Quinton L Fivelman

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 1:1. 2002
  2. pmc Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum
    Quinton L Fivelman
    ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 48:4097-102. 2004
  3. ncbi request reprint Improved synchronous production of Plasmodium falciparum gametocytes in vitro
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 154:119-23. 2007
  4. pmc Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains
    Quinton L Fivelman
    Third Floor ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 51:2265-7. 2007
  5. pmc Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil
    Colin J Sutherland
    Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market, Capper St, London, WC1E 6AU, UK
    Malar J 7:240. 2008
  6. ncbi request reprint Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases
    David C Warhurst
    Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK
    Biochem Pharmacol 73:1910-26. 2007
  7. pmc Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes
    Sarah Sharp
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Eukaryot Cell 5:1206-14. 2006
  8. pmc Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Biol 6:e139. 2008
  9. doi request reprint A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum
    Werner Leber
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Int J Parasitol 39:645-53. 2009
  10. ncbi request reprint The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification
    Jason A Young
    Department of Cell Biology ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Biochem Parasitol 143:67-79. 2005

Collaborators

Detail Information

Publications10

  1. pmc Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 1:1. 2002
    ..The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously...
  2. pmc Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum
    Quinton L Fivelman
    ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 48:4097-102. 2004
    ..The relevance of in vitro interactions to in vivo treatment is discussed...
  3. ncbi request reprint Improved synchronous production of Plasmodium falciparum gametocytes in vitro
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 154:119-23. 2007
    ..The protocol described lends itself to large scale culturing and harvesting of synchronous parasites suitable for biochemical assays, northern blots, flow cytometry, microarrays and proteomic analysis...
  4. pmc Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains
    Quinton L Fivelman
    Third Floor ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 51:2265-7. 2007
    ..Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed...
  5. pmc Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil
    Colin J Sutherland
    Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market, Capper St, London, WC1E 6AU, UK
    Malar J 7:240. 2008
    ..Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for treatment of acute malaria cases in European hospitals and clinics...
  6. ncbi request reprint Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases
    David C Warhurst
    Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK
    Biochem Pharmacol 73:1910-26. 2007
    ..Importance of LAR for potency against CQ-R parasites probably reflects ability to block efflux by hydrophobic interaction with PfCRT but may relate to beta-haematin inhibition in vacuolar lipid...
  7. pmc Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes
    Sarah Sharp
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Eukaryot Cell 5:1206-14. 2006
    ..We also provide evidence that for both asexual parasites and gametocytes, var and stevor transcription patterns are not linked to each other...
  8. pmc Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Biol 6:e139. 2008
    ..falciparum, and demonstrates the feasibility of selective inhibition of a crucial regulator of the malaria parasite life cycle...
  9. doi request reprint A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum
    Werner Leber
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Int J Parasitol 39:645-53. 2009
    ....
  10. ncbi request reprint The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification
    Jason A Young
    Department of Cell Biology ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Biochem Parasitol 143:67-79. 2005
    ..gnf.org/publications/Gametocyte), shed light on the components of molecular mechanisms underlying parasite sexual development and other areas of malarial parasite biology...