Affiliation: London School of Hygiene and Tropical Medicine
Horn D. Nuclear gene transcription and chromatin in Trypanosoma brucei. Int J Parasitol. 2001;31:1157-65 pubmed
..Here, I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins. ..
..These enzymes are now being characterised and assessed for chemotherapeutic potential. ..
Horn D. Directional enrichment of directly cloned PCR products. Biotechniques. 2005;39:40, 42, 44, 46 pubmed
Horn D. Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. BMC Genomics. 2008;9:2 pubmed publisher
..The findings reveal how trypanosomatids may compensate for a paucity of canonical Pol II promoters and subsequent widespread constitutive RNA polymerase II transcription. ..
Horn D, McCulloch R. Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Curr Opin Microbiol. 2010;13:700-5 pubmed publisher
..We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation...