanistan
    Toby Leslie
    London School of Hygiene and Tropical Medicine, London, UK Health Protection and Research Organisation, Kabul, Afghanistan
    BMJ 348:g3730. 2014
  2. pmc An outbreak of hepatic veno-occlusive disease in Western afghanistan associated with exposure to wheat flour contaminated with pyrrolizidine alkaloids
    Faizullah Kakar
    Ministry of Public Health, Kabul, Afganistan
    J Toxicol 2010:313280. 2010
  3. pmc Prevalence and molecular basis of glucose-6-phosphate dehydrogenase deficiency in Afghan populations: implications for treatment policy in the region
    Toby Leslie
    HealthNet TPO, Kabul, Afghanistan
    Malar J 12:230. 2013
  4. pmc Overdiagnosis and mistreatment of malaria among febrile patients at primary healthcare level in Afghanistan: observational study
    Toby Leslie
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMJ 345:e4389. 2012
  5. pmc Field trial of three different Plasmodium vivax-detecting rapid diagnostic tests with and without evaporative cool box storage in Afghanistan
    Amy F W Mikhail
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:169. 2011
  6. pmc Subsidized sales of insecticide-treated nets in Afghan refugee camps demonstrate the feasibility of a transition from humanitarian aid towards sustainability
    Jan H Kolaczinski
    HealthNet International, University Town, P, O, Box 889, Peshawar, Pakistan
    Malar J 3:15. 2004
  7. doi Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan
    T Leslie
    Health Protection and Research Organisation, Kabul, Afghanistan
    Epidemiol Infect 139:728-35. 2011
  8. pmc The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan
    Toby Leslie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 7:e1000283. 2010
  9. pmc Epidemic of Plasmodium falciparum malaria involving substandard antimalarial drugs, Pakistan, 2003
    Toby Leslie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Emerg Infect Dis 15:1753-9. 2009
  10. ncbi Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial
    Toby Leslie
    HealthNet TPO Malaria and Leishmaniasis Control Programme, Peshawar, Northwest Frontier Province, Pakistan
    JAMA 297:2201-9. 2007

Collaborators

Detail Information

Publications19

  1. ncbi Rapid diagnostic tests to improve treatment of malaria and other febrile illnesses: patient randomised effectiveness trial in primary care clinics in Afghanistan
    Toby Leslie
    London School of Hygiene and Tropical Medicine, London, UK Health Protection and Research Organisation, Kabul, Afghanistan
    BMJ 348:g3730. 2014
    ..To assess the impact of rapid diagnostic tests on the diagnostic accuracy and treatment of malaria and non-severe fever in an Asian setting...
  2. pmc An outbreak of hepatic veno-occlusive disease in Western afghanistan associated with exposure to wheat flour contaminated with pyrrolizidine alkaloids
    Faizullah Kakar
    Ministry of Public Health, Kabul, Afganistan
    J Toxicol 2010:313280. 2010
    ..Eating a more varied diet including meat and fruit may be protective. Prevention and control measures will rely on community awareness and agricultural interventions to ensure safety of the food supply...
  3. pmc Prevalence and molecular basis of glucose-6-phosphate dehydrogenase deficiency in Afghan populations: implications for treatment policy in the region
    Toby Leslie
    HealthNet TPO, Kabul, Afghanistan
    Malar J 12:230. 2013
    ..This study assessed the prevalence and genotype of G6PD deficiency in Afghan populations and examined the need for routine G6PD testing as a malaria treatment and control tool...
  4. pmc Overdiagnosis and mistreatment of malaria among febrile patients at primary healthcare level in Afghanistan: observational study
    Toby Leslie
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMJ 345:e4389. 2012
    ..To assess the accuracy of malaria diagnosis and treatment at primary level clinics in Afghanistan...
  5. pmc Field trial of three different Plasmodium vivax-detecting rapid diagnostic tests with and without evaporative cool box storage in Afghanistan
    Amy F W Mikhail
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:169. 2011
    ..The potential for locally made evaporative cooling boxes (ECB) to protect the tests from heat damage in high summer temperatures was also investigated...
  6. pmc Subsidized sales of insecticide-treated nets in Afghan refugee camps demonstrate the feasibility of a transition from humanitarian aid towards sustainability
    Jan H Kolaczinski
    HealthNet International, University Town, P, O, Box 889, Peshawar, Pakistan
    Malar J 3:15. 2004
    ..Here we outline the strategy and document the progress to provide guidance for replication of similar approaches in other chronic refugee situations...
  7. doi Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan
    T Leslie
    Health Protection and Research Organisation, Kabul, Afghanistan
    Epidemiol Infect 139:728-35. 2011
    ..The study highlights the challenges of identifying infectious agents in low-resource settings; it is the first reported occurrence of plague in Afghanistan...
  8. pmc The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan
    Toby Leslie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 7:e1000283. 2010
    ..If the level of protection was sufficient, antirelapse therapy could become more widely available. We therefore tested the hypothesis that G6PD deficiency is protective against vivax malaria infection...
  9. pmc Epidemic of Plasmodium falciparum malaria involving substandard antimalarial drugs, Pakistan, 2003
    Toby Leslie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Emerg Infect Dis 15:1753-9. 2009
    ..However, chemical analysis of the drug showed that it was substandard. As global incidence decreases and epidemics become more of a threat, enhanced quality assurance of control interventions is essential...
  10. ncbi Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial
    Toby Leslie
    HealthNet TPO Malaria and Leishmaniasis Control Programme, Peshawar, Northwest Frontier Province, Pakistan
    JAMA 297:2201-9. 2007
    ..The antifolates are an important and affordable antimalarial class to which it is often assumed P vivax malaria is intrinsically resistant...
  11. pmc Knowledge, attitudes, and practices regarding avian influenza (H5N1), Afghanistan
    Toby Leslie
    Research Department, Afghan Public Health Institute, Ministry of Public Health, Kabul, Afghanistan
    Emerg Infect Dis 14:1459-61. 2008
    ..A survey conducted in 2 affected and 3 unaffected provinces found that greater knowledge about reducing exposure was associated with higher socioeconomic status, residence in affected provinces, and not owning backyard poultry...
  12. pmc A randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in Northwest Frontier Province, Pakistan
    Toby Leslie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 3:e2861. 2008
    ..Safe and effective use of PQ without the need for G6PD testing would be ideal. The efficacy and safety of an 8-week, once weekly PQ regimen was compared with current standard treatment (chloroquine alone) and a 14-day PQ regimen...
  13. ncbi Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan
    Naeem Durrani
    HealthNet International, Malaria and Leishmaniasis Control Programme, University Town, Peshawar, Pakistan
    Trop Med Int Health 10:521-9. 2005
    ..In Afghanistan, one option for slowing the spread of resistance and improving treatment outcomes is the use of artemisinin combination therapy (ACT)...
  14. pmc Spatial epidemiology of Plasmodium vivax, Afghanistan
    Simon Brooker
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Emerg Infect Dis 12:1600-2. 2006
    ..Remote sensing enabled development of a risk map, thereby providing a valuable tool to help guide malaria control strategies...
  15. pmc Deployment of ACT antimalarials for treatment of malaria: challenges and opportunities
    Christopher J M Whitty
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:S7. 2008
    ..The higher cost of ACT creates a market for fake drugs. Addressing these problems is now a priority. This review outlines current evidence, possible solutions and research priorities...
  16. pmc Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76
    Khalid Beshir
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 54:3714-6. 2010
    ..We provide in vivo data to support the in vitro correlation between pfcrt SVMNT and increased resistance to the metabolite of amodiaquine...
  17. ncbi Compliance with 14-day primaquine therapy for radical cure of vivax malaria--a randomized placebo-controlled trial comparing unsupervised with supervised treatment
    Toby Leslie
    HealthNet International, Peshawar, Pakistan
    Trans R Soc Trop Med Hyg 98:168-73. 2004
    ..Unsupervised treatment with 14-day PQ when combined with simple instruction can avert a significant amount of the morbidity associated with relapse in populations where G6PD deficiency is either absent or readily diagnosable...
  18. pmc Visceral leishmaniasis in Afghanistan
    Toby Leslie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    CMAJ 175:245. 2006
  19. pmc Risk factors for anthroponotic cutaneous Leishmaniasis at the household level in Kabul, Afghanistan
    Richard Reithinger
    HealthNet TPO, Kabul, Afghanistan
    PLoS Negl Trop Dis 4:e639. 2010
    ..ACL is a protozoan disease transmitted to humans by the bite of phlebotomine sand flies. Although not fatal, ACL can lead to considerable stigmatization of affected populations...