Diana Elbourne

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. pmc Investigating the relationship between predictability and imbalance in minimisation: a simulation study
    Gladys C McPherson
    Health Services Research Unit, University of Aberdeen, Health Sciences Building, 3rd Floor Foresterhill, Aberdeen, AB25 2ZD, UK
    Trials 14:86. 2013
  2. pmc Use of randomisation in clinical trials: a survey of UK practice
    Gladys C McPherson
    Health Services Research Unit, University of Aberdeen, 3rd Floor, Foresterhill, Aberdeen, AB25 2ZD, UK
    Trials 13:198. 2012
  3. pmc Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital setting in Uganda: study protocol
    Nicola J Robertson
    Institute for Women s Health, 86 96 Chenies Mews, University College London, London, UK
    Trials 12:138. 2011
  4. pmc Alcohol and fatal life trajectories in Russia: understanding narrative accounts of premature male death in the family
    Lyudmila Saburova
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    BMC Public Health 11:481. 2011
  5. pmc Control of hyperglycaemia in paediatric intensive care (CHiP): study protocol
    Duncan Macrae
    Paediatric Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    BMC Pediatr 10:5. 2010
  6. pmc Maximising engagement, motivation and long term change in a Structured Intensive Education Programme in Diabetes for children, young people and their families: Child and Adolescent Structured Competencies Approach to Diabetes Education (CASCADE)
    Deborah Christie
    Child and Adolescent Psychological Services, University College Hospital, London, UK
    BMC Pediatr 9:57. 2009
  7. pmc Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Australia
    BMC Pediatr 10:15. 2010
  8. pmc Community health and medical provision: impact on neonates (the CHAMPION trial)
    Peter Boone
    Effective Intervention, Centre for Economic Performance, London School of Economics, Houghton Street, London, UK
    BMC Pediatr 7:26. 2007
  9. pmc Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported
    Marion K Campbell
    Health Services Research Unit, University of Aberdeen, Aberdeen, UK
    BMC Med Res Methodol 4:9. 2004
  10. pmc Assessing subgroup effects with binary data: can the use of different effect measures lead to different conclusions?
    Ian R White
    Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    BMC Med Res Methodol 5:15. 2005

Collaborators

Detail Information

Publications42

  1. pmc Investigating the relationship between predictability and imbalance in minimisation: a simulation study
    Gladys C McPherson
    Health Services Research Unit, University of Aberdeen, Health Sciences Building, 3rd Floor Foresterhill, Aberdeen, AB25 2ZD, UK
    Trials 14:86. 2013
    ....
  2. pmc Use of randomisation in clinical trials: a survey of UK practice
    Gladys C McPherson
    Health Services Research Unit, University of Aberdeen, 3rd Floor, Foresterhill, Aberdeen, AB25 2ZD, UK
    Trials 13:198. 2012
    ..However, there is uncertainty as to which is the most preferred method of randomisation in any given setting and to what extent more complex methods are actually being implemented in the field...
  3. pmc Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital setting in Uganda: study protocol
    Nicola J Robertson
    Institute for Women s Health, 86 96 Chenies Mews, University College London, London, UK
    Trials 12:138. 2011
    ..However, the greatest burden of perinatal asphyxia falls in low and mid-resource settings where it is unclear whether therapeutic hypothermia is safe and effective...
  4. pmc Alcohol and fatal life trajectories in Russia: understanding narrative accounts of premature male death in the family
    Lyudmila Saburova
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    BMC Public Health 11:481. 2011
    ..Building on an earlier case-control study, this unique qualitative study investigates the perceived interplay between men's drinking careers, their employment and family history, health and eventual death...
  5. pmc Control of hyperglycaemia in paediatric intensive care (CHiP): study protocol
    Duncan Macrae
    Paediatric Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    BMC Pediatr 10:5. 2010
    ..Children show similar hyperglycaemic responses to surgery or critical illness. However it is not known whether tight control will benefit children given maturational differences and different disease spectrum...
  6. pmc Maximising engagement, motivation and long term change in a Structured Intensive Education Programme in Diabetes for children, young people and their families: Child and Adolescent Structured Competencies Approach to Diabetes Education (CASCADE)
    Deborah Christie
    Child and Adolescent Psychological Services, University College Hospital, London, UK
    BMC Pediatr 9:57. 2009
    ..Therefore there is a need for novel interventions and health delivery mechanisms aimed at young people and their families to help improve control and reduce complications, illness burden and costs to the NHS...
  7. pmc Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis
    Lisa M Askie
    NHMRC Clinical Trials Centre, University of Sydney, Australia
    BMC Pediatr 10:15. 2010
    ....
  8. pmc Community health and medical provision: impact on neonates (the CHAMPION trial)
    Peter Boone
    Effective Intervention, Centre for Economic Performance, London School of Economics, Houghton Street, London, UK
    BMC Pediatr 7:26. 2007
    ..If successful, the trial is designed so that it should be possible to substantially scale up the project in regions with similarly high neonatal mortality throughout Andhra Pradesh and elsewhere...
  9. pmc Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported
    Marion K Campbell
    Health Services Research Unit, University of Aberdeen, Aberdeen, UK
    BMC Med Res Methodol 4:9. 2004
    ..Similarly, the need for appropriate standards of reporting of cluster trials is more widely acknowledged...
  10. pmc Assessing subgroup effects with binary data: can the use of different effect measures lead to different conclusions?
    Ian R White
    Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    BMC Med Res Methodol 5:15. 2005
    ..Risk ratios were similar between subgroups defined by level of clinical suspicion (P = 0.14), but odds ratios and risk differences differed strongly between subgroups (P < 0.001)...
  11. pmc The reporting of methods for reducing and detecting bias: an example from the WHO Misoprostol Third Stage of Labour equivalence randomised controlled trial
    Gilda Piaggio
    UNDP UNFPA WHO World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    BMC Med Res Methodol 3:19. 2003
    ....
  12. pmc Methods for economic evaluation of a factorial-design cluster randomised controlled trial of a nutrition supplement and an exercise programme among healthy older people living in Santiago, Chile: the CENEX study
    Damian G Walker
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    BMC Health Serv Res 9:85. 2009
    ..The purpose of this paper is to describe in detail the methods that will be used to estimate the incremental costs and cost-effectiveness of the interventions...
  13. pmc The HIM (Health for Izhevsk Men) trial protocol
    Susannah Tomkins
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Health Serv Res 8:69. 2008
    ....
  14. pmc CESAR: conventional ventilatory support vs extracorporeal membrane oxygenation for severe adult respiratory failure
    Giles J Peek
    Department of Cardiothoracic Surgery, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    BMC Health Serv Res 6:163. 2006
    ....
  15. pmc Methods of data collection and analysis for the economic evaluation alongside a national, multi-centre trial in the UK: conventional ventilation or ECMO for Severe Adult Respiratory Failure (CESAR)
    Mariamma M Thalanany
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR4 7TJ, UK
    BMC Health Serv Res 8:94. 2008
    ..Given the high cost of treatment, ECMO is considered an expensive technology for many funding systems. However, conventional treatment for severe respiratory failure is also one of the more costly forms of care in any health system...
  16. ncbi request reprint Ultrasonography in the diagnosis and management of developmental hip dysplasia (UK Hip Trial): clinical and economic results of a multicentre randomised controlled trial
    Diana Elbourne
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, UK
    Lancet 360:2009-17. 2002
    ..Our objectives were to assess clinical effectiveness and net cost of ultrasonography compared with clinical assessment alone, to provide guidance for management of infants with clinical hip instability...
  17. ncbi request reprint Extending the CONSORT statement to cluster randomized trials: for discussion
    D R Elbourne
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Stat Med 20:489-96. 2001
    ..These suggestions should be formally evaluated. Further work is required to consider the cases of more levels and of stratified or pair-matched cluster randomized trials...
  18. ncbi request reprint Meta-analyses involving cross-over trials: methodological issues
    Diana R Elbourne
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 31:140-9. 2002
    ..This paper concentrates on RCTs of a different design-two-period, two-treatment cross-over trials...
  19. pmc Hip dysplasia and ultrasound imaging of whole populations: the precautionary principle revisited
    D Elbourne
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Arch Dis Child Fetal Neonatal Ed 90:F2-3. 2005
  20. doi request reprint Views of emergency research (VERA): a qualitative study of women and their partners' views of recruitment to trials in severe postpartum haemorrhage
    Claire Snowdon
    Medical Statistics Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Midwifery 28:800-8. 2012
    ..to explore women's and their partners' views of recruitment to emergency trials in severe postpartum haemorrhage (PPH)...
  21. pmc The Good Schools Toolkit to prevent violence against children in Ugandan primary schools: study protocol for a cluster randomised controlled trial
    Karen M Devries
    London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK
    Trials 14:232. 2013
    ..We aim to evaluate the effectiveness of the Good School Toolkit, developed by Raising Voices, in preventing violence against children attending school and in improving child mental health and educational outcomes...
  22. ncbi request reprint Meta-analysis combining parallel and cross-over clinical trials. III: The issue of carry-over
    Francois Curtin
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, UK
    Stat Med 21:2161-73. 2002
    ....
  23. pmc A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]
    Alan D Dangour
    Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Nutr J 10:22. 2011
    ....
  24. pmc Grandparenting and psychosocial health among older Chileans: a longitudinal analysis
    Emily M Grundy
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Aging Ment Health 16:1047-57. 2012
    ..To investigate factors associated with Chilean grandparents' provision of help to grandchildren and associations between provision of such help and grandparents' mental well-being two years later...
  25. ncbi request reprint Meta-analysis combining parallel and cross-over clinical trials. II: Binary outcomes
    Francois Curtin
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, UK
    Stat Med 21:2145-59. 2002
    ..As its computation is similar in cross-over and parallel trials, it is the method of choice to pool results from parallel and cross-over trials in a combined design meta-analysis...
  26. doi request reprint Information-hungry and disempowered: a qualitative study of women and their partners' experiences of severe postpartum haemorrhage
    Claire Snowdon
    Medical Statistics Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Midwifery 28:791-9. 2012
    ..to explore how severe postpartum haemorrhage (PPH) and its management is experienced by women and their partners, and how they later view events...
  27. pmc The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials
    Claire Snowdon
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Trials 11:65. 2010
    ..These are essential prerequisites to considering the implications of future policies and practice subsequent to bereavement following a child's enrollment in a trial...
  28. pmc The STRIPES trial--support to rural India's public education system
    Alex Eble
    The London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trials 11:10. 2010
    ..In both intervention arms additional after-school instruction and learning materials will be offered to all eligible children and in one arm girls will also receive an additional 'kit' with a uniform and clothes...
  29. ncbi request reprint "It was a snap decision": parental and professional perspectives on the speed of decisions about participation in perinatal randomised controlled trials
    Claire Snowdon
    London School of Hygiene and Tropical Medicine, London, UK
    Soc Sci Med 62:2279-90. 2006
    ..Although there was evidence of parental vulnerability in each trial context, they largely felt that they acted swiftly and responsibly in the best interests of their child in accordance with the timeframes that were set for them...
  30. doi request reprint Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial
    Alan D Dangour
    London School of Hygiene and Tropical Medicine, United Kingdom
    Am J Clin Nutr 91:1725-32. 2010
    ..Increased consumption of n-3 (omega-3) long-chain polyunsaturated fatty acids (LC PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may maintain cognitive function in later life...
  31. pmc Effect of a nutrition supplement and physical activity program on pneumonia and walking capacity in Chilean older people: a factorial cluster randomized trial
    Alan D Dangour
    Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001023. 2011
    ..We investigated the effectiveness and cost-effectiveness of a national nutritional supplementation program and/or a physical activity intervention among older people in Chile...
  32. pmc A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPA
    Alan D Dangour
    Nutrition and Public Health Intervention Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Nutr J 5:20. 2006
    ..The link between cognitive ability, visual function and quality of life among older people suggests that this novel line of research may have considerable public health importance...
  33. pmc The EPICS Trial: Enabling Parents to Increase Child Survival through the introduction of community-based health interventions in rural Guinea Bissau
    Vera Mann
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    BMC Public Health 9:279. 2009
    ..Effective Intervention plans to expand the project to a much larger region if there is good evidence after two and a half years that the project is generating a cost-effective, sustainable reduction in child mortality...
  34. ncbi request reprint Meta-analysis combining parallel and cross-over clinical trials. I: Continuous outcomes
    Francois Curtin
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1 7HT, UK
    Stat Med 21:2131-44. 2002
    ..Differences in the weight estimation between WMD and SWMD can also accentuate the relative weight of cross-over trials, which must be considered a case of design-specific bias...
  35. pmc A factorial-design cluster randomised controlled trial investigating the cost-effectiveness of a nutrition supplement and an exercise programme on pneumonia incidence, walking capacity and body mass index in older people living in Santiago, Chile: the CEN
    Alan D Dangour
    Nutrition and Public Health Intervention Research Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Nutr J 6:14. 2007
    ..No information is currently available on the cost-effectiveness of the supplementation programme...
  36. pmc The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial
    Haleema Shakur
    Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trials 11:40. 2010
    ..At present there is little reliable evidence from randomised trials on the effectiveness of tranexamic acid in the treatment of postpartum haemorrhage...
  37. ncbi request reprint Data monitoring in randomized controlled trials: surveys of recent practice and policies
    Felicity Clemens
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Clin Trials 2:22-33. 2005
    ..Three interlinked surveys were carried out as part of the DAMOCLES project to explore recent and current DMC practice and policy...
  38. doi request reprint Effectiveness of bereavement interventions in neonatal intensive care: a review of the evidence
    Sheila Harvey
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Semin Fetal Neonatal Med 13:341-56. 2008
    ..Future research using innovative and sensitive RCTs and consensus amongst relevant stakeholders is suggested...
  39. pmc The efficacy of a brief intervention in reducing hazardous drinking in working age men in Russia: the HIM (Health for Izhevsk men) individually randomised parallel group exploratory trial
    Elizabeth Allen
    Medical Statistics Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Trials 12:238. 2011
    ....
  40. doi request reprint Improvement in neonatal intensive care unit care: a cluster randomised controlled trial of active dissemination of information
    Dominique Acolet
    Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK
    Arch Dis Child Fetal Neonatal Ed 96:F434-9. 2011
    ..Research findings are not rapidly or fully implemented into policies and practice in care...
  41. ncbi request reprint Equipoise: a case study of the views of clinicians involved in two neonatal trials
    Jo Garcia
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Clin Trials 1:170-8. 2004
    ....
  42. ncbi request reprint Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement
    Gilda Piaggio
    Statistics and Informatics Services Group, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    JAMA 295:1152-60. 2006
    ..The intent is to improve reporting of noninferiority and equivalence trials, enabling readers to assess the validity of their results and conclusions...