Stephen D Lawn

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. doi request reprint HIV-associated tuberculosis: relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Med 11:231. 2013
  2. pmc Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies
    Stephen D Lawn
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Infect Dis 13:407. 2013
  3. doi request reprint Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review
    Stephen D Lawn
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med 11:253. 2013
  4. pmc Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis
    S D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 17:636-43. 2013
  5. doi request reprint Diagnosis of pulmonary tuberculosis
    Stephen D Lawn
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Curr Opin Pulm Med 19:280-8. 2013
  6. pmc Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:1323-8. 2010
  7. ncbi request reprint Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    AIDS 21:335-41. 2007
  8. pmc Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e57907. 2013
  9. ncbi request reprint Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited
    Catherine Orrell
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Antivir Ther 12:83-8. 2007
  10. pmc Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    BMC Infect Dis 7:99. 2007

Detail Information

Publications64

  1. doi request reprint HIV-associated tuberculosis: relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Med 11:231. 2013
    ..We determined the relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays...
  2. pmc Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies
    Stephen D Lawn
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Infect Dis 13:407. 2013
    ..Finally, we consider how the assay could be used in combination with other assays and outline the types of studies that are required to build the evidence base concerning its use. ..
  3. doi request reprint Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review
    Stephen D Lawn
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Med 11:253. 2013
    ..We review the frequency and spectrum of adverse drug reactions and immune reconstitution inflammatory syndrome (IRIS) resulting from combined treatment, and highlight the challenges of managing HIV-associated drug-resistant TB...
  4. pmc Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis
    S D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 17:636-43. 2013
    ..Rapid means of ruling in or ruling out tuberculosis (TB) would permit more efficient management of patients starting antiretroviral treatment (ART)...
  5. doi request reprint Diagnosis of pulmonary tuberculosis
    Stephen D Lawn
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Curr Opin Pulm Med 19:280-8. 2013
    ..This review summarizes the recent literature on the developments in diagnostics for pulmonary tuberculosis (TB)...
  6. pmc Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:1323-8. 2010
    ....
  7. ncbi request reprint Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    AIDS 21:335-41. 2007
    ..To determine the burden and impact of immune reconstitution disease (IRD) associated with tuberculosis (TB) among patients initiating antiretroviral treatment (ART) in sub-Saharan Africa...
  8. pmc Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e57907. 2013
    ..To determine the proportion, characteristics and outcomes of patients who transfer-out from an antiretroviral therapy (ART) service in a South African township...
  9. ncbi request reprint Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited
    Catherine Orrell
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Antivir Ther 12:83-8. 2007
    ....
  10. pmc Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    BMC Infect Dis 7:99. 2007
    ..We studied determinants of ELISPOT responses among patients with advanced HIV infection (but without active TB) living in a South African community with very high TB notification rates...
  11. pmc Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e27763. 2011
    ..The time-point when the CD4+ count is assumed to change potentially biases effect estimates but methods used to estimate this are infrequently reported...
  12. pmc Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 23:1717-25. 2009
    ..To determine the short-term and long-term risks of tuberculosis (TB) associated with CD4 cell recovery during antiretroviral therapy (ART)...
  13. pmc Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers
    Sophia Pathai
    International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel Street, London WC1E 7HT, UK
    Mech Ageing Dev 134:338-45. 2013
    ..42 vs. 0.31, p=0.02) but not with frailty. Ocular parameters may aid in determining biological age, warranting investigation in longitudinal studies. ..
  14. pmc Prevalent and incident tuberculosis are independent risk factors for mortality among patients accessing antiretroviral therapy in South Africa
    Ankur Gupta
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e55824. 2013
    ..However, published data are contradictory as to whether TB is a risk factor for mortality that is independent of CD4 cell counts and other patient characteristics...
  15. pmc Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e25098. 2011
    ....
  16. pmc High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa
    Katharina Kranzer
    Department of Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e25244. 2011
    ..To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test..
  17. pmc Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Med 8:e1001067. 2011
    ..However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown...
  18. ncbi request reprint Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, and Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    AIDS 23:1875-80. 2009
    ..In one half of such patients, this assay could reduce the mean time to diagnosis by approximately 3 weeks. Furthermore, detectable urinary LAM may predict the development of TB immune reconstitution disease...
  19. pmc Tuberculosis incidence rates during 8 years of follow-up of an antiretroviral treatment cohort in South Africa: comparison with rates in the community
    Ankur Gupta
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e34156. 2012
    ..We compared these rates with those of HIV-uninfected individuals living in the same community...
  20. pmc Changing mortality risk associated with CD4 cell response to antiretroviral therapy in South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 23:335-42. 2009
    ..To determine the relationship between mortality risk and the CD4 cell response to antiretroviral therapy (ART)...
  21. ncbi request reprint Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, South Africa
    AIDS 20:1605-12. 2006
    ..To determine burden and risk factors for tuberculosis (TB) in an antiretroviral treatment (ART) programme and its impact on ART outcomes...
  22. pmc Indoor social networks in a South African township: potential contribution of location to tuberculosis transmission
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 7:e39246. 2012
    ..We therefore quantified time spent and contacts met in indoor locations and public transport by residents of a South African township with a very high TB burden...
  23. doi request reprint Increased ocular lens density in HIV-infected individuals with low nadir CD4 counts in South Africa: evidence of accelerated aging
    Sophia Pathai
    International Center for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    J Acquir Immune Defic Syndr 63:307-14. 2013
    ..The relationship of lens density measurements with clinical and demographic characteristics in HIV-infected individuals in comparison with a matched population of HIV-seronegative individuals was investigated...
  24. pmc Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa
    BMC Infect Dis 12:47. 2012
    ..However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse clinical populations. We therefore explored pathogen and host factors potentially impacting LAM detection...
  25. pmc Plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) and early mortality risk among patients enrolling for antiretroviral treatment in South Africa
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 7:41. 2007
    ..The practical utility of plasma suPAR in assessing short-term all-cause mortality risk was evaluated in patients with advanced immunodeficiency enrolling in an antiretroviral treatment (ART) programme in South Africa...
  26. doi request reprint Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test
    Stephen D Lawn
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 13:349-61. 2013
    ..A rapid, accurate point-of-care diagnostic test that is affordable and can be readily implemented is urgently needed. Investment in the tuberculosis diagnostics pipeline should remain a major priority for funders and researchers...
  27. doi request reprint Community viral load and CD4 count distribution among people living with HIV in a South African Township: implications for treatment as prevention
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Acquir Immune Defic Syndr 63:498-505. 2013
    ..This study aimed to describe CD4 count and VL distributions among HIV-infected individuals in a South African township to gain insights into the potential impact of ART scale-up on community HIV transmission risk...
  28. doi request reprint Clinical significance of lipoarabinomannan detection in urine using a low-cost point-of-care diagnostic assay for HIV-associated tuberculosis
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 26:1635-43. 2012
    ..We determined the characteristics and outcomes of such patients...
  29. pmc Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile HIV service in Cape Town, South Africa: a cross-sectional study
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    PLoS Med 9:e1001281. 2012
    ..This study aimed to assess feasibility, uptake, yield, treatment outcomes, and costs of adding an active tuberculosis case-finding program to an existing mobile HIV testing service...
  30. pmc Strategies to reduce early morbidity and mortality in adults receiving antiretroviral therapy in resource-limited settings
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Curr Opin HIV AIDS 5:18-26. 2010
    ..We focus on articles providing insights into this burden of disease and strategies to address it...
  31. pmc Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
    Graeme Meintjes
    Institute of Infectious Diseases and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 8:516-23. 2008
    ..It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data...
  32. pmc Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factors
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 55:e17-23. 2010
    ..To investigate antiretroviral treatment (ART) interruption in a long-term treatment cohort in South Africa...
  33. pmc Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting
    Motasim Badri
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 8:89. 2008
    ..However, the practical utility of CD4 cell count measurements as an alternative monitoring strategy has not been rigorously assessed...
  34. pmc Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa
    Katharina Kranzer
    Department of Medicine, Faculty of Health Sciences, The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e13801. 2010
    ..Programme reports typically focus on loss to follow-up and mortality among patients receiving ART. However, little is known about linkage and retention in care of individuals prior to starting ART...
  35. pmc Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:e1-8. 2011
    ..To assess sustainability of programmatic outcomes in a community-based antiretroviral therapy (ART) service in South Africa during 7 years of scale-up...
  36. pmc Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa
    BMC Infect Dis 12:21. 2012
    ..The present study therefore compared the treatment outcomes in adolescents with those of young adults at a public sector community-based ART programme in Cape Town, South Africa...
  37. doi request reprint Drug-resistant tuberculosis: time for visionary political leadership
    Ibrahim Abubakar
    Centre for Infectious Disease Epidemiology, Department of Infection and Population Health, University College London, London, UK
    Lancet Infect Dis 13:529-39. 2013
    ..Visionary political leadership is needed to curb the rise of MDR and XDR tuberculosis worldwide, through sustained funding and the implementation of global and regional action plans...
  38. pmc Frailty in HIV-infected adults in South Africa
    Sophia Pathai
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Acquir Immune Defic Syndr 62:43-51. 2013
    ..We determined the prevalence and predictors of frailty in a population of HIV-infected individuals in South Africa...
  39. ncbi request reprint Determinants of mortality and nondeath losses from an antiretroviral treatment service in South Africa: implications for program evaluation
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 43:770-6. 2006
    ..Understanding the determinants of key outcome measures--including death and nondeath losses--would assist in program evaluation and development...
  40. pmc Temporal association between incident tuberculosis and poor virological outcomes in a South African antiretroviral treatment service
    Ankur Gupta-Wright
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom and The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 64:261-70. 2013
    ..The temporal relationship between incident tuberculosis (TB) and virological outcomes during antiretroviral therapy (ART) is poorly defined. This was studied in a cohort in Cape Town, South Africa...
  41. doi request reprint Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Cape Town, South Africa
    Lancet Infect Dis 10:489-98. 2010
    ..Data from randomised controlled trials are needed to underpin further development of public-health policy...
  42. pmc Delays in starting antiretroviral therapy in patients with HIV-associated tuberculosis accessing non-integrated clinical services in a South African township
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 11:258. 2011
    ..We examined the timing of ART among patients receiving care provided by non-integrated TB and ART services in Cape Town, South Africa...
  43. pmc Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa
    Joseph N Jarvis
    Department of Medicine, Division of Infectious Diseases, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 48:856-62. 2009
    ..Screening for cryptococcal antigen in patients who enroll in ART programs may identify those at risk of cryptococcal meningitis and permit targeted use of preemptive therapy...
  44. pmc Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing
    Sophia Pathai
    International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel Street, London WC1E 7HT, UK Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa Electronic address
    Mech Ageing Dev 134:400-6. 2013
    ..Longitudinal studies are warranted to assess the integration of retinal vascular calibre and lens density with systemic markers to develop an overall index of biological ageing in HIV infection. ..
  45. pmc An incentivized HIV counseling and testing program targeting hard-to-reach unemployed men in Cape Town, South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 59:e28-34. 2012
    ..Innovative strategies are needed to increase uptake of testing among men. This study assessed the effectiveness of incentivized mobile HCT in reaching unemployed men in Cape Town, South Africa...
  46. pmc Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa
    Stephen D Lawn
    The Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 57:136-40. 2011
    ..7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines...
  47. pmc Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Infect Dis 204:S1159-67. 2011
    ..Further development and implementation of these tools is vital to permit rapid and effective screening for TB in ART services, which is an essential component of patient care...
  48. ncbi request reprint Provider-initiated HIV testing increases access of patients with HIV-associated tuberculosis to antiretroviral treatment
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 101:258-62. 2011
    ..We sought to determine the impact of the introduction of provider-initiated HIV-testing in TB clinics in 2005 on subsequent referrals of patients with HIV-associated TB at a community-based ART service in Cape Town...
  49. pmc Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study
    Sophia Pathai
    International Centre for Eye Health, Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e57422. 2013
    ..We assessed features of the corneal endothelium that are known to be associated with biological aging, and cellular senescence markers in HIV-infected adults...
  50. doi request reprint Antiretroviral treatment uptake in patients with HIV-associated TB attending co-located TB and ART services
    Mweete Debra Nglazi
    University of Cape Town, South Africa
    S Afr Med J 102:936-9. 2012
    ..Delivery of integrated care for patients with HIV-associated TB is challenging. We assessed the uptake and timing of antiretroviral treatment (ART) among eligible patients attending a primary care service with co-located ART and TB clinics...
  51. ncbi request reprint Tuberculosis control in South Africa--will HAART help?
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa
    S Afr Med J 96:502-4. 2006
  52. pmc Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control
    Robin Wood
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, UCT Observatory, Cape Town 7925, South Africa
    Am J Respir Crit Care Med 175:87-93. 2007
    ..We conducted a cross-sectional survey of pulmonary TB (PTB) and HIV infection in a community of 13,000 with high HIV prevalence and high TB notification rate and a well-functioning DOTS TB control program...
  53. pmc Tuberculosis transmission to young children in a South African community: modeling household and community infection risks
    Robin Wood
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Faculty of Health Sciences, Cape Town, South Africa
    Clin Infect Dis 51:401-8. 2010
    ..A model was used to explore the interactions between prevalence of adult tuberculosis infection, adult-to-child contacts, and household ventilation, which could result in such a high annual risk of tuberculosis infection...
  54. pmc Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions
    Lewis J Haddow
    Division of Immunology, Infection and Inflammatory Disease, King s College London, London, UK
    Lancet Infect Dis 10:791-802. 2010
    ..As for definitions of tuberculosis-associated IRIS, definitions for cryptococcal IRIS should be regarded as preliminary until further insights into the immunopathology of IRIS permit their refinement...
  55. doi request reprint Optimum time to start antiretroviral therapy in patients with HIV-associated tuberculosis: before or after tuberculosis diagnosis?
    Andrew D Kerkhoff
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    AIDS 25:1003-6. 2011
    ....
  56. pmc Differing spectrum of HIV-associated ophthalmic disease among patients starting antiretroviral therapy in India and South Africa
    Sophia Pathai
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 16:356-9. 2011
    ..This difference persisted after adjusting for confounding factors (adjusted odds ratio=11.32, 95% confidence interval: 2.67-48.13), confirming a marked geographical difference in the prevalence of HIV-associated retinal disease...
  57. pmc Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 10:93-102. 2010
    ..Concerted action is needed to develop intensified case finding as an important method for control of tuberculosis...
  58. pmc Characteristics and early outcomes of patients with Xpert MTB/RIF-negative pulmonary tuberculosis diagnosed during screening before antiretroviral therapy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Rd, Observatory 7925, Cape Town, South Africa
    Clin Infect Dis 54:1071-9. 2012
    ..We determined the characteristics and early ART program outcomes of such patients...
  59. pmc High diagnostic yield of tuberculosis from screening urine samples from HIV-infected patients with advanced immunodeficiency using the Xpert MTB/RIF assay
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 60:289-94. 2012
    ..Urine Xpert testing provides a means of rapid TB diagnosis in patients with advanced immunodeficiency and poor prognosis. These data are indicative of high rates of TB dissemination and renal involvement in this clinical population...
  60. pmc Antiretroviral treatment as prevention: impact of the 'test and treat' strategy on the tuberculosis epidemic
    Robin Wood
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Curr HIV Res 9:383-92. 2011
    ..In this paper we explore the expected "TB dividend" of wider access to ART and also explore the potential of the "test and treat" strategy to impact on TB transmission, particularly in the heavily burdened setting of sub- Saharan Africa...
  61. pmc Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 12:201-9. 2012
    ..We assessed the diagnostic accuracy of a urine antigen test Determine TB-LAM Ag (Determine TB-LAM; Alere, Waltham, MA, USA) for screening for HIV-associated pulmonary tuberculosis before antiretroviral therapy (ART)...
  62. doi request reprint Drug-resistant tuberculosis--current dilemmas, unanswered questions, challenges, and priority needs
    Alimuddin Zumla
    University College London, Centre for Clinical Microbiology, Division of Infection and Immunity, London, UK
    J Infect Dis 205:S228-40. 2012
    ....
  63. pmc Immune reconstitution and "unmasking" of tuberculosis during antiretroviral therapy
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Am J Respir Crit Care Med 177:680-5. 2008
    ....
  64. pmc Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review
    Stephen D Lawn
    University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:103. 2012
    ..Whether this might be related to the assay itself or to the challenges associated with study design is discussed...