J M Kelly
Affiliation: London School of Hygiene and Tropical Medicine
- Kelly J, McRobert L, Baker D. Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. Proc Natl Acad Sci U S A. 2006;103:6706-11 pubmed..These unusual properties suggest that P. falciparum chromosomes contain a class of "regional" centromere distinct from those described in other eukaryotes, including the human host. ..
- Francisco A, Lewis M, Jayawardhana S, Taylor M, Chatelain E, Kelly J. Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrob Agents Chemother. 2015;59:4653-61 pubmed publisher..This in vivo screening model for Chagas disease is predictive, reproducible and adaptable to diverse treatment schedules. It should provide greater assurance that drugs are not advanced prematurely into clinical trial. ..
- Ghashghaei O, Kielland N, Revés M, Taylor M, Kelly J, Di Pietro O, et al. Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases. Molecules. 2018;23: pubmed publisher..cruzi, with excellent selectivity indexes and favorable molecular properties, thereby emerging as promising hits for the treatment of Chagas disease and sleeping sickness. ..
- Campos M, Phelan J, Francisco A, Taylor M, Lewis M, Pain A, et al. Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. Sci Rep. 2017;7:14407 pubmed publisher..cruzi, demonstrate that this can result in multi-drug resistance, and indicate that vigilance will be required if benznidazole is used in combination therapy. ..