Research Topics
| Anneke C HesselingSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
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Detail Information
Publications
The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected childrenAnneke C Hesseling
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg, 7505, South Africa
Vaccine 25:14-8. 2007..We estimate the risk of disseminated BCG disease in HIV-infected children in a setting highly endemic for tuberculosis and HIV...
Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 casesH Simon Schaaf
Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
BMC Infect Dis 7:140. 2007..The clinical, radiological and microbiological features of culture-confirmed childhood tuberculosis diagnosed at two referral hospitals are described...
Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitisFreda Maree
Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa
Pediatr Infect Dis J 26:13-8. 2007..We investigated mycobacterial genotypic diversity in children with TBM and analyzed the relationship among genotype, clinical presentation and outcome...
Childhood drug-resistant tuberculosis in the Western Cape Province of South AfricaH Simon Schaaf
Department of Paediatrics and Child Health, Tygerberg Children s Hospital and Stellenbosh University, Tygerberg, South Africa
Acta Paediatr 95:523-8. 2006..Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics...
Use of light-emitting diode fluorescence microscopy to detect acid-fast bacilli in sputumBen J Marais
Desmond Tutu TB Centre, Cape Town, South Africa
Clin Infect Dis 47:203-7. 2008..We evaluated the diagnostic performance of fluorescence microscopy, using novel light-emitting diode (LED) technology as an alternative to the conventional mercury vapor lamp (MVP)...
Radiographic signs and symptoms in children treated for tuberculosis: possible implications for symptom-based screening in resource-limited settingsBen J Marais
Desmond Tutu TB Centre and the Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
Pediatr Infect Dis J 25:237-40. 2006....
Paediatric use of second-line anti-tuberculosis agents: a reviewJames A Seddon
Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
Tuberculosis (Edinb) 92:9-17. 2012..This article reviews the available second-line drugs currently used in the treatment of MDR-TB in children and discusses medication properties and adverse effects while potential interactions with antiretroviral therapy are explored...
Operational challenges in managing Isoniazid Preventive Therapy in child contacts: a high-burden setting perspectiveSusan S van Wyk
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
BMC Public Health 11:544. 2011..We describe the management of children under five years of age in household contact with a smear and/or culture-positive adult TB case...
A refined symptom-based approach to diagnose pulmonary tuberculosis in childrenBen J Marais
Desmond Tutu Tuberculosis Centre and Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
Pediatrics 118:e1350-9. 2006..This study aimed to determine the value of well-defined symptoms to diagnose childhood pulmonary tuberculosis in a tuberculosis-endemic area...
Surveillance of antituberculosis drug resistance among children from the Western Cape Province of South Africa--an upward trendH Simon Schaaf
Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
Am J Public Health 99:1486-90. 2009..We assessed the prevalence of antituberculosis drug resistance among children with tuberculosis (TB) in the Western Cape Province of South Africa...
Recurrent culture-confirmed tuberculosis in human immunodeficiency virus-infected childrenH Simon Schaaf
Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa
Pediatr Infect Dis J 24:685-91. 2005..CONCLUSION: Recurrent TB in HIV-infected children is common in a high burden TB setting. Both relapse and reinfection occur...
A proposed radiological classification of childhood intra-thoracic tuberculosisBen J Marais
Department of Paediatrics and Child Health, Centre for TB Research and Education CENTRE, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, PO Box 19063, Cape Town, South Africa
Pediatr Radiol 34:886-94. 2004..The hope is that the proposed classification will clarify concepts and stimulate discussion that may lead to future consensus...
A proposed comprehensive classification of tuberculosis disease severity in childrenCatherine A Wiseman
Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
Pediatr Infect Dis J 31:347-52. 2012..There is no existing approach that comprehensively characterizes the spectrum and severity of pediatric TB. This limits accurate classification of patients and comparison across cohorts...
Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South AfricaBen J Marais
Ukwanda Centre for Rural Health, Faculty of Health Sciences, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
J Clin Microbiol 44:3539-43. 2006..The overrepresentation of Beijing and Haarlem genotype families in children with drug-resistant TB demonstrates their contribution to transmitted drug resistance and their potential importance in the emergent drug-resistant TB epidemic...
Resistant Mycobacterium bovis Bacillus Calmette-Guérin disease: implications for management of Bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected childrenAnneke C Hesseling
Center for Tuberculosis Research and Education, Department of Pediatrics and Child Health, Tygerberg Children s Hospital, Tygerberg, South Africa
Pediatr Infect Dis J 23:476-9. 2004..Treatment guidelines for BCG disease with consideration of inherent and possible acquired drug resistance should be established in settings with high rates of vertical HIV transmission and routine BCG vaccination...
Effect of Ascaris Lumbricoides specific IgE on tuberculin skin test responses in children in a high-burden setting: a cross-sectional community-based studyNelda van Soelen
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
BMC Infect Dis 12:211. 2012..Our aim was to investigate whether helminth infection could influence the ability to generate an appropriate Th1 immune response that is characterized by a positive tuberculin skin test (TST), in M.tb exposed children...
Hearing loss in patients on treatment for drug-resistant tuberculosisJames A Seddon
Faculty of Health Sciences, Stellenbosch University
Eur Respir J 40:1277-86. 2012..Finally it makes the recommendation that a standardised testing methodology and classification system should be used...
Culture-confirmed multidrug-resistant tuberculosis in children: clinical features, treatment, and outcomeJames A Seddon
Desmond Tutu Tuberculosis Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
Clin Infect Dis 54:157-66. 2012..Multidrug-resistant (MDR) tuberculosis in children is frequently associated with delayed diagnosis and treatment. There is limited evidence regarding the management and outcome of children with MDR-tuberculosis...
Making BCG vaccination programmes safer in the HIV eraTippi K Mak
Department of Public Health and Epidemiology, Swiss Tropical Institute, CH-4002 Basel, Switzerland
Lancet 372:786-7. 2008
Tuberculous lymphadenitis as a cause of persistent cervical lymphadenopathy in children from a tuberculosis-endemic areaBen J Marais
Desmond Tutu TB Center and Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Cape Town, South Africa
Pediatr Infect Dis J 25:142-6. 2006....
Scoring systems for the diagnosis of childhood tuberculosis: are we making progress?Anneke C Hesseling
Int J Tuberc Lung Dis 11:245. 2007
