Affiliation: London School of Hygiene and Tropical Medicine
- Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial casesFrank Dudbridge
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Cancer Epidemiol Biomarkers Prev 21:262-72. 2012..This can be explained by incomplete linkage disequilibrium between the tested marker and the underlying causal variant...
- Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophreniaJames M S Wason
MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, UK
BMC Genet 11:80. 2010..This is compared to two other commonly used multimarker GLMs: one with a main-effect parameter for each SNP; one with a parameter for each haplotype...
- A flexible model for association analysis in sibships with missing genotype dataFrank Dudbridge
London School of Hygiene and Tropical Medicine, London, UK
Ann Hum Genet 75:428-38. 2011..Compared to summing over all possible untransmitted alleles, we achieve similar power with considerable reductions in computation time...
- 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association ConsortiumHelen Warren
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
Cancer Epidemiol Biomarkers Prev 21:1783-91. 2012..Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686)...
- Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in menNick Orr
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
PLoS Genet 7:e1002290. 2011..Additional studies of well-defined patient subgroups could provide further insight into the biological basis of breast cancer development...
- Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variationPetroula Proitsi
King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
Neurobiol Aging 33:1843.e9-17. 2012..Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD...