Research Topics
| Katharina KranzerSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
| Collaborators
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Detail Information
Publications
The benefits to communities and individuals of screening for active tuberculosis disease: a systematic reviewK Kranzer
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Int J Tuberc Lung Dis 17:432-46. 2013..Before screening programmes are recommended, evidence is needed of individual and/or community-level benefits...- Unstructured treatment interruption of antiretroviral therapy in clinical practice: a systematic reviewKatharina Kranzer
Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 16:1297-313. 2011..To characterize the frequency, reasons, risk factors, and consequences of unstructured anti-retroviral treatment interruptions... 
Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile HIV service in Cape Town, South Africa: a cross-sectional studyKatharina Kranzer
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
PLoS Med 9:e1001281. 2012..This study aimed to assess feasibility, uptake, yield, treatment outcomes, and costs of adding an active tuberculosis case-finding program to an existing mobile HIV testing service...- Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic reviewKatharina Kranzer
Department of Clinical Research, London School of Hygiene and Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom
J Int AIDS Soc 15:17383. 2012..This review aims to quantify patients along the continuum of care in sub-Saharan Africa and review possible interventions... - Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methodsKatharina Kranzer
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 6:e27763. 2011..The time-point when the CD4+ count is assumed to change potentially biases effect estimates but methods used to estimate this are infrequently reported... - Incentivized recruitment of a population sample to a mobile HIV testing service increases the yield of newly diagnosed cases, including those in need of antiretroviral therapyK Kranzer
Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
HIV Med 13:132-7. 2012.... - Individual, household and community factors associated with HIV test refusal in rural MalawiKatharina Kranzer
London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 13:1341-50. 2008..To investigate individual, household and community factors associated with HIV test refusal in a counselling and testing programme offered at population level in rural Malawi... - Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysisKatharina Kranzer
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Lancet Infect Dis 10:93-102. 2010..Concerted action is needed to develop intensified case finding as an important method for control of tuberculosis... - High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South AfricaKatharina Kranzer
Department of Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 6:e25244. 2011..To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test.. - Linkage to HIV care and antiretroviral therapy in Cape Town, South AfricaKatharina Kranzer
Department of Medicine, Faculty of Health Sciences, The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
PLoS ONE 5:e13801. 2010..Programme reports typically focus on loss to follow-up and mortality among patients receiving ART. However, little is known about linkage and retention in care of individuals prior to starting ART... - Quality of induced sputum using a human-powered nebuliser in a mobile human immunodeficiency virus testing service in South AfricaK Kranzer
Department of Medicine, University of Cape Town, Cape Town, South Africa
Int J Tuberc Lung Dis 15:1077-81. 2011..To investigate the quality of induced sputum samples using a human-powered (HPN) and an electric-powered nebuliser (EPN)... - Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factorsKatharina Kranzer
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
J Acquir Immune Defic Syndr 55:e17-23. 2010..To investigate antiretroviral treatment (ART) interruption in a long-term treatment cohort in South Africa... - Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategyStephen D Lawn
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
AIDS 24:1323-8. 2010.... 
Estimating the need for antiretroviral treatment and an assessment of a simplified HIV/AIDS case definition in rural MalawiNuala McGrath
London School of Hygiene and Tropical Medicine, London, UK
AIDS 21:S105-13. 2007..We estimated HIV prevalence and assessed field staging of individuals to estimate the burden of HIV disease needing treatment in rural Malawi...- Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South AfricaMweete D Nglazi
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa
BMC Infect Dis 12:21. 2012..The present study therefore compared the treatment outcomes in adolescents with those of young adults at a public sector community-based ART programme in Cape Town, South Africa... - An incentivized HIV counseling and testing program targeting hard-to-reach unemployed men in Cape Town, South AfricaMweete D Nglazi
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, and the Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
J Acquir Immune Defic Syndr 59:e28-34. 2012..Innovative strategies are needed to increase uptake of testing among men. This study assessed the effectiveness of incentivized mobile HCT in reaching unemployed men in Cape Town, South Africa... - Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South AfricaMweete D Nglazi
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
J Acquir Immune Defic Syndr 56:e1-8. 2011..To assess sustainability of programmatic outcomes in a community-based antiretroviral therapy (ART) service in South Africa during 7 years of scale-up... - What happens to ART-eligible patients who do not start ART? Dropout between screening and ART initiation: a cohort study in Karonga, MalawiNuala McGrath
London School of Hygiene and Tropical Medicine, London, UK
BMC Public Health 10:601. 2010..We aimed to investigate the outcome of those who are eligible but do not start ART in the Malawi programme, factors associated with this dropout, and reasons for not starting treatment, in a prospective cohort study... - Provider-initiated HIV testing increases access of patients with HIV-associated tuberculosis to antiretroviral treatmentStephen D Lawn
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town
S Afr Med J 101:258-62. 2011..We sought to determine the impact of the introduction of provider-initiated HIV-testing in TB clinics in 2005 on subsequent referrals of patients with HIV-associated TB at a community-based ART service in Cape Town... - Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution diseaseStephen D Lawn
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, and Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
AIDS 23:1875-80. 2009..In one half of such patients, this assay could reduce the mean time to diagnosis by approximately 3 weeks. Furthermore, detectable urinary LAM may predict the development of TB immune reconstitution disease... - Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resourcesStephen D Lawn
Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Cape Town, South Africa
Lancet Infect Dis 10:489-98. 2010..Data from randomised controlled trials are needed to underpin further development of public-health policy... - Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective studyStephen D Lawn
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
PLoS Med 8:e1001067. 2011..However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown... - Linkage to HIV care from a mobile testing unit in South Africa by different CD4 count strataDarshini Govindasamy
Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
J Acquir Immune Defic Syndr 58:344-52. 2011..The linkage and barriers of linkage to facility-based HIV care from a mobile HIV testing unit have not previously been described... - Risk factors, barriers and facilitators for linkage to antiretroviral therapy care: a systematic reviewDarshini Govindasamy
Medecins Sans Frontieres, Cape Town, South Africa
AIDS 26:2059-67. 2012..To characterize patient and programmatic factors associated with retention in care during the pre-antiretroviral therapy (ART) period and linkage to ART care... - Early initiation of antiretroviral therapy and associated reduction in mortality, morbidity and defaulting in a nurse-managed, community cohort in LesothoNathan Ford
Medecins Sans Frontieres, University of Cape Town, South Africa
AIDS 24:2645-50. 2010..Lesotho has supported earlier initiation since 2008. We assessed outcomes comparing early (CD4 cell counts >200 cells/μl) and late (CD4 cell counts ≤200 cells/μl) initiation... - Treatment interruption and variation in tablet taking behaviour result in viral failure: a case-control study from Cape Town, South AfricaLisa Noelle Ncaca
Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa
PLoS ONE 6:e23088. 2011..Understanding of the impact of non-structured treatment interruption (TI) and variation in tablet-taking on failure of first-line antiretroviral therapy (ART) is limited in a resource-poor setting... - Antiretroviral therapy for control of the HIV-associated tuberculosis epidemic in resource-limited settingsStephen D Lawn
The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Clin Chest Med 30:685-99, viii. 2009..This article provides an in-depth review of these issues... - Antiretroviral therapy outcomes among adolescents and youth in rural ZimbabweHelen Bygrave
Southern Africa Medical Unit, Medecins Sans Frontieres, Cape Town, South Africa
PLoS ONE 7:e52856. 2012..70, 95%CI 1.62-4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults... - Safety of efavirenz in first-trimester of pregnancy: a systematic review and meta-analysis of outcomes from observational cohortsNathan Ford
Medecins Sans Frontieres, University of Cape Town, Cape Town, South Africa
AIDS 24:1461-70. 2010..Data on efavirenz safety in first trimester pregnancy are conflicting. We conducted a systematic review and meta-analysis of the available evidence from observational cohorts... - Systematic review of TST responses in people living with HIV in under-resourced settings: implications for isoniazid preventive therapyAndrew D Kerkhoff
School of Medicine and Health Sciences, The George Washington University, Washington DC, USA
PLoS ONE 7:e49928. 2012..However, it is not known what proportions of patients will benefit from IPT if implemented without targeting according to TST status. We therefore determined the proportions of PLWH who test TST-positive...