Frank Dudbridge

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi request reprint Gene-environment dependence creates spurious gene-environment interaction
    Frank Dudbridge
    Department of Non communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK Electronic address
    Am J Hum Genet 95:301-7. 2014
  2. pmc Conditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal
    Benjamin H Mullin
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    BMC Genet 14:107. 2013
  3. pmc Power and predictive accuracy of polygenic risk scores
    Frank Dudbridge
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Genet 9:e1003348. 2013
  4. pmc Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases
    Frank Dudbridge
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:262-72. 2012
  5. pmc Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia
    James M S Wason
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, UK
    BMC Genet 11:80. 2010
  6. ncbi request reprint A flexible model for association analysis in sibships with missing genotype data
    Frank Dudbridge
    London School of Hygiene and Tropical Medicine, London, UK
    Ann Hum Genet 75:428-38. 2011
  7. ncbi request reprint Genetic prediction of quantitative lipid traits: comparing shrinkage models to gene scores
    Helen Warren
    Department of Non communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Genet Epidemiol 38:72-83. 2014
  8. pmc 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium
    Helen Warren
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:1783-91. 2012
  9. pmc Early and current socio-economic position and cardiometabolic risk factors in the Indian Migration Study
    Ulla Sovio
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Eur J Prev Cardiol 20:844-53. 2013
  10. pmc Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men
    Nick Orr
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    PLoS Genet 7:e1002290. 2011

Detail Information

Publications15

  1. ncbi request reprint Gene-environment dependence creates spurious gene-environment interaction
    Frank Dudbridge
    Department of Non communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK Electronic address
    Am J Hum Genet 95:301-7. 2014
    ..In addition to existing concerns about mechanistic interpretations, we suggest further caution in reporting interactions for genetic markers. ..
  2. pmc Conditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal
    Benjamin H Mullin
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    BMC Genet 14:107. 2013
    ..The latter five SNPs were genotyped in this study to test for association with BMD parameters in a family-based population of 769 Caucasian women...
  3. pmc Power and predictive accuracy of polygenic risk scores
    Frank Dudbridge
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Genet 9:e1003348. 2013
    ..Therefore, polygenic scores currently have more utility for association testing than predicting complex traits, but prediction will become more feasible as sample sizes continue to grow...
  4. pmc Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases
    Frank Dudbridge
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:262-72. 2012
    ..This can be explained by incomplete linkage disequilibrium between the tested marker and the underlying causal variant...
  5. pmc Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia
    James M S Wason
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR, UK
    BMC Genet 11:80. 2010
    ..This is compared to two other commonly used multimarker GLMs: one with a main-effect parameter for each SNP; one with a parameter for each haplotype...
  6. ncbi request reprint A flexible model for association analysis in sibships with missing genotype data
    Frank Dudbridge
    London School of Hygiene and Tropical Medicine, London, UK
    Ann Hum Genet 75:428-38. 2011
    ..Compared to summing over all possible untransmitted alleles, we achieve similar power with considerable reductions in computation time...
  7. ncbi request reprint Genetic prediction of quantitative lipid traits: comparing shrinkage models to gene scores
    Helen Warren
    Department of Non communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Genet Epidemiol 38:72-83. 2014
    ..Instead, the most important choice for the prediction model is the number of SNPs and selection of the most predictive SNPs to include. However further comparisons, in larger samples and for other phenotypes, would still be of interest. ..
  8. pmc 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium
    Helen Warren
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 21:1783-91. 2012
    ..Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686)...
  9. pmc Early and current socio-economic position and cardiometabolic risk factors in the Indian Migration Study
    Ulla Sovio
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Eur J Prev Cardiol 20:844-53. 2013
    ..The aim of this study is to estimate the associations of early and current socio-economic position (SEP) on adult cardiometabolic risk factors in the Indian Migration Study (N = 7,067)...
  10. pmc Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men
    Nick Orr
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    PLoS Genet 7:e1002290. 2011
    ..Additional studies of well-defined patient subgroups could provide further insight into the biological basis of breast cancer development...
  11. pmc Two novel pathway analysis methods based on a hierarchical model
    Marina Evangelou
    Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, CB2 0SR, UK, JDRF Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK and Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Bioinformatics 30:690-7. 2014
    ..Hierarchical models have been advocated as a way to integrate SNP and pathway effects in the same model, but their computational complexity has prevented them being applied on a genome-wide scale to date...
  12. ncbi request reprint Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis
    Eleonora Staines-Urias
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Int J Epidemiol 41:1764-75. 2012
    ..Pre-eclampsia is thought to have a polygenic basis, but the identification of susceptibility genes and the quantification of associated risks have been elusive owing to lack of replication from published genetic association studies...
  13. ncbi request reprint Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits
    Richard J Silverwood
    Faculty of Epidemiology and Population Health, Centre for Statistical Methodology and Bloomsbury Centre for Genetic Epidemiology and Statistics, London School of Hygiene and Tropical Medicine, London, UK, Department of Epidemiology and Public Health, University College London, London, UK, MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK, Genetics, R and D, GlaxoSmithKline, Stevenage, UK, Division of Health Sciences, University of Warwick, Warwick, Coventry, UK, Center for Applied Genomics, Abramson Research Center, Children s Hospital of Philadelphia, Philadelphia, PA, USA and Institute of Cardiovascular Science, University College London, London, UK Faculty of Epidemiology and Population Health, Centre for Statistical Methodology and Bloomsbury Centre for Genetic Epidemiology and Statistics, London School of Hygiene and Tropical Medicine, London, UK, Department of Epidemiology and Public Health, University College London, London, UK, MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK, Genetics, R and D, GlaxoSmithKline, Stevenage, UK, Division of Health Sciences, University of Warwick, Warwick, Coventry, UK
    Int J Epidemiol 43:1781-90. 2014
    ..In principle, Mendelian randomization could address concerns that the apparent protective effect of light-to-moderate drinking might reflect 'sick-quitters' and confounding...
  14. pmc Evaluation of seven common lipid associated loci in a large Indian sib pair study
    Sajjad Rafiq
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lipids Health Dis 11:155. 2012
    ..Given the rising prevalence of metabolic disorders and heart disease in the Indian sub-continent, these studies could be of future clinical relevance...
  15. ncbi request reprint Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation
    Petroula Proitsi
    King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
    Neurobiol Aging 33:1843.e9-17. 2012
    ..Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD...