Katharina Kranzer

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. doi request reprint Community viral load and CD4 count distribution among people living with HIV in a South African Township: implications for treatment as prevention
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Acquir Immune Defic Syndr 63:498-505. 2013
  2. doi request reprint The benefits to communities and individuals of screening for active tuberculosis disease: a systematic review
    K Kranzer
    Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Int J Tuberc Lung Dis 17:432-46. 2013
  3. doi request reprint Unstructured treatment interruption of antiretroviral therapy in clinical practice: a systematic review
    Katharina Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 16:1297-313. 2011
  4. pmc Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile HIV service in Cape Town, South Africa: a cross-sectional study
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    PLoS Med 9:e1001281. 2012
  5. pmc Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review
    Katharina Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom
    J Int AIDS Soc 15:17383. 2012
  6. pmc Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e27763. 2011
  7. pmc Incentivized recruitment of a population sample to a mobile HIV testing service increases the yield of newly diagnosed cases, including those in need of antiretroviral therapy
    K Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    HIV Med 13:132-7. 2012
  8. doi request reprint Quality of induced sputum using a human-powered nebuliser in a mobile human immunodeficiency virus testing service in South Africa
    K Kranzer
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:1077-81. 2011
  9. pmc Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa
    Katharina Kranzer
    Department of Medicine, Faculty of Health Sciences, The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e13801. 2010
  10. pmc Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 10:93-102. 2010

Detail Information

Publications33

  1. doi request reprint Community viral load and CD4 count distribution among people living with HIV in a South African Township: implications for treatment as prevention
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Acquir Immune Defic Syndr 63:498-505. 2013
    ..This study aimed to describe CD4 count and VL distributions among HIV-infected individuals in a South African township to gain insights into the potential impact of ART scale-up on community HIV transmission risk...
  2. doi request reprint The benefits to communities and individuals of screening for active tuberculosis disease: a systematic review
    K Kranzer
    Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Int J Tuberc Lung Dis 17:432-46. 2013
    ..Before screening programmes are recommended, evidence is needed of individual and/or community-level benefits...
  3. doi request reprint Unstructured treatment interruption of antiretroviral therapy in clinical practice: a systematic review
    Katharina Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 16:1297-313. 2011
    ..To characterize the frequency, reasons, risk factors, and consequences of unstructured anti-retroviral treatment interruptions...
  4. pmc Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile HIV service in Cape Town, South Africa: a cross-sectional study
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    PLoS Med 9:e1001281. 2012
    ..This study aimed to assess feasibility, uptake, yield, treatment outcomes, and costs of adding an active tuberculosis case-finding program to an existing mobile HIV testing service...
  5. pmc Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review
    Katharina Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom
    J Int AIDS Soc 15:17383. 2012
    ..This review aims to quantify patients along the continuum of care in sub-Saharan Africa and review possible interventions...
  6. pmc Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods
    Katharina Kranzer
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e27763. 2011
    ..The time-point when the CD4+ count is assumed to change potentially biases effect estimates but methods used to estimate this are infrequently reported...
  7. pmc Incentivized recruitment of a population sample to a mobile HIV testing service increases the yield of newly diagnosed cases, including those in need of antiretroviral therapy
    K Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    HIV Med 13:132-7. 2012
    ....
  8. doi request reprint Quality of induced sputum using a human-powered nebuliser in a mobile human immunodeficiency virus testing service in South Africa
    K Kranzer
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:1077-81. 2011
    ..To investigate the quality of induced sputum samples using a human-powered (HPN) and an electric-powered nebuliser (EPN)...
  9. pmc Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa
    Katharina Kranzer
    Department of Medicine, Faculty of Health Sciences, The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 5:e13801. 2010
    ..Programme reports typically focus on loss to follow-up and mortality among patients receiving ART. However, little is known about linkage and retention in care of individuals prior to starting ART...
  10. pmc Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 10:93-102. 2010
    ..Concerted action is needed to develop intensified case finding as an important method for control of tuberculosis...
  11. pmc Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factors
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 55:e17-23. 2010
    ..To investigate antiretroviral treatment (ART) interruption in a long-term treatment cohort in South Africa...
  12. doi request reprint Individual, household and community factors associated with HIV test refusal in rural Malawi
    Katharina Kranzer
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:1341-50. 2008
    ..To investigate individual, household and community factors associated with HIV test refusal in a counselling and testing programme offered at population level in rural Malawi...
  13. pmc High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa
    Katharina Kranzer
    Department of Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e25244. 2011
    ..To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test..
  14. pmc Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:1323-8. 2010
    ....
  15. ncbi request reprint Estimating the need for antiretroviral treatment and an assessment of a simplified HIV/AIDS case definition in rural Malawi
    Nuala McGrath
    London School of Hygiene and Tropical Medicine, London, UK
    AIDS 21:S105-13. 2007
    ..We estimated HIV prevalence and assessed field staging of individuals to estimate the burden of HIV disease needing treatment in rural Malawi...
  16. pmc Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 56:e1-8. 2011
    ..To assess sustainability of programmatic outcomes in a community-based antiretroviral therapy (ART) service in South Africa during 7 years of scale-up...
  17. pmc Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa
    BMC Infect Dis 12:21. 2012
    ..The present study therefore compared the treatment outcomes in adolescents with those of young adults at a public sector community-based ART programme in Cape Town, South Africa...
  18. pmc An incentivized HIV counseling and testing program targeting hard-to-reach unemployed men in Cape Town, South Africa
    Mweete D Nglazi
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 59:e28-34. 2012
    ..Innovative strategies are needed to increase uptake of testing among men. This study assessed the effectiveness of incentivized mobile HCT in reaching unemployed men in Cape Town, South Africa...
  19. pmc What happens to ART-eligible patients who do not start ART? Dropout between screening and ART initiation: a cohort study in Karonga, Malawi
    Nuala McGrath
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Public Health 10:601. 2010
    ..We aimed to investigate the outcome of those who are eligible but do not start ART in the Malawi programme, factors associated with this dropout, and reasons for not starting treatment, in a prospective cohort study...
  20. ncbi request reprint Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, and Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    AIDS 23:1875-80. 2009
    ..In one half of such patients, this assay could reduce the mean time to diagnosis by approximately 3 weeks. Furthermore, detectable urinary LAM may predict the development of TB immune reconstitution disease...
  21. pmc Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Med 8:e1001067. 2011
    ..However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown...
  22. ncbi request reprint Provider-initiated HIV testing increases access of patients with HIV-associated tuberculosis to antiretroviral treatment
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
    S Afr Med J 101:258-62. 2011
    ..We sought to determine the impact of the introduction of provider-initiated HIV-testing in TB clinics in 2005 on subsequent referrals of patients with HIV-associated TB at a community-based ART service in Cape Town...
  23. doi request reprint Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Cape Town, South Africa
    Lancet Infect Dis 10:489-98. 2010
    ..Data from randomised controlled trials are needed to underpin further development of public-health policy...
  24. pmc Linkage to HIV care from a mobile testing unit in South Africa by different CD4 count strata
    Darshini Govindasamy
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    J Acquir Immune Defic Syndr 58:344-52. 2011
    ..The linkage and barriers of linkage to facility-based HIV care from a mobile HIV testing unit have not previously been described...
  25. pmc Treatment interruption and variation in tablet taking behaviour result in viral failure: a case-control study from Cape Town, South Africa
    Lisa Noelle Ncaca
    Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e23088. 2011
    ..Understanding of the impact of non-structured treatment interruption (TI) and variation in tablet-taking on failure of first-line antiretroviral therapy (ART) is limited in a resource-poor setting...
  26. doi request reprint Risk factors, barriers and facilitators for linkage to antiretroviral therapy care: a systematic review
    Darshini Govindasamy
    Medecins Sans Frontieres, Cape Town, South Africa
    AIDS 26:2059-67. 2012
    ..To characterize patient and programmatic factors associated with retention in care during the pre-antiretroviral therapy (ART) period and linkage to ART care...
  27. doi request reprint Early initiation of antiretroviral therapy and associated reduction in mortality, morbidity and defaulting in a nurse-managed, community cohort in Lesotho
    Nathan Ford
    Medecins Sans Frontieres, University of Cape Town, South Africa
    AIDS 24:2645-50. 2010
    ..Lesotho has supported earlier initiation since 2008. We assessed outcomes comparing early (CD4 cell counts >200 cells/μl) and late (CD4 cell counts ≤200 cells/μl) initiation...
  28. pmc Linkage to HIV, TB and non-communicable disease care from a mobile testing unit in Cape Town, South Africa
    Darshini Govindasamy
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS ONE 8:e80017. 2013
    ..HIV counseling and testing may serve as an entry point for non-communicable disease screening...
  29. pmc Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe
    Helen Bygrave
    Southern Africa Medical Unit, Medecins Sans Frontieres, Cape Town, South Africa
    PLoS ONE 7:e52856. 2012
    ..70, 95%CI 1.62-4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults...
  30. pmc Antiretroviral therapy for control of the HIV-associated tuberculosis epidemic in resource-limited settings
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
    Clin Chest Med 30:685-99, viii. 2009
    ..This article provides an in-depth review of these issues...
  31. doi request reprint Strengthening the HIV cascade to ensure an effective future ART response in sub-Saharan Africa
    Darshini Govindasamy
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Trans R Soc Trop Med Hyg 108:1-3. 2014
    ..A combined package of interventions found to be effective in the pre-ART and ART period might be effective for reducing attrition in both periods. Further operational research in this area is needed to identify local solutions. ..
  32. doi request reprint Safety of efavirenz in first-trimester of pregnancy: a systematic review and meta-analysis of outcomes from observational cohorts
    Nathan Ford
    Medecins Sans Frontieres, University of Cape Town, Cape Town, South Africa
    AIDS 24:1461-70. 2010
    ..Data on efavirenz safety in first trimester pregnancy are conflicting. We conducted a systematic review and meta-analysis of the available evidence from observational cohorts...
  33. pmc Systematic review of TST responses in people living with HIV in under-resourced settings: implications for isoniazid preventive therapy
    Andrew D Kerkhoff
    School of Medicine and Health Sciences, The George Washington University, Washington DC, USA
    PLoS ONE 7:e49928. 2012
    ..However, it is not known what proportions of patients will benefit from IPT if implemented without targeting according to TST status. We therefore determined the proportions of PLWH who test TST-positive...